SG11202000053TA - Anti-cd47 antibodies and uses thereof - Google Patents
Anti-cd47 antibodies and uses thereofInfo
- Publication number
- SG11202000053TA SG11202000053TA SG11202000053TA SG11202000053TA SG11202000053TA SG 11202000053T A SG11202000053T A SG 11202000053TA SG 11202000053T A SG11202000053T A SG 11202000053TA SG 11202000053T A SG11202000053T A SG 11202000053TA SG 11202000053T A SG11202000053T A SG 11202000053TA
- Authority
- SG
- Singapore
- Prior art keywords
- antibodies
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/323—Arteriosclerosis, Stenosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762540118P | 2017-08-02 | 2017-08-02 | |
US201862657094P | 2018-04-13 | 2018-04-13 | |
PCT/US2018/044384 WO2019027903A1 (en) | 2017-08-02 | 2018-07-30 | ANTI-CD47 ANTIBODIES AND USES THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202000053TA true SG11202000053TA (en) | 2020-02-27 |
Family
ID=65233054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202000053TA SG11202000053TA (en) | 2017-08-02 | 2018-07-30 | Anti-cd47 antibodies and uses thereof |
Country Status (14)
Country | Link |
---|---|
US (1) | US11401329B2 (he) |
EP (1) | EP3661965A4 (he) |
JP (1) | JP7262440B2 (he) |
KR (1) | KR102646468B1 (he) |
CN (1) | CN111183155B (he) |
AU (1) | AU2018312222B2 (he) |
BR (1) | BR112020001679A2 (he) |
CA (1) | CA3071860A1 (he) |
IL (1) | IL272330A (he) |
MX (1) | MX2020001309A (he) |
NZ (1) | NZ761568A (he) |
SG (1) | SG11202000053TA (he) |
WO (1) | WO2019027903A1 (he) |
ZA (1) | ZA202000373B (he) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA51208A (fr) | 2017-12-01 | 2020-10-07 | Seattle Genetics Inc | Anticorps (masqués) contre cd47 et leurs utilisations pour le traîtement du cancer |
US12037391B2 (en) | 2018-05-08 | 2024-07-16 | Phanes Therapeutics, Inc. | Anti-DLL3 antibodies and uses thereof |
CA3136450A1 (en) * | 2019-04-18 | 2020-10-22 | Qlsf Biotherapeutics Inc. | Antibodies that target human cd47 |
PH12021553197A1 (en) * | 2019-06-19 | 2022-11-07 | Lepu Biopharma Co Ltd | Anti-cd47 antibodies and uses thereof |
WO2021003082A1 (en) * | 2019-07-03 | 2021-01-07 | Phanes Therapeutics, Inc. | Anti-claudin 18.2/anti-cd47 bispecific antibodies and uses thereof |
US20220332848A1 (en) * | 2019-07-16 | 2022-10-20 | Nanjing GenScript Biotech Co., Ltd. | Anti-cd47/anti-ctla-4 bispecific antibody and preparation method therefor and application thereof |
EP3999107A1 (en) | 2019-07-16 | 2022-05-25 | Gilead Sciences, Inc. | Hiv vaccines and methods of making and using |
TW202108631A (zh) * | 2019-08-21 | 2021-03-01 | 大陸商和鉑醫藥(上海)有限責任公司 | 一種抗cd47抗原結合蛋白及其應用 |
PL4045083T3 (pl) | 2019-10-18 | 2024-05-13 | Forty Seven, Inc. | Terapie skojarzone do leczenia zespołów mielodysplastycznych i ostrej białaczki szpikowej |
EP4052040A1 (en) | 2019-10-31 | 2022-09-07 | Forty Seven, Inc. | Anti-cd47 and anti-cd20 based treatment of blood cancer |
US20230042316A1 (en) * | 2019-11-20 | 2023-02-09 | Abvision, Inc. | Monoclonal antibodies that target human cd47 protein |
WO2021126538A1 (en) * | 2019-12-17 | 2021-06-24 | Phanes Therapeutics, Inc. | Bispecific antibodies with alternatively matched interchain cycteines and uses thereof |
SI4081305T1 (sl) | 2019-12-24 | 2025-03-31 | Carna Biosciences, Inc. | Spojine, ki modulirajo diacilglicerol kinazo |
