SG11202000997YA - Improved method for producing antibody-drug conjugate - Google Patents
Improved method for producing antibody-drug conjugateInfo
- Publication number
- SG11202000997YA SG11202000997YA SG11202000997YA SG11202000997YA SG11202000997YA SG 11202000997Y A SG11202000997Y A SG 11202000997YA SG 11202000997Y A SG11202000997Y A SG 11202000997YA SG 11202000997Y A SG11202000997Y A SG 11202000997YA SG 11202000997Y A SG11202000997Y A SG 11202000997YA
- Authority
- SG
- Singapore
- Prior art keywords
- improved method
- drug conjugate
- producing antibody
- antibody
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017167691 | 2017-08-31 | ||
| PCT/JP2018/032056 WO2019044947A1 (en) | 2017-08-31 | 2018-08-30 | Improved method for producing antibody-drug conjugate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202000997YA true SG11202000997YA (en) | 2020-03-30 |
Family
ID=65525614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202000997YA SG11202000997YA (en) | 2017-08-31 | 2018-08-30 | Improved method for producing antibody-drug conjugate |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11945882B2 (en) |
| EP (1) | EP3677589B1 (en) |
| JP (3) | JP7366745B2 (en) |
| KR (2) | KR102816741B1 (en) |
| CN (1) | CN111051330A (en) |
| AU (2) | AU2018327171B2 (en) |
| BR (1) | BR112020003646A2 (en) |
| CA (1) | CA3073924C (en) |
| IL (2) | IL272965B1 (en) |
| SG (1) | SG11202000997YA (en) |
| TW (2) | TW202506195A (en) |
| WO (1) | WO2019044947A1 (en) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019012847A2 (en) * | 2017-01-17 | 2019-12-10 | Daiichi Sankyo Co Ltd | antibody or antibody functional fragment, polynucleotide, expression vector, host cells, method for producing an antibody of interest or antibody functional fragment and for producing an antibody-drug conjugate, antibody-drug conjugate, pharmaceutical composition , antitumor drug; and, method of treating a tumor. |
| US20210128741A1 (en) * | 2017-08-23 | 2021-05-06 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate preparation and lyophilization for same |
| JP7366745B2 (en) * | 2017-08-31 | 2023-10-23 | 第一三共株式会社 | Improved manufacturing method for antibody-drug conjugates |
| WO2020022363A1 (en) | 2018-07-25 | 2020-01-30 | 第一三共株式会社 | Effective method for manufacturing antibody-drug conjugate |
| WO2020027100A1 (en) | 2018-07-31 | 2020-02-06 | 第一三共株式会社 | Treatment of metastatic brain tumor by administration of antibody-drug conjugate |
| KR20210042120A (en) | 2018-08-06 | 2021-04-16 | 다이이찌 산쿄 가부시키가이샤 | Combination of antibody-drug conjugate and tubulin inhibitor |
| EP3854418A4 (en) | 2018-09-20 | 2022-07-27 | Daiichi Sankyo Company, Limited | TREATMENT OF HER3 MUTANT CANCER BY ADMINISTRATION OF AN ANTI-HER3 ANTIBODY-DRUG CONJUGATE |
| EA202191641A1 (en) | 2018-12-11 | 2021-09-13 | Дайити Санкио Компани, Лимитед | ANTIBODY-DRUG CONJUGATE COMBINATION WITH PARP INHIBITOR |
| SG11202106635WA (en) | 2018-12-21 | 2021-07-29 | Daiichi Sankyo Co Ltd | Combination of antibody-drug conjugate and kinase inhibitor |
| CN111686259B (en) * | 2019-05-26 | 2023-08-08 | 成都百利多特生物药业有限责任公司 | A kind of antibody drug conjugate containing SN38 |
| CN113939318A (en) * | 2019-05-29 | 2022-01-14 | 第一三共株式会社 | Formulation of antibody-drug conjugates |
