SI2124944T1 - Derivati pirazolo b piridina kot inhibitorji fosfodiesteraze - Google Patents

Derivati pirazolo b piridina kot inhibitorji fosfodiesteraze

Info

Publication number: SI2124944T1
Authority: SI; Slovenia
Prior art keywords: åpyridine; pyrazolo; derivatives; phosphodiesterase inhibitors; phosphodiesterase
Prior art date: 2007-03-14

Application number

SI200830590T

Other languages

English (en)

Inventor

Sonali Rudra

Nidhi Gupta

Lalit Kumar Baregama

Ritu Agarwal

Vinayak Vasantrao Khairnar

Mandadapu Raghu Ramaiah

Venkata P Palle

Sarala Balachandran

Atul Kondaskar

Manohar Salla

Abhijit Ray

Sunanda G Dastidar

Lalitha Vijaykrishnan

Original Assignee

Ranbaxy Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-14

Filing date

2008-03-14

Publication date

2012-05-31

2008-03-14 Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd

2012-05-31 Publication of SI2124944T1 publication Critical patent/SI2124944T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Virology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Transplantation (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
AIDS & HIV (AREA)
Hematology (AREA)
Diabetes (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SI200830590T 2007-03-14 2008-03-14 Derivati pirazolo b piridina kot inhibitorji fosfodiesteraze SI2124944T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IN550DE2007		2007-03-14
PCT/IB2008/050943 WO2008111010A1 (en)	2007-03-14	2008-03-14	Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
EP08737621A EP2124944B1 (en)	2007-03-14	2008-03-14	Pyrazolo[3,4-b]pyridine derivatives as phosphodiesterase inhibitors

Publications (1)

Publication Number	Publication Date
SI2124944T1 true SI2124944T1 (sl)	2012-05-31

Family

ID=39575541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200830590T SI2124944T1 (sl)	2007-03-14	2008-03-14	Derivati pirazolo b piridina kot inhibitorji fosfodiesteraze

Country Status (22)

Country	Link
US (1)	US8420666B2 (sl)
EP (1)	EP2124944B1 (sl)
JP (1)	JP5671236B2 (sl)
KR (1)	KR101568884B1 (sl)
CN (2)	CN103497185A (sl)
AP (1)	AP2453A (sl)
AT (1)	ATE545417T1 (sl)
AU (1)	AU2008224541B2 (sl)
CA (1)	CA2680625C (sl)
CY (1)	CY1112805T1 (sl)
DK (1)	DK2124944T3 (sl)
EA (1)	EA018670B9 (sl)
ES (1)	ES2382715T3 (sl)
HK (1)	HK1138758A1 (sl)
HR (1)	HRP20120361T1 (sl)
MX (1)	MX2009009793A (sl)
NZ (1)	NZ579645A (sl)
PL (1)	PL2124944T3 (sl)
PT (1)	PT2124944E (sl)
SI (1)	SI2124944T1 (sl)
WO (1)	WO2008111010A1 (sl)
ZA (1)	ZA200906418B (sl)

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ES2710522T3 (es) *	2009-12-08	2019-04-25	Univ Vanderbilt	Procedimientos y composiciones para la extracción de venas y autotransplante
US10034861B2 (en) *	2016-07-04	2018-07-31	H. Lundbeck A/S	1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
WO2018049271A1 (en) *	2016-09-09	2018-03-15	Flx Bio, Inc.	Chemokine receptor modulators and uses thereof
JOP20190126A1 (ar)	2016-12-22	2019-05-28	H Lundbeck As	بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
EA037544B1 (ru) *	2017-04-04	2021-04-12	Х. Лундбекк А/С	ПРИМЕНЕНИЕ 1H-ПИРАЗОЛО[4,3-b]ПИРИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ PDE1
AR113926A1 (es)	2017-12-14	2020-07-01	H Lundbeck As	Derivados de 1h-pirazolo[4,3-b]piridinas
PL3723807T3 (pl)	2017-12-14	2022-01-24	H. Lundbeck A/S	Leczenie skojarzone obejmujące podawanie 1h-pirazolo[4,3-b]pirydyn
US10766893B2 (en)	2017-12-20	2020-09-08	H. Lundbeck A/S	1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
TW201927784A (zh)	2017-12-20	2019-07-16	丹麥商Ｈ朗德貝克公司	作為pde1抑制劑之大環
US11535611B2 (en)	2017-12-20	2022-12-27	H. Lundbeck A/S	Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors
CN113200997B (zh) *	2021-05-07	2023-10-03	上海合全医药有限公司	2,5-二氧杂-8-氮杂螺[3.5]壬烷及其盐的合成方法

