SI3560953T1 - Celica - Google Patents

Celica

Info

Publication number: SI3560953T1
Authority: SI; Slovenia
Prior art keywords: cell
Prior art date: 2014-12-24

Application number

SI201531999T

Other languages

English (en)

Inventor

Martin Pule

Shaun Cordoba

Shimobi Onuoha

Simon Thomas

Original Assignee

Autolus Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-12-24

Filing date

2015-12-23

Publication date

2024-05-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55066668&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3560953(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-12-23 Application filed by Autolus Limited filed Critical Autolus Limited

2024-05-31 Publication of SI3560953T1 publication Critical patent/SI3560953T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
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- A61K40/4212—CD22, BL-CAM, siglec-2 or sialic acid binding Ig-related lectin 2
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/80—Vaccine for a specifically defined cancer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/505—CD4; CD8
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
General Engineering & Computer Science (AREA)
Hematology (AREA)
Toxicology (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Oncology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Developmental Biology & Embryology (AREA)
Virology (AREA)

SI201531999T 2014-12-24 2015-12-23 Celica SI3560953T1 (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB201423172		2014-12-24
EP19172397.2A EP3560953B1 (en)	2014-12-24	2015-12-23	Cell

Publications (1)

Publication Number	Publication Date
SI3560953T1 true SI3560953T1 (sl)	2024-05-31

Family

ID=55066668

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI201531999T SI3560953T1 (sl)	2014-12-24	2015-12-23	Celica

Country Status (26)

Country	Link
US (7)	US11091532B2 (sl)
EP (3)	EP3560953B1 (sl)
JP (5)	JP6633081B2 (sl)
KR (6)	KR20230152824A (sl)
CN (2)	CN107002045A (sl)
AU (5)	AU2015370679C1 (sl)
BR (1)	BR112017013690A2 (sl)
CA (2)	CA2970440A1 (sl)
CL (3)	CL2017001314A1 (sl)
DK (2)	DK3560953T5 (sl)
ES (2)	ES2976197T3 (sl)
FI (1)	FI3560953T3 (sl)
HR (1)	HRP20240357T1 (sl)
HU (2)	HUE046262T2 (sl)
IL (4)	IL274903B (sl)
LT (1)	LT3560953T (sl)
MX (1)	MX2017006233A (sl)
PL (2)	PL3560953T3 (sl)
PT (2)	PT3560953T (sl)
RS (1)	RS65343B1 (sl)
RU (2)	RU2022102250A (sl)
SG (2)	SG11201704084VA (sl)
SI (1)	SI3560953T1 (sl)
SM (1)	SMT202400134T1 (sl)
WO (1)	WO2016102965A1 (sl)
ZA (1)	ZA201703381B (sl)