| MX2022015695A (en) | 2020-06-08 | 2023-03-21 | Baili Bio Chengdu Pharmaceutical Co Ltd | Camptothecin drug having high-stability hydrophilic connecting unit and conjugate thereof. |
| EP4171650A1 (en) | 2020-06-24 | 2023-05-03 | AstraZeneca UK Limited | Combination of antibody-drug conjugate and atr inhibitor |
| WO2021260582A1 (en) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and aurora b inhibitor |
| WO2021260583A1 (en) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and dna-pk inhibitor |
| CN116194109A (en) | 2020-06-24 | 2023-05-30 | 阿斯利康(英国)有限公司 | Combinations of antibody-drug conjugates and ATM inhibitors |
| CN116615248A (en) | 2020-06-24 | 2023-08-18 | 阿斯利康(英国)有限公司 | Combination of antibody-drug conjugate and CDK9 inhibitor |
| CA3186205A1 (en) | 2020-07-17 | 2022-01-20 | Daiichi Sankyo Company, Limited | Method for producing antibody-drug conjugate |
| CN116348115A (en) | 2020-10-09 | 2023-06-27 | 阿斯利康(英国)有限公司 | Combinations of Antibody-Drug Conjugates and PARP1 Selective Inhibitors |
| BR112023008845A2 (en) * | 2020-11-11 | 2023-10-03 | Daiichi Sankyo Co Ltd | PHARMACEUTICAL COMPOSITION, AND TREATMENT METHOD |
| WO2022102695A1 (en) | 2020-11-12 | 2022-05-19 | 第一三共株式会社 | Treatment for mesothelioma through administration of anti-b7-h3 antibody-drug conjugate |
| TW202300148A (en) * | 2021-03-17 | 2023-01-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | Preparation method of camptothecin derivatives |
| CN117157304A (en) * | 2021-04-15 | 2023-12-01 | 江苏恒瑞医药股份有限公司 | Crystal form of irinotecan analogue and preparation method thereof |
| CN113264983A (en) * | 2021-05-20 | 2021-08-17 | 联宁(苏州)生物制药有限公司 | Synthetic method of linker LND1088 for antibody-conjugated drug |
| CN113336823A (en) * | 2021-05-28 | 2021-09-03 | 联宁(苏州)生物制药有限公司 | Synthetic method for antibody-conjugated drug linker LND1067 |
| CN113402584A (en) * | 2021-07-06 | 2021-09-17 | 联宁(苏州)生物制药有限公司 | Synthetic method of intermediate LND1067-L1 of antibody-coupled drug linker |
| CN113527418B (en) * | 2021-07-16 | 2022-05-03 | 成都普康唯新生物科技有限公司 | A kind of preparation method of ADC linker |
| CA3224492A1 (en) | 2021-07-19 | 2023-01-26 | Xiaojun Han | Immunoconjugates and methods |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| WO2023083381A1 (en) | 2021-11-15 | 2023-05-19 | 成都百利多特生物药业有限责任公司 | Bispecific antibody-camptothecin drug conjugate and pharmaceutical use thereof |
| US20250025568A1 (en) | 2021-11-18 | 2025-01-23 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and parp1 selective inhibitor |
| WO2023097604A1 (en) | 2021-12-02 | 2023-06-08 | 岩唐生物科技(杭州)有限责任公司 | Isolated polypeptide and use thereof |
| IL313262A (en) | 2021-12-03 | 2024-08-01 | Systimmune Inc | Antibody pair against human TROP2 and drug CAMPTOTHECIN and its medical use |
| CN118434422A (en) | 2021-12-28 | 2024-08-02 | 阿斯利康(英国)有限公司 | Combination of antibody-drug conjugates and RASG12C inhibitors |
| KR20240130087A (en) | 2021-12-28 | 2024-08-28 | 아스트라제네카 유케이 리미티드 | Combination of antibody-drug conjugates and ATR inhibitors |
| KR20240165390A (en) | 2022-03-16 | 2024-11-22 | 아스트라제네카 유케이 리미티드 | Scoring Methodology for Anti-TROP2 Antibody-Drug Conjugate Therapy |
