SG11201805645QA - Lsd1 inhibitors - Google Patents
Lsd1 inhibitorsInfo
- Publication number
- SG11201805645QA SG11201805645QA SG11201805645QA SG11201805645QA SG11201805645QA SG 11201805645Q A SG11201805645Q A SG 11201805645QA SG 11201805645Q A SG11201805645Q A SG 11201805645QA SG 11201805645Q A SG11201805645Q A SG 11201805645QA SG 11201805645Q A SG11201805645Q A SG 11201805645QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- compounds
- san diego
- present
- Prior art date
Links
- 229940123628 Lysine (K)-specific demethylase 1A inhibitor Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 101001050886 Homo sapiens Lysine-specific histone demethylase 1A Proteins 0.000 abstract 1
- 102100024985 Lysine-specific histone demethylase 1A Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229920004482 WACKER® Polymers 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
- C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562272082P | 2015-12-29 | 2015-12-29 | |
| US201662295369P | 2016-02-15 | 2016-02-15 | |
| PCT/US2016/060379 WO2017116558A1 (fr) | 2015-12-29 | 2016-11-03 | Inhibiteurs de lsd1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201805645QA true SG11201805645QA (en) | 2018-07-30 |
Family
ID=57472003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201805645QA SG11201805645QA (en) | 2015-12-29 | 2016-11-03 | Lsd1 inhibitors |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9809541B2 (fr) |
| EP (1) | EP3397616B1 (fr) |
| JP (1) | JP6916795B2 (fr) |
| KR (1) | KR102720551B1 (fr) |
| CN (1) | CN108884029B (fr) |
| AU (1) | AU2016382463B2 (fr) |
| CA (1) | CA3009805C (fr) |
| IL (1) | IL260217B (fr) |
| MX (1) | MX384792B (fr) |
| SG (1) | SG11201805645QA (fr) |
| WO (1) | WO2017116558A1 (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014306149B2 (en) | 2013-08-06 | 2019-09-19 | Imago Biosciences Inc. | KDM1A inhibitors for the treatment of disease |
| SMT201900620T1 (it) | 2014-02-13 | 2020-01-14 | Incyte Corp | Ciclopropilammine come inibitori di lsd1 |
| WO2015123465A1 (fr) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines en tant qu'inhibiteurs de lsd1 |
| US9695167B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors |
| RS66458B1 (sr) | 2015-02-12 | 2025-02-28 | Imago Biosciences Inc | Kdm1a inhibitor i njegova primena u terapiji |
| UA122688C2 (uk) | 2015-04-03 | 2020-12-28 | Інсайт Корпорейшн | Гетероциклічні сполуки як інгібітори lsd1 |
| PH12018500317B1 (en) | 2015-08-12 | 2023-01-11 | Incyte Holdings Corp | Salts of an lsd1 inhibitor |
| US10059668B2 (en) * | 2015-11-05 | 2018-08-28 | Mirati Therapeutics, Inc. | LSD1 inhibitors |
| WO2017195216A1 (fr) * | 2016-05-09 | 2017-11-16 | Jubilant Biosys Limited | Composés cyclopropyl-amides utilisés comme inhibiteurs doubles de lsd1/hdac |
| US11390590B2 (en) | 2016-08-16 | 2022-07-19 | Imago Biosciences, Inc. | Methods and processes for the preparation of KDM1A inhibitors |
| US20190256930A1 (en) | 2016-11-03 | 2019-08-22 | Oryzon Genomics, S.A. | Biomarkers for determining responsiveness to lsd1 inhibitors |
| JP7082806B2 (ja) * | 2017-07-07 | 2022-06-09 | 学校法人自治医科大学 | 多能性幹細胞からのテラトーマ形成抑制剤及びその用途 |
| ES3001085T3 (es) | 2017-08-03 | 2025-03-04 | Oryzon Genomics Sa | Métodos de tratar alteraciones del comportamiento |
| US11685782B2 (en) | 2017-10-23 | 2023-06-27 | Children's Medical Center Corporation | Methods of treating cancer using LSD1 inhibitors in combination with immunotherapy |
