SI22407A - Application of coenzyme q10 for more effective breeding of animals and obtaining animal tissues with increased content of this coenzyme - Google Patents

Abstract

The subject of invention is a new application of coenzyme Q10 as additive or supplement to animal fodder or liquids for animals in their breeding to increase the efficiency of breeding and enrich animal tissues, particularly meat, with coenzyme Q10. The subjects of invention are also animal tissues, first of all coenzyme Q10-enriched meat. In addition to all kinds of meat, bone, skin, etc., poultry eggs and milk from diary animals are also understood under animal tissues in the frame of the invention. The invention comprises the application of coenzyme Q10 for a more efficient breeding of animals and obtaining of meat with increased content of this coenzyme, where the transfer of coenzyme Q10 into animals is done through ingestion or direct transfer into or onto the body, where coenzyme Q10 is in a suitable water-soluble or water-insoluble form, preferentially in a form with increased bioavailability, so that animals ingest or are given enzyme Q10 in other ways all their life or for a certain period any time in their life, preferably in the phases of growth, and/or for any period prior to slaughter, still more preferably during the phases of growth and/or 3 to 90 days prior to slaughter, and that animals ingest it in quantities of 1 to 1000 mg, more preferably 1 to 20 mg. Coenzyme Q10 is added to fodder or liquids for animals, where fodder can be any animal food, either unprocessed or processed, natural or artificial or industrially prepared.

Description

USE OF COIENTS Q10 FOR EFFICIENT BREEDING OF ANIMALS AND PRODUCTION OF ANIMAL TISSUES WITH INCREASED CONTENT OF THESE COINS

The object of the invention is the new use of coenzyme Q10 as an additive or. supplements to animal feed or animal fluids in animal breeding to enhance the breeding efficiency and enrich animal tissues, in particular meat with coenzyme Q10. The invention also relates to animal tissues, in particular meat enriched with coenzyme Q10. The animal tissues of the invention mean in addition to all types of meat, bone, skin, etc. also poultry eggs and milk from dairy animals.

Coenzyme Q10 (CoQ10) is a lipophilic water-insoluble substance, essential for the functioning of the human body, as it participates as a coenzyme in many metabolic processes; is crucial in cellular energy generation processes. It is known that the amount of CoQ10 in human tissues is therefore proportional to the activity of the individual tissue; thus, the highest concentrations are observed in the heart muscle. CoQ10 deficiency is reflected in reduced vitality, resistance, etc., but in contrast, sufficient amounts of CoQ10 increase vitality and resistance and facilitate the treatment of a variety of diseases and eliminate a range of health problems.

Man provides sufficient amounts of CoQ10 in the body through synthesis and nutrition, but with age and for some other reasons, e.g. due to certain drugs, the synthesis of endogenous CoQ10 is reduced so that intake of CoQ10 with normal foods is no longer sufficient. Therefore, in order to maintain the level of CoQ10 in the body, it is necessary to consume increased amounts of CoQ10, usually around 20-50 mg, and in some cases 100 and more mg daily. To this end, the use of CoQ10 in the form of nutritional supplements, in particular in the form of capsules, is widespread, while conventional foods are not sufficient for this purpose. The content of CoQ10 in food is relatively low (some mg / kg), higher (ca 10-40 mg / kg) only in foods that contain more fat, which is not desirable for health reasons. Such foods often also contain more cholesterol, which has additional negative health effects.