| JP7667870B2 (en) | 2022-03-25 | 2025-04-23 | バイリ-バイオ(チェンドゥ)ファーマスーティカル シーオー.,エルティーディー. | DNA toxic dimers and their complexes |
| EP4514391A1 (en) | 2022-04-27 | 2025-03-05 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor |
| WO2023218378A1 (en) | 2022-05-11 | 2023-11-16 | Daiichi Sankyo Company, Limited | Combination of an antibody specific for a tumor antigen and a cd47 inhibitor |
| US20250360222A1 (en) | 2022-07-28 | 2025-11-27 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and bispecific checkpoint inhibitor |
| CN117752813A (en) | 2022-09-26 | 2024-03-26 | 成都百利多特生物药业有限责任公司 | Anti-CD33 antibodies and anti-CD33 antibody-drug conjugates and their uses |
| CN117338949A (en) * | 2022-09-30 | 2024-01-05 | 成都百利多特生物药业有限责任公司 | An auristatin drug and its conjugate with a highly stable hydrophilic linking unit |
| WO2024116094A1 (en) | 2022-11-30 | 2024-06-06 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugates and dnmt inhibitors |
| EP4653016A1 (en) | 2023-01-17 | 2025-11-26 | SystImmune, Inc. | Conjugate of eribulin drug |
| CN120813389A (en) | 2023-03-14 | 2025-10-17 | 第一三共株式会社 | Combination of anti-CDH 6 antibody-drug conjugate and VEGF inhibitor |
| EP4691497A1 (en) | 2023-03-31 | 2026-02-11 | Daiichi Sankyo Company, Limited | Combination of anti-cdh6 antibody-drug conjugate and hif-2alpha inhibitor |
| TW202446421A (en) | 2023-04-10 | 2024-12-01 | 日商第一三共股份有限公司 | Combination of anti-b7-h3 antibody-drug conjugate and atr inhibitor or atm inhibitor |
| WO2025005240A1 (en) | 2023-06-30 | 2025-01-02 | 第一三共株式会社 | Antibody-drug conjugate production method including purification step using activated carbon material |
| WO2025088496A1 (en) | 2023-10-24 | 2025-05-01 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and anti-pd-1/tim-3 bispecific binding protein |
| WO2025120513A1 (en) | 2023-12-05 | 2025-06-12 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and blood brain barrier-penetrant parp1 selective inhibitor |
| WO2025180999A1 (en) | 2024-02-26 | 2025-09-04 | Lonza Ltd | Electrochemical oxidative decarboxylation of alpha-amino acids |
| WO2025238587A1 (en) | 2024-05-16 | 2025-11-20 | Daiichi Sankyo Company, Limited | Combination of anti-b7-h3 antibody-drug conjugate and androgen receptor signaling inhibitor |
Family Cites Families (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
| US5637770A (en) | 1991-01-16 | 1997-06-10 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
| JP3008226B2 (en) | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | Hexacyclic compounds |
| DE69233254T2 (en) | 1991-06-14 | 2004-09-16 | Genentech, Inc., South San Francisco | Humanized Heregulin antibody |
| JP3091774B2 (en) * | 1991-07-04 | 2000-09-25 | 三井化学株式会社 | Crystalline propanol solvate of fluoran compound, process for producing the same, and recording material containing the crystalline propanol solvate |
| JP3359955B2 (en) * | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | Antitumor agent |
| JPH0680091A (en) * | 1992-09-01 | 1994-03-22 | Honda Motor Co Ltd | Door sash color change method and tape material used for this method |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US6504029B1 (en) | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
