SG10201913643YA - N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors - Google Patents
N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitorsInfo
- Publication number
- SG10201913643YA SG10201913643YA SG10201913643YA SG10201913643YA SG10201913643YA SG 10201913643Y A SG10201913643Y A SG 10201913643YA SG 10201913643Y A SG10201913643Y A SG 10201913643YA SG 10201913643Y A SG10201913643Y A SG 10201913643YA SG 10201913643Y A SG10201913643Y A SG 10201913643YA
- Authority
- SG
- Singapore
- Prior art keywords
- benzamides
- phenylsulfonyl
- bcl
- inhibitors
- related compounds
- Prior art date
Links
- 239000012664 BCL-2-inhibitor Substances 0.000 title 1
- 229940123711 Bcl2 inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- ZBGWAJQUDSCDPB-UHFFFAOYSA-N n-(benzenesulfonyl)benzamide Chemical class C=1C=CC=CC=1C(=O)NS(=O)(=O)C1=CC=CC=C1 ZBGWAJQUDSCDPB-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662371504P | 2016-08-05 | 2016-08-05 | |
| US201762454101P | 2017-02-03 | 2017-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201913643YA true SG10201913643YA (en) | 2020-03-30 |
Family
ID=59677319
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900135YA SG11201900135YA (en) | 2016-08-05 | 2017-08-04 | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
| SG10201913643YA SG10201913643YA (en) | 2016-08-05 | 2017-08-04 | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900135YA SG11201900135YA (en) | 2016-08-05 | 2017-08-04 | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10829488B2 (en) |
| EP (3) | EP4129999A1 (en) |
| JP (2) | JP6651180B2 (en) |
| KR (2) | KR102376764B1 (en) |
| CN (2) | CN110483501B (en) |
| AU (2) | AU2017305508B2 (en) |
| BR (1) | BR112019001666A2 (en) |
| CA (1) | CA3031419C (en) |
| CY (1) | CY1123859T1 (en) |
| DK (1) | DK3494115T3 (en) |
| ES (1) | ES2849959T3 (en) |
| HR (1) | HRP20202073T1 (en) |
| HU (1) | HUE053414T2 (en) |
| IL (2) | IL264059B (en) |
| LT (1) | LT3494115T (en) |
| MX (2) | MX381588B (en) |
| MY (1) | MY199409A (en) |
| PE (1) | PE20190711A1 (en) |
| PH (1) | PH12019500231A1 (en) |
| PT (1) | PT3494115T (en) |
| RS (1) | RS61821B1 (en) |
| RU (2) | RU2722560C1 (en) |
| SA (1) | SA519401020B1 (en) |
| SG (2) | SG11201900135YA (en) |
| SI (1) | SI3494115T1 (en) |
| SM (1) | SMT202100025T1 (en) |
| WO (1) | WO2018027097A1 (en) |
| ZA (2) | ZA201900240B (en) |
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| EP3426655A1 (en) * | 2016-03-10 | 2019-01-16 | Assia Chemical Industries Ltd. | Solid state forms of venetoclax and processes for preparation of venetoclax |
| AU2017305508B2 (en) * | 2016-08-05 | 2021-01-07 | The Regents Of The University Of Michigan | N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors |
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| CA3057886A1 (en) * | 2017-04-18 | 2018-10-25 | Shanghai Fochon Pharmaceutical Co., Ltd. | Bcl-2 inhibitors as apoptosis-inducing agents |
| US11420968B2 (en) | 2018-04-29 | 2022-08-23 | Beigene, Ltd. | Bcl-2 inhibitors |
| CN110772640B (en) * | 2018-07-31 | 2023-02-03 | 苏州亚盛药业有限公司 | Synergistic antitumor effect of Bcl-2 inhibitors in combination with rituximab and/or bendamustine or with CHOP |
| EP3672594B1 (en) * | 2018-07-31 | 2021-09-29 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases |
| US11491167B2 (en) | 2018-07-31 | 2022-11-08 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of Bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| CN110772521A (en) * | 2018-07-31 | 2020-02-11 | 苏州亚盛药业有限公司 | Bcl-2 inhibitor or Bcl-2/Bcl-xL inhibitor and BTK inhibitor combination product and application thereof |
| US20210275522A1 (en) * | 2018-11-23 | 2021-09-09 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical compositions and use thereof |
| TWI770503B (en) * | 2019-05-13 | 2022-07-11 | 大陸商蘇州亞盛藥業有限公司 | Method and composition for predicting efficacy of bcl2/bcl-xl inhibitors |
| WO2021000899A1 (en) * | 2019-07-02 | 2021-01-07 | Ascentage Pharma (Suzhou) Co., Ltd. | A PHARMACEUTICAL COMBINATION CONTAINING mTOR INHIBITOR AND USE THEREOF |