-2With the desire to consume the required amounts of CoQ10 with food, several different technologies and special forms of CoQ10 have recently been developed to allow the addition of CoQ10 to foods, especially low fat foods. Of particular importance are the various water-soluble forms of CoQ10, e.g. based on solubilization with beta-cyclodextrin (Prosek et al., Sl. Patent 21783, WO 2005/111224 A2), micro and nanocapsules and the like. However, in this way it is possible to enrich only processed foods, that is, food products to which CoQ10 is added in a suitable form or. appropriately during the manufacturing process. Thus, there are already a number of different CoQ10-enriched food products on the market that are replacing CoQ10 in the form of nutritional supplements, while such an approach is not suitable for enriching primary, i.e. unprocessed or non-processed foods. basic foods such as meat, vegetables and fruits. A particular problem is meat, which may be an important source of CoQ10 in the diet, but it also contains significant amounts in the healthy diet of unwanted fats and cholesterol. So e.g. 1 kg of chicken meat contains ca 6-25 mg CoQ10 / kg and ca 10-100 g fat and up to 600 mg cholesterol / kg, 1 kg pork and beef ca 20-35 mg CoQ10 and ca 15-350 g fat and ca 600-800 mg of cholesterol in kg of meat, which shows that the amount of CoQ10 in meat is related to the amount of fat and cholesterol. Therefore, replacing the CoQ10 deficit by ingesting increased amounts of more fatty meat, which otherwise contains more CoQ10, is neither a sufficient nor a suitable solution.

Meat therefore contains significant amounts of CoQ10 but not sufficient to consume sufficient quantities of CoQ10 with normal amounts of meat. This is especially true for the more desolate species. portions of meat containing less fat, e.g. chicken meat, in particular chicken breasts containing only ca 6-10 mg CoQ10 / kg. In addition, fats and cholesterol in meat reduce fitness for a healthy diet. The very problem of excessive fat and cholesterol content (and thus of inadequate CoQ10 ratio) in meat and meat products is solved in various ways, such as the removal of fatty parts by trimming, extracting, thinning products with non-meat components, etc., which are problematic. in terms of economy, technological complexity, effects on sensory properties of products, etc. Procedures for removing cholesterol, which is present not only in fat but also in muscle tissue, are particularly demanding. Therefore, there is a constant need to enrich meat for human and animal consumption with CoQ10 in a simple, natural and economical way. There is also a constant need

-3 on reducing the amount of fat and cholesterol, respectively. after improving the ratio of CoQ10 content to fats and cholesterol in meat and meat products in a simple, economical and natural way.

There is an ongoing problem in animal breeding in increasing feed efficiency and meat production efficiency. meat masses. For this purpose, different feed additives or feed additives are used in breeding. feeds rich in various substances that accelerate the weight gain of animals or meat masses and, on the other hand, substances that increase resistance or improve the health of these animals. However, existing feed additives such as various vitamins, proteins, minerals can also have adverse effects on animals, and the accumulation of these substances in the tissues of animals may also pose a potential risk to people who consume the meat or meat thus obtained. meat products from it. In addition, the effect or. the yield of individual substances varies depending on the individual animal and the feeding period with these additives. In particular, feed efficiency is not adequately addressed in this way. Therefore, there is a continuing need for an easy way to maximize feed utilization, increase animal meat gain and positive animal health effects with as few different, possibly natural, substances that would not cause contamination of meat and meat products, but possibly improve the quality of meat and other animal tissues and products thereof.

A problem that has not been adequately solved so far is the enrichment of meat with CoQ10 and the increase in the ratio of CoQ10 to fat and cholesterol in meat - due to an increase in the amount of CoQ10 with equal or reduced fat and cholesterol content. Ingesting such meat would consume larger amounts of CoQ10 and reduce the need for nutritional supplements or medications with CoQ10. Therefore, ingesting the same amounts of CoQ10, you could consume smaller amounts of meat, respectively. meat products and thus lower amounts of harmful fats and cholesterol, the amount of which would be further reduced due to the lower content in the meat or meat produced in this way. meat products.

An additional problem that has not been adequately solved so far is the breeding of animals with increased meat gain or weight gain. animal weight and increased feed utilization, using as few different, preferably natural substances as possible, preferably with a positive

-4 effects on animal health, all of which would have positive effects on the economics of animal breeding and meat production and its quality.