| JPH08337584A (en) | 1995-04-10 | 1996-12-24 | Dai Ichi Seiyaku Co Ltd | Fused hexacyclic amino compound, pharmaceutical containing the same, and process for producing the same |
| SG50747A1 (en) | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| JPH1095802A (en) | 1995-12-28 | 1998-04-14 | Tanabe Seiyaku Co Ltd | Camptothecin derivatives |
| CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| US5968511A (en) | 1996-03-27 | 1999-10-19 | Genentech, Inc. | ErbB3 antibodies |
| TW527183B (en) | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| JPH1171280A (en) | 1997-06-26 | 1999-03-16 | Tanabe Seiyaku Co Ltd | Pharmaceutical composition |
| JPH1192405A (en) | 1997-09-19 | 1999-04-06 | Dai Ichi Seiyaku Co Ltd | Medicinal complex |
| US6071719A (en) | 1998-03-11 | 2000-06-06 | Smithkline Beecham Corporation | DNA encoding ECR 673: A 7-transmembrane G-protein coupled receptor |
| DK2180007T4 (en) | 1998-04-20 | 2017-11-27 | Roche Glycart Ag | Glycosylation technique for antibodies to enhance antibody-dependent cell cytotoxicity |
| US6835807B1 (en) | 1998-05-22 | 2004-12-28 | Daiichi Pharmaceuticals Co., Ltd. | Drug complex and drug delivery system |
| CN1661044A (en) | 1998-10-30 | 2005-08-31 | 第一制药株式会社 | DDS compound and method for measurement thereof |
| DK1176195T3 (en) | 1999-04-09 | 2013-06-24 | Kyowa Hakko Kirin Co Ltd | Method for controlling the activity of immunologically functional molecule |
| ES2662581T3 (en) | 1999-06-25 | 2018-04-09 | Immunogen, Inc. | Treatment methods using anti-ErbB-maitansinoid antibody conjugates |
| AU784045B2 (en) | 1999-06-25 | 2006-01-19 | Genentech Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| JP2002060351A (en) | 2000-03-22 | 2002-02-26 | Dai Ichi Seiyaku Co Ltd | Dds compound comprising drug having hydroxy group |
| CN1449412A (en) | 2000-06-29 | 2003-10-15 | 第一制药株式会社 | DDS compound and process for the preparation thereof |
| BR0112417A (en) | 2000-07-13 | 2003-07-01 | Daiichi Seiyaku Co | Pharmaceutical compositions containing dds compound |
| EA013224B1 (en) | 2000-10-06 | 2010-04-30 | Киова Хакко Кирин Ко., Лтд. | Cells producing antibody compositions |
| US20030018989A1 (en) | 2001-03-29 | 2003-01-23 | Brennan Thomas J. | Transgenic mice containing GPCR5-1 gene disruptions |
| EP1283053A1 (en) | 2001-08-09 | 2003-02-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibitors of HER3 activity |
| TWI313609B (en) | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| JP4663232B2 (en) | 2001-11-01 | 2011-04-06 | ザ ユーエービー リサーチ ファウンデーション | Combination of antibodies selective for tumor necrosis factor-related apoptosis-inducing ligand receptor and other therapeutic agents |
| US20050123536A1 (en) | 2001-11-20 | 2005-06-09 | Che-Leung Law | Treatment of immunological disorders using anti-dc30 antibodies |
| US8877901B2 (en) | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| US9745380B2 (en) | 2002-03-01 | 2017-08-29 | Immunomedics, Inc. | RS7 antibodies |
| ATE417067T1 (en) | 2002-03-01 | 2008-12-15 | Immunomedics Inc | RS7 ANTIBODIES |
| CA2498264A1 (en) | 2002-09-09 | 2004-05-13 | Nura, Inc. | G protein coupled receptors and uses thereof |
