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SG11202004833SA - IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS - Google Patents

IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS

Info

Publication number
SG11202004833SA
SG11202004833SA SG11202004833SA SG11202004833SA SG11202004833SA SG 11202004833S A SG11202004833S A SG 11202004833SA SG 11202004833S A SG11202004833S A SG 11202004833SA SG 11202004833S A SG11202004833S A SG 11202004833SA SG 11202004833S A SG11202004833S A SG 11202004833SA
Authority
SG
Singapore
Prior art keywords
immunotherapies
effector cells
ipsc derived
derived effector
enhanced
Prior art date
Application number
SG11202004833SA
Inventor
Bahram Valamehr
Ryan Bjordahl
Tom Lee
Svetlana Gaidarova
Original Assignee
Fate Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fate Therapeutics Inc filed Critical Fate Therapeutics Inc
Publication of SG11202004833SA publication Critical patent/SG11202004833SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K40/4255—Mesothelin [MSLN]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Virology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11202004833SA 2017-12-08 2018-11-30 IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS SG11202004833SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762596659P 2017-12-08 2017-12-08
US201862657626P 2018-04-13 2018-04-13
PCT/US2018/063362 WO2019112899A2 (en) 2017-12-08 2018-11-30 IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS

Publications (1)

Publication Number Publication Date
SG11202004833SA true SG11202004833SA (en) 2020-06-29

Family

ID=66749947

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202004833SA SG11202004833SA (en) 2017-12-08 2018-11-30 IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS

Country Status (12)