The object and object of the invention is an economical and simple process for the enrichment of meat of different animals with CoQ10, resulting in different types of meat with an increased amount of CoQ10 and an improved ratio of CoQ10 to fats and cholesterol, and the use of such meat and products thereof in human and animal nutrition. It is also an object and object of the invention to have a simple breeding process for animals using as few different, preferably natural substances as possible, thereby increasing the animal's weight gain and feed utilization and thereby the cost-effective breeding. Animals are warm-blooded animals intended for consumption, such as poultry, small animals, pigs, cattle, rabbits, horses, game and others, in particular those whose meat or meat. parts of meat and skin contain less CoQ10 or. more cholesterol and fat.

The objects and objectives of the invention are simultaneously accomplished in a surprising and original way by adding CoQ10 in a suitable form, either alone or as a feed ingredient, or as a feed additive in liquid or solid form to the livestock diet, or in other appropriate ways, at appropriate stages of growth oz. a reasonable time before slaughter.

According to the invention, the tasks and objectives are solved by the use of CoQ10 and by the process of introduction or. the feeding of animals with suitable forms of CoQ10 and the use of the meat and meat products thus obtained on this basis, according to independent claims.

The essence of the invention is the new use of CoQ10 in a suitable animal feeding form and a process for feeding animals with a suitable CoQ10 form. with feed or liquids supplemented with CoQ10 in suitable form, or with nutritional supplements containing CoQ10 in suitable growth stages and suitable time before slaughter, thus solving the invention in an original, simple and cost-effective manner at the same time as several problems and tasks. According to the invention with CoQ10, a single natural supplement to animal nutrition achieves several effects at the same time, namely increasing weight gain, improving feed efficiency, increasing CoQ10 content in meat, and reducing cholesterol and fat content, respectively. improving the coefficient between CoQ10 content and cholesterol and fats in meat or different tissues. This also enables the production of meat products. tissue products with improved characteristics for human and animal health and the use of meat or tissues and articles thereof for the purpose of healthy eating.

-5It is important that CoQ10 has virtually no adverse effects on organisms, nor does it accumulate beyond the specific boundary that is for the organism or organism. individual tissues are acceptable, but on the contrary - it has many positive effects on humans and animals. This, on the one hand, represents an additional advantage over other feed additives for increasing the gain, and on the other hand, not only allows humans and animals to be completely safe but also to benefit from the meat or meat consumption. tissues and products enriched with CoQ10 of the present invention. The invention therefore enables the simple and economical production of functional food of meat or meat. tissues of animals and products derived therefrom, ie foods with positive effects on the health of humans and animals consuming those foods.

CoQ10 in an appropriate form is administered to animals, e.g. by adding CoQ10 to the feed, respectively. liquids that they ingest, or even separately. For this purpose we use feeds with CoQ10 suitable formulation, feed additives containing CoQ10, feed additives for animals containing CoQ10, various nutritional supplements for animals containing CoQ10, e.g. hard or soft capsules, tablets, syrups, droplets, suspensions, emulsions and other suitable forms based on various water-soluble or non-soluble CoQ10 forms, preferably forms that exhibit greater CoQ10 bioavailability. Feed can be natural, such as grass, hay, corn, vegetables, etc., or artificial, such as a variety of industrially prepared feeds. In addition, CoQ10 can be administered with injectable forms, transdermal forms, implants and the like.

In the above methods, a few mg to a few 100 mg CoQ10 / kg body weight / day are administered, e.g. 1-500 mg or more, preferably 1-50 mg, more preferably 1-20 mg of CoQ10 / kg body weight / day, in one or more daily portions. The amount is adjusted to the growth phase by increasing the daily doses in the growth-intensive stages, while the doses are reduced or even dropped in the initial stages of animal development and in the slow-growth stages. With this CoQ10 dosing regimen, the optimal effects of feed gain and utilization are achieved, and partly the amounts of CoQ10 in animal tissues, and the ratio of CoQ10 to fat or fat. cholesterol. CoQ10 concentration can be significantly increased, and fat and cholesterol levels can be further reduced by re-dosing or increasing CoQ10 doses for some time before slaughter. If only to increase the amount of CoQ10 in the tissues and improve the cholesterol ratio

