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SG11201912071QA - Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use - Google Patents

Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use

Info

Publication number
SG11201912071QA
SG11201912071QA SG11201912071QA SG11201912071QA SG11201912071QA SG 11201912071Q A SG11201912071Q A SG 11201912071QA SG 11201912071Q A SG11201912071Q A SG 11201912071QA SG 11201912071Q A SG11201912071Q A SG 11201912071QA SG 11201912071Q A SG11201912071Q A SG 11201912071QA
Authority
SG
Singapore
Prior art keywords
mtsp
polypeptides
methods
serine protease
membrane type
Prior art date
Application number
SG11201912071QA
Inventor
Edwin Madison
Vanessa Soros
Mikhail Popkov
Original Assignee
Catalyst Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catalyst Biosciences Inc filed Critical Catalyst Biosciences Inc
Publication of SG11201912071QA publication Critical patent/SG11201912071QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21109—Matriptase (3.4.21.109)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Photolithography (AREA)
  • Beans For Foods Or Fodder (AREA)
SG11201912071QA 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use SG11201912071QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762523735P 2017-06-22 2017-06-22
US201862664051P 2018-04-27 2018-04-27
PCT/US2018/038844 WO2018237201A1 (en) 2017-06-22 2018-06-21 MODIFIED MEMBRANE-LIKE SERINE PROTEASE-1 POLYPEPTIDES (MTSP-1) AND METHODS OF USE

Publications (1)

Publication Number Publication Date
SG11201912071QA true SG11201912071QA (en) 2020-01-30

Family

ID=63015005

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10202110492YA SG10202110492YA (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
SG10202110500TA SG10202110500TA (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
SG11201912071QA SG11201912071QA (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG10202110492YA SG10202110492YA (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
SG10202110500TA SG10202110500TA (en) 2017-06-22 2018-06-21 Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use

Country Status (18)

Country Link
US (5) US10781435B2 (en)
EP (1) EP3641801A1 (en)
JP (3) JP7091373B2 (en)
KR (1) KR102675270B1 (en)
CN (1) CN111107870A (en)
AU (2) AU2018290281B2 (en)
BR (1) BR112019027583A2 (en)
CA (2) CA3177086A1 (en)
CL (3) CL2019003813A1 (en)
CO (1) CO2020000584A2 (en)
IL (2) IL308949A (en)
JO (1) JOP20190288A1 (en)
MX (1) MX2019015402A (en)
PE (1) PE20200697A1 (en)
PH (1) PH12019502838A1 (en)
SG (3) SG10202110492YA (en)
WO (1) WO2018237201A1 (en)
ZA (1) ZA202000332B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
CN105939767B (en) 2014-01-08 2018-04-06 弗洛设计声能学公司 Sound electrophoretic apparatus with alliteration electrophoresis chamber
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
AU2018385759B2 (en) 2017-12-14 2021-10-21 Flodesign Sonics, Inc. Acoustic transducer driver and controller
US20220362351A1 (en) * 2019-07-03 2022-11-17 Palleon Pharmaceuticals Inc. Recombinant sialidases and methods of using the same
US11396529B2 (en) * 2020-11-12 2022-07-26 National Sun Yat-Sen University Isolated peptide, anti-cancer medicinal composition including the same and method of specifically reducing or inhibiting activities of cancer cells using the same
JP2024502359A (en) * 2021-01-08 2024-01-18 バーテックス ファーマシューティカルズ インコーポレイテッド factor B protease
CN113456527B (en) * 2021-07-30 2023-04-07 北京清大赛尔生物科技有限公司 NADH microcapsule preparation and preparation method and application thereof
WO2024205149A1 (en) * 2023-03-24 2024-10-03 카오티에스 주식회사 Novel granzyme fusion protein and use thereof
CN119570766B (en) * 2025-02-08 2025-05-16 上海锴泰生物科技有限公司 Collagenase mutant, gene fragment, recombinant plasmid, recombinant expression system, collagen peptide, and preparation method and use thereof