Country Link
US (1) US20210015859A1 (en)
EP (1) EP3720946A4 (en)
JP (2) JP2021505131A (en)
KR (1) KR20200097749A (en)
CN (1) CN111556892A (en)
AU (2) AU2018381191B2 (en)
BR (1) BR112020010597A2 (en)
CA (1) CA3083109A1 (en)
IL (2) IL275180B1 (en)
MX (1) MX2020005477A (en)
SG (1) SG11202004833SA (en)
WO (1) WO2019112899A2 (en)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
EP4083192A1 (en) 2017-12-22 2022-11-02 Fate Therapeutics, Inc. Enhanced immune effector cells and use thereof
SG11202007156QA (en) 2018-02-09 2020-08-28 Nat Univ Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
SG11202008976YA (en) 2018-04-02 2020-10-29 Nat Univ Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
US12378572B2 (en) 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
PE20211959A1 (en) * 2019-02-15 2021-09-30 Editas Medicine Inc IMMUNOTHERAPY MODIFIED NATURAL KILLER (NK) CELLS
CA3131533A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
CN113906133A (en) * 2019-04-11 2022-01-07 菲特治疗公司 CD3 reconstitution in engineered iPSCs and immune effector cells
US20220281971A1 (en) * 2019-07-17 2022-09-08 National University Of Singapore Functional Binders Synthesized and Secreted by Immune Cells
AU2020314969A1 (en) * 2019-07-17 2022-02-03 Fate Therapeutics, Inc. Immune effector cell engineering and use thereof
EP4025224A1 (en) 2019-09-05 2022-07-13 CRISPR Therapeutics AG Universal donor cells
MX2022003414A (en) * 2019-09-25 2022-04-18 Fate Therapeutics Inc EFFECTOR CELLS WITH MULTIPLE OBJECTIVES AND THEIR USE.
BR112022006440A2 (en) * 2019-10-07 2022-07-05 Fate Therapeutics Inc ENHANCED CHIMERIC ANTIGEN RECEPTOR FOR IMMUNE EFFECTOR CELL HANDLING AND USE THEREOF
CN114761545A (en) * 2019-10-09 2022-07-15 蓝岩治疗有限公司 Cells with persistent transgene expression
JP7664913B2 (en) * 2019-10-17 2025-04-18 フェイト セラピューティクス，インコーポレイテッド Enhanced chimeric antigen receptor effector cell engineering and uses thereof for immunization
CA3160423A1 (en) * 2019-12-06 2021-06-10 Fate Therapeutics, Inc. Enhancement of ipsc-derived effector immune cell using small compounds
EP3858999A1 (en) * 2020-01-30 2021-08-04 Aelian Biotechnology GmbH Safe harbor loci
CN111269326A (en) * 2020-02-28 2020-06-12 南京北恒生物科技有限公司 Novel chimeric antigen receptors and their uses
AU2021261681A1 (en) * 2020-04-24 2022-12-08 Merus N.V. Treatment of cancers with an antibody that binds LGR5 and EGFR
AU2021264068A1 (en) * 2020-04-30 2022-12-08 The Translational Genomics Research Institute Neoantigen-informed tumor-infiltrating lymphocyte cancer immunotherapy
CN113801238A (en) * 2020-06-11 2021-12-17 南京北恒生物科技有限公司 Engineered immune cells expressing NK inhibitory molecules and uses thereof
MX2022015863A (en) * 2020-06-19 2023-03-23 Fate Therapeutics Inc Combining ipsc-derived effector cell types for immunotherapy use.
CN113528452B (en) * 2020-07-06 2023-06-06 上海鑫湾生物科技有限公司 Immune cells co-expressing IL-21 and hrCD16 chimeric receptors and their application
EP4185616A1 (en) * 2020-07-24 2023-05-31 Cellectis S.A. T-cells expressing immune cell engagers in allogenic settings
CN114276996A (en) * 2020-09-28 2022-04-05 未来智人再生医学研究院(广州)有限公司 Pluripotent stem cell derivative expressing PD-1/PD-L1 blocking substance and application
EP4222267A1 (en) * 2020-09-30 2023-08-09 Vor Biopharma Inc. Chimeric antigen receptor expression systems
CA3194850A1 (en) * 2020-10-09 2022-04-14 Dan Lu Engineered ipsc and armed immune effector cells
EP4237004A4 (en) * 2020-10-28 2024-12-11 SRI International GENETICALLY MODIFIED ANTIGEN-SPECIFIC NATURAL KILLER CELLS FOR IN-SITU SYNTHESIS OF PROTEINS
CN114426953A (en) * 2020-10-29 2022-05-03 未来智人再生医学研究院(广州)有限公司 Pluripotent stem cell derivative for expressing IL-12 and application thereof
CN114507643A (en) * 2020-10-29 2022-05-17 未来智人再生医学研究院(广州)有限公司 Pluripotent stem cell derivative for expressing IL-2 and application thereof
CN114457022A (en) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 Pluripotent stem cell expressing OX40 activated antibody and derivative and application thereof