| US20080260744A1 (en) | 2002-09-09 | 2008-10-23 | Omeros Corporation | G protein coupled receptors and uses thereof |
| CA2508831C (en) | 2002-12-13 | 2012-05-01 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| US20040202666A1 (en) | 2003-01-24 | 2004-10-14 | Immunomedics, Inc. | Anti-cancer anthracycline drug-antibody conjugates |
| WO2005040825A2 (en) | 2003-10-24 | 2005-05-06 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 20 (gpr20) |
| JP2007527872A (en) | 2004-02-26 | 2007-10-04 | イノテック ファーマシューティカルズ コーポレイション | Isoquinoline derivatives and methods of use thereof |
| CA2558399C (en) | 2004-03-02 | 2015-05-19 | Seattle Genetics, Inc. | Partially loaded antibodies and methods of their conjugation |
| CA2564076C (en) | 2004-05-19 | 2014-02-18 | Medarex, Inc. | Chemical linkers and conjugates thereof |
| BRPI0510883B8 (en) | 2004-06-01 | 2021-05-25 | Genentech Inc | drug-antibody conjugate compound, pharmaceutical composition, method of manufacturing a drug-antibody conjugate compound, and uses of a formulation, a drug-antibody conjugate and a chemotherapeutic agent, and a combination |
| JP2005343837A (en) * | 2004-06-04 | 2005-12-15 | Fuji Photo Film Co Ltd | Method for producing 1,3-dioxolane-4,6-dione compound |
| KR20180004850A (en) | 2004-07-22 | 2018-01-12 | 제넨테크, 인크. | Her2 antibody composition |
| US8802820B2 (en) | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| JP2008521828A (en) | 2004-11-29 | 2008-06-26 | シアトル ジェネティックス, インコーポレイテッド | Engineered antibodies and immunoconjugates |
| US20060135546A1 (en) * | 2004-12-16 | 2006-06-22 | Jagadevappa Basavaraja | Methods for the purification of 20(S)- camptothecin |
| PL1846030T3 (en) | 2005-01-21 | 2019-05-31 | Genentech Inc | Fixed dosing of her antibodies |
| DE102005009099A1 (en) | 2005-02-28 | 2006-08-31 | Ktb Tumorforschungsgesellschaft Mbh | New camptothecin-peptide derivatives, useful for treating cancer |
| DE102005009084A1 (en) | 2005-02-28 | 2006-08-31 | Ktb Tumorforschungsgesellschaft Mbh | New anthracyclin-peptide derivatives, useful for treating cancer, especially of the prostate, are cleaved, in the tumor, by prostate-specific antigen to release active antitumor agent and are transported by serum albumen |
| NZ561137A (en) | 2005-03-08 | 2011-09-30 | Pharmacia & Upjohn Co Llc | Stable anti-CTLA-4 antibody compositions with chelating agents |
| US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| KR101566393B1 (en) | 2005-08-03 | 2015-11-05 | 이뮤노젠 아이엔씨 | Immunoconjugate formulation |
| AR056857A1 (en) | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | DIRECTED ANTIBODIES TO HER-3 (RECEIVER OF THE HUMAN EPIDERMAL GROWTH FACTOR-3) AND ITS USES |
| US20080131428A1 (en) | 2006-02-24 | 2008-06-05 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
| SI2032606T1 (en) | 2006-05-30 | 2014-02-28 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| BRPI0711249A2 (en) | 2006-05-30 | 2012-03-13 | Genentech, Inc. | ANTIBODIES, POLYNUCLEOTIDES, VECTORS, HOST CELLS, METHODS FOR MANUFACTURING AN ANTIBODY, TO DETECTION THE PRESENCE OF CD2 IN A BIOLOGICAL SAMPLE, TO TREAT A PROLIFERATIVE B-CELL DIFFERENCE, CELL FOR PROLIBA CULAR, CELL FOR CIBLES ANTI-BODY DRUG CONJUGATE. IMMUNOCONJUGATES, PHARMACEUTICAL COMPOSITIONS, PHARMACEUTICAL FORMULATIONS, ANTIBODY-DRUG CONJUGATE, ANTIBODY-DRUG CONJUGATE COMPOUNDS, B-CELL DETECTION TEST AND MANUFACTURING ARTICLE |
