SI9011223B - Indenoindolne spojine - Google Patents

Indenoindolne spojine Download PDF

Info

Publication number: SI9011223B
Authority: SI; Slovenia
Prior art keywords: tetrahydro; formula; indole; cis; hydrogen
Prior art date: 1989-06-22

Application number

SI9011223A

Other languages

English (en)

Slovenian (sl)

Other versions

SI9011223A (en

Inventor

Malcolm Sainsbury

Howard G. Shertzer

Original Assignee

University Of Bath

University Of Cincinnati

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-22

Filing date

1990-06-22

Publication date

1998-08-31

1990-06-22 Application filed by University Of Bath, University Of Cincinnati filed Critical University Of Bath

1997-10-31 Publication of SI9011223A publication Critical patent/SI9011223A/sl

1998-08-31 Publication of SI9011223B publication Critical patent/SI9011223B/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Toxicology (AREA)
Hematology (AREA)
Diabetes (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

SI9011223A 1989-06-22 1990-06-22 Indenoindolne spojine SI9011223B (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8902274A SE8902274D0 (sv)	1989-06-22	1989-06-22	Indenoidole compounds ii
YU122390A YU122390A (sh)	1989-06-22	1990-06-22	Indenoindolova jedinjenja ii

Publications (2)

Publication Number	Publication Date
SI9011223A SI9011223A (en)	1997-10-31
SI9011223B true SI9011223B (sl)	1998-08-31

Family

ID=20376370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9011223A SI9011223B (sl)	1989-06-22	1990-06-22	Indenoindolne spojine

Country Status (34)

Country	Link
EP (1)	EP0409410B1 (xx)
JP (1)	JP3064411B2 (xx)
KR (1)	KR920702679A (xx)
CN (1)	CN1033029C (xx)
AT (1)	ATE135688T1 (xx)
BG (1)	BG60317B2 (xx)
CA (1)	CA2060897A1 (xx)
DD (1)	DD297960A5 (xx)
DE (1)	DE69025998T2 (xx)
DK (1)	DK0409410T3 (xx)
DZ (1)	DZ1428A1 (xx)
ES (1)	ES2084660T3 (xx)
FI (1)	FI100800B (xx)
GR (1)	GR3019779T3 (xx)
HR (1)	HRP920903B1 (xx)
HU (1)	HUT59097A (xx)
IE (1)	IE74682B1 (xx)
IL (1)	IL94830A (xx)
IS (1)	IS3590A7 (xx)
LT (1)	LT3675B (xx)
LV (1)	LV10253B (xx)
MX (1)	MX21244A (xx)
MY (1)	MY107311A (xx)
NO (1)	NO177932C (xx)
NZ (1)	NZ234175A (xx)
PL (1)	PL167761B1 (xx)
PT (1)	PT94468B (xx)
RO (1)	RO111573B1 (xx)
RU (1)	RU2104270C1 (xx)
SE (1)	SE8902274D0 (xx)
SI (1)	SI9011223B (xx)
WO (1)	WO1990015799A1 (xx)
YU (1)	YU122390A (xx)
ZA (1)	ZA904827B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT99232A (pt) *	1990-10-16	1992-09-30	Univ Bath	Processo de preparacao de compostos de indeno-indolo de composicoes farmaceuticas, e de estabilizacao de compostos susceptiveis de deterioracao oxidadtiva
JPH0656669A (ja) *	1992-06-11	1994-03-01	Asahi Breweries Ltd	活性酸素消去作用を持つプテリン誘導体製剤
SE9302431D0 (sv) *	1993-07-16	1993-07-16	Ab Astra	Use of indenoindole compounds
CA2128283A1 (fr) *	1993-07-20	1995-01-21	Paul Caubere	(thia)cycloalkyl¬b\|indoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2000034285A2 (en) *	1998-12-04	2000-06-15	American Home Products Corporation	Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
US6288099B1 (en)	1998-12-04	2001-09-11	American Home Products Corporation	Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
FR2826009B1 (fr) *	2001-06-13	2003-08-15	Servier Lab	Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US8153671B2 (en)	2005-07-14	2012-04-10	Irm Llc	Heterotetracyclic compounds as TPO mimetics
DE102006047231B4 (de) *	2006-10-04	2009-02-12	Hemmerling, Hans-Jörg, Dr.	Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
EP3597184A3 (en) *	2011-06-16	2020-04-22	Korea Research Institute of Chemical Technology	Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
ES2863985T3 (es)	2012-12-14	2021-10-13	Korea Res Inst Chemical Tech	Nuevo compuesto, sal farmacéuticamente aceptable o isómero óptico del mismo, método para prepararlo y composición farmacéutica para la prevención o el tratamiento de enfermedades virales que lo contienen como ingrediente activo
CN115916763A (zh)	2020-04-20	2023-04-04	诺华股份有限公司	抗病毒素1,3-二氧代茚化合物

