NO177932C - Analogifremgangsmåte ved fremstilling av terapeutisk aktive indenoindolforbindelser - Google Patents

Analogifremgangsmåte ved fremstilling av terapeutisk aktive indenoindolforbindelser

Info

Publication number: NO177932C
Authority: NO; Norway
Prior art keywords: lower alkyl; hydrogen; group; cor; preparation
Prior art date: 1989-06-22

Application number

NO915049A

Other languages

English (en)

Norwegian (no)

Other versions

NO915049L (no

NO177932B (no

NO915049D0 (no

Inventor

Malcolm Sainsbury

Howard G Shertzer

Original Assignee

Univ Bath

Univ Cincinnati

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-22

Filing date

1991-12-20

Publication date

1995-12-20

1991-12-20 Application filed by Univ Bath, Univ Cincinnati filed Critical Univ Bath

1991-12-20 Publication of NO915049D0 publication Critical patent/NO915049D0/no

1992-02-21 Publication of NO915049L publication Critical patent/NO915049L/no

1995-06-12 Priority to NO952303A priority Critical patent/NO300063B1/no

1995-09-11 Publication of NO177932B publication Critical patent/NO177932B/no

1995-12-20 Publication of NO177932C publication Critical patent/NO177932C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Toxicology (AREA)
Hematology (AREA)
Diabetes (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

NO915049A 1989-06-22 1991-12-20 Analogifremgangsmåte ved fremstilling av terapeutisk aktive indenoindolforbindelser NO177932C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO952303A NO300063B1 (no)	1989-06-22	1995-06-12	Nye indenoindolforbindelser og anvendelse av indenoindolforbindelsene som antioksydanter

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8902274A SE8902274D0 (sv)	1989-06-22	1989-06-22	Indenoidole compounds ii
PCT/GB1990/000949 WO1990015799A1 (en)	1989-06-22	1990-06-20	Indenoindole compounds ii

Publications (4)

Publication Number	Publication Date
NO915049D0 NO915049D0 (no)	1991-12-20
NO915049L NO915049L (no)	1992-02-21
NO177932B NO177932B (no)	1995-09-11
NO177932C true NO177932C (no)	1995-12-20

Family

ID=20376370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO915049A NO177932C (no)	1989-06-22	1991-12-20	Analogifremgangsmåte ved fremstilling av terapeutisk aktive indenoindolforbindelser

Country Status (34)

Country	Link
EP (1)	EP0409410B1 (xx)
JP (1)	JP3064411B2 (xx)
KR (1)	KR920702679A (xx)
CN (1)	CN1033029C (xx)
AT (1)	ATE135688T1 (xx)
BG (1)	BG60317B2 (xx)
CA (1)	CA2060897A1 (xx)
DD (1)	DD297960A5 (xx)
DE (1)	DE69025998T2 (xx)
DK (1)	DK0409410T3 (xx)
DZ (1)	DZ1428A1 (xx)
ES (1)	ES2084660T3 (xx)
FI (1)	FI100800B (xx)
GR (1)	GR3019779T3 (xx)
HR (1)	HRP920903B1 (xx)
HU (1)	HUT59097A (xx)
IE (1)	IE74682B1 (xx)
IL (1)	IL94830A (xx)
IS (1)	IS3590A7 (xx)
LT (1)	LT3675B (xx)
LV (1)	LV10253B (xx)
MX (1)	MX21244A (xx)
MY (1)	MY107311A (xx)
NO (1)	NO177932C (xx)
NZ (1)	NZ234175A (xx)
PL (1)	PL167761B1 (xx)
PT (1)	PT94468B (xx)
RO (1)	RO111573B1 (xx)
RU (1)	RU2104270C1 (xx)
SE (1)	SE8902274D0 (xx)
SI (1)	SI9011223B (xx)
WO (1)	WO1990015799A1 (xx)
YU (1)	YU122390A (xx)
ZA (1)	ZA904827B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT99232A (pt) *	1990-10-16	1992-09-30	Univ Bath	Processo de preparacao de compostos de indeno-indolo de composicoes farmaceuticas, e de estabilizacao de compostos susceptiveis de deterioracao oxidadtiva
JPH0656669A (ja) *	1992-06-11	1994-03-01	Asahi Breweries Ltd	活性酸素消去作用を持つプテリン誘導体製剤
SE9302431D0 (sv) *	1993-07-16	1993-07-16	Ab Astra	Use of indenoindole compounds
CA2128283A1 (fr) *	1993-07-20	1995-01-21	Paul Caubere	(thia)cycloalkyl¬b\|indoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2000034285A2 (en) *	1998-12-04	2000-06-15	American Home Products Corporation	Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
US6288099B1 (en)	1998-12-04	2001-09-11	American Home Products Corporation	Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
FR2826009B1 (fr) *	2001-06-13	2003-08-15	Servier Lab	Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US8153671B2 (en)	2005-07-14	2012-04-10	Irm Llc	Heterotetracyclic compounds as TPO mimetics
DE102006047231B4 (de) *	2006-10-04	2009-02-12	Hemmerling, Hans-Jörg, Dr.	Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
EP3597184A3 (en) *	2011-06-16	2020-04-22	Korea Research Institute of Chemical Technology	Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
ES2863985T3 (es)	2012-12-14	2021-10-13	Korea Res Inst Chemical Tech	Nuevo compuesto, sal farmacéuticamente aceptable o isómero óptico del mismo, método para prepararlo y composición farmacéutica para la prevención o el tratamiento de enfermedades virales que lo contienen como ingrediente activo
CN115916763A (zh)	2020-04-20	2023-04-04	诺华股份有限公司	抗病毒素1,3-二氧代茚化合物

