SG11201808762XA - Diagnostic methods for patient specific therapeutic decision making in cancer care - Google Patents
Diagnostic methods for patient specific therapeutic decision making in cancer careInfo
- Publication number
- SG11201808762XA SG11201808762XA SG11201808762XA SG11201808762XA SG11201808762XA SG 11201808762X A SG11201808762X A SG 11201808762XA SG 11201808762X A SG11201808762X A SG 11201808762XA SG 11201808762X A SG11201808762X A SG 11201808762XA SG 11201808762X A SG11201808762X A SG 11201808762XA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pecs
- pct
- street
- aggregate
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000002405 diagnostic procedure Methods 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 3
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000035899 viability Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111011110111010101111101011111011101011101111100110111011111011110111111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ...... ... WO 2017/174609 Al 12 October 2017(12.10.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C12N 5/09 (2010.01) kind AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/EP2017/058034 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, 4 April 2017 (04.04.2017) KP, MD, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (25) Filing Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, TH, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (30) Priority Data: ZA, ZM, ZW. 1605759.8 4 April 2016 (04.04.2016) GB (84) Designated States (unless otherwise indicated, for every (71) Applicant: HUMELTIS [HU/HU]; 20 Ififisag Utja, 7624 kind Pecs (HU). GM, of regional protection available): ARIPO (BW, GH, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: PONGRACZ, Judit, Erzsebet; Morolo street TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 11., 7694 Hossziiheteny (HU). RAPP, Judit; Banky Donat TJ, street 19., 7633 Pecs (HU). RACZ, Evelin; Csillagkoz DK, 11/b, 7626 Pecs (HU). LV, SM, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (74) Agents: LEE, Nicholas, John et al.; Kilburn & Strode GW, KM, ML, MR, NE, SN, TD, TG). LLP, 20 Red Lion Street, London Greater London WC1R Published: 4PJ (GB). — with international search report (Art. 21(3)) = 1-1 C:r © 7r IN 11 IN 1-1 (54) Title: DIAGNOSTIC METHODS FOR PATIENT SPECIFIC THERAPEUTIC DECISION MAKING IN CANCER CARE 0 N (57) : The present invention relates to a 3-Dimensional (3D) tissue culture aggregate of cells derived from a neoplastic tis- sue sample, wherein < 30% of total number cells are cells capable of interfering with reaggregation. It also relates to a method of making such a 3D aggregate and a method for assessing the effectiveness of an anti-neoplasm treatment by measuring the effect of said treatment on the viability of a three dimensional (3D) neoplasm tissue culture aggregate.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201605759 | 2016-04-04 | ||
| PCT/EP2017/058034 WO2017174609A1 (en) | 2016-04-04 | 2017-04-04 | Diagnostic methods for patient specific therapeutic decision making in cancer care |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201808762XA true SG11201808762XA (en) | 2018-11-29 |
Family
ID=58609360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201808762XA SG11201808762XA (en) | 2016-04-04 | 2017-04-04 | Diagnostic methods for patient specific therapeutic decision making in cancer care |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20190128870A1 (en) |
| EP (1) | EP3440199A1 (en) |
| JP (1) | JP2019513418A (en) |
| KR (1) | KR20190003549A (en) |
| CN (1) | CN109563486A (en) |
| AU (1) | AU2017245629A1 (en) |
| CA (1) | CA3019873A1 (en) |
| IL (1) | IL262121A (en) |
| MX (1) | MX2018012143A (en) |
| PH (1) | PH12018502147A1 (en) |
| RU (1) | RU2018138503A (en) |
| SG (1) | SG11201808762XA (en) |
| WO (1) | WO2017174609A1 (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| US10174289B2 (en) | 2014-05-28 | 2019-01-08 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| US11584916B2 (en) | 2014-10-17 | 2023-02-21 | Children's Hospital Medical Center | Method of making in vivo human small intestine organoids from pluripotent stem cells |
| CA3016641A1 (en) | 2016-05-05 | 2017-11-09 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| KR102546194B1 (en) | 2016-11-04 | 2023-06-21 | 칠드런즈 호스피탈 메디칼 센터 | Liver-Like Organ Compositions and Methods of Making and Using The Same |
| WO2018106628A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
| WO2018191673A1 (en) | 2017-04-14 | 2018-10-18 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | COMPOSITIONS OF ESOPHAGIAN TISSUES AND / OR ORGANOIDS AND THEIR MANUFACTURING PROCESSES |
