[go: up one dir, main page]

SG11202008433QA - Compounds including a mutant kras sequence and a lipid and uses thereof - Google Patents

Compounds including a mutant kras sequence and a lipid and uses thereof

Info

Publication number
SG11202008433QA
SG11202008433QA SG11202008433QA SG11202008433QA SG11202008433QA SG 11202008433Q A SG11202008433Q A SG 11202008433QA SG 11202008433Q A SG11202008433Q A SG 11202008433QA SG 11202008433Q A SG11202008433Q A SG 11202008433QA SG 11202008433Q A SG11202008433Q A SG 11202008433QA
Authority
SG
Singapore
Prior art keywords
lipid
compounds including
mutant kras
kras sequence
sequence
Prior art date
Application number
SG11202008433QA
Inventor
Peter Demuth
Julian Adams
Martin Steinbuck
Original Assignee
Elicio Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elicio Therapeutics Inc filed Critical Elicio Therapeutics Inc
Publication of SG11202008433QA publication Critical patent/SG11202008433QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001164—GTPases, e.g. Ras or Rho
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/05—Hydrolases acting on acid anhydrides (3.6) acting on GTP; involved in cellular and subcellular movement (3.6.5)
    • C12Y306/05002—Small monomeric GTPase (3.6.5.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11202008433QA 2018-03-02 2019-03-01 Compounds including a mutant kras sequence and a lipid and uses thereof SG11202008433QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862637879P 2018-03-02 2018-03-02
PCT/US2019/020404 WO2019169332A1 (en) 2018-03-02 2019-03-01 Compounds including a mutant kras sequence and a lipid and uses thereof

Publications (1)

Publication Number Publication Date
SG11202008433QA true SG11202008433QA (en) 2020-09-29

Family

ID=67805548

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202008433QA SG11202008433QA (en) 2018-03-02 2019-03-01 Compounds including a mutant kras sequence and a lipid and uses thereof

Country Status (14)

Country Link
US (2) US12138301B2 (en)
EP (1) EP3758713A4 (en)
JP (2) JP7419268B2 (en)
KR (2) KR20250047830A (en)
CN (2) CN112118847B (en)
AU (1) AU2019226586B2 (en)
BR (1) BR112020017645A2 (en)
CA (1) CA3092679A1 (en)
IL (1) IL277100B2 (en)
MA (1) MA52435A (en)
MX (1) MX2020009149A (en)
SA (1) SA520420064B1 (en)
SG (1) SG11202008433QA (en)
WO (1) WO2019169332A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12138301B2 (en) 2018-03-02 2024-11-12 Elicio Therapeutics, Inc. Compounds including a mutant KRAS sequence and a lipid and uses thereof
CN112203663A (en) * 2018-03-02 2021-01-08 伊莱西奥治疗有限公司 CPG amphiphilic molecules and uses thereof
JP2024508725A (en) * 2021-02-10 2024-02-28 上海吉倍生物技術有限公司 Epitope peptide of RAS G13D variant and T cell receptor that recognizes RAS G13D variant
KR102753583B1 (en) 2021-11-11 2025-01-10 의료법인 명지의료재단 Antigen Composition For Inducing KRAS Specific Activated T Cell
KR102818249B1 (en) 2021-11-11 2025-06-10 의료법인 명지의료재단 Manufacturing Method of KRAS Specific Activated Cell Using KRAS Antigen Composition
KR102732909B1 (en) 2021-12-29 2024-11-20 의료법인 명지의료재단 Pharmaceutical Composition For Preventing Or Treating Lung Papillary Adenocarcinoma Comprising K-ras Specific Activated T Cell And Manufacturing Method Thereof
KR102732912B1 (en) 2021-12-29 2024-11-20 의료법인 명지의료재단 Pharmaceutical Composition For Preventing Or Treating Lung Adenocarcinoma Comprising K-ras Specific Activated T Cell And Manufacturing Method Thereof
KR102732911B1 (en) 2021-12-29 2024-11-20 의료법인 명지의료재단 Pharmaceutical Composition For Preventing Or Treating Breast Cancer Comprising K-ras Specific Activated T Cell And Manufacturing Method Thereof
KR102732910B1 (en) 2021-12-29 2024-11-20 의료법인 명지의료재단 Pharmaceutical Composition For Preventing Or Treating Colorectal Cancer Comprising K-ras Specific Activated T Cell And Manufacturing Method Thereof
KR102732913B1 (en) 2021-12-29 2024-11-20 의료법인 명지의료재단 Pharmaceutical Composition For Preventing Or Treating Melanoma Comprising K-ras Specific Activated T Cell And Manufacturing Method Thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6168778B1 (en) * 1990-06-11 2001-01-02 Nexstar Pharmaceuticals, Inc. Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes
GB9103974D0 (en) * 1991-02-26 1991-04-10 Norsk Hydro As Therapeutically useful peptides or peptide fragments
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US7709002B1 (en) * 1996-04-19 2010-05-04 The United States Of America As Represented By The Department Of Health And Human Services Mutated ras peptides for generation of CD8+Cytotoxic T lymphocytes
DE69714033T2 (en) 1996-04-19 2003-02-13 The Government Of The United States Of America, As Represented By The Secretary National Institute Of Health MUTED RAS PEPTIDES TO GENERATE CD8 + CYTITOXIC T LYMPHOIZYTES
JPWO2005001116A1 (en) 2003-06-17 2006-08-24 明治乳業株式会社 Use of Toll-like receptor forced expression cells
JP2008500275A (en) 2003-12-31 2008-01-10 セントカー・インコーポレーテツド Novel recombinant protein having an N-terminal free thiol
US20080299138A1 (en) 2007-05-25 2008-12-04 Duffy Karen E Toll-Like Receptor 3 Modulators and Uses Thereof
US20120264810A1 (en) 2009-09-22 2012-10-18 The University Of British Columbia Compositions and methods for enhancing cellular uptake and intracellular delivery of lipid particles
US20120328701A1 (en) * 2011-01-24 2012-12-27 Anterios, Inc. Nanoparticle compositions, formulations thereof, and uses therefor
WO2013151771A1 (en) 2012-04-05 2013-10-10 Massachusetts Institute Of Technology Immunostimulatory compositions and methods of use thereof
TW201402813A (en) 2012-05-09 2014-01-16 Gradalis Inc Bi-functional short-hairpin RNA (bi-shRNA) specific for single-nucleotide KRAS mutations
US9913907B2 (en) 2012-07-16 2018-03-13 Kyowa Hakko Kirin Co., Ltd. RNAi pharmaceutical composition for suppressing expression of KRAS gene
AR095882A1 (en) 2013-04-22 2015-11-18 Hoffmann La Roche ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R WITH A TLR9 AGONIST
EP3061547B1 (en) 2013-10-24 2019-12-04 Daicel Corporation Method for producing dispersion liquid containing silver nanoparticles, and dispersion liquid containing silver nanoparticles
US20170246288A1 (en) * 2014-09-11 2017-08-31 Vedantra Pharmaceuticals, Inc. Multilamellar lipid vesicle compositions and methods of use
US10940201B2 (en) 2015-09-30 2021-03-09 Shionogi & Co., Ltd. Nucleic acid derivative having immunostimulatory activity
WO2017127473A1 (en) 2016-01-19 2017-07-27 The University Of North Carolina At Chapel Hill Methods and compositions using rna interference for inhibition of kras
CN110506107A (en) 2016-11-30 2019-11-26 阿德瓦希斯公司 Immunogenic compositions targeting recurrent cancer mutations and methods of use
JP2020510650A (en) 2017-02-23 2020-04-09 アルファ−オ ペプティデス アクツィエンゲゼルシャフト Self-assembling protein nanoparticles encapsulating immunostimulatory nucleic acids
TW201919712A (en) * 2017-08-10 2019-06-01 法商塞勒尼斯醫療控股公司 Cargomers
CN112203663A (en) 2018-03-02 2021-01-08 伊莱西奥治疗有限公司 CPG amphiphilic molecules and uses thereof
US12138301B2 (en) 2018-03-02 2024-11-12 Elicio Therapeutics, Inc. Compounds including a mutant KRAS sequence and a lipid and uses thereof