CN115087488A (zh) | 2020-02-14 | 2022-09-20 | 震动疗法股份有限公司 | 与ccr8结合的抗体和融合蛋白及其用途 |
WO2021191870A1 (en) | 2020-03-27 | 2021-09-30 | Dcprime B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
TWI869582B (zh) * | 2020-04-10 | 2025-01-11 | 大陸商和記黃埔醫藥(上海)有限公司 | 抗cd47抗體及其用途 |
KR102757518B1 (ko) * | 2020-12-07 | 2025-01-21 | (주)이노베이션바이오 | Cd47에 특이적인 항체 및 이의 용도 |
US20230312709A1 (en) * | 2020-12-23 | 2023-10-05 | Guangdong Feipeng Pharmaceutical Co., Ltd. | Antibody targeting CD47 and application thereof |
EP4296282A4 (en) * | 2021-02-19 | 2025-02-26 | SHAPERON Inc. | SINGLE DOMAIN ANTIBODIES AGAINST CD47 AND USE THEREOF |
WO2022190058A1 (en) | 2021-03-12 | 2022-09-15 | Dcprime B.V. | Methods of vaccination and use of cd47 blockade |
TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症 |
CN117396478A (zh) | 2021-06-23 | 2024-01-12 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
US11932634B2 (en) | 2021-06-23 | 2024-03-19 | Gilead Sciences, Inc. | Diacylglycerol kinase modulating compounds |
KR20240023628A (ko) | 2021-06-23 | 2024-02-22 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
KR20240023629A (ko) | 2021-06-23 | 2024-02-22 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
US20250129155A1 (en) * | 2021-06-30 | 2025-04-24 | Innobation Bio Co., Ltd. | Humanized antibody specific for cd47 and pharmaceutical composition for preventing or treating cd47-related diseases comprising the same |
US20230183216A1 (en) | 2021-10-28 | 2023-06-15 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
CR20240173A (es) | 2021-10-29 | 2024-06-20 | Gilead Sciences Inc | Compuestos de cd73 |
EP4452414A2 (en) | 2021-12-22 | 2024-10-30 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
WO2023122615A1 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Parp7抑制劑 |
HUE069263T2 (hu) | 2022-03-17 | 2025-02-28 | Gilead Sciences Inc | Ikarosz cink-ujj család degradálói és azok alkalmazása |
US20230355796A1 (en) | 2022-03-24 | 2023-11-09 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
WO2023191117A1 (ko) * | 2022-03-28 | 2023-10-05 | (주)이노베이션바이오 | 친화도가 성숙된 cd47에 특이적인 인간화 항체 |
TWI876305B (zh) | 2022-04-05 | 2025-03-11 | 美商基利科學股份有限公司 | 用於治療結腸直腸癌之組合療法 |
IL316058A (he) | 2022-04-21 | 2024-11-01 | Gilead Sciences Inc | תרכובות מודולציות של kras g12d |
IL317958A (he) | 2022-07-01 | 2025-02-01 | Gilead Sciences Inc | Cd73 תרכובות |
EP4554628A1 (en) | 2022-07-12 | 2025-05-21 | Gilead Sciences, Inc. | Hiv immunogenic polypeptides and vaccines and uses thereof |
WO2024064668A1 (en) | 2022-09-21 | 2024-03-28 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY |
CN120225509A (zh) | 2022-12-22 | 2025-06-27 | 吉利德科学公司 | Prmt5抑制剂及其用途 |
WO2024215754A1 (en) | 2023-04-11 | 2024-10-17 | Gilead Sciences, Inc. | Kras modulating compounds |
WO2024220917A1 (en) | 2023-04-21 | 2024-10-24 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
WO2025006720A1 (en) | 2023-06-30 | 2025-01-02 | Gilead Sciences, Inc. | Kras modulating compounds |
WO2025024811A1 (en) | 2023-07-26 | 2025-01-30 | Gilead Sciences, Inc. | Parp7 inhibitors |
US20250066328A1 (en) | 2023-07-26 | 2025-02-27 | Gilead Sciences, Inc. | Parp7 inhibitors |
US20250101042A1 (en) | 2023-09-08 | 2025-03-27 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
