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SI1023898T1 - Cyano-indoles as serotonine reuptake inhibitors and as 5-HT2c receptor ligands - Google Patents

Cyano-indoles as serotonine reuptake inhibitors and as 5-HT2c receptor ligands

Info

Publication number
SI1023898T1
SI1023898T1 SI200030063T SI200030063T SI1023898T1 SI 1023898 T1 SI1023898 T1 SI 1023898T1 SI 200030063 T SI200030063 T SI 200030063T SI 200030063 T SI200030063 T SI 200030063T SI 1023898 T1 SI1023898 T1 SI 1023898T1
Authority
SI
Slovenia
Prior art keywords
alkyl
cycloalkyl
indoles
cyano
receptor ligands
Prior art date
Application number
SI200030063T
Other languages
English (en)
Slovenian (sl)
Inventor
Gilbert Lavielle
Olivier Muller
Bernard Cimetiere
Mark Millan
Alain Gobert
Jean-Michel Rivet
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1023898T1 publication Critical patent/SI1023898T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI200030063T 1999-01-26 2000-01-26 Cyano-indoles as serotonine reuptake inhibitors and as 5-HT2c receptor ligands SI1023898T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9900801A FR2788772B1 (fr) 1999-01-26 1999-01-26 Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP00400193A EP1023898B1 (fr) 1999-01-26 2000-01-26 Cyano-indoles en tant qu' inhibiteurs de recapture de sérotonine et ligands du récepteur 5-HT2c

Publications (1)

Publication Number Publication Date
SI1023898T1 true SI1023898T1 (en) 2003-06-30

Family

ID=9541208

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030063T SI1023898T1 (en) 1999-01-26 2000-01-26 Cyano-indoles as serotonine reuptake inhibitors and as 5-HT2c receptor ligands

Country Status (22)

Country Link
US (1) US6239129B1 (no)
EP (1) EP1023898B1 (no)
JP (1) JP2000212162A (no)
KR (1) KR100445389B1 (no)
CN (1) CN1155570C (no)
AT (1) ATE234093T1 (no)
AU (1) AU761084B2 (no)
BR (1) BR0000158A (no)
CA (1) CA2297279C (no)
DE (1) DE60001591T2 (no)
DK (1) DK1023898T3 (no)
EA (1) EA003146B1 (no)
ES (1) ES2193923T3 (no)
FR (1) FR2788772B1 (no)
HK (1) HK1029584A1 (no)
HU (1) HUP0000308A2 (no)
MX (1) MXPA00000856A (no)
NO (1) NO314801B1 (no)
NZ (1) NZ502494A (no)
PL (1) PL338027A1 (no)
SI (1) SI1023898T1 (no)
ZA (1) ZA200000336B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001247562A (ja) * 2000-03-07 2001-09-11 Daicel Chem Ind Ltd アミド化合物及びその製造方法
CN1267424C (zh) * 2000-11-20 2006-08-02 比奥维特罗姆股份公司 作为5－羟色胺5ht－2受体的激动剂或拮抗剂的哌嗪基吡嗪化合物
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
US6777437B2 (en) 2001-03-29 2004-08-17 Bristol-Myers Squibb Company Cyclopropylindole derivatives as selective serotonin reuptake inhibitors
NZ537982A (en) * 2002-09-17 2007-05-31 Hoffmann La Roche 2,7-substituted indoles and their use as 5-HT6 modulators
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
CN1886133B (zh) * 2003-12-04 2010-12-01 财团法人卫生研究院 吲哚化合物
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK181190D0 (da) * 1990-07-30 1990-07-30 Lundbeck & Co As H 3-aryl-indol- eller 3-aryl-indazolderivater
TW270114B (no) * 1993-10-22 1996-02-11 Hoffmann La Roche
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
US5912256A (en) * 1996-06-20 1999-06-15 Eli Lilly And Company Compounds having effects on serotonin-related systems
JP3560986B2 (ja) * 1997-01-13 2004-09-02 山之内製薬株式会社 ５―ｈｔ２ｃ受容体作用薬及びアミノアルキルインダゾール誘導体

Also Published As

Publication number Publication date
HUP0000308A2 (en) 2002-06-29
EA200000068A3 (ru) 2000-10-30
ZA200000336B (en) 2000-08-15
EA200000068A2 (ru) 2000-08-28
HK1029584A1 (en) 2001-04-06
JP2000212162A (ja) 2000-08-02
HU0000308D0 (en) 2000-03-28
EA003146B1 (ru) 2003-02-27
MXPA00000856A (es) 2002-03-08
BR0000158A (pt) 2000-09-19
AU761084B2 (en) 2003-05-29
CN1266057A (zh) 2000-09-13
US6239129B1 (en) 2001-05-29
CN1155570C (zh) 2004-06-30
NO20000373L (no) 2000-07-27
NO20000373D0 (no) 2000-01-25
NZ502494A (en) 2001-06-29
DE60001591D1 (de) 2003-04-17
DE60001591T2 (de) 2003-12-24
ES2193923T3 (es) 2003-11-16
ATE234093T1 (de) 2003-03-15
KR20010006587A (ko) 2001-01-26
FR2788772B1 (fr) 2001-03-02
NO314801B1 (no) 2003-05-26
PL338027A1 (en) 2000-07-31
EP1023898A1 (fr) 2000-08-02
EP1023898B1 (fr) 2003-03-12
FR2788772A1 (fr) 2000-07-28
CA2297279C (fr) 2004-05-18
AU1355300A (en) 2000-07-27
CA2297279A1 (fr) 2000-07-26
KR100445389B1 (ko) 2004-08-25
DK1023898T3 (da) 2003-06-10

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