SI3494120T1 - Oksadiazolopiridinski derivati za uporabo kot inhibitorji grelin o-acil transferaze (GOAT) - Google Patents
Oksadiazolopiridinski derivati za uporabo kot inhibitorji grelin o-acil transferaze (GOAT)Info
- Publication number
- SI3494120T1 SI3494120T1 SI201730770T SI201730770T SI3494120T1 SI 3494120 T1 SI3494120 T1 SI 3494120T1 SI 201730770 T SI201730770 T SI 201730770T SI 201730770 T SI201730770 T SI 201730770T SI 3494120 T1 SI3494120 T1 SI 3494120T1
- Authority
- SI
- Slovenia
- Prior art keywords
- ghrelin
- goat
- inhibitors
- acyl transferase
- oxadiazolopyridine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16183047 | 2016-08-05 | ||
| EP17743064.2A EP3494120B1 (en) | 2016-08-05 | 2017-07-31 | Oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
| PCT/EP2017/069274 WO2018024653A1 (en) | 2016-08-05 | 2017-07-31 | Oxadiazolopyridine derivates for use as ghrelin o-acyl transferase (goat) inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3494120T1 true SI3494120T1 (sl) | 2021-08-31 |
Family
ID=56609762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201730770T SI3494120T1 (sl) | 2016-08-05 | 2017-07-31 | Oksadiazolopiridinski derivati za uporabo kot inhibitorji grelin o-acil transferaze (GOAT) |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US9994591B2 (sl) |
| EP (1) | EP3494120B1 (sl) |
| JP (1) | JP6651054B2 (sl) |
| KR (1) | KR102496075B1 (sl) |
| CN (1) | CN109843891B (sl) |
| AR (1) | AR109296A1 (sl) |
| AU (1) | AU2017307033B2 (sl) |
| CA (1) | CA3033058A1 (sl) |
| CL (1) | CL2019000274A1 (sl) |
| CO (1) | CO2019000601A2 (sl) |
| CY (1) | CY1124381T1 (sl) |
| DK (1) | DK3494120T3 (sl) |
| EA (1) | EA037277B1 (sl) |
| ES (1) | ES2874587T3 (sl) |
| HR (1) | HRP20210908T1 (sl) |
| HU (1) | HUE054928T2 (sl) |
| IL (1) | IL264506B (sl) |
| LT (1) | LT3494120T (sl) |
| MA (1) | MA45843B1 (sl) |
| MX (1) | MX2019001427A (sl) |
| MY (1) | MY197064A (sl) |
| PE (1) | PE20190414A1 (sl) |
| PH (1) | PH12019500254A1 (sl) |
| PL (1) | PL3494120T3 (sl) |
| PT (1) | PT3494120T (sl) |
| RS (1) | RS61937B1 (sl) |
| SA (1) | SA519401039B1 (sl) |
| SG (1) | SG11201811804QA (sl) |
| SI (1) | SI3494120T1 (sl) |
| TW (1) | TWI749042B (sl) |
| UA (1) | UA124267C2 (sl) |
| WO (1) | WO2018024653A1 (sl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7225253B2 (ja) * | 2018-02-02 | 2023-02-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのピラゾール置換及びインダゾール置換オキサジアゾロピリジン誘導体 |
| JP7083397B2 (ja) | 2018-02-02 | 2022-06-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのトリアゾロピリミジン誘導体 |
| PE20210175A1 (es) * | 2018-02-02 | 2021-01-29 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina sustituidos con heterociclilo para usar como inhibidores de ghrelin o-aciltransferasa (goat) |
| JP7015396B2 (ja) * | 2018-02-02 | 2022-02-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤としての、ベンジル－、（ピリジン－３－イル）メチル－または（ピリジン－４－イル）メチル置換オキサジアゾロピリジン誘導体 |
| TW202140440A (zh) | 2020-02-28 | 2021-11-01 | 美商克力歐普股份有限公司 | Gpr40激動劑 |
| EP4153599B1 (en) | 2020-05-22 | 2024-03-13 | Boehringer Ingelheim International GmbH | Process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate |
| JP2023526353A (ja) | 2020-05-22 | 2023-06-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルキル７－アミノ－５－メチル－［１，２，５］オキサジアゾロ［３，４－ｂ］ピリジンカルボキシレートの連続製造方法 |
| CN112014340A (zh) * | 2020-09-01 | 2020-12-01 | 广西玮美生物科技有限公司 | 非人灵长类动物胃饥饿素的检测方法 |
| CN118652261B (zh) * | 2024-05-29 | 2025-02-07 | 南京理工大学 | 一种耐热荧光活性含能化合物及其合成方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2241496B1 (es) | 2004-04-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridina. |
| CA2671984A1 (en) | 2006-12-11 | 2008-06-19 | Boehringer Ingelheim International Gmbh | New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds |
| US8454971B2 (en) | 2007-02-15 | 2013-06-04 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| US7994122B2 (en) | 2007-06-15 | 2011-08-09 | Zealand Pharma A/S | Glucagon analogues |
| EA020537B1 (ru) | 2008-12-15 | 2014-11-28 | Зилэнд Фарма А/С | Аналоги глюкагона |
| EA020520B1 (ru) | 2008-12-15 | 2014-11-28 | Зилэнд Фарма А/С | Аналоги глюкагона |
| CN102282166B (zh) | 2008-12-15 | 2015-04-01 | 西兰制药公司 | 胰高血糖素类似物 |
