PE20190414A1 - Derivados de oxadiazolopiridina para el uso como inhibidores de ghrelin o-aciltransferasa (goat) - Google Patents
Derivados de oxadiazolopiridina para el uso como inhibidores de ghrelin o-aciltransferasa (goat)Info
- Publication number
- PE20190414A1 PE20190414A1 PE2019000271A PE2019000271A PE20190414A1 PE 20190414 A1 PE20190414 A1 PE 20190414A1 PE 2019000271 A PE2019000271 A PE 2019000271A PE 2019000271 A PE2019000271 A PE 2019000271A PE 20190414 A1 PE20190414 A1 PE 20190414A1
- Authority
- PE
- Peru
- Prior art keywords
- ghrelin
- goat
- aciltransferase
- inhibitors
- oxadiazolopyridine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Referido a derivados de oxadiazolopiridina de formula (I), en donde X es CH o N; R1 se selecciona entre CH3, -CH2OH y Cl; R2 se selecciona, independientemente entre si, entre H, F, Cl, Br, I, CN, C1-6-alquilo, C3-7-cicloalquilo, entre otros; n es 1, 2 o 3. Estos compuestos se fijan a ghrelin O-acil transferasa (GOAT) e inhiben su actividad. Tambien se refiere a metodos de fabricacion y su uso adecuado para el tratamiento y la prevencion de enfermedades, tales como enfermedades metabolicas, diabetes mellitus tipo 2, la obesidad, entre otros.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16183047 | 2016-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20190414A1 true PE20190414A1 (es) | 2019-03-19 |
Family
ID=56609762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019000271A PE20190414A1 (es) | 2016-08-05 | 2017-07-31 | Derivados de oxadiazolopiridina para el uso como inhibidores de ghrelin o-aciltransferasa (goat) |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US9994591B2 (es) |
| EP (1) | EP3494120B1 (es) |
| JP (1) | JP6651054B2 (es) |
| KR (1) | KR102496075B1 (es) |
| CN (1) | CN109843891B (es) |
| AR (1) | AR109296A1 (es) |
| AU (1) | AU2017307033B2 (es) |
| CA (1) | CA3033058A1 (es) |
| CL (1) | CL2019000274A1 (es) |
| CO (1) | CO2019000601A2 (es) |
| CY (1) | CY1124381T1 (es) |
| DK (1) | DK3494120T3 (es) |
| EA (1) | EA037277B1 (es) |
| ES (1) | ES2874587T3 (es) |
| HR (1) | HRP20210908T1 (es) |
| HU (1) | HUE054928T2 (es) |
| IL (1) | IL264506B (es) |
| LT (1) | LT3494120T (es) |
| MA (1) | MA45843B1 (es) |
| MX (1) | MX384847B (es) |
| MY (1) | MY197064A (es) |
| PE (1) | PE20190414A1 (es) |
| PH (1) | PH12019500254A1 (es) |
| PL (1) | PL3494120T3 (es) |
| PT (1) | PT3494120T (es) |
| RS (1) | RS61937B1 (es) |
| SA (1) | SA519401039B1 (es) |
| SG (1) | SG11201811804QA (es) |
| SI (1) | SI3494120T1 (es) |
| TW (1) | TWI749042B (es) |
| UA (1) | UA124267C2 (es) |
| WO (1) | WO2018024653A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20200331A (es) * | 2018-02-02 | 2020-09-03 | Boehringer Ingelheim Int | Derivados de oxadiazolopirisdina sustituidos con heterociclilo para usar como inhibidores de ghrelin o-aciltrasferasa (goat) |
| WO2019149658A1 (en) * | 2018-02-02 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
| BR112020013082A2 (pt) | 2018-02-02 | 2020-12-01 | Boehringer Ingelheim International Gmbh | derivados de oxadiazolopiridina benzil-, (piridin-3-il)metil- ou (piridin-4-il)metil- substituídos como inibidores de grelina o-acil transferase (goat) |
| BR112020014436A2 (pt) | 2018-02-02 | 2020-12-01 | Boehringer Ingelheim International Gmbh | derivados de triazolopirimidina, composição farmacêutica e seus usos como inibidores de grelina o-acil transferase (goat) |
| EP4110788A4 (en) | 2020-02-28 | 2024-08-28 | Kallyope, Inc. | Gpr40 agonists |
| PL4153599T3 (pl) | 2020-05-22 | 2024-07-15 | Boehringer Ingelheim International Gmbh | Sposób wytwarzania 7-amino-5-metylo-[1,2,5]oksadiazolo[3,4-b]pirydynokarboksylanu alkilu |
| WO2021233884A1 (en) | 2020-05-22 | 2021-11-25 | Boehringer Ingelheim International Gmbh | Continuous process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate |
| CN112014340A (zh) * | 2020-09-01 | 2020-12-01 | 广西玮美生物科技有限公司 | 非人灵长类动物胃饥饿素的检测方法 |
| CN118652261B (zh) * | 2024-05-29 | 2025-02-07 | 南京理工大学 | 一种耐热荧光活性含能化合物及其合成方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2241496B1 (es) | 2004-04-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridina. |
| WO2008071646A1 (en) | 2006-12-11 | 2008-06-19 | Boehringer Ingelheim International Gmbh | New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds |
| JP6017754B2 (ja) | 2007-02-15 | 2016-11-02 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | グルカゴン／ｇｌｐ−１受容体コアゴニスト |
| EP2158214B1 (en) | 2007-06-15 | 2011-08-17 | Zealand Pharma A/S | Glucagon analogues |