CN114457028A (en) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 Pluripotent stem cell expressing CD38 antibody, derivative and application thereof
CN114525258A (en) * 2020-10-30 2022-05-24 未来智人再生医学研究院(广州)有限公司 Pluripotent stem cell expressing PCSK9 blocker or derivative thereof and application
CN114517184A (en) * 2020-10-30 2022-05-20 未来智人再生医学研究院(广州)有限公司 Pluripotent stem cell expressing adipsin or derivative thereof and application thereof
CN114457031A (en) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 Pluripotent stem cell expressing B7-H5 blocking substance or derivative thereof and application
CN114457025A (en) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 A pluripotent stem cell expressing BTLA blocker or its derivative and application
CN114525254A (en) * 2020-10-30 2022-05-24 未来智人再生医学研究院(广州)有限公司 FGF-21-expressing pluripotent stem cell or derivative thereof and application
WO2022095902A1 (en) * 2020-11-03 2022-05-12 Hangzhou Qihan Biotechnology Co., Ltd. Systems and methods for enhanced immunotherapies
CN120025983A (en) * 2020-11-03 2025-05-23 南京北恒生物科技有限公司 Chimeric antigen receptor targeting CD7 and its use
WO2022098914A1 (en) * 2020-11-04 2022-05-12 Fate Therapeutics, Inc. Engineered ipsc and persistent immune effector cells
IL302476A (en) * 2020-11-04 2023-06-01 Fate Therapeutics Inc Induced pluripotent stem cells and immune effector cells for heterogeneous tumor control
WO2022113056A1 (en) * 2020-11-30 2022-06-02 Crispr Therapeutics Ag Gene-edited natural killer cells
MX2023006395A (en) 2020-12-03 2023-06-15 Century Therapeutics Inc GENETICALLY DESIGNED CELLS AND USES OF THESE.
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
WO2022133169A1 (en) 2020-12-18 2022-06-23 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
CN114645018A (en) * 2020-12-18 2022-06-21 未来智人再生医学研究院(广州)有限公司 A pluripotent stem cell expressing CD38 targeting inhibitor and its derivative and application
CN114645020A (en) * 2020-12-21 2022-06-21 未来智人再生医学研究院(广州)有限公司 Pluripotent stem cell expressing targeted NR4A1 inhibitory factor, and derivative and application thereof
CN114657135A (en) * 2020-12-22 2022-06-24 未来智人再生医学研究院(广州)有限公司 Pluripotent stem cell expressing Tim-3 targeted inhibitory factor, derivative and application thereof
WO2022137181A1 (en) * 2020-12-23 2022-06-30 Crispr Therapeutics Ag Co-use of lenalidomide with car-t cells
JP2024501831A (en) * 2020-12-23 2024-01-16 ティーシーアール２ セラピューティクス インク． Compositions and methods for TCR reprogramming using fusion proteins
US11473060B2 (en) 2020-12-30 2022-10-18 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into NK cells
KR20230146008A (en) 2020-12-31 2023-10-18 크리스퍼 테라퓨틱스 아게 universal donor cells
CA3204417A1 (en) * 2021-01-29 2022-08-04 Allogene Therapeutics, Inc. Knockdown or knockout of one or more of tap2, nlrc5, ?2m, trac, rfx5, rfxap and rfxank to mitigate t cell recognition of allogeneic cell products
US20240299543A1 (en) * 2021-02-02 2024-09-12 Carisma Therapeutics Inc. Self-polarizing immune cells
CN117377756A (en) * 2021-03-05 2024-01-09 菲克特生物科学股份有限公司 Engineered immune cell therapy
MX2023011927A (en) * 2021-04-07 2023-10-23 Century Therapeutics Inc COMPOSITIONS AND METHODS FOR THE GENERATION OF GAMMA-DELTA T LYMPHOCYTES FROM INDUCED PLURIPOTENT STEM CELLS.
JP2024521619A (en) * 2021-05-27 2024-06-04 サナ バイオテクノロジー，インコーポレイテッド Hypoimmunogenic cells containing engineered HLA-E or HLA-G
US20230016422A1 (en) * 2021-06-23 2023-01-19 Crispr Therapeutics Ag Engineered cells with improved protection from natural killer cell killing
WO2023006082A1 (en) * 2021-07-30 2023-02-02 启愈生物技术(上海)有限公司 Antigen targeting, anti-cd16a, and immune effector cell activating trifunctional fusion protein, and application thereof
WO2023019185A1 (en) * 2021-08-10 2023-02-16 Gentibio, Inc. Compositions and methods for engineering stable tregs
CN114107378A (en) * 2021-09-13 2022-03-01 钦元再生医学(珠海)有限公司 Preparation method of universal CAR-T cell