| ITMI20061473A1 (en) | 2006-07-26 | 2008-01-27 | Indena Spa | DERIVATIVES OF CAMPTOTECIN WITH ANTITUMORAL ACTIVITY |
| EP2109607A1 (en) | 2006-12-21 | 2009-10-21 | Schering Corporation | Pyrrolo[3, 2-a]pyridine derivatives for inhibiting ksp kinesin activity |
| EP2129396B1 (en) | 2007-02-16 | 2013-08-21 | Merrimack Pharmaceuticals, Inc. | Antibodies against erbb3 and uses thereof |
| KR20100014527A (en) | 2007-03-22 | 2010-02-10 | 슬로안-케테링인스티튜트퍼캔서리서치 | Uses of monoclonal antibody 8h9 |
| US8354102B2 (en) | 2007-05-15 | 2013-01-15 | Hoffmann-La Roche Inc. | Antibodies directed to mGluR7 |
| CA2722696C (en) | 2008-04-30 | 2021-08-10 | Immunogen, Inc. | Cross-linkers and their uses |
| JP5539971B2 (en) | 2008-05-13 | 2014-07-02 | ジェネンテック, インコーポレイテッド | Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry |
| BRPI0918652B1 (en) | 2008-09-17 | 2021-10-19 | Chiasma, Inc. | PHARMACEUTICAL COMPOSITION INCLUDING A HYDROPHOBIC MEDIUM AND A SOLID FORM WHICH INCLUDES POLYPEPTIDE AND MEDIUM CHAIN FATTY ACID SALT, PRODUCTION PROCESS AND ORAL DOSAGE FORM |
| US8927694B2 (en) | 2008-11-18 | 2015-01-06 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| DK2396036T3 (en) | 2009-02-13 | 2017-10-16 | Immunomedics Inc | Immune conjugates with an intracellular cleavable compound |
| US20120171201A1 (en) | 2009-07-22 | 2012-07-05 | Enzon Pharmaceuticals, Inc. | Methods of treating her2 positive cancer with her2 receptor antagonist in combination with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| JP5829520B2 (en) | 2009-08-20 | 2015-12-09 | 国立大学法人 千葉大学 | Colchicine derivatives |
| CA2775350A1 (en) | 2009-09-24 | 2011-03-31 | Seattle Genetics, Inc. | Dr5 ligand drug conjugates |
| ES2781299T3 (en) | 2009-11-13 | 2020-09-01 | Daiichi Sankyo Europe Gmbh | Materials and methods to treat or prevent diseases associated with HER-3 |
| ES2978177T3 (en) | 2009-12-02 | 2024-09-06 | Immunomedics Inc | Combining radioimmunotherapy and antibody-drug conjugates to improve cancer therapy |
| RU2604067C2 (en) | 2010-05-13 | 2016-12-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Glucagon superfamily peptides exhibiting nuclear hormone receptor activity |
| BR112012029281B1 (en) | 2010-05-17 | 2020-12-08 | Livtech, Inc | antibody to human trop-2, monoclonal antibody to human trop-2, antibody-derived antibody fragment, hybridoma, conjugate, pharmaceutical composition, use of pharmaceutical composition, method to detect a tumor and kit to treat, diagnose or detect a tumor |
| US20110300150A1 (en) | 2010-05-18 | 2011-12-08 | Scott Eliasof | Compositions and methods for treatment of autoimmune and other disease |
| WO2011155579A1 (en) | 2010-06-10 | 2011-12-15 | 北海道公立大学法人札幌医科大学 | ANTI-Trop-2 ANTIBODY |
| CN103096933A (en) | 2010-07-12 | 2013-05-08 | CovX科技爱尔兰有限公司 | Multifunctional antibody conjugates |
| WO2012019024A2 (en) | 2010-08-04 | 2012-02-09 | Immunogen, Inc. | Her3-binding molecules and immunoconjugates thereof |
| CA2815154A1 (en) | 2010-08-06 | 2012-02-09 | U3 Pharma Gmbh | Use of her3 binding agents in prostate treatment |