WO2025054530A1 (en) | 2023-09-08 | 2025-03-13 | Gilead Sciences, Inc. | Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds |
WO2025096589A1 (en) | 2023-11-03 | 2025-05-08 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
US20250230168A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
Family Cites Families (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
AU1583397A (en) | 1996-01-30 | 1997-08-22 | Brigham And Women's Hospital | Antibodies for modulating cd47-mediated neutrophil transmigration |
DE19952960A1 (de) | 1999-11-03 | 2001-05-10 | Mark Andre Freyberg | Verfahren zur Identifizierung von anti-apoptotisch wirksamen Verbindungen |
GB9930706D0 (en) | 1999-12-24 | 2000-02-16 | Medical Res Council | Composition for inhibiting macrophage activity |
AU2002315052A1 (en) | 2001-05-15 | 2002-11-25 | Emory University | Polynucleotides and polypeptides relating to the modulation of sirp alpha-cd47 |
JP3936673B2 (ja) | 2003-06-02 | 2007-06-27 | 国立大学法人群馬大学 | Cd47部分ペプチドと抗shps−1モノクロナール抗体 |
WO2005019254A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of a bilin-binding protein with affinity for a given target |
EP1693385A4 (en) | 2003-11-11 | 2009-11-04 | Chugai Pharmaceutical Co Ltd | ANTI-CD47 ANTIBODIES HUMANIZED |
WO2007033221A2 (en) | 2005-09-13 | 2007-03-22 | The General Hospital Corporation | Methods and compositions for inhibition of immune responses |
US20090191202A1 (en) | 2005-09-29 | 2009-07-30 | Jamieson Catriona Helen M | Methods for manipulating phagocytosis mediated by CD47 |
EP2027151A2 (en) | 2006-05-15 | 2009-02-25 | Viral Logic Systems Technology Corp. | Cd47 related compositions and methods for treating immunological diseases and disorders |
US8377448B2 (en) | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
EP2076537B1 (en) | 2006-10-06 | 2018-08-22 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Prevention of tissue ischemia, related methods and compositions |
WO2009046541A1 (en) | 2007-10-11 | 2009-04-16 | University Health Network | MODULATION OF SIRPα - CD47 INTERACTION FOR INCREASING HUMAN HEMATOPOIETIC STEM CELL ENGRAFTMENT AND COMPOUNDS THEREFOR |
ES2735144T3 (es) * | 2008-01-15 | 2019-12-16 | Univ Leland Stanford Junior | Métodos para manipular fagocitosis mediada por CD47 |
EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
KR20110112299A (ko) | 2008-12-19 | 2011-10-12 | 노파르티스 아게 | 자가면역 및 염증성 장애의 치료에 사용하기 위한 가용성 폴리펩티드 |
WO2010083253A2 (en) | 2009-01-14 | 2010-07-22 | Viral Logic Systems Technology Corp. | Cd47 related compositions and methods for treating immunological diseases and disorders |
HRP20150553T1 (hr) | 2009-05-15 | 2015-08-28 | University Health Network | Sastavi i metode za lijeäśenje hematoloških maligniteta ciljajuä†i sirp - cd47 interakciju |
ES2927646T3 (es) | 2009-09-15 | 2022-11-08 | Univ Leland Stanford Junior | Terapia anti-CD47 sinérgica para cánceres hematológicos |
JP2013507115A (ja) | 2009-10-09 | 2013-03-04 | サノフイ | 「終末糖化産物受容体」への結合のためのポリペプチド、さらにはそれを含む組成物及び方法 |
TW201130511A (en) | 2009-12-22 | 2011-09-16 | Novartis Ag | Soluble proteins for use as therapeutics |
US20110206696A1 (en) | 2010-01-25 | 2011-08-25 | The Washington University | Methods for inhibiting bone loss and bone metastasis |
DK2569013T3 (da) | 2010-05-14 | 2017-02-13 | Univ Leland Stanford Junior | Humaniserede og kimære monoklonale antistoffer til cd47 |
