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SI3153171T1 - Samidorfan (ALKS 33) v kombinaciji z buprenorfinom za zdravljenje depresivnih motenj - Google Patents

Samidorfan (ALKS 33) v kombinaciji z buprenorfinom za zdravljenje depresivnih motenj

Info

Publication number
SI3153171T1
SI3153171T1 SI201231474T SI201231474T SI3153171T1 SI 3153171 T1 SI3153171 T1 SI 3153171T1 SI 201231474 T SI201231474 T SI 201231474T SI 201231474 T SI201231474 T SI 201231474T SI 3153171 T1 SI3153171 T1 SI 3153171T1
Authority
SI
Slovenia
Prior art keywords
samidorphan
alks
buprenorphine
treatment
combination
Prior art date
Application number
SI201231474T
Other languages
English (en)
Inventor
Daniel Deaver
Elliott Ehrich
Original Assignee
Alkermes Pharma Ireland Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Pharma Ireland Limited filed Critical Alkermes Pharma Ireland Limited
Publication of SI3153171T1 publication Critical patent/SI3153171T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4748Quinolines; Isoquinolines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201231474T 2011-12-15 2012-12-14 Samidorfan (ALKS 33) v kombinaciji z buprenorfinom za zdravljenje depresivnih motenj SI3153171T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161576233P 2011-12-15 2011-12-15
EP16201359.3A EP3153171B1 (en) 2011-12-15 2012-12-14 Samidorphan (alks 33) in combination with buprenorphine for the treatment of depressive disorders

Publications (1)

Publication Number Publication Date
SI3153171T1 true SI3153171T1 (sl) 2019-01-31

Family

ID=47757653

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201231474T SI3153171T1 (sl) 2011-12-15 2012-12-14 Samidorfan (ALKS 33) v kombinaciji z buprenorfinom za zdravljenje depresivnih motenj

Country Status (25)

Country Link
US (8) US8822488B2 (sl)
EP (3) EP3415148A1 (sl)
JP (2) JP6038170B2 (sl)
KR (1) KR101996108B1 (sl)
CN (2) CN104159586A (sl)
AU (1) AU2012351806C1 (sl)
BR (1) BR112014012409B8 (sl)
CA (1) CA2858812C (sl)
CY (1) CY1121081T1 (sl)
DK (1) DK3153171T3 (sl)
EA (1) EA030609B8 (sl)
ES (2) ES2692771T3 (sl)
HR (1) HRP20181950T1 (sl)
HU (1) HUE041883T2 (sl)
IL (1) IL232785B (sl)
LT (1) LT3153171T (sl)
MX (1) MX375348B (sl)
PL (1) PL3153171T3 (sl)
PT (1) PT3153171T (sl)
RS (1) RS58322B1 (sl)
SI (1) SI3153171T1 (sl)
SM (1) SMT201800664T1 (sl)
TR (1) TR201815154T4 (sl)
WO (1) WO2013088243A1 (sl)
ZA (1) ZA201405029B (sl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE043963T2 (hu) 2009-12-04 2019-09-30 Alkermes Pharma Ireland Ltd Morfinán származékok gyógyszer-túladagolás kezelésére
PT3446565T (pt) 2010-08-23 2024-01-29 Alkermes Pharma Ireland Ltd Métodos para tratar o aumento de peso induzido por antipsicóticos
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
CA2858812C (en) 2011-12-15 2019-02-26 Alkermes Pharma Ireland Limited Compositions of buprenorphine and mu-opioid receptor antagonists
US9656961B2 (en) 2013-05-24 2017-05-23 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
WO2014190270A1 (en) 2013-05-24 2014-11-27 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
TWI768557B (zh) 2015-02-02 2022-06-21 美商佛瑪治療公司 作為hdac抑制劑之3-烷基-4-醯胺基-雙環[4,5,0]羥肟酸
WO2016126726A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors
US10555935B2 (en) 2016-06-17 2020-02-11 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors
WO2022101444A1 (en) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

