SG11201900135YA - N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors - Google Patents
N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitorsInfo
- Publication number
- SG11201900135YA SG11201900135YA SG11201900135YA SG11201900135YA SG11201900135YA SG 11201900135Y A SG11201900135Y A SG 11201900135YA SG 11201900135Y A SG11201900135Y A SG 11201900135YA SG 11201900135Y A SG11201900135Y A SG 11201900135YA SG 11201900135Y A SG11201900135Y A SG 11201900135YA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- ann arbor
- compounds
- english
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000012664 BCL-2-inhibitor Substances 0.000 title abstract 2
- 229940123711 Bcl2 inhibitor Drugs 0.000 title abstract 2
- ZBGWAJQUDSCDPB-UHFFFAOYSA-N n-(benzenesulfonyl)benzamide Chemical class C=1C=CC=CC=1C(=O)NS(=O)(=O)C1=CC=CC=C1 ZBGWAJQUDSCDPB-UHFFFAOYSA-N 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940054066 benzamide antipsychotics Drugs 0.000 abstract 1
- 150000003936 benzamides Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000012546 transfer Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization MD HIM 0 11101 0I0 11111 01 II 0 011101 010 HO 11011110 EEO ill OEN International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/027097 Al 08 February 2018 (08.02.2018) WIP0 I PCT (51) International Patent Classification: C07D 471/04 (2006.01) A61P 35/00 (2006.01) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. A61K 31/437 (2006.01) (84) Designated States (unless otherwise indicated, for every (21) International Application Number: PCT/US2017/045428 kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (22) International Filing Date: 04 August 2017 (04.08.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (25) Filing Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (26) Publication Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (30) Priority Data: 62/371,504 05 August 2016 (05.08.2016) US Published: 62/454,101 03 February 2017 (03.02.2017) US — with international search report (Art. 21(3)) (71) Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US/US]; Office Of Technology Trans- fer, 1600 Huron Parkway, 2nd Floor, Ann Arbor, MI 48109-2590 (US). (72) Inventors: WANG, Chia, Wei; 3040 Cedarbrook Road, Ann Arbor, MI 48015 (US). CHEN, Jianyong; 2659 Ar- rowwood Trail, Ann Arbor, MI 48105 (US). _ = Agent: NAPOLI, James, J.; Marshall, Gerstein & Borun = (74) LLP, 233 S. Wacker Drive, 6300 Willis Tower, Chicago, IL _ 60606-6357 (US). — (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = = = = = = = = Title: N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS = (54) = (57) : The present disclosure provides compounds having Formula I-A: and the = 0 4.-A 0 pharmaceutically acceptable salts and solvates thereof, wherein A, X 1 , X2, X3 R la, R lb E, T and = are as defined as set forth in the specification. The present disclosure also provides o NH compounds of Formula I-A for use to treat a disease, disorder, or condition responsive to 1 s'... ) o Bc1-2 protein inhibition such as cancer. = — 1-1 x 2 , ,. .. x 3 /. n n N .4 I N H E IN C:r C N ) © IN ei io R la © ---.... 101 R1b 11 CI I-A 0 ei C
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662371504P | 2016-08-05 | 2016-08-05 | |
| US201762454101P | 2017-02-03 | 2017-02-03 | |
| PCT/US2017/045428 WO2018027097A1 (en) | 2016-08-05 | 2017-08-04 | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201900135YA true SG11201900135YA (en) | 2019-02-27 |
Family
ID=59677319
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900135YA SG11201900135YA (en) | 2016-08-05 | 2017-08-04 | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
| SG10201913643YA SG10201913643YA (en) | 2016-08-05 | 2017-08-04 | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201913643YA SG10201913643YA (en) | 2016-08-05 | 2017-08-04 | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10829488B2 (en) |
| EP (3) | EP4129999A1 (en) |
| JP (2) | JP6651180B2 (en) |
| KR (2) | KR102376764B1 (en) |
| CN (2) | CN110483501B (en) |
| AU (2) | AU2017305508B2 (en) |
| BR (1) | BR112019001666A2 (en) |
| CA (1) | CA3031419C (en) |
| CY (1) | CY1123859T1 (en) |
| DK (1) | DK3494115T3 (en) |
| ES (1) | ES2849959T3 (en) |
| HR (1) | HRP20202073T1 (en) |
| HU (1) | HUE053414T2 (en) |
| IL (2) | IL264059B (en) |
| LT (1) | LT3494115T (en) |
| MX (2) | MX381588B (en) |
| MY (1) | MY199409A (en) |