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EP4282419A1 (en)	2012-12-20	2023-11-29	Purdue Research Foundation	Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
GB201415347D0 (en) *	2014-08-29	2014-10-15	Ucl Business Plc	Signalling system
JP6633081B2 (ja)	2014-12-24	2020-01-22	ユーシーエルビジネスリミテッド	細胞
CN114891816B (zh)	2015-02-06	2025-01-21	新加坡国立大学	核酸、包含其的工程免疫细胞及其制备方法和用途
CA2978186A1 (en)	2015-03-05	2016-09-09	Fred Hutchinson Cancer Research Center	Immunomodulatory fusion proteins and uses thereof
GB201503742D0 (en)	2015-03-05	2015-04-22	Ucl Business Plc	Chimeric antigen receptor
PT3280729T (pt)	2015-04-08	2022-08-01	Novartis Ag	Terapias para cd20, terapias para cd22 e terapias de combinação com uma célula que expressa o recetor de antigénio quimérico (car) para cd19
GB201507115D0 (en) *	2015-04-27	2015-06-10	Ucl Business Plc	Nucleic Acid Construct
GB201507119D0 (en) *	2015-04-27	2015-06-10	Ucl Business Plc	Nucleic Acid Construct
US11173179B2 (en)	2015-06-25	2021-11-16	Icell Gene Therapeutics Llc	Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof
SG10201913682QA (en)	2015-06-25	2020-03-30	Icell Gene Therapeutics Llc	CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF
JP7282521B2 (ja)	2016-04-08	2023-05-29	パーデュー・リサーチ・ファウンデイション	Ｃａｒｔ細胞療法のための方法および組成物
GB201610512D0 (en)	2016-06-16	2016-08-03	Autolus Ltd	Chimeric antigen receptor
GB201610515D0 (en) *	2016-06-16	2016-08-03	Autolus Ltd	Cell
CN109562126A (zh)	2016-06-24	2019-04-02	美商生物细胞基因治疗有限公司	嵌合抗原受体(car)、组合物及其使用方法
CN117298260A (zh) *	2016-09-02	2023-12-29	莱蒂恩技术公司	用DuoCAR治疗癌症的组合物和方法
CA3039646A1 (en)	2016-10-07	2018-04-12	Novartis Ag	Chimeric antigen receptors for the treatment of cancer
JP2019536480A (ja)	2016-11-22	2019-12-19	ナショナルユニバーシティオブシンガポール	Ｔ細胞悪性腫瘍の免疫療法のためのｃｄ７発現およびキメラ抗原受容体の遮断
AU2017366739B2 (en)	2016-12-02	2023-11-23	Angeles Therapeutics, Inc.	Synthetic immune receptors and methods of use thereof
EP3556772A4 (en) *	2016-12-13	2020-09-09	Carsgen Therapeutics Ltd	HUMANIZED ANTI-CD19 ANTIBODY AND TARGETING IMMUNE EFFICIENT CELL CD19
US20190336533A1 (en) *	2016-12-28	2019-11-07	Green Cross Lab Cell Corporation	Chimeric antigen receptor and natural killer cells expressing same
US11649288B2 (en)	2017-02-07	2023-05-16	Seattle Children's Hospital	Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
EP4501352A3 (en)	2017-02-28	2025-04-16	Endocyte, Inc.	Compositions and methods for car t cell therapy
EP3595706A1 (en)	2017-03-17	2020-01-22	Fred Hutchinson Cancer Research Center	Immunomodulatory fusion proteins and uses thereof
EP3609914A4 (en) *	2017-04-14	2021-04-14	The General Hospital Corporation	LYMPHOCYTES T RECEPTOR OF CHEMERICAL ANTIGENS TARGETING THE TUMOR MICRO-ENVIRONMENT
ES2905377T3 (es) *	2017-04-18	2022-04-08	Autolus Ltd	Célula
US11344578B2 (en)	2017-04-19	2022-05-31	Board Of Regents, The University Of Texas System	Immune cells expressing engineered antigen receptors
KR20200005655A (ko)	2017-05-15	2020-01-15	더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈	비시스트론성 키메라성 항원 수용체 및 이의 용도
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CN109385402A (zh) *	2017-08-11	2019-02-26	上海恒润达生生物科技有限公司	一种等比例混合两种靶点cart细胞的制备方法及应用
CN107446937B (zh) *	2017-09-05	2020-12-25	深圳华云生物技术有限公司	嵌合抗原受体及其表达基因、光控调节的嵌合抗原受体修饰的t细胞及其应用
US20200230221A1 (en)	2017-09-19	2020-07-23	Massachusetts Institute Of Technology	Compositions for chimeric antigen receptor t cell therapy and uses thereof
CN111629735B (zh) *	2017-10-16	2024-05-17	莱蒂恩技术公司	用于用抗cd22免疫治疗来治疗癌症的组合物和方法
CN109988242A (zh) *	2018-01-02	2019-07-09	武汉波睿达生物科技有限公司	联合嵌合抗原受体、表达载体、慢病毒及t细胞
CN108101994B (zh) *	2018-01-04	2020-09-15	广东万海细胞生物科技有限公司	抗cd19抗体及其应用
SG11202006886VA (en)	2018-01-22	2020-08-28	Seattle Childrens Hospital Dba Seattle Childrens Res Inst	Methods of use for car t cells
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ES2976197T3 (es)	2024-07-26
SG10202111107RA (en)	2021-11-29
PT3560953T (pt)	2024-03-26
ES2744910T3 (es)	2020-02-26
CN114107212A (zh)	2022-03-01
KR20230152824A (ko)	2023-11-03
EP3560953A1 (en)	2019-10-30
AU2020213352A1 (en)	2020-08-27
RS65343B1 (sr)	2024-04-30
KR102376244B1 (ko)	2022-03-21
CA2970440A1 (en)	2016-06-30
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PL3237442T3 (pl)	2020-02-28
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