| CA3103392A1 (fr) | 2018-05-11 | 2019-11-14 | Imago Biosciences, Inc. | Inhibiteurs de kdm1a pour le traitement d'une maladie |
| WO2020047198A1 (fr) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Sels d'un inhibiteur de lsd1 et leurs procédés de préparation |
| KR20210141933A (ko) | 2019-03-20 | 2021-11-23 | 오리존 지노믹스 에스.에이. | 경계성 인격 장애의 치료 방법 |
| MX2021011254A (es) | 2019-03-20 | 2021-10-01 | Oryzon Genomics Sa | Metodos de tratamiento del trastorno por deficit de atencion e hiperactividad. |
| EP3994280A1 (fr) | 2019-07-05 | 2022-05-11 | Oryzon Genomics, S.A. | Biomarqueurs et procédés pour le traitement personnalisé d'un cancer du poumon à petites cellules au moyen d'inhibiteurs de kdm1a |
| MX2023011779A (es) | 2021-04-08 | 2023-11-22 | Oryzon Genomics Sa | Combinaciones de inhibidores de lsd1 para el tratamiento de canceres mieloides. |
| GB202115017D0 (en) | 2021-10-20 | 2021-12-01 | Univ London Queen Mary | Sequential treatments and biomarkers to reverse resistance to kinase inhibitors |
| EP4419093A1 (fr) | 2021-10-20 | 2024-08-28 | Queen Mary University of London | Traitements séquentiels et biomarqueurs pour inverser la résistance à des inhibiteurs de kinase |
| CN116768797A (zh) * | 2022-03-16 | 2023-09-19 | 成都苑东生物制药股份有限公司 | 一种吡唑类衍生物、其制备方法及用途 |
| JP2025516648A (ja) | 2022-05-09 | 2025-05-30 | オリゾン・ゲノミクス・ソシエダッド・アノニマ | Ｌｓｄ１阻害薬を用いるｎｆ１変異腫瘍の治療法 |
| WO2023217758A1 (fr) | 2022-05-09 | 2023-11-16 | Oryzon Genomics, S.A. | Méthodes de traitement d'une tumeur maligne des gaines des nerfs périphériques (tmgnp) à l'aide d'inhibiteurs de lsd1 |
| AU2023385514A1 (en) | 2022-11-24 | 2025-07-10 | Oryzon Genomics, S.A. | Combinations of lsd1 inhibitors and menin inhibitors for treating cancer |
| WO2024229406A1 (fr) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Polythérapie pour une maladie ou un trouble lié à ras |
| WO2025034702A1 (fr) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 destiné à être utilisé dans le traitement d'une maladie ou d'un trouble lié à une protéine ras |
| KR20250024570A (ko) * | 2023-08-09 | 2025-02-19 | 전남대학교산학협력단 | 골질환 예방 또는 치료용 약학 조성물 |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7244751B2 (en) | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
| JP2010502743A (ja) | 2006-09-11 | 2010-01-28 | キュリス，インコーポレイテッド | 抗増殖薬剤としての多機能性低分子 |
| WO2010043721A1 (fr) * | 2008-10-17 | 2010-04-22 | Oryzon Genomics, S.A. | Inhibiteurs d’oxydases et leur utilisation |
| WO2010084160A1 (fr) * | 2009-01-21 | 2010-07-29 | Oryzon Genomics S.A. | Dérivés de phénylcyclopropylamine et leur utilisation médicale |
| CA2812683C (fr) | 2009-09-25 | 2017-10-10 | Oryzon Genomics S.A. | Inhibiteurs de demethylase-1 specifique de la lysine et leur utilisation |
| EP2486002B1 (fr) | 2009-10-09 | 2019-03-27 | Oryzon Genomics, S.A. | Acétamides d'hétéroaryl- et aryl-cyclopropylamine substitués et leur utilisation |
| ES2607081T3 (es) | 2010-04-19 | 2017-03-29 | Oryzon Genomics, S.A. | Inhibidores de desmetilasa específica de lisina-1 y su uso |
| BR112013002164B1 (pt) | 2010-07-29 | 2021-11-09 | Oryzon Genomics S.A. | Inibidores de desmetilase à base de arilciclopropilamina de lsd1, seus usos, e composição farmacêutica |