-6and fats respectively. to reduce their amount, this can only be achieved by increasing doses of CoQ10 before slaughter. This optimizes the consumption of CoQ10 with respect to the effects on the growth and quality of meat in terms of the concentration of CoQ10, fat and cholesterol, respectively. the ratio of CoQ10 to fat and cholesterol levels, which is particularly important in terms of economy. In this way, with a minimal consumption of CoQ10, we can achieve up to a few ten percent increase in weight gain and from a few percent up to 100 percent or more increase in the amount of CoQ10 in individual tissues or tissues. parts of the meat, while falling, for example. the amount of cholesterol also by tens of percent. Thus, the present invention significantly improves weight gain and at the same time increases the health suitability of the meat obtained or. parts of animals and products thereof for human and animal consumption. The upstream dose of CoQ10 is practically unlimited, it depends only on the effects desired to achieve it.

By the procedure or. CoQ10 supplementation regimens can be influenced by the desired effects, either by increasing the CoQ10 content and its ratio to cholesterol and fat, or by increasing weight gain, or both. Addition of CoQ10 in the intensive growth phases primarily increases weight gain, while adding a few weeks or at least several days before slaughter increases the tissue CoQ10 content. Both effects increased health and increment - optimally achieved by a combination of feeding in both periods, with the addition of CoQ10 supplementation also influencing the relative increases in individual tissues or tissues. parts of animals.

A typical example is the chickens - broilers that are slaughtered on day 42, ie at the end of intensive growth. In the optimal CoQ10 dosing regimen, averaging 5 mg of water-soluble CoQ10 / kg body weight / day 20 days before slaughter, weight gain increased by about 30% with ca. 5% less consumption compared to the control group not receiving CoQ10. feed, and the CoQ10 concentration was significantly increased in total, e.g. she even doubled in the flesh of her breast. A slight increase in the amount of CoQ10 typically occurs in tissues that already contain larger amounts of this substance. At the same time, the amount of cholesterol in individual tissues was significantly reduced, especially in breast meat by more than half. The index of CoQ10 against cholesterol levels even more than doubled in individual tissues. Cholesterol is reduced by almost 30% even in the subcutaneous adipose tissue. With appropriate dose escalation, these effects may be exacerbated.

-7The content of CoQ10 in tissues can also be increased by gradually increasing the amount of CoQ10. In chickens, by gradually increasing the daily dose in the last 20 days before slaughter from 5 mg / kg body weight to 10 mg / kg body weight, a CoQ10 content of 25-60% higher in individual tissues is achieved than in the constant addition of 5 mg / kg body weight.

Chickens were added to CoQ10 ca 1 month before slaughter. With daily supplementation of 10 mg CoQ10 / kg body weight, CoQ10 content in meat increases by an average of about 6-8 mg / kg, with a marked increase also in tissues in which the increase in CoQ10 content in chickens is less than that of e.g. in the heart and thighs, which is due to a general lack of CoQ10 at an older age. The amount of cholesterol in meat decreases by about 15-20%, in the heart by about 30%. In laying hens, CoQ10 content in eggs is also increased, e.g. at a dose of 7 mg CoQ10 / kg body weight by about 60-70%, at a dose of e.g. 10 mg / kg body weight by as much as 100%.

