[go: up one dir, main page]

SG11202002300QA - Aztreonam derivatives and uses thereof - Google Patents

Aztreonam derivatives and uses thereof

Info

Publication number
SG11202002300QA
SG11202002300QA SG11202002300QA SG11202002300QA SG11202002300QA SG 11202002300Q A SG11202002300Q A SG 11202002300QA SG 11202002300Q A SG11202002300Q A SG 11202002300QA SG 11202002300Q A SG11202002300Q A SG 11202002300QA SG 11202002300Q A SG11202002300Q A SG 11202002300QA
Authority
SG
Singapore
Prior art keywords
aztreonam derivatives
aztreonam
derivatives
Prior art date
Application number
SG11202002300QA
Inventor
Eric Gordon
Matthew Duncton
John Freund
Original Assignee
Arixa Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arixa Pharmaceuticals Inc filed Critical Arixa Pharmaceuticals Inc
Publication of SG11202002300QA publication Critical patent/SG11202002300QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/78Halides of sulfonic acids
    • C07C309/79Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms
    • C07C309/82Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms of a carbon skeleton substituted by singly-bound oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
SG11202002300QA 2017-10-02 2018-10-01 Aztreonam derivatives and uses thereof SG11202002300QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762566909P 2017-10-02 2017-10-02
PCT/US2018/053778 WO2019070595A1 (en) 2017-10-02 2018-10-01 Aztreonam derivatives and uses thereof

Publications (1)

Publication Number Publication Date
SG11202002300QA true SG11202002300QA (en) 2020-04-29

Family

ID=63963503

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202002300QA SG11202002300QA (en) 2017-10-02 2018-10-01 Aztreonam derivatives and uses thereof

Country Status (12)

Country Link
US (3) US10280161B2 (en)
EP (1) EP3676247B8 (en)
JP (1) JP6991345B2 (en)
KR (1) KR102455390B1 (en)
CN (1) CN111448182A (en)
AU (1) AU2018345321B2 (en)
BR (1) BR112020006594A2 (en)
CA (1) CA3077474A1 (en)
IL (1) IL273571A (en)
MX (1) MX2020004071A (en)
SG (1) SG11202002300QA (en)
WO (1) WO2019070595A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020006594A2 (en) * 2017-10-02 2020-12-15 Arixa Pharmaceuticals, Inc. AZTREONAM DERIVATIVES AND USES OF THE SAME
EP3860999B9 (en) 2018-10-01 2024-08-14 Arixa Pharmaceuticals, Inc. Derivatives of relebactam and uses thereof
BR112021017874A2 (en) 2019-03-12 2021-12-07 Arixa Pharmaceuticals Inc Crystalline form of an avibactam derivative
US11565999B2 (en) 2019-04-25 2023-01-31 Arixa Pharmaceuticals, Inc. Methods of synthesizing aztreonam derivatives
CA3152300C (en) 2019-08-29 2024-04-30 Arixa Pharmaceuticals, Inc. Orally administered combinations of beta lactam antibiotics and avibactam derivatives for treating bacterial infections
CN112047840A (en) * 2020-08-31 2020-12-08 山东药品食品职业学院 Synthesis method of 7-bromo-2, 2-dimethylheptanoic acid ethyl ester and product obtained by synthesis
CN112661716A (en) * 2020-12-31 2021-04-16 山东金城柯瑞化学有限公司 Preparation method of trityl aminothiazoly loximate
CN115448920B (en) * 2022-10-14 2025-01-03 广州楷石医药有限公司 A β-lactamase inhibitor and its application
CN118561730B (en) * 2024-07-03 2024-11-22 北京世纪迈劲生物科技有限公司 A method for preparing aztreonam main ring intermediate