| US20130303545A1 (en) | 2010-09-30 | 2013-11-14 | Tamara Maes | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| US20140163041A1 (en) | 2011-02-08 | 2014-06-12 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for myeloproliferative or lymphoproliferative diseases or disorders |
| WO2012135113A2 (fr) * | 2011-03-25 | 2012-10-04 | Glaxosmithkline Llc | Cyclopropylamines en tant qu'inhibiteurs de lsd1 |
| WO2012138845A1 (fr) | 2011-04-08 | 2012-10-11 | Merck Sharp & Dohme Corp. | Composés à cyclopropyle substitué, compositions contenant de tels composés et méthodes de traitement |
| WO2013022047A1 (fr) | 2011-08-09 | 2013-02-14 | 武田薬品工業株式会社 | Composés de cyclopropanamine |
| RS58475B1 (sr) | 2011-10-20 | 2019-04-30 | Oryzon Genomics Sa | Jedinjenja (hetero)aril ciklopropilamina kao lsd1 inhibitori |
| EP2768805B1 (fr) * | 2011-10-20 | 2020-03-25 | Oryzon Genomics, S.A. | Composés (hétéro)aryl cyclopropyl comme inhibiteurs de lsd1 |
| CA2880117C (fr) | 2012-07-27 | 2021-04-06 | The Broad Institute, Inc. | Inhibiteurs d'histone-desacetylases |
| US9751885B2 (en) | 2012-10-12 | 2017-09-05 | Takeda Pharmaceutical Company Limited | Cyclopropanamine compound and use thereof |
| WO2014084298A1 (fr) | 2012-11-28 | 2014-06-05 | 京都府公立大学法人 | Inhibiteur sélectif de lsd1 à structure lysine |
| EP2740474A1 (fr) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Dérivés de cyclopropylamine utiles comme inhibiteurs d'histone-déméthylases kdm1a |
| WO2014164867A1 (fr) | 2013-03-11 | 2014-10-09 | Imago Biosciences | Inhibiteurs de kdm1a pour le traitement d'une maladie |
| WO2014194280A2 (fr) | 2013-05-30 | 2014-12-04 | The Board of Regents of the Nevada System of Higher Education on behalf of the University of | Nouveaux inhibiteurs suicides de la lsd1 ciblant les cellules cancéreuses exprimant le sox2 |
| WO2015089192A1 (fr) | 2013-12-11 | 2015-06-18 | Quanticel Pharmaceuticals, Inc. | Inhibiteur de la déméthylase-1 spécifique de la lysine |
| WO2015123437A1 (fr) * | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines en tant qu'inhibiteurs de lsd1 |
| WO2015123465A1 (fr) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines en tant qu'inhibiteurs de lsd1 |
| SMT201900620T1 (it) * | 2014-02-13 | 2020-01-14 | Incyte Corp | Ciclopropilammine come inibitori di lsd1 |
| EP3105219B9 (fr) * | 2014-02-13 | 2018-10-03 | Incyte Corporation | Cyclopropylamines en tant qu'inhibiteurs de lsd1 |
| EP3129369A1 (fr) | 2014-04-11 | 2017-02-15 | Takeda Pharmaceutical Company Limited | Composé de cyclopropanamine et son utilisation |
| HUE057895T2 (hu) | 2014-05-01 | 2022-06-28 | Celgene Quanticel Res Inc | Lizinspecifikus demetiláz-1 inhibitorai |
| CN107074787B (zh) | 2014-09-05 | 2020-10-27 | 赛尔基因昆蒂赛尔研究公司 | 赖氨酸特异性脱甲基酶-1的抑制剂 |
| JP6636031B2 (ja) | 2015-01-30 | 2020-01-29 | ジェネンテック， インコーポレイテッド | 治療用化合物およびその使用 |
| RS66458B1 (sr) | 2015-02-12 | 2025-02-28 | Imago Biosciences Inc | Kdm1a inhibitor i njegova primena u terapiji |
| UA122688C2 (uk) | 2015-04-03 | 2020-12-28 | Інсайт Корпорейшн | Гетероциклічні сполуки як інгібітори lsd1 |
| WO2017109061A1 (fr) | 2015-12-23 | 2017-06-29 | Ieo - Istituto Europeo Di Oncologia S.R.L. | Dérivés de spirocyclopropylamine utiles en tant qu'inhibiteurs d'histone déméthylases kdm1a |
-
2016
- 2016-11-03 EP EP16805585.3A patent/EP3397616B1/fr active Active
- 2016-11-03 CN CN201680077382.5A patent/CN108884029B/zh active Active
