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SI3157527T1 - Inhibitorji ezh2 za zdravljenje limfoma - Google Patents

Inhibitorji ezh2 za zdravljenje limfoma

Info

Publication number
SI3157527T1
SI3157527T1 SI201531951T SI201531951T SI3157527T1 SI 3157527 T1 SI3157527 T1 SI 3157527T1 SI 201531951 T SI201531951 T SI 201531951T SI 201531951 T SI201531951 T SI 201531951T SI 3157527 T1 SI3157527 T1 SI 3157527T1
Authority
SI
Slovenia
Prior art keywords
ezh2 inhibitors
treating lymphoma
lymphoma
treating
ezh2
Prior art date
Application number
SI201531951T
Other languages
English (en)
Inventor
Heike Keilhack
Lone Ottesen
Larisa Reyderman
L. Danielle JOHNSTON
Sarah K. Knutson
Original Assignee
Epizyme, Inc.
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme, Inc., Eisai R&D Management Co., Ltd. filed Critical Epizyme, Inc.
Publication of SI3157527T1 publication Critical patent/SI3157527T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201531951T 2014-06-17 2015-06-17 Inhibitorji ezh2 za zdravljenje limfoma SI3157527T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462013522P 2014-06-17 2014-06-17
US201462036265P 2014-08-12 2014-08-12
EP15809540.6A EP3157527B1 (en) 2014-06-17 2015-06-17 Ezh2 inhibitors for treating lymphoma
PCT/US2015/036310 WO2015195848A1 (en) 2014-06-17 2015-06-17 Ezh2 inhibitors for treating lymphoma

Publications (1)

Publication Number Publication Date
SI3157527T1 true SI3157527T1 (sl) 2023-09-29

Family

ID=54936086

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201531951T SI3157527T1 (sl) 2014-06-17 2015-06-17 Inhibitorji ezh2 za zdravljenje limfoma

Country Status (21)

Country Link
US (5) US10166238B2 (sl)
EP (2) EP4252851A3 (sl)
JP (1) JP6779793B2 (sl)
KR (2) KR102497728B1 (sl)
CN (2) CN113289022A (sl)
AU (3) AU2015277139A1 (sl)
BR (1) BR112016029492A2 (sl)
CA (1) CA2952074C (sl)
DK (1) DK3157527T3 (sl)
EA (1) EA038337B1 (sl)
ES (1) ES2948442T3 (sl)
FI (1) FI3157527T3 (sl)
HU (1) HUE062158T2 (sl)
IL (3) IL309539A (sl)
LT (1) LT3157527T (sl)
MX (2) MX2021007651A (sl)
PL (1) PL3157527T3 (sl)
PT (1) PT3157527T (sl)
SG (2) SG10201811128RA (sl)
SI (1) SI3157527T1 (sl)
WO (1) WO2015195848A1 (sl)

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CA2841142C (en) 2010-06-23 2020-12-15 Ryan D. Morin Biomarkers for non-hodgkin lymphomas and uses thereof
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EP3659606A1 (en) 2012-10-15 2020-06-03 Epizyme, Inc. Methods of treating cancer
ES2863996T3 (es) 2013-12-06 2021-10-13 Epizyme Inc Terapia de combinación para el tratamiento del cáncer
SG10201811128RA (en) * 2014-06-17 2019-01-30 Epizyme Inc Ezh2 inhibitors for treating lymphoma
AU2015331729A1 (en) * 2014-10-16 2017-04-13 Epizyme, Inc. Method for treating cancer
MX383484B (es) * 2014-11-17 2025-03-11 Epizyme Inc Método para tratar el cáncer.
AR102767A1 (es) 2014-12-05 2017-03-22 Lilly Co Eli Inhibidores de ezh2
SG11201708286PA (en) 2015-04-20 2017-11-29 Epizyme Inc Combination therapy for treating cancer
AU2016275051A1 (en) 2015-06-10 2017-12-07 Epizyme, Inc. EZH2 inhibitors for treating lymphoma
SG10201909199PA (en) 2015-08-24 2019-11-28 Epizyme Inc Method for treating cancer
TW201718598A (zh) 2015-08-27 2017-06-01 美國禮來大藥廠 Ezh2抑制劑
CA3011186A1 (en) 2016-01-29 2017-08-03 Epizyme, Inc. Combination therapy for treating cancer
WO2017210395A1 (en) 2016-06-01 2017-12-07 Epizyme, Inc. Use of ezh2 inhibitors for treating cancer
US11147819B2 (en) 2016-06-17 2021-10-19 Epizyme, Inc. EZH2 inhibitors for treating cancer
CA3050696A1 (en) * 2017-01-20 2018-07-26 Constellation Pharmaceuticals, Inc. Solid dispersions of (r)-n-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1h-indole-3-carboxamide
US11642346B2 (en) 2017-03-31 2023-05-09 Epizyme, Inc. Combination therapy for treating cancer
AU2018275123A1 (en) 2017-06-02 2020-01-30 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
WO2019014191A1 (en) * 2017-07-10 2019-01-17 Constellation Pharmaceuticals, Inc. GENE EXPRESSION INDUCED BY EZH2 INHIBITOR
JP7399079B2 (ja) 2017-09-05 2023-12-15 エピザイム,インコーポレイティド 癌を処置するための併用療法
US20220298222A1 (en) * 2019-08-22 2022-09-22 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and an enhancer of zeste homolog 2 (ezh2) inhibitor and related methods
CN110960525A (zh) * 2019-11-26 2020-04-07 济南大学 新型eed-ezh2相互作用抑制剂的确定和评价
CN110950834A (zh) * 2019-11-26 2020-04-03 济南大学 新型eed-ezh2相互作用小分子抑制剂的确定和评价
AU2021280314A1 (en) * 2020-05-28 2022-12-08 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
WO2024229406A1 (en) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors

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CA2810998C (en) * 2010-09-10 2024-04-09 Robert Allen Copeland Inhibitors of human ezh2, and methods of use thereof
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TW201733984A (zh) 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
CA2850570A1 (en) 2011-09-30 2013-04-04 Glaxosmithkline Llc Methods of treating cancer
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HRP20170295T1 (hr) 2012-04-13 2017-04-21 Epizyme, Inc. Oblik soli inhibitora ljudske histonske metiltransferaze ezh2
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KR20170095656A (ko) 2016-02-15 2017-08-23 동부대우전자 주식회사 방열구조를 갖는 세탁기

Also Published As

Publication number Publication date
AU2020244382A1 (en) 2020-10-29
US10166238B2 (en) 2019-01-01
DK3157527T3 (da) 2023-07-03
EA038337B1 (ru) 2021-08-11
MX2016016744A (es) 2017-11-30
ES2948442T3 (es) 2023-09-12
IL309539A (en) 2024-02-01
HUE062158T2 (hu) 2023-10-28
AU2022263523A1 (en) 2022-12-08
IL285201B1 (en) 2024-01-01
IL285201A (en) 2021-08-31
PL3157527T3 (pl) 2023-08-07
CA2952074C (en) 2022-08-30
US20170216300A1 (en) 2017-08-03
MX2021007651A (es) 2021-08-11
CA2952074A1 (en) 2015-12-23
US11642347B2 (en) 2023-05-09
EP3157527A4 (en) 2018-05-23
EA201692285A1 (ru) 2017-06-30
EP3157527B1 (en) 2023-05-24
CN106999498B (zh) 2021-06-08
AU2020244382B2 (en) 2022-08-04
BR112016029492A2 (pt) 2017-10-17
EP4252851A3 (en) 2023-11-22
SG11201610273VA (en) 2017-01-27
SG10201811128RA (en) 2019-01-30
CN113289022A (zh) 2021-08-24
US20200022987A1 (en) 2020-01-23
FI3157527T3 (fi) 2023-07-25
JP2017518334A (ja) 2017-07-06
EP3157527A1 (en) 2017-04-26
WO2015195848A8 (en) 2016-07-07
KR102497728B1 (ko) 2023-02-09
PT3157527T (pt) 2023-06-30
JP6779793B2 (ja) 2020-11-04
CN106999498A (zh) 2017-08-01
IL285201B2 (en) 2024-05-01
US20190175604A1 (en) 2019-06-13
US20200323866A1 (en) 2020-10-15
EP4252851A2 (en) 2023-10-04
MX383866B (es) 2025-03-14
WO2015195848A1 (en) 2015-12-23
IL249438A0 (en) 2017-02-28
LT3157527T (lt) 2023-07-25
US20240058348A1 (en) 2024-02-22
NZ727108A (en) 2023-09-29
KR20230031963A (ko) 2023-03-07
AU2015277139A1 (en) 2016-12-22
EA201692285A8 (ru) 2018-01-31
KR20170052558A (ko) 2017-05-12

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