1989
- 1989-06-22 SE SE8902274A patent/SE8902274D0/xx unknown
1990
- 1990-06-13 IS IS3590A patent/IS3590A7/is unknown
- 1990-06-20 AT AT90306718T patent/ATE135688T1/de active
- 1990-06-20 IE IE224790A patent/IE74682B1/en not_active IP Right Cessation
- 1990-06-20 DE DE69025998T patent/DE69025998T2/de not_active Expired - Fee Related
- 1990-06-20 JP JP2508940A patent/JP3064411B2/ja not_active Expired - Fee Related
- 1990-06-20 DZ DZ900114A patent/DZ1428A1/fr active
- 1990-06-20 WO PCT/GB1990/000949 patent/WO1990015799A1/en active IP Right Grant
- 1990-06-20 HU HU904825A patent/HUT59097A/hu unknown
- 1990-06-20 DK DK90306718.9T patent/DK0409410T3/da active
- 1990-06-20 MX MX21244A patent/MX21244A/es unknown
- 1990-06-20 RO RO149127A patent/RO111573B1/ro unknown
- 1990-06-20 RU SU5010937A patent/RU2104270C1/ru active
- 1990-06-20 EP EP90306718A patent/EP0409410B1/en not_active Expired - Lifetime
- 1990-06-20 PL PL90285752A patent/PL167761B1/pl unknown
- 1990-06-20 CA CA002060897A patent/CA2060897A1/en not_active Abandoned
- 1990-06-20 ES ES90306718T patent/ES2084660T3/es not_active Expired - Lifetime
- 1990-06-21 IL IL9483090A patent/IL94830A/en not_active IP Right Cessation
- 1990-06-21 DD DD90341939A patent/DD297960A5/de not_active IP Right Cessation
- 1990-06-21 MY MYPI90001050A patent/MY107311A/en unknown
- 1990-06-21 ZA ZA904827A patent/ZA904827B/xx unknown
- 1990-06-21 NZ NZ234175A patent/NZ234175A/xx unknown
- 1990-06-22 CN CN90104933A patent/CN1033029C/zh not_active Expired - Fee Related
- 1990-06-22 PT PT94468A patent/PT94468B/pt not_active IP Right Cessation
- 1990-06-22 SI SI9011223A patent/SI9011223B/sl unknown
- 1990-06-22 YU YU122390A patent/YU122390A/sh unknown
1991
- 1991-12-19 FI FI915999A patent/FI100800B/fi active
- 1991-12-20 NO NO915049A patent/NO177932C/no unknown
- 1991-12-20 BG BG095667A patent/BG60317B2/bg unknown
- 1991-12-23 KR KR1019910701951A patent/KR920702679A/ko not_active Application Discontinuation
1992
- 1992-10-02 HR HRP-1223/90A patent/HRP920903B1/xx not_active IP Right Cessation
1993
- 1993-06-14 LV LVP-93-568A patent/LV10253B/xx unknown
- 1993-08-30 LT LTIP912A patent/LT3675B/lt not_active IP Right Cessation
1996
- 1996-04-29 GR GR960401159T patent/GR3019779T3/el unknown