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US237A (en) 1837-06-15 Egbert beale
US5990A (en) 1848-12-26 of baltimore
US5795A (en) 1848-09-19 Saddletree for carts
US569A (en) 1838-01-09 Caruiag-e-spiiln g
US844A (en) 1838-07-17 Boiler for
US5324A (en) 1847-10-09 Cooking-stove
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4002531A (en) 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
DE3921528A1 (en) 1989-06-30 1991-01-10 Draegerwerk Ag MEASURING CELL FOR ELECTROCHEMICAL GAS DETECTION
US5256643A (en) 1990-05-29 1993-10-26 The Government Of The United States Human cripto protein
US5262522A (en) 1991-11-22 1993-11-16 Immunex Corporation Receptor for oncostatin M and leukemia inhibitory factor
WO1994028024A1 (en) 1993-06-01 1994-12-08 Enzon, Inc. Carbohydrate-modified polymer conjugates with erythropoietic activity
US5457035A (en) 1993-07-23 1995-10-10 Immunex Corporation Cytokine which is a ligand for OX40
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
KR100203824B1 (en) 1994-03-31 1999-06-15 스티븐 엠. 오드리 Compositions and methods for stimulating megakaryocyte growth and differentiation
US5795569A (en) 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
US6448369B1 (en) 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
US5985263A (en) 1997-12-19 1999-11-16 Enzon, Inc. Substantially pure histidine-linked protein polymer conjugates
WO1999045964A1 (en) 1998-03-12 1999-09-16 Shearwater Polymers, Incorporated Poly(ethylene glycol) derivatives with proximal reactive groups
EP1095243A2 (en) 1998-07-03 2001-05-02 Neles Field Controls Oy Method and arrangement for measuring fluid
US6153394A (en) 1998-09-18 2000-11-28 Board Of Trustees Operating Michigan State University Immunoassay for equine protozoal myeloencephalitis in horses
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
CA2364690A1 (en) 1999-02-28 2000-10-19 Washington University Novel transduction molecules and methods for using same
WO2000053232A1 (en) 1999-03-12 2000-09-14 Georgetown University Matriptase, a serine protease and its applications
JO2291B1 (en) 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythopintin derivatives
CZ299516B6 (en) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Erythropoietin glycoprotein conjugate, process for its preparation and use and pharmaceutical composition containing thereof
US6461802B1 (en) 1999-08-02 2002-10-08 Agfa-Gevaert Adhesive layer for polyester film
US7030231B1 (en) 1999-09-30 2006-04-18 Catalyst Biosciences, Inc. Membrane type serine protease 1 (MT-SP1) and uses thereof
WO2001032711A2 (en) 1999-10-21 2001-05-10 Board Of Trustees Of The University Of Arkansas Adeno-associated virus aav rep78 major regulatory protein, mutants thereof and uses thereof
ES2256082T3 (en) 1999-12-22 2006-07-16 Nektar Therapeutics Al, Corporation DERIVATIVES OF HYDROSOLUBLE POLYMERS WITH ESTERIC IMPEDIMENT.
US6413507B1 (en) 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
US7700341B2 (en) 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
US6602498B2 (en) 2000-02-22 2003-08-05 Shearwater Corporation N-maleimidyl polymer derivatives
ES2290142T3 (en) 2000-05-16 2008-02-16 Bolder Biotechnology, Inc. METHODS FOR REPLEGATION OF PROTEINS CONTAINING FREE CISTEINE RESIDUES.
GB0103110D0 (en) 2000-08-25 2001-03-28 Aventis Pharma Inc A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1
US7157596B2 (en) 2000-09-08 2007-01-02 Dendreon Corporation Inhibitors of serine protease activity of matriptase or MTSP1
EP1345628B1 (en) 2000-12-20 2011-04-13 F. Hoffmann-La Roche AG Conjugates of erythropoietin (epo) with polyethylene glycol (peg)
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
AU2002305052A1 (en) 2001-03-13 2002-09-24 Corvas International, Inc. Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
WO2002077267A2 (en) 2001-03-27 2002-10-03 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembran serine protease 9, the encoded polypeptides and methods based thereon
KR20040080940A (en) 2001-05-14 2004-09-20 덴드레온 코포레이션 Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
KR20040004642A (en) 2001-05-23 2004-01-13 덴드레온 샌 디에고 엘엘씨 Conjugates activated by cell surface proteases and therapeutic uses thereof
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
WO2003035892A2 (en) 2001-10-19 2003-05-01 The Scripps Research Institute Novel methods for introducing molecules into cells and vectors and compositions for use in such methods
AU2002352524B2 (en) 2001-11-07 2007-10-04 Nektar Therapeutics Branched polymers and their conjugates
US8188231B2 (en) 2002-09-27 2012-05-29 Xencor, Inc. Optimized FC variants
US7192468B2 (en) 2002-04-15 2007-03-20 Fluor Technologies Corporation Configurations and method for improved gas removal
WO2003104394A2 (en) 2002-05-21 2003-12-18 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon
US20060024289A1 (en) * 2002-10-02 2006-02-02 Ruggles Sandra W Cleavage of VEGF and VEGF receptor by wild-type and mutant proteases
CN101124484A (en) 2002-10-02 2008-02-13 催化剂生物科学有限公司 Method for making and screening proteases with altered specificity