| PE (1) | PE20190711A1 (en) |
| PH (1) | PH12019500231A1 (en) |
| PT (1) | PT3494115T (en) |
| RS (1) | RS61821B1 (en) |
| RU (2) | RU2722560C1 (en) |
| SA (1) | SA519401020B1 (en) |
| SG (2) | SG11201900135YA (en) |
| SI (1) | SI3494115T1 (en) |
| SM (1) | SMT202100025T1 (en) |
| WO (1) | WO2018027097A1 (en) |
| ZA (2) | ZA201900240B (en) |
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| EP3426655A1 (en) * | 2016-03-10 | 2019-01-16 | Assia Chemical Industries Ltd. | Solid state forms of venetoclax and processes for preparation of venetoclax |
| AU2017305508B2 (en) * | 2016-08-05 | 2021-01-07 | The Regents Of The University Of Michigan | N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors |
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| CA3057886A1 (en) * | 2017-04-18 | 2018-10-25 | Shanghai Fochon Pharmaceutical Co., Ltd. | Bcl-2 inhibitors as apoptosis-inducing agents |
| US11420968B2 (en) | 2018-04-29 | 2022-08-23 | Beigene, Ltd. | Bcl-2 inhibitors |
| CN110772640B (en) * | 2018-07-31 | 2023-02-03 | 苏州亚盛药业有限公司 | Synergistic antitumor effect of Bcl-2 inhibitors in combination with rituximab and/or bendamustine or with CHOP |
| EP3672594B1 (en) * | 2018-07-31 | 2021-09-29 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases |
| US11491167B2 (en) | 2018-07-31 | 2022-11-08 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of Bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| CN110772521A (en) * | 2018-07-31 | 2020-02-11 | 苏州亚盛药业有限公司 | Bcl-2 inhibitor or Bcl-2/Bcl-xL inhibitor and BTK inhibitor combination product and application thereof |
| US20210275522A1 (en) * | 2018-11-23 | 2021-09-09 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical compositions and use thereof |
| TWI770503B (en) * | 2019-05-13 | 2022-07-11 | 大陸商蘇州亞盛藥業有限公司 | Method and composition for predicting efficacy of bcl2/bcl-xl inhibitors |
| WO2021000899A1 (en) * | 2019-07-02 | 2021-01-07 | Ascentage Pharma (Suzhou) Co., Ltd. | A PHARMACEUTICAL COMBINATION CONTAINING mTOR INHIBITOR AND USE THEREOF |
| TW202114664A (en) * | 2019-07-31 | 2021-04-16 | 大陸商蘇州亞盛藥業有限公司 | Combination product of a bcl-2/bcl-xl inhibitor and a chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| CN112852959A (en) | 2019-11-27 | 2021-05-28 | 苏州亚盛药业有限公司 | Methods and compositions for predicting anti-cancer efficacy of compounds targeting apoptotic pathways |
| CN119097631A (en) | 2019-12-03 | 2024-12-10 | 苏州亚盛药业有限公司 | N-(Phenylsulfonyl)benzamide and related compounds as BCL-2 inhibitors |
| US20220323465A1 (en) * | 2019-12-04 | 2022-10-13 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical combination and use thereof |
| KR20220100992A (en) | 2019-12-06 | 2022-07-18 | 록쏘 온콜로지, 인코포레이티드 | Administration of Bruton's Tyrosine Kinase Inhibitors |
| WO2021175321A1 (en) | 2020-03-06 | 2021-09-10 | Ascentage Pharma (Suzhou) Co., Ltd. | Crystalline forms or amorphous forms of n- (phenyl sulfonyl) benzamide compounds or its salts or solvates |
| CN115244051B (en) * | 2020-03-12 | 2024-10-18 | 南京明德新药研发有限公司 | Benzo five-membered ring compound |
| CN116969936A (en) | 2020-04-15 | 2023-10-31 | 百济神州有限公司 | BCL-2 inhibitors |
| WO2021227763A1 (en) * | 2020-05-14 | 2021-11-18 | Ascentage Pharma (Suzhou) Co., Ltd. | Hplc analysis method for n- (phenylsulfonyl) benzamide compound |
| US20230159524A1 (en) * | 2020-07-01 | 2023-05-25 | Ascentage Pharma (Suzhou) Co., Ltd. | Methods for synthesizing n-(phenylsulfonyl)benzamide compounds and intermediates thereof |
| CN111537654B (en) * | 2020-07-07 | 2020-11-10 | 上海亚盛医药科技有限公司 | HPLC analysis method of N- (phenylsulfonyl) benzamide compound |
| AU2021306781A1 (en) * | 2020-07-10 | 2023-03-02 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Sulfonylbenzamide derivative and conjugate thereof, preparation method therefor and use thereof |
| CN114057728A (en) * | 2020-08-06 | 2022-02-18 | 北京诺诚健华医药科技有限公司 | Heterocyclic compounds as BCL-2 inhibitors |
| CN114073703B (en) * | 2020-08-21 | 2022-12-30 | 苏州亚盛药业有限公司 | Compositions and methods for treating nonalcoholic steatohepatitis |
| CN114073707A (en) * | 2020-08-21 | 2022-02-22 | 苏州亚盛药业有限公司 | Compositions and methods for treating systemic lupus erythematosus |
| EP4251137A4 (en) * | 2020-11-25 | 2024-10-16 | Ascentage Pharma (Suzhou) Co., Ltd. | Solid dispersion, pharmaceutical preparations, preparation method, and application thereof |
