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SI2076502T1 - Substitutirani karboksamidi kot antagonisti metabotropnih receptorjev skupine i - Google Patents

Substitutirani karboksamidi kot antagonisti metabotropnih receptorjev skupine i

Info

Publication number
SI2076502T1
SI2076502T1 SI200730695T SI200730695T SI2076502T1 SI 2076502 T1 SI2076502 T1 SI 2076502T1 SI 200730695 T SI200730695 T SI 200730695T SI 200730695 T SI200730695 T SI 200730695T SI 2076502 T1 SI2076502 T1 SI 2076502T1
Authority
SI
Slovenia
Prior art keywords
group
receptor antagonists
metabotropic receptor
substituted carboxamides
substituted
Prior art date
Application number
SI200730695T
Other languages
English (en)
Inventor
Ryan Thomas Backer
Matthew Joseph Fisher
Steven Lee Kuklish
Sean Patrick Hollinshead
Edward C R Smith
Kumiko Takeuchi
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SI2076502T1 publication Critical patent/SI2076502T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200730695T 2006-06-08 2007-06-07 Substitutirani karboksamidi kot antagonisti metabotropnih receptorjev skupine i SI2076502T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81183906P 2006-06-08 2006-06-08
EP07873705A EP2076502B1 (en) 2006-06-08 2007-06-07 Substituted carboxamides as group i metabotropic receptor antagonists
PCT/US2007/070572 WO2008103185A2 (en) 2006-06-08 2007-06-07 Substituted carboxamides as group i metabotropic receptor antagonists

Publications (1)

Publication Number Publication Date
SI2076502T1 true SI2076502T1 (sl) 2011-09-30

Family

ID=39673278

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200730695T SI2076502T1 (sl) 2006-06-08 2007-06-07 Substitutirani karboksamidi kot antagonisti metabotropnih receptorjev skupine i

Country Status (31)

Country Link
US (1) US7960419B2 (sl)
EP (1) EP2076502B1 (sl)
JP (1) JP5108878B2 (sl)
KR (1) KR101051559B1 (sl)
CN (1) CN101466691B (sl)
AT (1) ATE509921T1 (sl)
AU (1) AU2007347428B2 (sl)
BR (1) BRPI0712862A2 (sl)
CA (1) CA2652074C (sl)
CR (1) CR10410A (sl)
CY (1) CY1111588T1 (sl)
DK (1) DK2076502T3 (sl)
EA (1) EA014233B1 (sl)
EC (1) ECSP088939A (sl)
ES (1) ES2362949T3 (sl)
HK (1) HK1131984A1 (sl)
HR (1) HRP20110436T1 (sl)
IL (1) IL195632A (sl)
MA (1) MA30620B1 (sl)
MX (1) MX2008015485A (sl)
MY (1) MY148084A (sl)
NO (1) NO341474B1 (sl)
NZ (1) NZ573352A (sl)
PL (1) PL2076502T3 (sl)
PT (1) PT2076502E (sl)
RS (1) RS51818B (sl)
SI (1) SI2076502T1 (sl)
TN (1) TNSN08506A1 (sl)
UA (1) UA95480C2 (sl)
WO (1) WO2008103185A2 (sl)
ZA (1) ZA200809111B (sl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0804685D0 (en) 2008-03-13 2008-04-16 Univ Edinburgh Therapeutic compounds and their use
EA018001B1 (ru) 2008-04-04 2013-04-30 Эли Лилли Энд Компани 3-индазолил-4-пиридилизотиазолы
EP2443113A1 (en) * 2009-06-15 2012-04-25 The University Of Edinburgh Amido-isothiazole compounds and their use as inhibitors of 11beta-hsd1 for the treatment of metabolic syndrome and related disorders
KR101702159B1 (ko) 2009-09-16 2017-02-02 더 유니버시티 오브 에든버러 （４―페닐―피페리딘―1―일）―［５―（1ｈ―피라졸―４―일）―티오펜―３―일］―메탄온 화합물 및 그의 용도
JP5899202B2 (ja) 2010-04-29 2016-04-06 ザ ユニバーシティ オブ エディンバラ １１β−ＨＳＤ１の阻害剤としての３，３−二置換−（８−アザ−ビシクロ［３．２．１］オクタ−８−イル）−［５−（１Ｈ−ピラゾール−４−イル）−チオフェン−３−イル］−メタノン類
CN104768944B (zh) 2012-11-13 2017-03-29 日产化学工业株式会社 2‑吡啶酮化合物
BR112019005795A2 (pt) 2016-09-23 2019-06-18 Bayer Ag tienouracilas n3-ciclicamente substituídas e uso das mesmas
CN117567266B (zh) * 2023-11-07 2024-06-14 康龙化成手性医药技术(宁波)有限公司 一种制备2-甲基环丙羧酸的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL72091A0 (en) 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-aryl 5-isothiazolyl)urea derivatives
DE4328425A1 (de) 1993-08-24 1995-03-02 Basf Ag Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung
DK124393D0 (da) 1993-11-03 1993-11-03 Lundbeck & Co As H Compounds
DE19542372A1 (de) * 1995-11-14 1997-05-15 Bayer Ag Acylierte 5-Aminoisothiazole
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
JP3411262B2 (ja) * 1999-08-20 2003-05-26 萬有製薬株式会社 新規スピロ化合物
IL159926A0 (en) * 2001-08-06 2004-06-20 Pharmacia Italia Spa Aminoisoxazole derivatives active as kinase inhibitors
US20060281803A1 (en) * 2003-09-23 2006-12-14 Lindsley Craig W Pyrazole modulators of metabotropic glutamate receptors
CN1984899B (zh) * 2004-05-12 2011-07-27 先灵公司 Cxcr1和cxcr2趋化因子拮抗剂
CA2581657A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Thrombopoietin receptor agonists