1989
- 1989-06-22 SE SE8902274A patent/SE8902274D0/xx unknown
1990
- 1990-06-13 IS IS3590A patent/IS3590A7/is unknown
- 1990-06-20 AT AT90306718T patent/ATE135688T1/de active
- 1990-06-20 IE IE224790A patent/IE74682B1/en not_active IP Right Cessation
- 1990-06-20 DE DE69025998T patent/DE69025998T2/de not_active Expired - Fee Related
- 1990-06-20 JP JP2508940A patent/JP3064411B2/ja not_active Expired - Fee Related
- 1990-06-20 DZ DZ900114A patent/DZ1428A1/fr active
- 1990-06-20 WO PCT/GB1990/000949 patent/WO1990015799A1/en active IP Right Grant
- 1990-06-20 HU HU904825A patent/HUT59097A/hu unknown
- 1990-06-20 DK DK90306718.9T patent/DK0409410T3/da active
- 1990-06-20 MX MX21244A patent/MX21244A/es unknown
- 1990-06-20 RO RO149127A patent/RO111573B1/ro unknown
- 1990-06-20 RU SU5010937A patent/RU2104270C1/ru active
- 1990-06-20 EP EP90306718A patent/EP0409410B1/en not_active Expired - Lifetime
- 1990-06-20 PL PL90285752A patent/PL167761B1/pl unknown
- 1990-06-20 CA CA002060897A patent/CA2060897A1/en not_active Abandoned
- 1990-06-20 ES ES90306718T patent/ES2084660T3/es not_active Expired - Lifetime
- 1990-06-21 IL IL9483090A patent/IL94830A/en not_active IP Right Cessation
- 1990-06-21 DD DD90341939A patent/DD297960A5/de not_active IP Right Cessation
- 1990-06-21 MY MYPI90001050A patent/MY107311A/en unknown
- 1990-06-21 ZA ZA904827A patent/ZA904827B/xx unknown
- 1990-06-21 NZ NZ234175A patent/NZ234175A/xx unknown
- 1990-06-22 CN CN90104933A patent/CN1033029C/zh not_active Expired - Fee Related
- 1990-06-22 PT PT94468A patent/PT94468B/pt not_active IP Right Cessation
- 1990-06-22 SI SI9011223A patent/SI9011223B/sl unknown
- 1990-06-22 YU YU122390A patent/YU122390A/sh unknown
1991
- 1991-12-19 FI FI915999A patent/FI100800B/fi active
- 1991-12-20 NO NO915049A patent/NO177932C/no unknown
- 1991-12-20 BG BG095667A patent/BG60317B2/bg unknown
- 1991-12-23 KR KR1019910701951A patent/KR920702679A/ko not_active Application Discontinuation
1992
- 1992-10-02 HR HRP-1223/90A patent/HRP920903B1/xx not_active IP Right Cessation
1993
- 1993-06-14 LV LVP-93-568A patent/LV10253B/xx unknown
- 1993-08-30 LT LTIP912A patent/LT3675B/lt not_active IP Right Cessation
1996
- 1996-04-29 GR GR960401159T patent/GR3019779T3/el unknown