US7939304B2 (en) * 2002-10-02 2011-05-10 Catalyst Biosciences, Inc. Mutant MT-SP1 proteases with altered substrate specificity or activity
KR20040040782A (en) 2002-11-08 2004-05-13 선바이오(주) Novel hexa-arm polyethylene glycol and its derivatives and the methods of preparation thereof
US7482117B2 (en) 2002-12-20 2009-01-27 Celera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
US7019019B2 (en) 2002-12-23 2006-03-28 Dendreon Corporation Matriptase inhibitors and methods of use
US20040147027A1 (en) 2003-01-28 2004-07-29 Troy Carol M. Complex for facilitating delivery of dsRNA into a cell and uses thereof
US20060178297A1 (en) 2003-01-28 2006-08-10 Troy Carol M Systems and methods for silencing expression of a gene in a cell and uses thereof
EP1596887B1 (en) 2003-02-26 2022-03-23 Nektar Therapeutics Polymer-factor viii moiety conjugates
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US7610156B2 (en) 2003-03-31 2009-10-27 Xencor, Inc. Methods for rational pegylation of proteins
KR100512483B1 (en) 2003-05-07 2005-09-05 선바이오(주) Novel Preparation method of PEG-maleimide PEG derivatives
KR101128320B1 (en) 2003-05-23 2012-04-12 넥타르 테라퓨틱스 Peg derivatives having an amidocarbonate linkage
US7595306B2 (en) 2003-06-09 2009-09-29 Alnylam Pharmaceuticals Inc Method of treating neurodegenerative disease
EP1732581A4 (en) 2003-06-20 2008-06-04 Univ California San Diego POLYPEPTIDE TRANSDUCTION AND FUSOGENIC PEPTIDES
US7439226B2 (en) 2003-09-30 2008-10-21 The United States Of America As Represented By The Department Of Health And Human Services Serine protease inhibitors
US20050227324A1 (en) 2003-12-19 2005-10-13 Genentech, Inc. Monovalent antibody fragments useful as therapeutics
AU2005244271B2 (en) 2004-04-12 2010-04-08 Vertex Pharmaceuticals Incorporated Cleavage of VEGF and VEGF receptor by wildtype and mutant MT-SP1
US8173144B2 (en) 2004-11-04 2012-05-08 L'oreal Administration of urea compounds for combating signs of cutaneous aging
EP1851543A2 (en) 2005-02-24 2007-11-07 Compugen Ltd. Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof
KR101393946B1 (en) * 2005-10-21 2014-05-12 카탈리스트 바이오사이언시즈, 인코포레이티드 Modified protease inhibiting complement activation
AU2011218753B2 (en) * 2005-10-21 2013-10-24 Vertex Pharmaceuticals Incorporated Modified proteases that inhibit complement activation
EP1940865A2 (en) 2005-11-01 2008-07-09 Arizona Board Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University Novel protein transduction domains and uses therefor
US7579318B2 (en) 2005-12-06 2009-08-25 Centre De La Recherche De La Scientifique Cell penetrating peptides for intracellular delivery of molecules
KR100859972B1 (en) 2006-02-20 2008-09-25 이화여자대학교 산학협력단 Cell membrane-penetrating peptide
EP1867661A1 (en) 2006-06-12 2007-12-19 Diatos Compositions and methods for delivering anti-activated ras antibodies into cells
CN107630011A (en) * 2006-07-05 2018-01-26 催化剂生物科学公司 Protease screening procedure and the protease thus differentiated
WO2008045148A2 (en) 2006-07-05 2008-04-17 Catalyst Biosciences, Inc. Protease screening methods and proteases identified thereby
CA2761310C (en) 2009-05-07 2017-02-28 Charles S. Craik Antibodies and methods of use thereof
CA2843684A1 (en) 2010-08-13 2012-02-16 Tufts University Compositions, kits and methods for treatment of macular degeneration using soluble membrane-independent cd59 protein
CA2843631A1 (en) 2011-10-14 2013-04-18 Alain Moreau Methods and kits for diagnosing and/or prognosing osteoarthritis
CA2861066C (en) 2012-01-12 2024-01-02 Yale University Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an e3 ubiquitin ligase
CA2868393A1 (en) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
US10029415B2 (en) 2012-08-16 2018-07-24 Stratasys, Inc. Print head nozzle for use with additive manufacturing system
US20160067357A1 (en) * 2012-08-17 2016-03-10 Apellis Pharmaceuticals, Inc. Detection of high risk drusen
CA2836167A1 (en) 2013-12-10 2015-06-10 Christina Xiaolin Dai Thickness increase spring
DK3137595T3 (en) 2014-04-29 2019-06-17 Novartis Ag New vertebrate cells and methods for recombinant expression of a polypeptide of interest
CN113621075B (en) 2014-08-08 2024-09-20 Alx肿瘤生物技术公司 SIRP-alpha variant constructs and uses thereof
US10689423B2 (en) 2015-01-13 2020-06-23 City Of Hope CTLA4-binding protein peptide-linker masks
EP3247708A4 (en) 2015-01-20 2018-09-12 Arvinas, Inc. Compounds and methods for the targeted degradation of the androgen receptor
BR112017027582A2 (en) 2015-07-06 2018-08-28 Regeneron Pharma method for inhibiting the growth of a tumor cell or promoting the elimination of a tumor cell, and pharmaceutical composition.
US11903996B2 (en) * 2015-10-07 2024-02-20 David C. Fritzinger Modulators of complement function
CN108366992A (en) 2015-11-02 2018-08-03 耶鲁大学 Proteolysis targets chimera compound and its methods for making and using same
CN113661239A (en) 2018-12-28 2021-11-16 催化剂生物科学公司 Modified urokinase-type plasminogen activator polypeptides and methods of use