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US3856795A (en) 1972-04-25 1974-12-24 American Home Prod Process for preparation of secondary amines from tertiary amines
US4032529A (en) 1974-09-20 1977-06-28 Sterling Drug Inc. Aminomethanobenzazocine intermediates
US3957793A (en) 1974-09-20 1976-05-18 Sterling Drug Inc. Hydroxyiminobenzazocines
US4127577A (en) 1975-11-24 1978-11-28 Sterling Drug Inc. Aminomethanobenzazocine process
US4205171A (en) 1976-01-12 1980-05-27 Sterling Drug Inc. Aminomethanobenzazocines and nitromethanobenzazocines
US4464378A (en) 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
GB8332556D0 (en) * 1983-12-06 1984-01-11 Reckitt & Colmann Prod Ltd Analgesic compositions
US4649200A (en) 1986-05-08 1987-03-10 Regents Of The University Of Minnesota Substituted pyrroles with opioid receptor activity
US4939264A (en) 1986-07-14 1990-07-03 Abbott Laboratories Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
US5258386A (en) 1991-06-05 1993-11-02 The United States Of America As Represented By The Secretary Of The Army (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents
US5607941A (en) 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
SE9103745D0 (sv) 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
EP0632041A1 (en) 1993-07-01 1995-01-04 Katholieke Universiteit Nijmegen New morphine derivatives having improved analgesic and narcotic properties
ATE229958T1 (de) 1996-01-10 2003-01-15 Glaxosmithkline Spa Heterocyclische kondensierte morphin-derivate
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WO2003079945A1 (en) * 2002-03-20 2003-10-02 Euro-Celtique S.A. Method of administering buprenorphine to treat depression
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ES2440590T3 (es) 2005-03-02 2014-01-29 Takeda Gmbh Nuevas sales de derivados de hexahidrofenantridina 6-heterociclil-sustituidos
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ES2586245T3 (es) 2007-08-09 2016-10-13 Rensselaer Polytechnic Institute Carboxamidas cuaternarias opioides
WO2009103004A1 (en) * 2008-02-14 2009-08-20 Alkermes, Inc. Selective opioid compounds
WO2009126931A2 (en) * 2008-04-11 2009-10-15 Xvasive, Inc. Combination therapy for bipolar disorder
EP2408303A4 (en) * 2009-03-19 2012-07-25 Alkermes Inc MORPHINANE DERIVATIVES HAVING HIGH ORAL BIOLOGICAL AVAILABILITY
US20120149724A1 (en) 2009-06-04 2012-06-14 The General Hospital Corporation Modulating endogenous beta-endorphin levels
US8530479B2 (en) * 2009-08-10 2013-09-10 Daljit Singh Dhanoa Deuterium-enriched alkyl sulfonamides
HUE043963T2 (hu) * 2009-12-04 2019-09-30 Alkermes Pharma Ireland Ltd Morfinán származékok gyógyszer-túladagolás kezelésére
US9211293B2 (en) * 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
CA2858812C (en) 2011-12-15 2019-02-26 Alkermes Pharma Ireland Limited Compositions of buprenorphine and mu-opioid receptor antagonists
US9656961B2 (en) * 2013-05-24 2017-05-23 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms

Also Published As

Publication number Publication date
PL3153171T3 (pl) 2019-02-28
US20190247387A1 (en) 2019-08-15
US9913837B2 (en) 2018-03-13
IL232785A0 (en) 2014-07-31
BR112014012409B1 (pt) 2022-08-23
AU2012351806C1 (en) 2016-06-16
EA030609B8 (ru) 2018-10-31
CA2858812A1 (en) 2013-06-20
US20180078543A1 (en) 2018-03-22
ZA201405029B (en) 2015-10-28
MX2014007042A (es) 2015-01-22
NZ624056A (en) 2016-07-29
US8822488B2 (en) 2014-09-02
JP6038170B2 (ja) 2016-12-07
ES2692771T3 (es) 2018-12-05
KR101996108B1 (ko) 2019-10-01
MX375348B (es) 2025-03-06
US9918978B2 (en) 2018-03-20
CN104159586A (zh) 2014-11-19
CN106727562B (zh) 2019-07-05
US20150051240A1 (en) 2015-02-19
US20130190342A1 (en) 2013-07-25
BR112014012409A2 (pt) 2017-06-13
CN106727562A (zh) 2017-05-31
JP2016222706A (ja) 2016-12-28
US10188643B2 (en) 2019-01-29
RS58322B1 (sr) 2019-03-29
KR20140107258A (ko) 2014-09-04
DK3153171T3 (en) 2018-11-19
WO2013088243A1 (en) 2013-06-20
US20170056392A1 (en) 2017-03-02
EP2790702B1 (en) 2020-04-01
US20160256450A1 (en) 2016-09-08
EA030609B1 (ru) 2018-08-31
LT3153171T (lt) 2018-12-10
AU2012351806B2 (en) 2016-03-10
JP2015505853A (ja) 2015-02-26
EP3153171A1 (en) 2017-04-12
US20180078542A1 (en) 2018-03-22
US10806731B2 (en) 2020-10-20
EP2790702A1 (en) 2014-10-22
HRP20181950T1 (hr) 2019-03-22
CA2858812C (en) 2019-02-26
BR112014012409B8 (pt) 2022-09-13
TR201815154T4 (tr) 2018-11-21
SMT201800664T1 (it) 2019-01-11
ES2791764T3 (es) 2020-11-05
US20210196703A1 (en) 2021-07-01
EP3153171B1 (en) 2018-09-19
EP3415148A1 (en) 2018-12-19
EA201491153A1 (ru) 2015-04-30
US9498474B2 (en) 2016-11-22
IL232785B (en) 2021-04-29
PT3153171T (pt) 2018-11-16
HUE041883T2 (hu) 2019-06-28
US10314838B2 (en) 2019-06-11
JP6403726B2 (ja) 2018-10-10
CY1121081T1 (el) 2019-12-11
AU2012351806A1 (en) 2014-05-15

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