KR20140014064A (ko) * | 2010-09-03 | 2014-02-05 | 스템 센트알엑스 인코포레이티드 | 신규한 조절 인자 및 사용 방법 |
US20140271683A1 (en) | 2010-12-21 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density Lipoprotein-Related Receptor |
MX2013014789A (es) | 2011-06-16 | 2014-01-20 | Novartis Ag | Proteinas solubles para utilizarse como productos terapeuticos. |
FR2977587B1 (fr) | 2011-07-08 | 2013-08-30 | Univ Reims Champagne Ardenne | Peptide antagoniste de la liaison entre le cd47 et une proteine appartenant a la famille des thrombospondines |
GB201200563D0 (en) * | 2012-01-13 | 2012-02-29 | Imp Innovations Ltd | Binding molecule |
CN104136037B (zh) | 2012-01-17 | 2018-02-23 | 小利兰·斯坦福大学托管委员会 | 高亲和力SIRP‑α试剂 |
US20140140989A1 (en) | 2012-02-06 | 2014-05-22 | Inhibrx Llc | Non-Platelet Depleting and Non-Red Blood Cell Depleting CD47 Antibodies and Methods of Use Thereof |
PL2812443T3 (pl) * | 2012-02-06 | 2020-01-31 | Inhibrx, Inc. | Przeciwciała CD47 i sposoby ich zastosowania |
US20140127269A1 (en) | 2012-02-13 | 2014-05-08 | The Schepens Eye Research Institute, Inc. | Anti-Inflammatory Peptide Derived From Thrombospondin-1 and Uses Thereof |
WO2014078373A1 (en) * | 2012-11-13 | 2014-05-22 | Iogenetics, Llc | Antimicrobial compositions |
AU2013353763B2 (en) | 2012-12-03 | 2018-09-13 | Novimmune S.A. | Anti-CD47 antibodies and methods of use thereof |
US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
EP2931751B1 (en) | 2012-12-12 | 2020-02-05 | Arch Oncology, Inc. | Therapeutic cd47 antibodies |
SMT201900623T1 (it) | 2012-12-17 | 2020-01-14 | Trillium Therapeutics Inc | Trattamento di cellule di malattia cd47+ con fusioni sirp alpha-fc |
WO2014121093A1 (en) | 2013-01-31 | 2014-08-07 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
CA2900256C (en) | 2013-02-05 | 2023-03-21 | Kim J. HASENKRUG | Cd47 targeted therapies for the treatment of infectious disease |
SG11201506132PA (en) * | 2013-02-06 | 2015-09-29 | Inhibrx Llc | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
CN114917336A (zh) | 2013-03-15 | 2022-08-19 | 小利兰·斯坦福大学托管委员会 | 用于实现治疗有效剂量的抗cd47剂的方法 |
US10064925B2 (en) | 2013-04-29 | 2018-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Use of anti-CD47 agents to enhance immunization |
WO2014186761A2 (en) | 2013-05-17 | 2014-11-20 | The Board Of Trustes Of The Leland Stanford Junior University | Methods for determining responsiveness to an anti-cd47 agent |
US10329354B2 (en) | 2013-09-18 | 2019-06-25 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of efferocytosis pathways for treatment of atherosclerotic disease |
CN106456748A (zh) | 2014-01-08 | 2017-02-22 | 小利兰·斯坦福大学托管委员会 | 小细胞肺癌的靶向疗法 |
EP3116544A4 (en) | 2014-03-11 | 2017-08-23 | The Board of Trustees of the Leland Stanford Junior University | Anti sirp-alpha antibodies and bi-specific macrophage enhancing antibodies |
US9527901B2 (en) | 2014-03-24 | 2016-12-27 | Macroimmune Inc | Recombinant bi-functional fusion proteins, preparations and methods for treating disease |
EP3131917B1 (en) | 2014-04-18 | 2020-06-17 | The Board of Trustees of the Leland Stanford Junior University | Humanized and chimeric monoclonal antibodies to cd99 |
