SI1553985T1 - Bifenili kot sredstva za slikanje pri Alzheimerjevi bolezni - Google Patents
Bifenili kot sredstva za slikanje pri Alzheimerjevi bolezniInfo
- Publication number
- SI1553985T1 SI1553985T1 SI200332079T SI200332079T SI1553985T1 SI 1553985 T1 SI1553985 T1 SI 1553985T1 SI 200332079 T SI200332079 T SI 200332079T SI 200332079 T SI200332079 T SI 200332079T SI 1553985 T1 SI1553985 T1 SI 1553985T1
- Authority
- SI
- Slovenia
- Prior art keywords
- biphenyls
- alzheimer
- disease
- imaging agents
- amyloid deposits
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 235000010290 biphenyl Nutrition 0.000 title 1
- 150000004074 biphenyls Chemical class 0.000 title 1
- 239000012216 imaging agent Substances 0.000 title 1
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 238000003384 imaging method Methods 0.000 abstract 2
- 102000009091 Amyloidogenic Proteins Human genes 0.000 abstract 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41582402P | 2002-10-04 | 2002-10-04 | |
EP03808140A EP1553985B1 (en) | 2002-10-04 | 2003-10-06 | Biphenyls as imaging agents in alzheimer's disease |
PCT/US2003/031466 WO2004032975A2 (en) | 2002-10-04 | 2003-10-06 | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1553985T1 true SI1553985T1 (sl) | 2012-01-31 |
Family
ID=32093786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200332079T SI1553985T1 (sl) | 2002-10-04 | 2003-10-06 | Bifenili kot sredstva za slikanje pri Alzheimerjevi bolezni |
Country Status (11)
Country | Link |
---|---|
US (1) | US20050271584A1 (sl) |
EP (1) | EP1553985B1 (sl) |
JP (1) | JP2006502220A (sl) |
AT (1) | ATE522230T1 (sl) |
AU (1) | AU2003277280A1 (sl) |
DK (1) | DK1553985T3 (sl) |
ES (1) | ES2370818T3 (sl) |
PT (1) | PT1553985E (sl) |
SI (1) | SI1553985T1 (sl) |
TW (1) | TW200413009A (sl) |
WO (1) | WO2004032975A2 (sl) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007002540A2 (en) * | 2005-06-24 | 2007-01-04 | Kung Hank F | Radiolabeled-pegylation of ligands for use as imaging agents |
JP4738419B2 (ja) | 2005-11-30 | 2011-08-03 | 富士フイルムRiファーマ株式会社 | アミロイドの凝集及び/又は沈着に起因する疾患の診断薬及び治療薬 |
WO2008118122A2 (en) * | 2006-05-08 | 2008-10-02 | Molecular Neuroimaging, Llc | Compounds and amyloid probes thereof for therapeutic and imaging uses |
WO2008124812A1 (en) * | 2007-04-10 | 2008-10-16 | The Trustees Of The University Of Pennsylvania | Phen-naphthalene and phen-quinoline derivatives and their use for binding and imaging amyloid plaques |
JP2010524965A (ja) * | 2007-04-19 | 2010-07-22 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | ジフェニル−ヘテロアリール誘導体並びにアミロイド斑への結合及び画像化のためのその使用 |
JP2011514343A (ja) * | 2008-02-27 | 2011-05-06 | アビッド レディオファーマシューティカルズ、インク. | 放射線標識a−ベータ結合化合物を用いたアミロイドプラークのガンマプローブ検出 |
US8557222B2 (en) * | 2008-04-04 | 2013-10-15 | Avid Radiopharmaceuticals, Inc. | Radiopharmaceutical imaging of neurodegenerative diseases |
EP2300481B1 (en) | 2008-05-30 | 2015-09-30 | Merck Sharp & Dohme Corp. | Novel substituted azabenzoxazoles |