- 2016-11-03 WO PCT/US2016/060379 patent/WO2017116558A1/fr active Application Filing
- 2016-11-03 KR KR1020187021819A patent/KR102720551B1/ko active Active
- 2016-11-03 JP JP2018534842A patent/JP6916795B2/ja active Active
- 2016-11-03 MX MX2018008052A patent/MX384792B/es unknown
- 2016-11-03 US US15/343,008 patent/US9809541B2/en active Active
- 2016-11-03 AU AU2016382463A patent/AU2016382463B2/en active Active
- 2016-11-03 CA CA3009805A patent/CA3009805C/fr active Active
- 2016-11-03 SG SG11201805645QA patent/SG11201805645QA/en unknown
-
2017
- 2017-10-05 US US15/725,949 patent/US10233152B2/en active Active
-
2018
- 2018-06-22 IL IL260217A patent/IL260217B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR102720551B1 (ko) | 2024-10-21 |
| US10233152B2 (en) | 2019-03-19 |
| IL260217A (en) | 2018-07-31 |
| IL260217B (en) | 2020-09-30 |
| US20170183308A1 (en) | 2017-06-29 |
| US20180127369A1 (en) | 2018-05-10 |
| JP2019504059A (ja) | 2019-02-14 |
| CN108884029A (zh) | 2018-11-23 |
| MX384792B (es) | 2025-03-14 |
| MX2018008052A (es) | 2019-03-14 |
| WO2017116558A1 (fr) | 2017-07-06 |
| US9809541B2 (en) | 2017-11-07 |
| AU2016382463B2 (en) | 2021-05-27 |
| EP3397616B1 (fr) | 2020-06-10 |
| JP6916795B2 (ja) | 2021-08-11 |
| CA3009805C (fr) | 2023-10-17 |
| AU2016382463A1 (en) | 2018-07-12 |
| EP3397616A1 (fr) | 2018-11-07 |
| CN108884029B (zh) | 2021-10-26 |
| KR20180117602A (ko) | 2018-10-29 |
| CA3009805A1 (fr) | 2017-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201805645QA (en) | Lsd1 inhibitors | |
| SG11201805300QA (en) | Heterocyclic compounds as immunomodulators | |
| SG11201810983PA (en) | Novel heterocyclic derivatives useful as shp2 inhibitors | |
| SG11201906891RA (en) | Methods for the administration of certain vmat2 inhibitors | |
| SG11201808990QA (en) | Compositions for topical application of compounds | |
| SG11201810171SA (en) | Kras g12c inhibitors | |
| SG11201809751XA (en) | Egfr inhibitor compounds | |
| SG11201808682XA (en) | Silicone atoms containing ivacaftor analogues | |
| SG11201803920TA (en) | Compounds and compositions useful for treating disorders related to ntrk | |
| SG11201907544VA (en) | Jak inhibitors containing a 4-membered heterocyclic amide | |
| SG11201804934PA (en) | Novel Compounds | |
| SG11201809299QA (en) | Formulations of an lsd1 inhibitor | |
| SG11201809714TA (en) | Piperidines as menin inhibitors | |
| SG11201804170RA (en) | Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders | |
| SG11201408769QA (en) | Methods of reducing the risk of a cardiovascular event in a subject on statin therapy | |
| SG11201900163PA (en) | Macrocycle kinase inhibitors | |
| SG11201808003RA (en) | Bromodomain inhibitors | |
| SG11201804309PA (en) | Antibody molecules to april and uses thereof | |
| SG11201907889YA (en) | Glycan-interacting compounds and methods of use | |
| SG11201408261UA (en) | Syringe | |
| SG11201906386XA (en) | Combination therapy involving diaryl macrocyclic compounds | |
| SG11201907356SA (en) | Piperidine-substituted mnk inhibitors and methods related thereto | |
| SG11201900554YA (en) | Spiro-lactam nmda modulators and methods of using same | |
| SG11201900405XA (en) | Compounds, compositions and methods for treating or preventing a sympton associated with gout or hyperuricemia | |
| SG11201805149XA (en) | Compositions comprising 15-hepe and methods of using the same |