WO2016023001A1 (en) | 2014-08-08 | 2016-02-11 | The Board Of Trustees Of The Leland Stanford Junior University | Multispecific high affinity pd-1 agents and methods of use |
CN113621075B (zh) | 2014-08-08 | 2024-09-20 | Alx肿瘤生物技术公司 | SIRP-α变体构建体及其用途 |
WO2016024021A1 (en) | 2014-08-15 | 2016-02-18 | Merck Patent Gmbh | Sirp-alpha immunoglobulin fusion proteins |
DK3656869T4 (da) | 2014-08-26 | 2025-05-19 | Univ Leland Stanford Junior | Transplantation af stamceller med en kombination af et stof, som er rettet mod stamceller, og modulation af immunregulatorisk signalering |
EP3194024B1 (en) | 2014-09-15 | 2020-08-05 | The Board of Trustees of the Leland Stanford Junior University | Targeting aneurysm disease by modulating phagocytosis pathways |
EP3012271A1 (en) | 2014-10-24 | 2016-04-27 | Effimune | Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases |
WO2016065329A1 (en) | 2014-10-24 | 2016-04-28 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance |
AU2015350190B2 (en) * | 2014-11-18 | 2021-08-05 | Janssen Pharmaceutica Nv | CD47 antibodies, methods, and uses |
HUE064960T2 (hu) | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
CA2972604C (en) * | 2014-12-30 | 2023-07-04 | Celgene Corporation | Anti-cd47 antibodies and uses thereof |
EP3247464B1 (en) | 2015-01-21 | 2019-09-18 | The Board of Trustees of the Leland Stanford Junior University | Use of tlr agonist and anti-cd47 agent to enhance phagocytosis of cancer cells |
EP3261671B1 (en) | 2015-02-27 | 2020-10-21 | The Board of Trustees of the Leland Stanford Junior University | Combination therapy for treatment of atherosclerosis |
WO2016141328A2 (en) | 2015-03-04 | 2016-09-09 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind cd47 |
EP3265481B1 (en) | 2015-03-05 | 2024-05-01 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
WO2016179399A1 (en) | 2015-05-06 | 2016-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | High affinity cd47 analogs |
CA2994935A1 (en) | 2015-05-18 | 2016-11-24 | Ab Initio Biotherapeutics, Inc. | Sirp polypeptide compositions and methods of use |
EP3349787A4 (en) | 2015-09-18 | 2019-03-27 | Arch Oncology, Inc. | THERAPEUTIC CD47 ANTIBODIES |
EP3353209B1 (en) * | 2015-09-21 | 2022-03-16 | Erasmus University Medical Center Rotterdam | Anti-cd47 antibodies and methods of use |
KR102472087B1 (ko) * | 2016-01-11 | 2022-11-29 | 포티 세븐, 인코포레이티드 | 인간화된, 마우스 또는 키메라 항-cd47 단클론 항체 |
US11291721B2 (en) | 2016-03-21 | 2022-04-05 | Marengo Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
AU2017248626B2 (en) | 2016-04-14 | 2024-05-09 | Ose Immunotherapeutics | New anti-SIRPa antibodies and their therapeutic applications |
CN106084052B (zh) * | 2016-06-17 | 2019-12-27 | 长春金赛药业股份有限公司 | 抗cd47单克隆抗体及其应用 |
BR112019000166A2 (pt) | 2016-07-06 | 2019-10-01 | Celgene Corp | anticorpos com baixa imunogenicidade e usos dos mesmos |
WO2018014067A1 (en) | 2016-07-19 | 2018-01-25 | Teva Pharmaceuticals Australia Pty Ltd | Anti-cd47 combination therapy |
JOP20190009A1 (ar) | 2016-09-21 | 2019-01-27 | Alx Oncology Inc | أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها |
MX2019004691A (es) | 2016-10-20 | 2019-12-09 | I Mab Biopharma Us Ltd | Anticuerpos monoclonales cd47 novedosos y sus usos. |
EP3529276A4 (en) | 2016-10-21 | 2020-06-17 | Arch Oncology, Inc. | CD47 THERAPEUTIC ANTIBODIES |