| TW202114664A (en) * | 2019-07-31 | 2021-04-16 | 大陸商蘇州亞盛藥業有限公司 | Combination product of a bcl-2/bcl-xl inhibitor and a chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| CN112852959A (en) | 2019-11-27 | 2021-05-28 | 苏州亚盛药业有限公司 | Methods and compositions for predicting anti-cancer efficacy of compounds targeting apoptotic pathways |
| CN119097631A (en) | 2019-12-03 | 2024-12-10 | 苏州亚盛药业有限公司 | N-(Phenylsulfonyl)benzamide and related compounds as BCL-2 inhibitors |
| US20220323465A1 (en) * | 2019-12-04 | 2022-10-13 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical combination and use thereof |
| KR20220100992A (en) | 2019-12-06 | 2022-07-18 | 록쏘 온콜로지, 인코포레이티드 | Administration of Bruton's Tyrosine Kinase Inhibitors |
| WO2021175321A1 (en) | 2020-03-06 | 2021-09-10 | Ascentage Pharma (Suzhou) Co., Ltd. | Crystalline forms or amorphous forms of n- (phenyl sulfonyl) benzamide compounds or its salts or solvates |
| CN115244051B (en) * | 2020-03-12 | 2024-10-18 | 南京明德新药研发有限公司 | Benzo five-membered ring compound |
| CN116969936A (en) | 2020-04-15 | 2023-10-31 | 百济神州有限公司 | BCL-2 inhibitors |
| WO2021227763A1 (en) * | 2020-05-14 | 2021-11-18 | Ascentage Pharma (Suzhou) Co., Ltd. | Hplc analysis method for n- (phenylsulfonyl) benzamide compound |
| US20230159524A1 (en) * | 2020-07-01 | 2023-05-25 | Ascentage Pharma (Suzhou) Co., Ltd. | Methods for synthesizing n-(phenylsulfonyl)benzamide compounds and intermediates thereof |
| CN111537654B (en) * | 2020-07-07 | 2020-11-10 | 上海亚盛医药科技有限公司 | HPLC analysis method of N- (phenylsulfonyl) benzamide compound |
| AU2021306781A1 (en) * | 2020-07-10 | 2023-03-02 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Sulfonylbenzamide derivative and conjugate thereof, preparation method therefor and use thereof |
| CN114057728A (en) * | 2020-08-06 | 2022-02-18 | 北京诺诚健华医药科技有限公司 | Heterocyclic compounds as BCL-2 inhibitors |
| CN114073703B (en) * | 2020-08-21 | 2022-12-30 | 苏州亚盛药业有限公司 | Compositions and methods for treating nonalcoholic steatohepatitis |
| CN114073707A (en) * | 2020-08-21 | 2022-02-22 | 苏州亚盛药业有限公司 | Compositions and methods for treating systemic lupus erythematosus |
| EP4251137A4 (en) * | 2020-11-25 | 2024-10-16 | Ascentage Pharma (Suzhou) Co., Ltd. | Solid dispersion, pharmaceutical preparations, preparation method, and application thereof |
| US20240316069A1 (en) * | 2020-12-28 | 2024-09-26 | Ascentage Pharma (Suzhou) Co., Ltd. | Methods of treating multiple sclerosis |
| JP2024504542A (en) * | 2021-02-01 | 2024-02-01 | アセンテージ ファーマ（スーチョウ）カンパニー，リミティド | Sulfonylbenzamide derivatives as BCL-2 inhibitors |
| EP4319800A1 (en) | 2021-04-07 | 2024-02-14 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for the treatment of cancer |
| JP2024528174A (en) | 2021-08-02 | 2024-07-26 | アセンテージ ファーマ（スーチョウ）カンパニー，リミティド | Pharmaceutical combinations and uses thereof |
| CN115260191B (en) * | 2022-09-29 | 2022-12-27 | 上海睿跃生物科技有限公司 | Piperidine compound and preparation method and application thereof |
| EP4421075A1 (en) * | 2023-02-27 | 2024-08-28 | KRKA, d.d., Novo mesto | Process for the preparation of venetoclax and intermediates used therein |
| WO2024184233A1 (en) | 2023-03-03 | 2024-09-12 | Ionctura Sa | Combination of roginolisib and bcl-2 inhibitor in the treatment of haematological malignancy |
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| US1021343A (en) | 1912-01-17 | 1912-03-26 | M A N Mfg Company | Locking-clamp. |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
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| US8624027B2 (en) | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
| CA2662320C (en) | 2006-09-05 | 2014-07-22 | Abbott Laboratories | Bcl inhibitors treating platelet excess |
| CA2671399A1 (en) | 2006-12-04 | 2008-06-12 | Abbott Laboratories | Companion diagnostic assays for cancer therapy |
| UA108193C2 (en) * | 2008-12-04 | 2015-04-10 | APOPTOZINDUCE FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTO-IMMUNE DISEASES | |
| MX363470B (en) | 2008-12-05 | 2019-03-25 | Abbvie Inc | Sulfonamide derivatives as bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases. |
| ES2593427T3 (en) | 2009-01-19 | 2016-12-09 | Abbvie Inc. | Agents inducing apoptosis for the treatment of cancer and autoimmune and immune diseases |