| EP2638066A4 (en) | 2010-11-09 | 2015-06-03 | Medimmune Llc | Antibody scaffold for homogenous conjugation |
| US20120121615A1 (en) | 2010-11-17 | 2012-05-17 | Flygare John A | Alaninyl maytansinol antibody conjugates |
| CN102786418B (en) * | 2011-05-18 | 2016-05-18 | 中国医学科学院药物研究所 | Chlorogenic acid brilliant II type sign and preparation method and apply in medicine and health products |
| WO2013068946A2 (en) | 2011-11-11 | 2013-05-16 | Rinat Neuroscience Corp. | Antibodies specific for trop-2 and their uses |
| US9427464B2 (en) | 2011-11-22 | 2016-08-30 | Chiome Bioscience Inc. | Anti-human TROP-2 antibody having an antitumor activity in vivo |
| HK1200714A1 (en) | 2011-12-14 | 2015-08-14 | Seattle Genetics, Inc. | Fgfr-binder-active agent conjugates |
| US20130280282A1 (en) | 2012-04-24 | 2013-10-24 | Daiichi Sankyo Co., Ltd. | Dr5 ligand drug conjugates |
| US20150152187A1 (en) | 2012-06-14 | 2015-06-04 | Ambrx, Inc. | Anti-PSMA Antibodies Conjugated to Nuclear Receptor Ligand Polypeptides |
| US10195288B2 (en) | 2012-10-11 | 2019-02-05 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate |
| WO2014061277A1 (en) | 2012-10-19 | 2014-04-24 | 第一三共株式会社 | Antibody-drug conjugate produced by binding through linker having hydrophilic structure |
| HK1219044A1 (en) | 2013-03-15 | 2017-03-24 | 艾伯维德国有限责任两合公司 | Anti-egfr antibody drug conjugate formulations |
| CN111228510B (en) | 2013-12-25 | 2024-06-18 | 第一三共株式会社 | Anti-TROP2 Antibody-Drug Conjugate |
| EP3973995A1 (en) | 2014-01-31 | 2022-03-30 | Daiichi Sankyo Company, Limited | Anti-her2 antibody-drug conjugate |
| WO2015142675A2 (en) | 2014-03-15 | 2015-09-24 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| TWI874262B (en) * | 2014-04-10 | 2025-02-21 | 日商第一三共股份有限公司 | Use of anti-her3 antibody drug conjugate |
| CN105085529A (en) * | 2014-05-15 | 2015-11-25 | 广东东阳光药业有限公司 | Novel crystal form of ibrutinib and preparation method thereof |
| US11098078B2 (en) | 2015-03-04 | 2021-08-24 | Jitsubo Co., Ltd. | Peptide synthesis method |
| ES2938186T3 (en) * | 2015-06-29 | 2023-04-05 | Daiichi Sankyo Co Ltd | Method for the selective manufacture of an antibody-drug conjugate |
| BR112019012847A2 (en) * | 2017-01-17 | 2019-12-10 | Daiichi Sankyo Co Ltd | antibody or antibody functional fragment, polynucleotide, expression vector, host cells, method for producing an antibody of interest or antibody functional fragment and for producing an antibody-drug conjugate, antibody-drug conjugate, pharmaceutical composition , antitumor drug; and, method of treating a tumor. |
| CN117838881A (en) * | 2017-08-31 | 2024-04-09 | 第一三共株式会社 | New method for preparing antibody-drug conjugates |
| JP7366745B2 (en) * | 2017-08-31 | 2023-10-23 | 第一三共株式会社 | Improved manufacturing method for antibody-drug conjugates |
-
2018
- 2018-08-30 JP JP2019539605A patent/JP7366745B2/en active Active
- 2018-08-30 WO PCT/JP2018/032056 patent/WO2019044947A1/en not_active Ceased
- 2018-08-30 AU AU2018327171A patent/AU2018327171B2/en active Active
- 2018-08-30 CN CN201880056466.XA patent/CN111051330A/en active Pending
- 2018-08-30 CA CA3073924A patent/CA3073924C/en active Active
- 2018-08-30 SG SG11202000997YA patent/SG11202000997YA/en unknown