Also Published As

Publication number	Publication date
CA2060897A1 (en)	1990-12-23
ATE135688T1 (de)	1996-04-15
HRP920903A2 (hr)	1994-04-30
DD297960A5 (de)	1992-01-30
DZ1428A1 (fr)	2004-09-13
SI9011223B (sl)	1998-08-31
NO915049L (no)	1992-02-21
AU644084B2 (en)	1993-12-02
MX21244A (es)	1994-03-31
JPH04505923A (ja)	1992-10-15
IE74682B1 (en)	1997-07-30
ES2084660T3 (es)	1996-05-16
EP0409410B1 (en)	1996-03-20
BG60317B2 (bg)	1994-07-25
AU5836990A (en)	1991-01-08
HRP920903B1 (en)	1998-06-30
PL167761B1 (pl)	1995-10-31
NZ234175A (en)	1992-12-23
NO177932B (no)	1995-09-11
GR3019779T3 (en)	1996-07-31
LV10253A (lv)	1994-10-20
FI100800B (fi)	1998-02-27
PT94468A (pt)	1991-02-08
NO915049D0 (no)	1991-12-20
RU2104270C1 (ru)	1998-02-10
HUT59097A (en)	1992-04-28
HU904825D0 (en)	1992-03-30
LT3675B (en)	1996-01-25
PL285752A1 (en)	1991-03-11
JP3064411B2 (ja)	2000-07-12
WO1990015799A1 (en)	1990-12-27
FI915999A0 (fi)	1991-12-19
IE902247A1 (en)	1991-01-16
IS3590A7 (is)	1990-12-23
IL94830A0 (en)	1991-04-15
MY107311A (en)	1995-11-30
ZA904827B (en)	1991-04-24
SE8902274D0 (sv)	1989-06-22
DE69025998D1 (de)	1996-04-25
DE69025998T2 (de)	1996-08-08
YU122390A (sh)	1992-09-07
SI9011223A (en)	1997-10-31
CN1033029C (zh)	1996-10-16
PT94468B (pt)	1997-12-31
CN1051554A (zh)	1991-05-22
RO111573B1 (ro)	1996-11-29
LTIP912A (en)	1995-03-27
IE902247L (en)	1990-12-22
DK0409410T3 (da)	1996-04-29
LV10253B (en)	1995-04-20
IL94830A (en)	1996-07-23
EP0409410A1 (en)	1991-01-23
KR920702679A (ko)	1992-10-06

Publication	Publication Date	Title
SG120493G (en)	1994-01-21	N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof
NO177932C (no)	1995-12-20	Analogifremgangsmåte ved fremstilling av terapeutisk aktive indenoindolforbindelser
ES2006142A6 (es)	1989-04-16	Un metodo para preparar derivados de acidos quinolincarboxilicos
NO161564C (no)	1989-08-30	Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-oxadiazolylderivater.
AU591640B2 (en)	1989-12-14	Quinolonecarboxylic acid derivatives
DE69008142D1 (de)	1994-05-19	4-Substituierten Imidazolen zur Senkung des intraokularen Druckes.
NO881835D0 (no)	1988-04-27	Fremgangsmaate for fremstilling av terapeutisk aktive bicykliske forbindelser.
SE8902273D0 (sv)	1989-06-22	Indenoindole compounds i
GR3001955T3 (en)	1992-11-23	N-phenethylaminoalkyl-benzamide anti-arrhythmia agents
JO1676B1 (en)	1992-08-09	Extra compounds indinol II
DE3167347D1 (en)	1985-01-03	New benzothiazine derivatives, processes for preparation thereof and use thereof
AU566243B2 (en)	1987-10-15	Optically active imidazolylpropanols
DE3782229D1 (de)	1992-11-19	Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
GB2021587A (en)	1979-12-05	Benzoquinolizines