| DK2370461T3 (da) | 2008-12-15 | 2013-12-16 | Zealand Pharma As | Glucagonanaloger |
| WO2010070255A1 (en) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Glucagon analogues |
| EA020520B1 (ru) | 2008-12-15 | 2014-11-28 | Зилэнд Фарма А/С | Аналоги глюкагона |
| KR20150116912A (ko) | 2008-12-15 | 2015-10-16 | 질랜드 파마 에이/에스 | 글루카곤 유사체 |
| EA022816B1 (ru) | 2009-07-13 | 2016-03-31 | Зилэнд Фарма А/С | Ацилированные аналоги глюкагона |
| UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
| EP2585482B1 (en) | 2010-06-24 | 2019-03-27 | Zealand Pharma A/S | Glucagon analogues |
| JP2015502380A (ja) | 2011-12-23 | 2015-01-22 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| EP2838891B1 (en) * | 2012-02-24 | 2017-08-02 | Takeda Pharmaceutical Company Limited | Aromatic ring compound as ghrelin o-acyltransferase inhibitor |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| UA118034C2 (uk) * | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
| EP3193939A4 (en) * | 2014-09-17 | 2018-10-24 | The Regents of The University of California | Small lipopeptidomimetic inhibitors of ghrelin o-acyl transferase |
| AR104673A1 (es) | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
| AR104672A1 (es) | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
| WO2019149658A1 (en) * | 2018-02-02 | 2019-08-08 | Boehringer Ingelheim International Gmbh | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
| BR112020014436A2 (pt) | 2018-02-02 | 2020-12-01 | Boehringer Ingelheim International Gmbh | derivados de triazolopirimidina, composição farmacêutica e seus usos como inibidores de grelina o-acil transferase (goat) |
| BR112020013082A2 (pt) | 2018-02-02 | 2020-12-01 | Boehringer Ingelheim International Gmbh | derivados de oxadiazolopiridina benzil-, (piridin-3-il)metil- ou (piridin-4-il)metil- substituídos como inibidores de grelina o-acil transferase (goat) |
| CR20200331A (es) | 2018-02-02 | 2020-09-03 | Boehringer Ingelheim Int | Derivados de oxadiazolopirisdina sustituidos con heterociclilo para usar como inhibidores de ghrelin o-aciltrasferasa (goat) |
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2017
- 2017-07-31 US US15/664,119 patent/US9994591B2/en active Active
- 2017-07-31 AU AU2017307033A patent/AU2017307033B2/en active Active
- 2017-07-31 EP EP17743064.2A patent/EP3494120B1/en active Active
- 2017-07-31 PE PE2019000271A patent/PE20190414A1/es unknown
- 2017-07-31 DK DK17743064.2T patent/DK3494120T3/da active
- 2017-07-31 PL PL17743064T patent/PL3494120T3/pl unknown
- 2017-07-31 RS RS20210702A patent/RS61937B1/sr unknown
- 2017-07-31 CN CN201780047100.1A patent/CN109843891B/zh active Active
- 2017-07-31 ES ES17743064T patent/ES2874587T3/es active Active
- 2017-07-31 HU HUE17743064A patent/HUE054928T2/hu unknown
- 2017-07-31 CA CA3033058A patent/CA3033058A1/en active Pending
- 2017-07-31 LT LTEP17743064.2T patent/LT3494120T/lt unknown
- 2017-07-31 MY MYPI2018002719A patent/MY197064A/en unknown
- 2017-07-31 MA MA45843A patent/MA45843B1/fr unknown
- 2017-07-31 MX MX2019001427A patent/MX384847B/es unknown
- 2017-07-31 KR KR1020197006448A patent/KR102496075B1/ko active Active
- 2017-07-31 JP JP2019506164A patent/JP6651054B2/ja active Active
- 2017-07-31 SI SI201730770T patent/SI3494120T1/sl unknown
- 2017-07-31 EA EA201990418A patent/EA037277B1/ru not_active IP Right Cessation
- 2017-07-31 WO PCT/EP2017/069274 patent/WO2018024653A1/en active Application Filing
- 2017-07-31 SG SG11201811804QA patent/SG11201811804QA/en unknown
- 2017-07-31 PT PT177430642T patent/PT3494120T/pt unknown
- 2017-07-31 UA UAA201901840A patent/UA124267C2/uk unknown
- 2017-08-04 AR ARP170102213A patent/AR109296A1/es unknown
- 2017-08-04 TW TW106126319A patent/TWI749042B/zh active
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2018
- 2018-05-09 US US15/974,882 patent/US10308667B2/en not_active Ceased
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2019
- 2019-01-22 CO CONC2019/0000601A patent/CO2019000601A2/es unknown
- 2019-01-28 IL IL264506A patent/IL264506B/en active IP Right Grant
- 2019-02-01 CL CL2019000274A patent/CL2019000274A1/es unknown
- 2019-02-05 SA SA519401039A patent/SA519401039B1/ar unknown
- 2019-02-06 PH PH12019500254A patent/PH12019500254A1/en unknown
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2020
- 2020-10-14 US US17/069,940 patent/USRE49446E1/en active Active
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2021
- 2021-06-08 HR HRP20210908TT patent/HRP20210908T1/hr unknown
- 2021-06-14 CY CY20211100525T patent/CY1124381T1/el unknown
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