- 2018-08-30 KR KR1020207008823A patent/KR102816741B1/en active Active
- 2018-08-30 EP EP18849765.5A patent/EP3677589B1/en active Active
- 2018-08-30 BR BR112020003646-3A patent/BR112020003646A2/en unknown
- 2018-08-30 US US16/642,245 patent/US11945882B2/en active Active
- 2018-08-30 KR KR1020257017894A patent/KR20250084239A/en active Pending
- 2018-08-31 TW TW113116133A patent/TW202506195A/en unknown
- 2018-08-31 TW TW107130664A patent/TWI843705B/en active
-
2020
- 2020-02-27 IL IL272965A patent/IL272965B1/en unknown
-
2023
- 2023-06-09 AU AU2023203615A patent/AU2023203615B2/en active Active
- 2023-07-04 JP JP2023109892A patent/JP7728821B2/en active Active
-
2024
- 2024-02-13 US US18/440,920 patent/US12503489B2/en active Active
-
2025
- 2025-08-13 JP JP2025134792A patent/JP2025169338A/en active Pending
- 2025-11-11 IL IL324591A patent/IL324591A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2023203615A1 (en) | 2023-07-06 |
| IL272965B1 (en) | 2025-12-01 |
| US20240376147A1 (en) | 2024-11-14 |
| EP3677589A4 (en) | 2021-04-21 |
| BR112020003646A2 (en) | 2020-09-01 |
| TWI843705B (en) | 2024-06-01 |
| TW202506195A (en) | 2025-02-16 |
| TW201918263A (en) | 2019-05-16 |
| JP7366745B2 (en) | 2023-10-23 |
| AU2018327171B2 (en) | 2023-03-09 |
| KR20250084239A (en) | 2025-06-10 |
| AU2018327171A1 (en) | 2020-03-26 |
| JPWO2019044947A1 (en) | 2020-10-15 |
| KR102816741B1 (en) | 2025-06-04 |
| JP2023126890A (en) | 2023-09-12 |
| US12503489B2 (en) | 2025-12-23 |
| JP2025169338A (en) | 2025-11-12 |
| US20200385422A1 (en) | 2020-12-10 |
| CA3073924C (en) | 2023-10-17 |
| CN111051330A (en) | 2020-04-21 |
| IL324591A (en) | 2026-01-01 |
| US11945882B2 (en) | 2024-04-02 |
| EP3677589A1 (en) | 2020-07-08 |
| CA3073924A1 (en) | 2019-03-07 |
| JP7728821B2 (en) | 2025-08-25 |
| AU2023203615B2 (en) | 2024-12-19 |
| WO2019044947A1 (en) | 2019-03-07 |
| EP3677589B1 (en) | 2025-11-26 |
| IL272965A (en) | 2020-04-30 |
| KR20200041993A (en) | 2020-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL324591A (en) | Improved methods for producing antibody-drug conjugate | |
| IL272964A (en) | Method for producing antibody-drug conjugate | |
| IL290959A (en) | Antibody-drug conjugate compisitions and methods for producing same | |
| IL293177A (en) | Method for producing an anti-her3 antibody-drug conjugate | |
| IL266790A (en) | Methods for producing anti-her2 antibody-drug conjugates | |
| SG11202100653YA (en) | Effective method for manufacturing antibody-drug conjugate | |
| HUE067382T2 (en) | Anti-muc1- exatecan antibody-drug conjugate | |
| LT3424955T (en) | Method for producing an anti-trop2 antibody-drug conjugate | |
| AU2015212265A1 (en) | Anti-HER2 antibody-drug conjugate | |
| PT3609540T (en) | Immunoconjugate synthesis method | |
| ZA201604531B (en) | Method for purifying cys-linked antibody-drug conjugates | |
| HUE059598T2 (en) | Method for producing metal-polymer resin conjugate | |
| SG11202003954QA (en) | Method for producing dihydroxyindoles | |
| SG11202000020RA (en) | Method for producing galactooligosaccharide | |
| PL3672926T3 (en) | Method for producing soluble fertilizer formulations | |
| EP3584247C0 (en) | Method for preparing canagliflozin amorphous form |