Similarly, it is possible to increase the increase and content of CoQ10 and to improve the index of fat and cholesterol in the meat of other farmed animals by adding the indicated amounts of CoQ10 in a suitable form during the intensive growth phase. before slaughter. Thus, daily supplementation of 10 mg CoQ10 / kg body weight during intensive growth of the first 3 months results in a weight gain of about 15% and an increase in CoQ10 content of about 20-45%. Addition to CoQ10 also increased over a further growth period of up to about 20 months, with an increase in CoQ10 even more pronounced, up to about 50%. At about 5-6 years old cattle, an increase in the amount of CoQ10 in meat and a reduction in the amount of fat and cholesterol are achieved by adding CoQ10 for one to two months before slaughter; an increase of CoQ10 in tissues of about 2060% (up to about 40 mg / kg) and a decrease of cholesterol by up to about 50% are achieved at 15 mg CoQ10. At a daily dose of 20 mg CoQ10 / kg body weight, the amount of CoQ10 is increased by up to about 75% and the amount of cholesterol is reduced by up to about 60%. It also reduces the amount of fat in meat by up to about 30%.

Therefore, it is an object of the invention to use and process for the use of CoQ10 for breeding animals with increased weight gain and increasing CoQ10 content. the ratio of CoQ10 content to cholesterol and fat in meat or other parts of animals,

-8months and other parts of animals with high CoQ10 content. the stated content coefficients and their use for human and animal consumption. The essence of the breeding regimen is the addition of CoQ10 in a suitable form at a time of intensive growth, primarily to achieve an increase in growth and in the second half of the animal's life to increase CoQ10 content and reduce cholesterol and fat content, respectively. improving their proportion, preferably 3 days to 3 months before slaughter. The duration of the first phase of supplementation (to increase growth) depends on the animal species and lasts for pigs for about 6 months, for cattle for about 18 months, and especially for the first 3 months, for chickens for about 1.5 months, for rabbits for about 3-4 months, similar to geese and ducks, etc. Adding CoQ10 for the first few days of animal life does not make sense. In animals with a short life span, such as in broiler piglets, the two stages of CoQ10 supplementation may overlap, so that the optimum time of CoQ10 supplementation is both 20 days before slaughter from the point of view of increasing CoQ10 content and the ratio of fat to cholesterol and from the standpoint of fat gain and economy.

The meat and other parts of the animals of the present invention are prepared in the usual manner, dried or non-dried meat products, such as pate, sausage, terrine, meat pulp, briquettes and other products. This gives products with increased CoQ10 content and reduced cholesterol and fat content. an improved ratio of CoQ10 content to cholesterol and fat content without adding this to the coenzyme during the preparation process, ie without using CoQ10 as an additive to these products and without specifically removing cholesterol and fat. This significantly increases the health status of food products of animal origin.

Therefore, articles of meat and other tissues obtained by breeding animals with the addition of CoQ10 are also the subject of the invention, their preparation and use.

The invention is explained but not limited to the embodiments.

The following materials were used: water-soluble CoQ10 according to the patent Sl 21783, WO 2005/111224 A2 (Q10Vital, Valens Int., Slovenia), All-Q (DSM, The Netherlands), CoQ10 (Daewoong Chemical Co., Korea), feedstuffs BRO- G and BRO-F2 (Perutnina Ptuj dd,

-9Slovenia), TL-starter and TL-PIT2 (Agrokombinat Maribor, Slovenia). The chickens were raised in Perutnina Ptuj d.d., Slovenia, other animals on private farms.

EXAMPLE 1 - Feed preparation with CoQ10

CoQ10 in the form of 7.5% aqueous suspension was added to conventional poultry feed. A premix was prepared, where CoQ10 was first diluted into 30 kg of maize meal, and then the premix was added in an appropriate proportion to a 60 kg blender for other raw materials. After mixing, 60 kg of homogeneous compound feed was obtained, where the CoQ10 concentration was 0.0042%.