| EP2370462B1 (en) | 2008-12-15 | 2014-07-16 | Zealand Pharma A/S | Glucagon analogues |
| UA104766C2 (uk) | 2009-07-13 | 2014-03-11 | Зіленд Фарма А/С | Ацильовані аналоги глюкагону |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| KR20130086343A (ko) | 2010-06-24 | 2013-08-01 | 질랜드 파마 에이/에스 | 글루카곤 유사체 |
| MX2014007120A (es) | 2011-12-23 | 2015-03-05 | Boehringer Ingelheim Int | Analogos de glucagon. |
| EP2838891B1 (en) * | 2012-02-24 | 2017-08-02 | Takeda Pharmaceutical Company Limited | Aromatic ring compound as ghrelin o-acyltransferase inhibitor |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| UA118034C2 (uk) * | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
| EP3193939A4 (en) * | 2014-09-17 | 2018-10-24 | The Regents of The University of California | Small lipopeptidomimetic inhibitors of ghrelin o-acyl transferase |
| AR104673A1 (es) | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
| AR104672A1 (es) | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
| JP7083397B2 (ja) | 2018-02-02 | 2022-06-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのトリアゾロピリミジン誘導体 |
| JP7225253B2 (ja) * | 2018-02-02 | 2023-02-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤として使用するためのピラゾール置換及びインダゾール置換オキサジアゾロピリジン誘導体 |
| PE20210175A1 (es) * | 2018-02-02 | 2021-01-29 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina sustituidos con heterociclilo para usar como inhibidores de ghrelin o-aciltransferasa (goat) |
| JP7015396B2 (ja) * | 2018-02-02 | 2022-02-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グレリンｏ－アシルトランスフェラーゼ（ｇｏａｔ）阻害剤としての、ベンジル－、（ピリジン－３－イル）メチル－または（ピリジン－４－イル）メチル置換オキサジアゾロピリジン誘導体 |
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2017
- 2017-07-31 LT LTEP17743064.2T patent/LT3494120T/lt unknown
- 2017-07-31 KR KR1020197006448A patent/KR102496075B1/ko active Active
- 2017-07-31 SG SG11201811804QA patent/SG11201811804QA/en unknown
- 2017-07-31 MX MX2019001427A patent/MX2019001427A/es unknown
- 2017-07-31 PT PT177430642T patent/PT3494120T/pt unknown
- 2017-07-31 MA MA45843A patent/MA45843B1/fr unknown
- 2017-07-31 DK DK17743064.2T patent/DK3494120T3/da active
- 2017-07-31 AU AU2017307033A patent/AU2017307033B2/en active Active
- 2017-07-31 UA UAA201901840A patent/UA124267C2/uk unknown
- 2017-07-31 ES ES17743064T patent/ES2874587T3/es active Active
- 2017-07-31 RS RS20210702A patent/RS61937B1/sr unknown
- 2017-07-31 MY MYPI2018002719A patent/MY197064A/en unknown
- 2017-07-31 US US15/664,119 patent/US9994591B2/en active Active
- 2017-07-31 WO PCT/EP2017/069274 patent/WO2018024653A1/en active Application Filing
- 2017-07-31 EP EP17743064.2A patent/EP3494120B1/en active Active
- 2017-07-31 PL PL17743064T patent/PL3494120T3/pl unknown
- 2017-07-31 EA EA201990418A patent/EA037277B1/ru not_active IP Right Cessation
- 2017-07-31 CN CN201780047100.1A patent/CN109843891B/zh active Active
- 2017-07-31 CA CA3033058A patent/CA3033058A1/en active Pending
- 2017-07-31 SI SI201730770T patent/SI3494120T1/sl unknown
- 2017-07-31 PE PE2019000271A patent/PE20190414A1/es unknown
- 2017-07-31 JP JP2019506164A patent/JP6651054B2/ja active Active
- 2017-07-31 HU HUE17743064A patent/HUE054928T2/hu unknown
- 2017-08-04 AR ARP170102213A patent/AR109296A1/es unknown
- 2017-08-04 TW TW106126319A patent/TWI749042B/zh active
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2018
- 2018-05-09 US US15/974,882 patent/US10308667B2/en not_active Ceased
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2019
- 2019-01-22 CO CONC2019/0000601A patent/CO2019000601A2/es unknown
- 2019-01-28 IL IL264506A patent/IL264506B/en active IP Right Grant
- 2019-02-01 CL CL2019000274A patent/CL2019000274A1/es unknown
- 2019-02-05 SA SA519401039A patent/SA519401039B1/ar unknown
- 2019-02-06 PH PH12019500254A patent/PH12019500254A1/en unknown
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2020
- 2020-10-14 US US17/069,940 patent/USRE49446E1/en active Active
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2021
- 2021-06-08 HR HRP20210908TT patent/HRP20210908T1/hr unknown
- 2021-06-14 CY CY20211100525T patent/CY1124381T1/el unknown
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