[go: up one dir, main page]

SI2094728T1 - Postopki za uporabo za humano-adaptivnost monoklonskih protiteles - Google Patents

Postopki za uporabo za humano-adaptivnost monoklonskih protiteles

Info

Publication number
SI2094728T1
SI2094728T1 SI200731225T SI200731225T SI2094728T1 SI 2094728 T1 SI2094728 T1 SI 2094728T1 SI 200731225 T SI200731225 T SI 200731225T SI 200731225 T SI200731225 T SI 200731225T SI 2094728 T1 SI2094728 T1 SI 2094728T1
Authority
SI
Slovenia
Prior art keywords
human
methods
monoclonal antibodies
adapting
adapting monoclonal
Prior art date
Application number
SI200731225T
Other languages
English (en)
Inventor
Shizhong Chen
Shanrong Zhao
Original Assignee
Janssen Biotech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech, Inc. filed Critical Janssen Biotech, Inc.
Publication of SI2094728T1 publication Critical patent/SI2094728T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/461Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1089Design, preparation, screening or analysis of libraries using computer algorithms
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI200731225T 2006-10-26 2007-10-25 Postopki za uporabo za humano-adaptivnost monoklonskih protiteles SI2094728T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86300806P 2006-10-26 2006-10-26
PCT/US2007/082516 WO2008052108A2 (en) 2006-10-26 2007-10-25 Methods for use in human-adapting monoclonal antibodies
EP07863509.1A EP2094728B1 (en) 2006-10-26 2007-10-25 Methods for use in human-adapting monoclonal antibodies

Publications (1)

Publication Number Publication Date
SI2094728T1 true SI2094728T1 (sl) 2013-06-28

Family

ID=39325420

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200731225T SI2094728T1 (sl) 2006-10-26 2007-10-25 Postopki za uporabo za humano-adaptivnost monoklonskih protiteles

Country Status (8)

Country Link
US (1) US8093068B2 (sl)
EP (1) EP2094728B1 (sl)
JP (1) JP5323710B2 (sl)
DK (1) DK2094728T3 (sl)
ES (1) ES2410886T3 (sl)
PT (1) PT2094728E (sl)
SI (1) SI2094728T1 (sl)
WO (1) WO2008052108A2 (sl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0917370A2 (pt) 2008-08-20 2015-11-17 Centocor Ortho Biotech Inc anticorpos anti-il-13 manipulados, composições, métodos e usos.
JO3437B1 (ar) * 2009-10-30 2019-10-20 Esai R & D Man Co Ltd أجسام مضادة محسنة مضادة للفراكتالكين البشري واستخداماتها
CN115043943A (zh) 2015-05-15 2022-09-13 综合医院公司 拮抗性抗肿瘤坏死因子受体超家族抗体
US11208452B2 (en) 2015-06-02 2021-12-28 Novo Nordisk A/S Insulins with polar recombinant extensions
MA43348A (fr) 2015-10-01 2018-08-08 Novo Nordisk As Conjugués de protéines
MA49339A (fr) 2017-04-05 2020-02-12 Novo Nordisk As Conjugués insuline-fc à extension oligomère
CN112028994B (zh) * 2020-07-30 2022-04-05 北京弘进久安生物科技有限公司 抗金黄色葡萄球菌肠毒素b的抗体、检测试纸及试剂盒
IL300930A (en) 2020-08-27 2023-04-01 Enosi Therapeutics Corp Methods and compositions for the treatment of autoimmune diseases and cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2724393A1 (fr) 1994-09-12 1996-03-15 Inst Nat Sante Rech Med Obtention d'un anticorps monoclonal recombinant humanise a partir d'un anticorps monoclonal murin, sa production en cellules d'insecte, et ses utilisations
US20050175986A1 (en) * 2000-05-09 2005-08-11 Smit Kline Beecham Corporation Human monoclonal antibody
CA2443862A1 (en) * 2001-04-17 2002-10-24 Peizhi Luo Structure-based construction of human antibody library
EP2298809A3 (en) * 2001-07-12 2012-02-15 FOOTE, Jefferson Super humanized antibodies
US20040067532A1 (en) * 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
US20050048578A1 (en) * 2003-06-26 2005-03-03 Epitomics, Inc. Methods of screening for monoclonal antibodies with desirable activity
US20050048617A1 (en) 2003-08-18 2005-03-03 Medimmune, Inc. Humanization of antibodies
US20050042664A1 (en) * 2003-08-22 2005-02-24 Medimmune, Inc. Humanization of antibodies
JP2009515516A (ja) * 2005-11-14 2009-04-16 バイオレン・インク 推定成熟cdrのブラスティングならびにコホートライブラリの作製およびスクリーニングによる抗体の超ヒト化

Also Published As

Publication number Publication date
JP2010508290A (ja) 2010-03-18
JP5323710B2 (ja) 2013-10-23
US20090137403A1 (en) 2009-05-28
ES2410886T3 (es) 2013-07-03
WO2008052108A3 (en) 2008-07-10
DK2094728T3 (da) 2013-07-01
PT2094728E (pt) 2013-05-27
EP2094728A4 (en) 2011-03-09
EP2094728B1 (en) 2013-04-10
EP2094728A2 (en) 2009-09-02
WO2008052108A2 (en) 2008-05-02
US8093068B2 (en) 2012-01-10

Similar Documents

Publication Publication Date Title
HRP20181616T1 (hr) Potpuno ljudska anti-vap-1 monoklonska antitijela
HK1194395A1 (zh) 抗體及其製備和使用方法
ZA200809662B (en) Modified humanised anti-interleukin-18 antibodies
IL180852A0 (en) Anti-cd154 antibodies
IL192419A0 (en) Anti-ephb4 antibodies and methods using same
ZA200809065B (en) Humanized c-Kit antibody
EP2021373A4 (en) MONOCLONAL ANTIBODY VCAM-1 SPECIFIC
EP2331579A4 (en) MONOCLONAL ANTIBODIES
SG10201601279SA (en) Monoclonal Antibody STRO-4
IL194787A0 (en) Anti-dll4 antibodies and methods using same
SI2178921T1 (sl) Monoklonska protitelesa proti glipikan-3
SG10201404801YA (en) Monoclonal antibody
GB0615662D0 (en) Antibody
IL200168A0 (en) Monoclonal anti-cxcl13 antibodies
PT2152290E (pt) Métodos para administrar anticorpos anti-il-5
EP1860120A4 (en) PROCESS FOR AN IMPROVED ANTIBODY
EP1998807A4 (en) METHODS OF HUMANIZING ANTIBODIES AND HUMANIZED ANTIBODIES THUS OBTAINED
IL231891A0 (en) Anti-2ephriinb antibodies and methods of using them
EP2094728A4 (en) METHODS OF ADAPTATION OF MONOCLONAL ANTIBODIES TO HUMAN BEINGS
EP2077325A4 (en) MONOCLONAL ANTIBODY AND ITS USE
ZA200809100B (en) Anti-DLL4 antibodies and methods using same
HK1158977A1 (zh) 抗膜鐵轉運蛋白 單克隆抗體及其用途
ZA200806053B (en) Anti-EphB4 antibodies and methods using same
PL382401A1 (pl) Przeciwciała anty-CD154
GB0606276D0 (en) Antibodies