Also Published As

Publication number Publication date
EP3758713A4 (en) 2021-12-29
MA52435A (en) 2021-01-06
AU2019226586B2 (en) 2024-08-29
US20250009888A1 (en) 2025-01-09
CN118421594A (en) 2024-08-02
IL277100B1 (en) 2025-02-01
CN112118847B (en) 2024-05-28
RU2020132290A (en) 2022-04-05
EP3758713A1 (en) 2021-01-06
JP2021517471A (en) 2021-07-26
IL277100A (en) 2020-10-29
MX2020009149A (en) 2021-01-15
CA3092679A1 (en) 2019-09-06
NZ768282A (en) 2024-10-25
SA520420064B1 (en) 2024-04-28
US20210060149A1 (en) 2021-03-04
KR20250047830A (en) 2025-04-04
IL277100B2 (en) 2025-06-01
US12138301B2 (en) 2024-11-12
WO2019169332A1 (en) 2019-09-06
KR102787353B1 (en) 2025-03-26
AU2019226586A1 (en) 2020-10-15
BR112020017645A2 (en) 2020-12-29
KR20200141994A (en) 2020-12-21
JP2024050594A (en) 2024-04-10
CN112118847A (en) 2020-12-22
JP7419268B2 (en) 2024-01-22

Similar Documents

Publication Publication Date Title
IL277100A (en) Compounds including a mutant kras sequence and a lipid and uses thereof
IL291593A (en) Methods and compounds for restoring mutant p53 function
IL261175A (en) Methods and compounds for restoring mutant p53 function
IL279153A (en) Mutant cpf1 endonucleases
PT3720442T (en) Inhibiting mutant idh-1
GB201812992D0 (en) Liposomes
GB201903827D0 (en) New compounds and methods
GB201903832D0 (en) New compounds and methods
IL281510A (en) A push chair
EP4050100A4 (en) Transaminase mutant and use thereof
HK40043596A (en) Compounds including a mutant kras sequence and a lipid and uses thereof
HK40043265B (en) Compounds including a mutant kras sequence and a lipid and uses thereof
GB201913110D0 (en) New compounds and methods
GB201903854D0 (en) Pillow
EP3844079A4 (en) A bag and related methods
GB201818904D0 (en) New formulations and methods
HK40097162A (en) Inhibiting mutant idh-1
PL3720442T3 (en) Inhibiting mutant idh-1
CA187398S (en) Pillow
CA194814S (en) Pillow
CA187541S (en) Zipper
HK40045257A (en) Mutant cpf1 endonucleases
AU2025205332A1 (en) Post-to-beam fastener
GB201908955D0 (en) Button development 05
GB201908608D0 (en) Button development 04