| WO2010093742A1 (en) | 2009-02-11 | 2010-08-19 | Abbott Laboratories | Methods and compositions for identifying, classifying and monitoring subject having bcl-2 family inhibitor-resistant tumors and cancers |
| MY155645A (en) * | 2009-05-26 | 2015-11-13 | Abbvie Bahamas Ltd | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| TWI520960B (en) * | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| KR102095698B1 (en) * | 2010-10-29 | 2020-04-01 | 애브비 인코포레이티드 | Solid dispersions containing an apoptosis-inducing agent |
| NZ708508A (en) * | 2010-11-23 | 2016-06-24 | Abbvie Bahamas Ltd | Methods of treatment using selective bcl-2 inhibitors |
| CA2817629C (en) | 2010-11-23 | 2019-08-13 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
| US10327687B2 (en) | 2015-12-30 | 2019-06-25 | Dexcom, Inc. | System and method for factory calibration or reduced calibration of an indwelling sensor based on sensitivity profile and baseline model of sensors |
| AU2017305508B2 (en) * | 2016-08-05 | 2021-01-07 | The Regents Of The University Of Michigan | N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors |
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2017
- 2017-08-04 AU AU2017305508A patent/AU2017305508B2/en active Active
- 2017-08-04 SG SG11201900135YA patent/SG11201900135YA/en unknown
- 2017-08-04 SM SM20210025T patent/SMT202100025T1/en unknown
- 2017-08-04 KR KR1020197002744A patent/KR102376764B1/en active Active
- 2017-08-04 KR KR1020217026744A patent/KR102429704B1/en active Active
- 2017-08-04 DK DK17754889.8T patent/DK3494115T3/en active
- 2017-08-04 SI SI201730535T patent/SI3494115T1/en unknown
- 2017-08-04 HU HUE17754889A patent/HUE053414T2/en unknown
- 2017-08-04 EP EP22179906.7A patent/EP4129999A1/en active Pending
- 2017-08-04 ES ES17754889T patent/ES2849959T3/en active Active
- 2017-08-04 CN CN201910626474.XA patent/CN110483501B/en active Active
- 2017-08-04 US US16/317,056 patent/US10829488B2/en active Active
- 2017-08-04 EP EP19184604.7A patent/EP3569601B1/en active Active
- 2017-08-04 PE PE2019000335A patent/PE20190711A1/en unknown
- 2017-08-04 EP EP17754889.8A patent/EP3494115B1/en active Active
- 2017-08-04 WO PCT/US2017/045428 patent/WO2018027097A1/en unknown
- 2017-08-04 JP JP2019506191A patent/JP6651180B2/en active Active
- 2017-08-04 CA CA3031419A patent/CA3031419C/en active Active
- 2017-08-04 MY MYPI2019000239A patent/MY199409A/en unknown
- 2017-08-04 LT LTEP17754889.8T patent/LT3494115T/en unknown
- 2017-08-04 MX MX2019001391A patent/MX381588B/en unknown
- 2017-08-04 HR HRP20202073TT patent/HRP20202073T1/en unknown
- 2017-08-04 PT PT177548898T patent/PT3494115T/en unknown
- 2017-08-04 RU RU2019105721A patent/RU2722560C1/en active
- 2017-08-04 CN CN201780035965.6A patent/CN109311871B/en active Active
- 2017-08-04 RS RS20201599A patent/RS61821B1/en unknown
- 2017-08-04 SG SG10201913643YA patent/SG10201913643YA/en unknown
- 2017-08-04 RU RU2020114660A patent/RU2744358C2/en active
- 2017-08-04 BR BR112019001666A patent/BR112019001666A2/en active IP Right Grant
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2018
- 2018-08-01 US US16/051,816 patent/US10221174B2/en active Active
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2019
- 2019-01-02 IL IL264059A patent/IL264059B/en active IP Right Grant
- 2019-01-14 ZA ZA2019/00240A patent/ZA201900240B/en unknown
- 2019-01-31 MX MX2020013014A patent/MX2020013014A/en unknown
- 2019-01-31 PH PH12019500231A patent/PH12019500231A1/en unknown
- 2019-02-04 SA SA519401020A patent/SA519401020B1/en unknown
- 2019-07-23 JP JP2019135624A patent/JP7205903B2/en active Active
- 2019-12-19 ZA ZA2019/08466A patent/ZA201908466B/en unknown
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2020
- 2020-09-17 US US17/023,426 patent/US11718613B2/en active Active
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2021
- 2021-01-15 CY CY20211100032T patent/CY1123859T1/en unknown
- 2021-04-06 IL IL282099A patent/IL282099B/en unknown
- 2021-04-06 AU AU2021202113A patent/AU2021202113B2/en active Active
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