KR101787112B1 (ko) * | 2008-06-09 | 2017-11-15 | 루드비히-막시밀리안스-우니버지테트 뮌헨 | 신경변성 질환 및/또는 단백질 응집과 연관된 질환과 관련된 단백질의 응집을 억제하기 위한 신규 약물 |
CN102256959B (zh) * | 2008-10-17 | 2014-01-08 | 比奥克罗密克斯药业有限公司 | 用于治疗的噻吩化合物 |
WO2010056900A1 (en) * | 2008-11-13 | 2010-05-20 | Avid Radiopharmaceuticals, Inc. | Histogram-based analysis method for the detection and diagnosis of neurodegenerative diseases |
KR101101977B1 (ko) * | 2009-04-09 | 2012-01-02 | (주)에스메디 | 2-아릴나프탈렌, 2-아릴퀴놀린 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물 |
CN102557969B (zh) * | 2011-11-01 | 2015-03-18 | 中国科学技术大学 | 环酮类衍生物及其作为淀粉样蛋白沉积物和神经纤维缠结的显像剂和聚集抑制剂的用途 |
JP2021501198A (ja) * | 2017-10-27 | 2021-01-14 | トランスフュージョン ヘルス,リミティド ライアビリティ カンパニー | フルオレンの誘導体を用いて造血幹細胞を増殖する組成物および方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2157071A (en) * | 1937-08-27 | 1939-05-02 | Dow Chemical Co | Alkyl ethers of meta-phenylphenol |
GB1091403A (en) * | 1964-01-24 | 1967-11-15 | Boots Pure Drug Co Ltd | Therapeutically active phenylalkane derivatives |
AU545825B2 (en) * | 1980-10-02 | 1985-08-01 | Fmc Corporation | Biphenylmethanols and derivatives thereof |
US5034384A (en) * | 1990-08-01 | 1991-07-23 | Merck & Co., Inc. | 2-(9-fluorenonyl)-carbapenem antibacterial agents |
US5192753A (en) * | 1991-04-23 | 1993-03-09 | Mcgeer Patrick L | Anti-rheumatoid arthritic drugs in the treatment of dementia |
US6168776B1 (en) * | 1994-07-19 | 2001-01-02 | University Of Pittsburgh | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
US5739166A (en) * | 1994-11-29 | 1998-04-14 | G.D. Searle & Co. | Substituted terphenyl compounds for the treatment of inflammation |
US5994379A (en) * | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
-
2003
- 2003-10-03 TW TW092127493A patent/TW200413009A/zh unknown
- 2003-10-06 JP JP2004543154A patent/JP2006502220A/ja active Pending
- 2003-10-06 PT PT03808140T patent/PT1553985E/pt unknown
- 2003-10-06 SI SI200332079T patent/SI1553985T1/sl unknown
- 2003-10-06 ES ES03808140T patent/ES2370818T3/es not_active Expired - Lifetime
- 2003-10-06 EP EP03808140A patent/EP1553985B1/en not_active Expired - Lifetime
- 2003-10-06 WO PCT/US2003/031466 patent/WO2004032975A2/en active Application Filing
- 2003-10-06 DK DK03808140.2T patent/DK1553985T3/da active
- 2003-10-06 US US10/529,850 patent/US20050271584A1/en not_active Abandoned
- 2003-10-06 AU AU2003277280A patent/AU2003277280A1/en not_active Abandoned
- 2003-10-06 AT AT03808140T patent/ATE522230T1/de active
Also Published As
Publication number | Publication date |
---|---|
ATE522230T1 (de) | 2011-09-15 |
EP1553985B1 (en) | 2011-08-31 |
EP1553985A2 (en) | 2005-07-20 |
WO2004032975A3 (en) | 2004-09-16 |
DK1553985T3 (da) | 2011-12-12 |
AU2003277280A8 (en) | 2004-05-04 |
AU2003277280A1 (en) | 2004-05-04 |
JP2006502220A (ja) | 2006-01-19 |
ES2370818T3 (es) | 2011-12-23 |
PT1553985E (pt) | 2011-11-30 |
TW200413009A (en) | 2004-08-01 |
US20050271584A1 (en) | 2005-12-08 |
WO2004032975A2 (en) | 2004-04-22 |
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