Also Published As

Publication number Publication date
CA2652074A1 (en) 2008-08-28
UA95480C2 (uk) 2011-08-10
PT2076502E (pt) 2011-06-07
CA2652074C (en) 2013-08-06
PL2076502T3 (pl) 2011-09-30
EA200870516A1 (ru) 2009-06-30
ATE509921T1 (de) 2011-06-15
CN101466691A (zh) 2009-06-24
JP5108878B2 (ja) 2012-12-26
NO20085028L (no) 2008-12-02
WO2008103185A2 (en) 2008-08-28
AU2007347428B2 (en) 2012-02-09
EP2076502B1 (en) 2011-05-18
AU2007347428A1 (en) 2008-08-28
HRP20110436T1 (hr) 2011-08-31
US20090182025A1 (en) 2009-07-16
MA30620B1 (fr) 2009-08-03
JP2009539874A (ja) 2009-11-19
KR101051559B1 (ko) 2011-07-22
MX2008015485A (es) 2009-03-06
MY148084A (en) 2013-02-28
NZ573352A (en) 2011-10-28
IL195632A (en) 2013-11-28
RS51818B (en) 2011-12-31
ES2362949T3 (es) 2011-07-15
HK1131984A1 (en) 2010-02-12
ZA200809111B (en) 2009-12-30
CN101466691B (zh) 2011-07-27
KR20090008460A (ko) 2009-01-21
WO2008103185A3 (en) 2008-10-30
ECSP088939A (es) 2009-01-30
DK2076502T3 (da) 2011-07-25
TNSN08506A1 (en) 2010-04-14
EP2076502A2 (en) 2009-07-08
CY1111588T1 (el) 2015-10-07
CR10410A (es) 2008-11-28
EA014233B1 (ru) 2010-10-29
NO341474B1 (no) 2017-11-27
IL195632A0 (en) 2009-09-01
US7960419B2 (en) 2011-06-14
BRPI0712862A2 (pt) 2012-12-18

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