EXAMPLE 2 - Feeding Chickens with CoQ10 Feed 20 days to slaughter

Water-soluble CoQ10 in water (7.5%) was added to the chicken feed to give a homogeneous feed containing 0.0042% CoQ10. Healthy chicks were harvested one day after hatching and housed separately in two groups of 25. The first group was fed CoQ10-free feed all the time until slaughter, and the second group for the first twenty days with the same feed as the first group, for the second twenty days (up to slaughter) and feed with CoQ10 added. Both groups were monitored for the weight, health and behavior of the animals, and after slaughter (day 42), concentrations of CoQ10, cholesterol and fat were determined in individual parts of the chickens using HPLC-MS and QTLC, namely in the meat of the thighs, dandruff and breast and hearts and liver. The results of the analyzes are given in Table 1 and Table 2. All animals were healthy, of normal behavior. The average weight of animals in the reference group increased 10.4-fold (from 217 g to 2258) and the weight in the test group increased 13.3-fold (from ^: 192 g to 2546 g), so that weight gain in to the test group 28% higher than in the reference group.

Table 1. Comparison of average CoQ10 content in 42-day-old chickens fed without (reference group) and first without, and last 20 days before slaughter with CoQ10 supplement (results are given in mg CoQ10 / kg of meat), and the ratios of CoQ10 content in the test group relative to the reference.

Breast Thighs Wings Hearts The liver Blood Reference group 7.8 24.2 11,0 92,3 132,2 3.5 Test group 13.6 25,2 12,1 100,1 158.1 5.7 Test / Reference sk. 1.74 1.04 1.10 1.08 1,2 1.63

Table 2. Comparison of cholesterol content for the group fed 42 days with feed without CoQ10 supplement (reference group) and the group fed first with feed without and last 20 days before slaughter with CoQ10 supplement (test group); the results are given in g / kg of meat.

Breast Thighs Wings Hearts Reference group 0.37 0.44 0.72 0.76 Test group 0.31 0.48 0.67 0.61

Table 3. CoQ10 and cholesterol x10 ' ² ratio.

Breast Thighs Wings Hearts Reference group 2.2 5.5 1.5 12.2 Test group 4.4 5,3 1.7 16.4

EXAMPLE 3 - Feeding Chickens with CoQ10 Feed 30 days to slaughter

Water-soluble CoQ10 in water (7.5%) was added to the chicken feed to give a homogeneous feed containing 0.0042% CoQ10. Healthy chicks were harvested one day after hatching and housed separately in two groups of 25. The first group was fed CoQ10-free feed all the time until slaughter, and the second group for the first ten days with the same feed as the first group, with 30 days remaining (up to slaughter) and feed with CoQ10 added. Both groups were monitored for weight, health and behavior of animals, and after slaughter (day 42), concentrations of CoQ10, cholesterol, were determined by HPLC-MS and QTLC.

-11and fats in individual parts of chickens, namely in meat of thighs, dandruff and breast, and hearts and livers. The results are given in Table 4 and Table 5.

Table 4. Comparison of average CoQ10 levels in 42-day-old chicks fed without (reference group) and first without, and with the addition of CoQ10 (test group) last 30 days before slaughter; the results are given in mg CoQ10 / kg.

Breast Thighs Wings Hearts The liver Blood Reference group 7.8 24.2 11,0 92,3 132,2 3.5 Test group 12.2 26.1 12,8 99.1 144.1 6,3 Test / Reference sk. 1.56 1.07 1.16 1.07 1.09 1.8

Table 5. Comparison of average cholesterol levels for the feed-fed group without CoQ10 supplement (reference group) and the feed-fed group first with no feed, and for the last 30 days before slaughter with CoQ10 supplement (test group); the results are given in g / kg.

Breast Thighs Wings Hearts Reference group 0.37 0.44 0.72 0.76 Test group 0.22 0.45 0.69 0.67

EXAMPLE 4 - Feeding Chickens for 40 Days with CoQ10 Feed

Water-soluble CoQ10 in water (7.5%) was added to the chicken feed to give a homogeneous feed containing 0.0042% CoQ10. Healthy chicks were harvested one day after hatching and housed separately in two groups of 25. The first group was fed CoQ10-free feed all the time until slaughter, and the second group was fed CoQ10-fed for 40 days (until slaughter). The weight, health and behavior of the animals were monitored in both groups, and after slaughter (day 42), HPLC-MS and QTLC were determined after slaughter

-12Concentrations of CoQ10, cholesterol and fat in individual parts of chickens, namely in the meat of the thighs, dandruff and breast and heart and liver. The results are given in Table 6 and Table 7.