Also Published As

Publication number	Publication date
CA2060897A1 (en)	1990-12-23
ATE135688T1 (de)	1996-04-15
HRP920903A2 (hr)	1994-04-30
DD297960A5 (de)	1992-01-30
DZ1428A1 (fr)	2004-09-13
NO915049L (no)	1992-02-21
AU644084B2 (en)	1993-12-02
MX21244A (es)	1994-03-31
JPH04505923A (ja)	1992-10-15
IE74682B1 (en)	1997-07-30
ES2084660T3 (es)	1996-05-16
EP0409410B1 (en)	1996-03-20
BG60317B2 (bg)	1994-07-25
AU5836990A (en)	1991-01-08
HRP920903B1 (en)	1998-06-30
PL167761B1 (pl)	1995-10-31
NZ234175A (en)	1992-12-23
NO177932B (no)	1995-09-11
GR3019779T3 (en)	1996-07-31
LV10253A (lv)	1994-10-20
FI100800B (fi)	1998-02-27
PT94468A (pt)	1991-02-08
NO915049D0 (no)	1991-12-20
RU2104270C1 (ru)	1998-02-10
HUT59097A (en)	1992-04-28
HU904825D0 (en)	1992-03-30
LT3675B (en)	1996-01-25
PL285752A1 (en)	1991-03-11
JP3064411B2 (ja)	2000-07-12
WO1990015799A1 (en)	1990-12-27
FI915999A0 (fi)	1991-12-19
IE902247A1 (en)	1991-01-16
IS3590A7 (is)	1990-12-23
IL94830A0 (en)	1991-04-15
MY107311A (en)	1995-11-30
ZA904827B (en)	1991-04-24
SE8902274D0 (sv)	1989-06-22
DE69025998D1 (de)	1996-04-25
DE69025998T2 (de)	1996-08-08
YU122390A (sh)	1992-09-07
SI9011223A (en)	1997-10-31
CN1033029C (zh)	1996-10-16
PT94468B (pt)	1997-12-31
NO177932C (no)	1995-12-20
CN1051554A (zh)	1991-05-22
RO111573B1 (ro)	1996-11-29
LTIP912A (en)	1995-03-27
IE902247L (en)	1990-12-22
DK0409410T3 (da)	1996-04-29
LV10253B (en)	1995-04-20
IL94830A (en)	1996-07-23
EP0409410A1 (en)	1991-01-23
KR920702679A (ko)	1992-10-06

Publication	Publication Date	Title
SI9011223B (sl)	1998-08-31	Indenoindolne spojine
JP2019517487A (ja)	2019-06-24	Ｐｔｐｎ１１の複素環式阻害剤
CA2413424A1 (en)	2001-12-27	Substituted bicyclic derivatives for the treatment of abnormal cell growth
YU128091A (sh)	1994-01-20	Derivati hinuklidina
MA26679A1 (fr)	2004-12-20	Derives de quinoleine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
YU97292A (sh)	1995-10-24	N-fenilalanil i n-fenilglicil derivati dipeptida l-azetidin-2-karboksilne kiseline
CA2358998A1 (en)	2000-08-03	Substituted bicyclic derivatives useful as anticancer agents
CA2392973A1 (en)	2001-06-07	Benzoimidazole derivatives useful as antiproliferative agents
IE892293L (en)	1990-01-15	Pyrrolidinyl-3-quinolone and naphthyridone- carboxylic acid¹derivatives
SI9400091A (en)	1994-12-31	Substituted pyrrolo(2,3-b)pyridine derivatives
ATE172731T1 (de)	1998-11-15	Pyrazolopyridinverbindung und verfahren zu ihrer herstellung
BRPI0911577B1 (pt)	2021-02-23	Derivados espiro-indol, seus usos no tratamento de doençasparasíticas, e composição farmacêutica
RU94020400A (ru)	1995-11-10	Производные индола, способ их получения, фармацевтическая композиция, способ лечения головной боли
NL300053I2 (nl)	2002-04-02	Indoolderivaten voor een behandeling van migraine.
AR031198A1 (es)	2003-09-10	Procedimiento para la preparacion de derivados de ciclopenta(b)diazepino(6,7,1)indol
ES2701730T3 (es)	2019-02-25	Proceso para la preparación de (-)-Huperzina A
RU97108048A (ru)	1999-05-20	Диазепиноиндолы - ингибиторы фосфодиэстераз-iv
MXPA04005157A (es)	2004-08-11	Procedimientos para la preparacion de derivados biciclicos sustituidos para el tratamiento del crecimiento celular anormal.
IT9048086A1 (it)	1991-12-21	Composizioni farmaceutiche comprendenti 3-ammino-e-caprolattami per il potenziamento dei processi di apprendimento e della memoria.
EP3661912A1 (en)	2020-06-10	Compounds for treating infections
HU9502810D0 (en)	1995-11-28	Pyrido(1,2,3-de)quinoxaline derivatives, process for preparing the same and their use in medicaments
GB2047683A (en)	1980-12-03	Pyrido[3,4-e]-as-triazines
EP0727993A1 (en)	1996-08-28	(non descriptive)-a method for delaying hiv individual aids by administration of substituted azaspirane compounds
WO1993007871A1 (en)	1993-04-29	Methods for the treatment of hyperlipidemia using azaspiranes
CN1279241A (zh)	2001-01-10	四环氟喹诺酮羧酸,其制备方法及其为活性成分药物组合物