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SG11202102427XA - Interleukin-2 polypeptide conjugates and their uses - Google Patents

Interleukin-2 polypeptide conjugates and their uses

Info

Publication number
SG11202102427XA
SG11202102427XA SG11202102427XA SG11202102427XA SG11202102427XA SG 11202102427X A SG11202102427X A SG 11202102427XA SG 11202102427X A SG11202102427X A SG 11202102427XA SG 11202102427X A SG11202102427X A SG 11202102427XA SG 11202102427X A SG11202102427X A SG 11202102427XA
Authority
SG
Singapore
Prior art keywords
interleukin
polypeptide conjugates
conjugates
polypeptide
Prior art date
Application number
SG11202102427XA
Inventor
Sigeng Chen
Yingchun Lu
Rashid, Md
Nickolas Knudsen
Feng Tian
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of SG11202102427XA publication Critical patent/SG11202102427XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202102427XA 2018-09-11 2019-09-11 Interleukin-2 polypeptide conjugates and their uses SG11202102427XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862729925P 2018-09-11 2018-09-11
US201962815964P 2019-03-08 2019-03-08
PCT/US2019/050709 WO2020056066A1 (en) 2018-09-11 2019-09-11 Interleukin-2 polypeptide conjugates and their uses

Publications (1)

Publication Number Publication Date
SG11202102427XA true SG11202102427XA (en) 2021-04-29

Family

ID=68104742

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202102427XA SG11202102427XA (en) 2018-09-11 2019-09-11 Interleukin-2 polypeptide conjugates and their uses

Country Status (23)

Country Link
US (2) US12049485B2 (en)
EP (2) EP3849614B1 (en)
JP (2) JP7441826B2 (en)
KR (1) KR20210057124A (en)
CN (2) CN116948006A (en)
AU (1) AU2019337610A1 (en)
BR (1) BR112021004488A2 (en)
CA (1) CA3111576A1 (en)
DK (1) DK3849614T3 (en)
ES (1) ES2972137T3 (en)
FI (1) FI3849614T3 (en)
HR (1) HRP20240016T1 (en)
HU (1) HUE065882T2 (en)
IL (1) IL281192A (en)
LT (1) LT3849614T (en)
MX (1) MX2021002575A (en)
PL (1) PL3849614T3 (en)
PT (1) PT3849614T (en)
RS (1) RS65268B1 (en)
SG (1) SG11202102427XA (en)
SI (1) SI3849614T1 (en)
SM (1) SMT202400087T1 (en)
WO (1) WO2020056066A1 (en)

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SG11202102427XA (en) * 2018-09-11 2021-04-29 Ambrx Inc Interleukin-2 polypeptide conjugates and their uses
MA54195A (en) 2018-11-08 2022-02-16 Synthorx Inc INTERLEUKIN 10 CONJUGATES AND THEIR USES
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CN113874390A (en) * 2019-05-24 2021-12-31 普罗维瓦疗法香港有限公司 IL-2 compositions and methods of use
CA3148135A1 (en) 2019-08-23 2021-03-04 Carolina E. CAFFARO Il-15 conjugates and uses thereof
CN114746122A (en) 2019-09-10 2022-07-12 新索思股份有限公司 IL-2 conjugates and methods of use to treat autoimmune diseases
CN110642934B (en) * 2019-09-10 2022-08-23 中国医学科学院北京协和医院 Long-acting interleukin-2 of target regulatory T cell and application thereof in treating autoimmune disease
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US20230272001A1 (en) * 2020-05-22 2023-08-31 Merck Sharp & Dohme Llc Novel processes for preparing conjugates of the il-2 protein
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CN112279906B (en) * 2020-10-30 2022-09-20 浙江新码生物医药有限公司 Human interleukin 2-polyethylene glycol conjugate, preparation method and application thereof
EP4352087A4 (en) * 2021-06-08 2025-05-14 Merck Sharp & Dohme LLC Functional cell-based potency assay for measuring biological activity of interleukin 2 (il-2) analogs
AU2022306788A1 (en) 2021-07-09 2024-01-04 Bright Peak Therapeutics Ag Conjugates of checkpoint inhibitors with il-2, and uses thereof
US20230201365A1 (en) 2021-07-09 2023-06-29 Bright Peak Therapeutics Ag Modified cd20 antibodies and uses thereof
WO2023281484A1 (en) * 2021-07-09 2023-01-12 Bright Peak Therapeutics Ag Synthetic il-7 and il-7 immunocytokines
CA3224147A1 (en) 2021-07-09 2023-01-12 Vijaya Raghavan PATTABIRAMAN Antibody conjugates and manufacture thereof
AU2022325498A1 (en) 2021-08-13 2024-02-01 Cytune Pharma Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer
CN113788890B (en) * 2021-09-01 2022-11-08 浙江新码生物医药有限公司 Human interleukin 2-polyethylene glycol conjugate and application thereof
CN113698468B (en) * 2021-09-01 2022-10-11 浙江新码生物医药有限公司 Human interleukin 2-polyethylene glycol conjugate and application thereof
CN114316019B (en) * 2021-12-10 2024-05-03 河北菲尼斯生物技术有限公司 Method for preparing PEG modified IL-2 by ion exchange chromatography
US20240132563A1 (en) 2022-02-23 2024-04-25 Bright Peak Therapeutics Ag Bifunctional cytokine compositions
CN114773433B (en) * 2022-06-23 2022-09-06 北京肿瘤医院(北京大学肿瘤医院) A kind of CD25 targeting polypeptide, molecular probe and application
WO2024150175A1 (en) 2023-01-11 2024-07-18 Bright Peak Therapeutics Ag Conditionally activated proteins and methods of use
US20240417436A1 (en) 2023-01-11 2024-12-19 Bright Peak Therapeutics Ag Conditionally activated immunocytokines and methods of use
CN117417292B (en) * 2023-02-20 2024-07-12 浙江新码生物医药有限公司 A non-natural amino acid containing heteroaryl groups and its use
WO2025148785A1 (en) * 2024-01-08 2025-07-17 Fbd Biologics Limited Engineered il-2 variants and methods of use thereof

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