WO2018081898A1 (en) | 2016-11-03 | 2018-05-11 | Trillium Therapeutics Inc. | Improvements in cd47 blockade therapy by hdac inhibitors |
WO2018081897A1 (en) | 2016-11-03 | 2018-05-11 | Trillium Therapeutics Inc. | Enhancement of cd47 blockade therapy by proteasome inhibitors |
EP3538557A4 (en) | 2016-11-08 | 2020-11-18 | Ablexis, LLC | ANTI-CD47 ANTIBODIES |
WO2018107058A1 (en) | 2016-12-09 | 2018-06-14 | Alector Llc | Anti-sirp-alpha antibodies and methods of use thereof |
-
2018
- 2018-07-30 MX MX2020001309A patent/MX2020001309A/es unknown
- 2018-07-30 WO PCT/US2018/044384 patent/WO2019027903A1/en unknown
- 2018-07-30 NZ NZ761568A patent/NZ761568A/en unknown
- 2018-07-30 CA CA3071860A patent/CA3071860A1/en active Pending
- 2018-07-30 CN CN201880050597.7A patent/CN111183155B/zh active Active
- 2018-07-30 KR KR1020207006052A patent/KR102646468B1/ko active Active
- 2018-07-30 AU AU2018312222A patent/AU2018312222B2/en active Active
- 2018-07-30 EP EP18840724.1A patent/EP3661965A4/en active Pending
- 2018-07-30 US US16/633,730 patent/US11401329B2/en active Active
- 2018-07-30 SG SG11202000053TA patent/SG11202000053TA/en unknown
- 2018-07-30 JP JP2020505360A patent/JP7262440B2/ja active Active
- 2018-07-30 BR BR112020001679-9A patent/BR112020001679A2/pt unknown
-
2020
- 2020-01-20 ZA ZA2020/00373A patent/ZA202000373B/en unknown
- 2020-01-29 IL IL272330A patent/IL272330A/he unknown
Also Published As
Publication number | Publication date |
---|---|
CN111183155A (zh) | 2020-05-19 |
KR20200033948A (ko) | 2020-03-30 |
MX2020001309A (es) | 2020-08-20 |
JP2020536488A (ja) | 2020-12-17 |
KR102646468B1 (ko) | 2024-03-11 |
IL272330A (he) | 2020-03-31 |
US11401329B2 (en) | 2022-08-02 |
AU2018312222A1 (en) | 2020-02-27 |
US20200207853A1 (en) | 2020-07-02 |
EP3661965A4 (en) | 2022-07-13 |
ZA202000373B (en) | 2023-09-27 |
WO2019027903A1 (en) | 2019-02-07 |
NZ761568A (en) | 2022-11-25 |
BR112020001679A2 (pt) | 2020-07-21 |
JP7262440B2 (ja) | 2023-04-21 |
CA3071860A1 (en) | 2019-02-07 |
CN111183155B (zh) | 2024-02-20 |
AU2018312222B2 (en) | 2024-11-21 |
EP3661965A1 (en) | 2020-06-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL272330A (he) | נוגדנים אנטי- cd47 ושימושים בהם | |
IL290842A (he) | נוגדנים אנטי–cd73 ושימושים בהם | |
ZA202102905B (en) | Anti-galectin-9 antibodies and uses thereof | |
ZA202101318B (en) | Anti-phf-tau antibodies and uses thereof | |
IL271477A (he) | נוגדני אנטי- cd166 ושימושים בהם | |
IL268734A (he) | נוגדנים אנטי- lag-3 ושימושים בהם | |
ZA201704467B (en) | Anti-cd47 antibodies and uses thereof | |
SG10202109691UA (en) | Anti-pacap antibodies and uses thereof | |
IL254517A0 (he) | נוגדנים כנגד muc16 ושימושים שלהם | |
IL269134A (he) | נוגדנים נגד par2 ושימושם | |
IL254954B (he) | נוגדנים אנטי-pacap ושימושיהם | |
ZA201901935B (en) | Anti-il-33 antibodies and uses thereof | |
IL273157A (he) | נוגדנים ספציפיים ל-axl ושימושים שלהם | |
IL272476A (he) | נוגדנים אנטי-אפלין ושימושים בהם | |
IL266049A (he) | נוגדנים נגד o1 ושימושיהם | |
GB201503387D0 (en) | Anti-carbapenem antibodies and uses thereof | |
IL264417A (he) | נוגדני אנטי-o2 ושימושיהם | |
IL266082A (he) | נוגדני אנטי- chikv ושימושם | |
IL274202A (he) | נוגדנים נגד גלקו-מוק1 ושימושים בהם | |
GB201712032D0 (en) | Antibodies and uses thereof | |
HK40018997B (en) | Anti-cd47 antibodies and uses thereof |