| US20240316069A1 (en) * | 2020-12-28 | 2024-09-26 | Ascentage Pharma (Suzhou) Co., Ltd. | Methods of treating multiple sclerosis |
| JP2024504542A (en) * | 2021-02-01 | 2024-02-01 | アセンテージ ファーマ（スーチョウ）カンパニー，リミティド | Sulfonylbenzamide derivatives as BCL-2 inhibitors |
| EP4319800A1 (en) | 2021-04-07 | 2024-02-14 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for the treatment of cancer |
| JP2024528174A (en) | 2021-08-02 | 2024-07-26 | アセンテージ ファーマ（スーチョウ）カンパニー，リミティド | Pharmaceutical combinations and uses thereof |
| CN115260191B (en) * | 2022-09-29 | 2022-12-27 | 上海睿跃生物科技有限公司 | Piperidine compound and preparation method and application thereof |
| EP4421075A1 (en) * | 2023-02-27 | 2024-08-28 | KRKA, d.d., Novo mesto | Process for the preparation of venetoclax and intermediates used therein |
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| ES2593427T3 (en) | 2009-01-19 | 2016-12-09 | Abbvie Inc. | Agents inducing apoptosis for the treatment of cancer and autoimmune and immune diseases |
| WO2010093742A1 (en) | 2009-02-11 | 2010-08-19 | Abbott Laboratories | Methods and compositions for identifying, classifying and monitoring subject having bcl-2 family inhibitor-resistant tumors and cancers |
| MY155645A (en) * | 2009-05-26 | 2015-11-13 | Abbvie Bahamas Ltd | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| TWI520960B (en) * | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| KR102095698B1 (en) * | 2010-10-29 | 2020-04-01 | 애브비 인코포레이티드 | Solid dispersions containing an apoptosis-inducing agent |
| NZ708508A (en) * | 2010-11-23 | 2016-06-24 | Abbvie Bahamas Ltd | Methods of treatment using selective bcl-2 inhibitors |
| CA2817629C (en) | 2010-11-23 | 2019-08-13 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
| US10327687B2 (en) | 2015-12-30 | 2019-06-25 | Dexcom, Inc. | System and method for factory calibration or reduced calibration of an indwelling sensor based on sensitivity profile and baseline model of sensors |
| AU2017305508B2 (en) * | 2016-08-05 | 2021-01-07 | The Regents Of The University Of Michigan | N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors |
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2017
- 2017-08-04 AU AU2017305508A patent/AU2017305508B2/en active Active
- 2017-08-04 SG SG11201900135YA patent/SG11201900135YA/en unknown
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- 2017-08-04 KR KR1020197002744A patent/KR102376764B1/en active Active
- 2017-08-04 KR KR1020217026744A patent/KR102429704B1/en active Active
- 2017-08-04 DK DK17754889.8T patent/DK3494115T3/en active
- 2017-08-04 SI SI201730535T patent/SI3494115T1/en unknown
- 2017-08-04 HU HUE17754889A patent/HUE053414T2/en unknown
- 2017-08-04 EP EP22179906.7A patent/EP4129999A1/en active Pending
- 2017-08-04 ES ES17754889T patent/ES2849959T3/en active Active
- 2017-08-04 CN CN201910626474.XA patent/CN110483501B/en active Active
- 2017-08-04 US US16/317,056 patent/US10829488B2/en active Active
- 2017-08-04 EP EP19184604.7A patent/EP3569601B1/en active Active
- 2017-08-04 PE PE2019000335A patent/PE20190711A1/en unknown
- 2017-08-04 EP EP17754889.8A patent/EP3494115B1/en active Active
- 2017-08-04 WO PCT/US2017/045428 patent/WO2018027097A1/en unknown
- 2017-08-04 JP JP2019506191A patent/JP6651180B2/en active Active
- 2017-08-04 CA CA3031419A patent/CA3031419C/en active Active
- 2017-08-04 MY MYPI2019000239A patent/MY199409A/en unknown
- 2017-08-04 LT LTEP17754889.8T patent/LT3494115T/en unknown
- 2017-08-04 MX MX2019001391A patent/MX381588B/en unknown
- 2017-08-04 HR HRP20202073TT patent/HRP20202073T1/en unknown
- 2017-08-04 PT PT177548898T patent/PT3494115T/en unknown
- 2017-08-04 RU RU2019105721A patent/RU2722560C1/en active
- 2017-08-04 CN CN201780035965.6A patent/CN109311871B/en active Active
- 2017-08-04 RS RS20201599A patent/RS61821B1/en unknown
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- 2017-08-04 RU RU2020114660A patent/RU2744358C2/en active
- 2017-08-04 BR BR112019001666A patent/BR112019001666A2/en active IP Right Grant
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2018
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2019
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- 2019-01-31 PH PH12019500231A patent/PH12019500231A1/en unknown
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- 2019-07-23 JP JP2019135624A patent/JP7205903B2/en active Active
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2020
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