Table 6. Comparison of average CoQ10 content in 42-day-old chicks fed without (reference group) and with the addition of CoQ10 (test group); the results are given in mg CoQ10 / kg.

Breast Thighs Wings Hearts The liver Blood Reference group 7.8 24.2 11,0 92,3 132,2 3.5 Test group 15.3 27.6 14,0 97.6 131.7 4.9 Test / Reference sk. 1.96 1.14 1,27 1.06 0.996 1.4

Table 7. Comparison of cholesterol content for the group fed for 40 days with feed without CoQ10 supplement (reference group) and the group fed with CoQ10 supplement (test group); the results are given in mg / kg.

Breast Thighs Wings Hearts Subcutaneous fat Reference group 0.37 0.44 0.72 0.76 0.95 Test group 0.28 0.41 0.68 0.72 0.70

Table 8. CoQ10 and cholesterol x10 ' ² ratio.

Breast Thighs Wings Hearts Reference group 2.2 5.5 1.5 12.2 Test group 4.9 6.2 1.8 13,9

EXAMPLE 5 - Feeding Chickens with CoQ10 Feed

-13Cows were fed for 21 days with natural feed supplemented with CoQ10 with improved water solubility by consuming an average of 7 mg CoQ10 / kg body weight per day. Using the HPLC-MS method, we analyzed the CoQ10 content of eggs before starting to add CoQ10 to feed, after 13 and after 21 days; the results are shown in Table 9.

Table 9. Increase in CoQ10 content in eggs; results are given per kg of yolk.

0 days 13 days 21 days CoQ10 content (mg / kg) 5.2 7.8 8.7 Increase index 1.5 1.67

EXAMPLE 6 - Meat-liver pate

From the meat and liver of chickens fed for the last 20 days before slaughter with feed to which CoQ10 was homogeneously added to a concentration of 0.008% as in Example 1. The poultry meat and liver of the hens bred in this way was prepared in the usual manner following an industrial recipe and analyzed for CoQ10, fat and cholesterol content. The results were compared with the results for comparative pate (Table 8).

Table 10. Comparison of CoQ10, fat and cholesterol content in meat and liver pate of normal fowls and chickens fed 20 days prior to slaughter with feed supplemented with CoQ10.

CoQ10 (mg / kg) Cholesterol (g / kg) Fat (g / 1kg) Reference pate 17,9 0.73 199 Test pate 24,8 0.67 182

The invention therefore encompasses the use of coenzyme Q10 for the more efficient breeding of animals and the production of animal tissues, that is to say, all types of meat, bone, skin, eggs of poultry and milk of dairy animals, with an increased content of this coenzyme, whereby the introduction of coenzyme Q10 in animals by ingestion or direct administration upstream or downstream of the coenzyme Q10 in

-14 appropriate water-soluble or non-water-soluble form, preferably in the form of increased bioavailability, and that animals with coenzyme Q10 ingest or receive in other ways throughout life, or for a fixed period at any time in life, preferably in growth phases and / or any time before slaughter, more preferably in growth phases and / or 3-90 days before slaughter, and that animals ingest 1-1000 mg of coenzyme Q10 per kg body weight per day, preferably 1-50 mg, more preferably 1-20 mg. Coenzyme Q10 is added to animal feed or fluids, the feed being any animal feed, whether unprocessed or processed, natural or artificial, or. industrially prepared. Coenzyme Q10 is in the form of suitable solid, semi-solid, semi-liquid or liquid preparations for administration to animals such as capsules, tablets, boluses, granules, powders, syrups, injectable forms, creams, ointments, implants and others. The duration of CoQ10 administration and CoQ10 doses are adjusted according to the desired effects, type of animal, economy and more. For increasing feed gain and yield, coenzyme Q10 is administered to animals at the time of growth, to increase coenzyme Q10 concentration and to the ratio of coenzyme Q10 concentration to cholesterol and / or cholesterol. for the fat in the tissues, a reasonable time before slaughter. The animals mentioned are poultry, small animals, cattle, pigs, rabbits and other animals, the meat and other parts of which are used for human and animal consumption.