| WO2019126626A1 (en) | 2017-12-21 | 2019-06-27 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| CN108130313B (en) * | 2017-12-28 | 2021-04-30 | 杭州枫霖科技有限公司 | Method for constructing three-dimensional glioma tissue based on biological 3D printing |
| WO2020023245A1 (en) | 2018-07-26 | 2020-01-30 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| SG11202102431YA (en) | 2018-09-12 | 2021-04-29 | Childrens Hospital Med Ct | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| KR102030127B1 (en) | 2019-01-10 | 2019-10-08 | 주식회사 보타닉센스 | Composition including undecane or undecanal as active ingredients for anti-allergy, improvement of atopic dermatitis, or skin regeneration |
| EP3976066A4 (en) | 2019-05-31 | 2023-06-28 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| CA3141814A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| DE102019132865B4 (en) * | 2019-12-03 | 2022-01-20 | Precomb Therapeutics Ag | METHOD AND DEVICE FOR THE ANALYSIS OF TISSUE SAMPLES |
| CN111690615B (en) * | 2020-06-12 | 2022-10-25 | 江苏信安佳医疗科技有限公司 | Special culture medium for nasopharyngeal carcinoma organoid and culture method without scaffold |
| KR102577816B1 (en) * | 2022-06-08 | 2023-09-12 | 차의과학대학교 산학협력단 | Preparation method of caf-integrated pancreatic cancer organoid and use thereof |
| CN117625541B (en) * | 2024-01-26 | 2024-04-02 | 零壹人工智能科技研究院(南京)有限公司 | Brain glioma organoid construction method and drug sensitivity detection method |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0900819A2 (en) * | 2009-05-05 | 2011-01-28 | Pecsi Tudomanyegyetem | Lung tissue culture |
| JP5774496B2 (en) | 2010-01-19 | 2015-09-09 | 株式会社ルネッサンス・エナジー・インベストメント | Method for culturing, evaluating and preserving cancer tissue-derived cell mass or cancer cell aggregate |
| HUE029316T2 (en) * | 2010-11-04 | 2017-03-28 | Univ Of Pecs | Tüdõszövetmodell |
| GB201100180D0 (en) * | 2011-01-06 | 2011-02-23 | Capsant Neurotechnologies Ltd | Tumour cell and tissue culture |
| US20140128272A1 (en) | 2012-11-08 | 2014-05-08 | Osaka Prefectural Hospital Organization | Method for Inducing Dormancy of Cancer Tissue-Derived Cell Mass and Method for Evaluating Treating Means with the Use of Cancer-Tissue-Derived Cell Mass |
| US10545133B2 (en) | 2013-05-13 | 2020-01-28 | The Johns Hopkins University | Molecular signatures of invasive cancer subpopulations |
| US20160123960A1 (en) | 2013-06-10 | 2016-05-05 | Millennium Pharmaceuticals, Inc. | Method for preparing three-dimensional, organotypic cell cultures and uses thereof |
| US20160274085A1 (en) | 2013-11-15 | 2016-09-22 | Molecular Response, Llc | 3d cell culture and ex vivo drug testing methods |
| TWI486451B (en) * | 2013-12-11 | 2015-06-01 | Ind Tech Res Inst | Isolated human liver cancer cell line and compound screening method |
| TWI461535B (en) * | 2013-12-11 | 2014-11-21 | Ind Tech Res Inst | Isolated human liver tumor cell line and method of agent screening |
| JP2017524377A (en) | 2014-06-20 | 2017-08-31 | ラトガース，ザ ステート ユニバーシティ オブ ニュー ジャージー | Single cell-derived organoid |
| WO2016022830A1 (en) | 2014-08-06 | 2016-02-11 | Oregon Health & Science University | Three-dimensional bioprinted pancreatic tumor model |
| CN105062973B (en) * | 2015-07-22 | 2018-04-17 | 中山大学 | One plant carries HPV feminine gender penis squamous cell carcinomas system that TP53 is mutated and application thereof |
-
2017
- 2017-04-04 JP JP2019503628A patent/JP2019513418A/en active Pending
- 2017-04-04 CA CA3019873A patent/CA3019873A1/en not_active Abandoned
- 2017-04-04 RU RU2018138503A patent/RU2018138503A/en not_active Application Discontinuation
- 2017-04-04 SG SG11201808762XA patent/SG11201808762XA/en unknown
- 2017-04-04 US US16/091,434 patent/US20190128870A1/en not_active Abandoned
- 2017-04-04 MX MX2018012143A patent/MX2018012143A/en unknown
- 2017-04-04 AU AU2017245629A patent/AU2017245629A1/en not_active Abandoned
- 2017-04-04 KR KR1020187032071A patent/KR20190003549A/en not_active Ceased
- 2017-04-04 WO PCT/EP2017/058034 patent/WO2017174609A1/en not_active Ceased
- 2017-04-04 EP EP17718845.5A patent/EP3440199A1/en not_active Withdrawn
- 2017-04-04 CN CN201780034789.4A patent/CN109563486A/en active Pending
-
2018
- 2018-10-04 IL IL262121A patent/IL262121A/en unknown
- 2018-10-04 PH PH12018502147A patent/PH12018502147A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20190128870A1 (en) | 2019-05-02 |
| RU2018138503A3 (en) | 2020-08-18 |
| MX2018012143A (en) | 2019-10-09 |
| AU2017245629A1 (en) | 2018-11-22 |
| IL262121A (en) | 2018-11-29 |
| CN109563486A (en) | 2019-04-02 |
| RU2018138503A (en) | 2020-05-12 |
| KR20190003549A (en) | 2019-01-09 |
| WO2017174609A1 (en) | 2017-10-12 |
| PH12018502147A1 (en) | 2019-07-15 |
| JP2019513418A (en) | 2019-05-30 |
| EP3440199A1 (en) | 2019-02-13 |
| CA3019873A1 (en) | 2017-10-12 |
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