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658849A (en) 1969-02-19 1972-04-25 Reynolds Tobacco Co R Treatment of 2-substituted aldehydes with lead dioxide
US4775670A (en) * 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
DE3045373A1 (en) 1980-12-02 1982-07-01 Henkel KGaA, 4000 Düsseldorf Use of 3-hydroxy-2,2-di:methyl-propionate ester(s) as fragrances - including new propyl ester
GB2113997B (en) * 1982-02-02 1985-07-03 Leo Pharm Prod Ltd Synergistic antibacterial compositions
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4652651A (en) 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
JPS60222480A (en) * 1984-04-20 1985-11-07 Kanegafuchi Chem Ind Co Ltd 2-azetidinone-1-sulfonic acid derivative
US5192785A (en) * 1989-09-03 1993-03-09 A. H. Robins Company, Incorporated Sulfamates as antiglaucoma agents
IT1270594B (en) 1994-07-07 1997-05-07 Recordati Chem Pharm CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN
FR2812635B1 (en) 2000-08-01 2002-10-11 Aventis Pharma Sa NOVEL HETEROCYCLIC COMPOUNDS, PREPARATION AND USE AS MEDICAMENTS IN PARTICULAR AS ANTI-BACTERIALS
WO2002092606A1 (en) 2001-05-15 2002-11-21 Takeda Chemical Industries, Ltd. Fused imidazolidine derivatives, process for preparation of the same and use thereof
CN101171251A (en) * 2005-05-09 2008-04-30 西科尔公司 Process for making aztreonam
WO2007083187A2 (en) * 2006-01-16 2007-07-26 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of monobactam antibiotic
UY30244A1 (en) 2006-03-30 2007-11-30 Tanabe Seiyaku Co A PROCESS TO PREPARE DERIVATIVES OF TETRAHYDROQUINOLINE
TW200924747A (en) 2007-09-07 2009-06-16 Xenoport Inc Simple pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
WO2009033079A1 (en) 2007-09-07 2009-03-12 Xenoport, Inc. Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
US20090099253A1 (en) 2007-10-15 2009-04-16 Xenoport, Inc. Internally Masked Neopentyl Sulfonyl Ester Cyclization Release Prodrugs of Acamprosate, Compositions Thereof, and Methods of Use
GB0801401D0 (en) 2008-01-25 2008-03-05 Barry Callebaut Ag Composition
US8987468B2 (en) 2008-02-04 2015-03-24 The Translational Genomics Research Institute Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives
EP2334636A2 (en) 2008-09-19 2011-06-22 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
WO2010065709A2 (en) 2008-12-03 2010-06-10 Amin Khan Hydroxamic acid derivatives, preparation and therapeutic uses thereof
CN101514200B (en) * 2009-03-31 2011-02-16 海南美大制药有限公司 Compound of aztreonam and a synthetic method thereof
MY174452A (en) 2009-10-14 2020-04-19 Schering Corp Substituted piperidines that increase p53 activity and the uses thereof
SMT201900482T1 (en) 2010-04-20 2019-09-09 Fujifilm Toyama Chemical Co Ltd Hydroxamic acid derivative
WO2011150380A1 (en) 2010-05-28 2011-12-01 Xenoport, Inc. Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders
KR101836554B1 (en) 2010-12-22 2018-04-19 메이지 세이카 파루마 가부시키가이샤 Optically-active diazabicyclooctane derivative and method for manufacturing same
US8772490B2 (en) 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
CN102127068B (en) * 2010-12-31 2012-08-29 山西普德药业股份有限公司 Method for synthesizing aztreonam compound
JP5915383B2 (en) 2011-05-30 2016-05-11 住友化学株式会社 Cyclohexanone compound and herbicide containing the same
US8796257B2 (en) 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
UY34585A (en) * 2012-01-24 2013-09-02 Aicuris Gmbh & Co Kg B-LACTAMIC COMPOUNDS REPLACED WITH AMIDINE, ITS PREPARATION AND USE
CN103232449B (en) * 2013-05-08 2014-04-09 四川省惠达药业有限公司 Aztreonam compound, as well as preparation method and pharmaceutical composition thereof
EP3122745B1 (en) * 2014-03-24 2019-02-27 Novartis AG Monobactam organic compounds for the treatment of bacterial infections
MX2017002967A (en) 2014-09-12 2017-05-30 Toyama Chemical Co Ltd Novel pharmaceutical composition containing hydroxamic acid derivative or salt thereof.
JPWO2016039432A1 (en) 2014-09-12 2017-06-22 富山化学工業株式会社 Method for using a combination of a novel hydroxamic acid derivative and an antibacterial substance
WO2016116788A1 (en) 2015-01-24 2016-07-28 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017045510A1 (en) 2015-09-16 2017-03-23 山东轩竹医药科技有限公司 Β-lactamase inhibitor and application thereof
US20170165371A1 (en) 2017-02-22 2017-06-15 Joel Steven Goldberg Novel synthesis of potential ester prodrugs
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
BR112020006594A2 (en) 2017-10-02 2020-12-15 Arixa Pharmaceuticals, Inc. AZTREONAM DERIVATIVES AND USES OF THE SAME

Also Published As

Publication number Publication date
US20210009580A1 (en) 2021-01-14
WO2019070595A1 (en) 2019-04-11
CA3077474A1 (en) 2019-04-11
EP3676247A1 (en) 2020-07-08
AU2018345321A1 (en) 2020-04-16
KR20200060490A (en) 2020-05-29
JP6991345B2 (en) 2022-01-12
US20190211006A1 (en) 2019-07-11
US10815228B2 (en) 2020-10-27
EP3676247B8 (en) 2023-04-12
US20190100516A1 (en) 2019-04-04
BR112020006594A2 (en) 2020-12-15
IL273571A (en) 2020-05-31
KR102455390B1 (en) 2022-10-17
US10280161B2 (en) 2019-05-07
JP2020536122A (en) 2020-12-10
AU2018345321B2 (en) 2021-05-20
MX2020004071A (en) 2020-07-28
CN111448182A (en) 2020-07-24
EP3676247B1 (en) 2023-03-08

Similar Documents

Publication Publication Date Title
IL273236A (en) Pyrazolopyrimidinone compounds and uses thereof
IL293377B1 (en) Hsd17b13 variants and uses thereof
IL273571A (en) Aztreonam derivatives and uses thereof
GB201708652D0 (en) Novel compounds and uses
GB201714745D0 (en) New compounds and uses
IL292488B1 (en) Pyridinamine-pyridone and pyrimidinamine-pyridone compounds
GB201714740D0 (en) New compounds and uses
GB201714734D0 (en) New compounds and uses
IL269836B (en) Substituted n-arylethyl-2-aminoquinoline-4-carboxamides and use thereof
SG11202008543RA (en) Pyrrolidineamide derivatives and uses thereof
SG11202002224XA (en) Composition and uses thereof
GB201714736D0 (en) New compounds and uses
IL292482B2 (en) Azaindolylpyridone and diazaindolylpyridone compounds
IL264473A (en) Gpr156 variants and uses thereof
GB201712110D0 (en) New compounds and uses
GB201700404D0 (en) Compounds and composistions
IL273671A (en) Cornulin (crnn) variants and uses thereof
IL269843B (en) Substituted n-arylethyl-2-arylquinoline-4-carboxamides and use thereof
GB201614224D0 (en) Compounds and uses thereof
GB2607546B (en) Functional composition and uses thereof
GB201720092D0 (en) New Compounds and uses
GB201719327D0 (en) New compounds and uses
GB201719233D0 (en) New compounds and uses
GB201714743D0 (en) New compounds and uses
GB201714849D0 (en) Composition and components