Animal tissues, including poultry eggs and milk from dairy animals are enriched in the invention with coenzyme Q10, which may contain reduced cholesterol and fat, and the ratio of coenzyme Q10 to cholesterol and the fat in them is improved.

Animal tissue products are intended for human and animal consumption and contain increased amounts of coenzyme Q10, lower cholesterol and fat, and the ratio of coenzyme Q10 to cholesterol and fat in them is improved. Tissues and tissue products are intended for human and animal consumption.

Feeds and fluids for animals according to the invention contain added coenzyme Q10.

The feed additives according to the invention contain added coenzyme Q10.

Preparations for administration to animals contain added coenzyme Q10.

The processes for the preparation of feeds and preparations with coenzyme Q10 according to the invention are characterized in that coenzyme Q10 is added at any stage during the preparation process or by interfering with the prepared feeds and preparations.

Claims (13)

Claims: Use of coenzyme Q10 for the more efficient breeding of animals and the production of animal tissues with an increased content of that coenzyme, characterized in that coenzyme Q10 is introduced into animals by ingestion or direct introduction into or onto the body, whereby coenzyme Q10 is in a suitable water-soluble or non-soluble form, preferably in the form of increased bioavailability, and that animals coenzyme Q10 ingest or consume. receive in other ways throughout life, or for a fixed period at any time in life, preferably in growth phases and / or any time before slaughter, more preferably in growth phases and / or 3-90 days before slaughter and for animals to consume 1-1000 mg coenzyme Q10 per kg body weight per day, preferably 1-50 mg, more preferably 1-20 mg. Use according to the preceding claims, characterized in that coenzyme Q10 is added to animal feed or fluids. Use according to the preceding claims, characterized in that the feed is any animal feed, whether unprocessed or processed, natural or artificial, or. industrially prepared. Use according to the preceding claims, characterized in that the coenzyme Q10 is in the form of suitable solid, semi-solid, semi-liquid or liquid preparations for administration to animals, such as capsules, tablets, boluses, granules, powders, syrups, injectable forms, creams, ointments, implants and others. Use according to the preceding claims, characterized in that the time and duration of CoQ10 supplementation and CoQ10 dosages are adjusted according to the desired effects, animal type, economy and more. Use according to the preceding claims, characterized in that coenzyme Q10 is administered to animals during growth, to increase the growth and yield of feed, to increase the concentration of coenzyme Q10 and the ratio of the concentration of coenzyme Q10 to cholesterol, respectively. and fat in the tissues for a reasonable time before slaughter. Use according to the preceding claims, characterized in that the animals are poultry, small animals, cattle, pigs, rabbits and other animals, the meat and other parts of which are used for human and animal consumption. -168. Animal tissues, including poultry eggs and milk from dairy animals prepared according to the preceding claims, are characterized in that the ratio of the amount of coenzyme Q10 to cholesterol and the fat in them is improved. Tissue products according to the preceding claims, characterized in that they are intended for human and animal consumption and contain increased amounts of coenzyme Q10, and that the ratio between the amount of coenzyme Q10 and cholesterol and the fat in them is improved. Tissues and tissue products as claimed in the preceding claims for human and animal consumption. 11. Feeds and fluids for animals, characterized in that they contain added coenzyme Q10. 12. Feed additives characterized by the addition of coenzyme Q10. Preparations for administration to animals according to the preceding claims, characterized in that they contain added coenzyme Q10. Processes for the preparation of feeds and preparations with coenzyme Q10, characterized in that coenzyme Q10 is added at any stage during the preparation process or by interfering with the prepared feeds and preparations.