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2008
- 2008-03-14 CN CN201310379773.0A patent/CN103497185A/zh active Pending
- 2008-03-14 SI SI200830590T patent/SI2124944T1/sl unknown
- 2008-03-14 WO PCT/IB2008/050943 patent/WO2008111010A1/en active Application Filing
- 2008-03-14 DK DK08737621.6T patent/DK2124944T3/da active
- 2008-03-14 CN CN200880014410A patent/CN101801376A/zh active Pending
- 2008-03-14 AU AU2008224541A patent/AU2008224541B2/en not_active Ceased
- 2008-03-14 EA EA200970852A patent/EA018670B9/ru not_active IP Right Cessation
- 2008-03-14 PT PT08737621T patent/PT2124944E/pt unknown
- 2008-03-14 PL PL08737621T patent/PL2124944T3/pl unknown
- 2008-03-14 MX MX2009009793A patent/MX2009009793A/es active IP Right Grant
- 2008-03-14 EP EP08737621A patent/EP2124944B1/en not_active Not-in-force
- 2008-03-14 JP JP2009553263A patent/JP5671236B2/ja not_active Expired - Fee Related
- 2008-03-14 KR KR1020097021120A patent/KR101568884B1/ko not_active Expired - Fee Related
- 2008-03-14 CA CA2680625A patent/CA2680625C/en not_active Expired - Fee Related
- 2008-03-14 US US12/531,043 patent/US8420666B2/en not_active Expired - Fee Related
- 2008-03-14 AP AP2009004977A patent/AP2453A/xx active
- 2008-03-14 NZ NZ579645A patent/NZ579645A/en not_active IP Right Cessation
- 2008-03-14 AT AT08737621T patent/ATE545417T1/de active
- 2008-03-14 ES ES08737621T patent/ES2382715T3/es active Active
2009
- 2009-09-15 ZA ZA200906418A patent/ZA200906418B/xx unknown
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- 2010-05-11 HK HK10104603.9A patent/HK1138758A1/xx not_active IP Right Cessation
2012
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Also Published As

Publication number	Publication date
HRP20120361T1 (hr)	2012-05-31
CA2680625A1 (en)	2008-09-18
AU2008224541B2 (en)	2013-08-22
NZ579645A (en)	2012-01-12
WO2008111010A1 (en)	2008-09-18
KR20090120505A (ko)	2009-11-24
PL2124944T3 (pl)	2012-08-31
KR101568884B1 (ko)	2015-11-12
ZA200906418B (en)	2010-05-26
AU2008224541A1 (en)	2008-09-18
EA018670B1 (ru)	2013-09-30
CA2680625C (en)	2016-02-23
CN103497185A (zh)	2014-01-08
ATE545417T1 (de)	2012-03-15
EA018670B9 (ru)	2014-01-30
AP2009004977A0 (en)	2009-10-31
DK2124944T3 (da)	2012-04-23
MX2009009793A (es)	2009-10-16
ES2382715T3 (es)	2012-06-12
AP2453A (en)	2012-08-31
JP5671236B2 (ja)	2015-02-18
EP2124944A1 (en)	2009-12-02
US8420666B2 (en)	2013-04-16
JP2010521451A (ja)	2010-06-24
US20100292196A1 (en)	2010-11-18
EP2124944B1 (en)	2012-02-15
CN101801376A (zh)	2010-08-11
HK1138758A1 (en)	2010-09-03
CY1112805T1 (el)	2016-02-10
PT2124944E (pt)	2012-05-17
EA200970852A1 (ru)	2010-04-30

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