EP4430165A4 (en) * 2021-11-08 2025-12-03 Fate Therapeutics Inc MANIPULATED EFFECTOR CELLS FOR TRANSPORTING ALLOGEN CELL THERAPIES INTO SOLID TUMORS
CN116103239A (en) * 2021-11-11 2023-05-12 南京北恒生物科技有限公司 Engineered immune cells and uses thereof
US20250035613A1 (en) * 2021-12-06 2025-01-30 WuXi Biologics Ireland Limited 3d bioassays to measure antibody-dependent cell-mediated cytotoxicity
CN114414541A (en) * 2021-12-17 2022-04-29 上海药明生物医药有限公司 Method for detecting killing effect of T cells by applying 3D cell imaging analysis system
JP2025501617A (en) * 2021-12-24 2025-01-22 ヘマセル バイオテクノロジー インコーポレイテッド Methods for producing human induced pluripotent stem cells by homologous recombination and integrase-mediated recombination
CN114317607B (en) * 2021-12-31 2024-08-02 苏州桑尼赛尔生物医药有限公司 Double-target general CAR-T cell fusing first-generation targeting CD7 CAR and second-generation targeting BCMA and preparation method thereof
CN118946585A (en) * 2022-03-25 2024-11-12 怡诺安有限公司 Anti-HLA-G chimeric antigen receptor and its use
JP7701453B2 (en) 2022-04-08 2025-07-01 フェイト セラピューティクス，インコーポレイティド Solid tumor targeting scaffold bearing cells and uses thereof
JP7707304B2 (en) 2022-04-08 2025-07-14 フェイト セラピューティクス，インコーポレイティド Chimeric antigen receptors for tumor targeting
CN116948012B (en) * 2022-04-13 2024-07-26 星奕昂(上海)生物科技有限公司 CD16 splice-resistant mutants enhance cell function
CN114478806B (en) * 2022-04-14 2022-07-01 呈诺再生医学科技(北京)有限公司 Chimeric receptor for improving killing activity of immune cells and application thereof
JP2025524353A (en) 2022-06-09 2025-07-30 ウモジャ バイオファーマ インコーポレイテッド Compositions and methods for NK cell differentiation
EP4299734A1 (en) * 2022-07-01 2024-01-03 ETH Zurich Cell line for discovering tcr antigens and uses thereof
KR20250042171A (en) 2022-07-27 2025-03-26 우모자 바이오파마 인코포레이티드 Differentiation of stem cells in suspension culture
CN116042527B (en) * 2022-09-07 2023-08-22 广州瑞臻再生医学科技有限公司 iPS cell line for promoting NK cell differentiation and construction method and application thereof
WO2024102954A1 (en) 2022-11-10 2024-05-16 Massachusetts Institute Of Technology Activation induced clipping system (aics)
CN116445414B (en) * 2023-03-03 2025-07-08 广州瑞臻再生医学科技有限公司 Method and application of enhanced NK cells derived from gene-modified pluripotent stem cells
CN116410336B (en) * 2023-06-02 2023-09-22 云南赛元生物技术有限公司 Chimeric antigen receptor encoding nucleotide, CAR-NK cell, construction method and application thereof
WO2025146467A1 (en) 2024-01-04 2025-07-10 Onk Therapeutics Limited Targeted il-15 construct delivery
WO2025158400A1 (en) * 2024-01-24 2025-07-31 Yale University Compositions and methods of natural killer cell hyperboosts for enhancement of nk cell therapy
CN117946973B (en) * 2024-03-26 2024-05-28 苏州艾凯利元生物科技有限公司 A CAR-iNK cell and its preparation method and application

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1777294A1 (en) * 2005-10-20 2007-04-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins
EP2537933A1 (en) * 2011-06-24 2012-12-26 Institut National de la Santé et de la Recherche Médicale (INSERM) An IL-15 and IL-15Ralpha sushi domain based immunocytokines
CA2908668C (en) * 2013-04-03 2023-03-14 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted t cells derived from pluripotent stem cells
JP2018522833A (en) * 2015-06-12 2018-08-16 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． Chimeric antigen receptor (CAR) constructs and disease treatment with T cells (CAR-T) or NK cells (CAR-NK) expressing CAR constructs
KR20180125435A (en) * 2015-09-25 2018-11-23 알토 바이오사이언스 코포레이션 Interleukin-15 superagens that significantly improve graft-versus-tumor activity
AU2016349504B2 (en) * 2015-11-04 2023-02-09 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
US11413309B2 (en) * 2016-01-20 2022-08-16 Fate Therapeutics, Inc. Compositions and methods for immune cell modulation in adoptive immunotherapies
CN106755107B (en) * 2016-11-22 2019-10-01 上海健信生物医药科技有限公司 A kind of CAR recruit and its application in oncotherapy

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