Also Published As

Publication number Publication date
KR20200030063A (en) 2020-03-19
WO2018237201A1 (en) 2018-12-27
IL271587A (en) 2020-02-27
SG10202110492YA (en) 2021-11-29
AU2022201445A1 (en) 2022-03-24
EP3641801A1 (en) 2020-04-29
KR102675270B1 (en) 2024-06-17
US12173337B2 (en) 2024-12-24
IL271587B1 (en) 2024-01-01
ZA202000332B (en) 2024-12-18
MX2019015402A (en) 2020-07-20
CO2020000584A2 (en) 2020-05-05
US20200291376A1 (en) 2020-09-17
US11401513B2 (en) 2022-08-02
CA3177086A1 (en) 2018-12-27
JP7091373B2 (en) 2022-06-27
NZ760116A (en) 2024-03-22
SG10202110500TA (en) 2021-11-29
US11807882B2 (en) 2023-11-07
CL2019003813A1 (en) 2020-05-29
PH12019502838A1 (en) 2020-09-21
CA3067851C (en) 2023-01-31
US10954501B2 (en) 2021-03-23
CA3067851A1 (en) 2018-12-27
US10781435B2 (en) 2020-09-22
JP2020528742A (en) 2020-10-01
IL271587B2 (en) 2024-05-01
US20190093097A1 (en) 2019-03-28
JOP20190288A1 (en) 2019-12-16
AU2018290281A1 (en) 2020-01-30
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BR112019027583A2 (en) 2020-10-06
US20210355474A1 (en) 2021-11-18
AU2022201445B2 (en) 2023-11-23
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JP2022120155A (en) 2022-08-17
AU2018290281B2 (en) 2021-12-16
PE20200697A1 (en) 2020-06-16
US20240018502A1 (en) 2024-01-18
US20210032617A1 (en) 2021-02-04
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CL2021003080A1 (en) 2022-08-12

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