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SG11201507176VA - Antibodies that bind il-23 - Google Patents

Antibodies that bind il-23

Info

Publication number
SG11201507176VA
SG11201507176VA SG11201507176VA SG11201507176VA SG11201507176VA SG 11201507176V A SG11201507176V A SG 11201507176VA SG 11201507176V A SG11201507176V A SG 11201507176VA SG 11201507176V A SG11201507176V A SG 11201507176VA SG 11201507176V A SG11201507176V A SG 11201507176VA
Authority
SG
Singapore
Prior art keywords
antibodies
bind
Prior art date
Application number
SG11201507176VA
Other languages
English (en)
Inventor
Catherine Brautigam Beidler
Stuart Willis Bright
Daniel Scott Girard
Kristine Kay Kikly
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SG11201507176VA publication Critical patent/SG11201507176VA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201507176VA 2013-03-08 2014-03-04 Antibodies that bind il-23 SG11201507176VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361774732P 2013-03-08 2013-03-08
PCT/US2014/020064 WO2014137962A1 (en) 2013-03-08 2014-03-04 Antibodies that bind il-23

Publications (1)

Publication Number Publication Date
SG11201507176VA true SG11201507176VA (en) 2015-10-29

Family

ID=51488096

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201507176VA SG11201507176VA (en) 2013-03-08 2014-03-04 Antibodies that bind il-23

Country Status (41)

Country Link
US (3) US9023358B2 (he)
EP (3) EP2964258B1 (he)
JP (1) JP6096938B2 (he)
KR (2) KR20170103037A (he)
CN (1) CN105307681B (he)
AP (1) AP2015008708A0 (he)
AR (1) AR094877A1 (he)
AU (1) AU2014226094C1 (he)
BR (1) BR112015019611B1 (he)
CA (1) CA2901462C (he)
CL (1) CL2015002388A1 (he)
CY (2) CY1123589T1 (he)
DK (1) DK2964258T3 (he)
EA (1) EA031524B1 (he)
EC (1) ECSP15038626A (he)
ES (1) ES2822662T3 (he)
FI (1) FIC20230030I1 (he)
FR (1) FR23C1036I2 (he)
HK (1) HK1212252A1 (he)
HR (1) HRP20201633T1 (he)
HU (2) HUE051357T2 (he)
IL (2) IL240731B (he)
JO (1) JOP20140049B1 (he)
LT (1) LT2964258T (he)
MA (1) MA38382A1 (he)
MX (1) MX370396B (he)
MY (1) MY171226A (he)
NL (1) NL301247I2 (he)
NO (1) NO2023037I1 (he)
PE (1) PE20151529A1 (he)
PH (1) PH12015501994B1 (he)
PL (1) PL2964258T3 (he)
PT (1) PT2964258T (he)
RS (1) RS60928B1 (he)
SG (1) SG11201507176VA (he)
SI (1) SI2964258T1 (he)
TN (1) TN2015000348A1 (he)
TW (1) TWI636063B (he)
UA (1) UA123198C2 (he)
WO (1) WO2014137962A1 (he)
ZA (1) ZA201505285B (he)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR102417A1 (es) * 2014-11-05 2017-03-01 Lilly Co Eli Anticuerpos biespecíficos anti-tnf- / anti-il-23
CN108135983A (zh) * 2015-10-30 2018-06-08 伊莱利利公司 抗cgrp /抗il-23双特异性抗体及其用途
AR111845A1 (es) 2017-05-03 2019-08-28 Lilly Co Eli Anticuerpos biespecíficos anti-cgrp / anti-il-23 y usos de los mismos
TWI744617B (zh) 2018-03-30 2021-11-01 美商美國禮來大藥廠 治療潰瘍性結腸炎之方法
TWI808397B (zh) 2018-09-11 2023-07-11 美商美國禮來大藥廠 治療牛皮癬之方法
TWI850365B (zh) 2019-04-22 2024-08-01 美商美國禮來大藥廠 治療克隆氏症(crohn's disease)的方法
AU2020368369A1 (en) 2019-10-15 2022-05-12 Eli Lilly And Company Recombinantly engineered, lipase/esterase-deficient mammalian cell lines
CA3164996A1 (en) 2019-12-20 2021-06-14 Novarock Biotherapeutics, Ltd. Anti-interleukin-23 p19 antibodies and methods of use thereof
CN111718414B (zh) * 2020-06-12 2021-03-02 江苏荃信生物医药有限公司 抗人白介素23单克隆抗体及其应用
WO2022041390A1 (zh) * 2020-08-28 2022-03-03 江苏荃信生物医药股份有限公司 包含高浓度抗人白介素23单克隆抗体的低粘度液体制剂及其制备方法
TW202224702A (zh) * 2020-09-10 2022-07-01 美商美國禮來大藥廠 治療性抗體調配物
US20240254217A1 (en) 2021-05-28 2024-08-01 Eli Lilly And Company Anti -il-23p19 antibody regulation of genes involved in ulcerative colitis
CN113698480B (zh) * 2021-09-18 2022-07-01 东大生物技术(苏州)有限公司 一组il-23单克隆抗体及其医药用途
EP4409298A1 (en) 2021-09-30 2024-08-07 Eli Lilly and Company Anti-il-23p19 antibody regulation of genes involved in bowel urgency in ulcerative colitis
WO2024077113A1 (en) * 2022-10-06 2024-04-11 Eli Lilly And Company Methods of treating fatigue in ulcerative colitis
WO2024178157A1 (en) 2023-02-22 2024-08-29 Eli Lilly And Company Regulation of genes in ulcerative colitis and the uses thereof
TW202500184A (zh) 2023-03-10 2025-01-01 美商美國禮來大藥廠 治療潰瘍性結腸炎之方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060284A (en) 1997-07-25 2000-05-09 Schering Corporation DNA encoding interleukin-B30
US7090847B1 (en) 1999-09-09 2006-08-15 Schering Corporation Mammalian cytokines; related reagents and methods
US7422743B2 (en) 2000-05-10 2008-09-09 Schering Corporation Mammalian receptor protein DCRS5;methods of treatment
DE602004022781D1 (de) 2003-03-10 2009-10-08 Schering Corp Verwendung von il-23-antagonisten; verwandte reagenzien
US8003108B2 (en) * 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
PL1896073T3 (pl) 2005-06-30 2013-08-30 Janssen Biotech Inc Przeciwciała anty-IL-23, kompozycje, sposoby i zastosowania
AU2006283194B9 (en) * 2005-08-25 2011-02-03 Eli Lilly And Company Anti-IL-23 Antibodies
CN101248088A (zh) * 2005-08-25 2008-08-20 伊莱利利公司 抗il-23抗体
WO2007027714A2 (en) * 2005-08-31 2007-03-08 Schering Corporation Engineered anti-il-23 antibodies
PT1971366E (pt) * 2005-12-29 2014-11-06 Janssen Biotech Inc Anticorpos humanos anti-il-23, composições, métodos e usos
EP2426144B1 (en) 2007-02-23 2018-10-31 Merck Sharp & Dohme Corp. Engineered anti-il-23p19 antibodies
MX2009009080A (es) * 2007-02-23 2009-11-02 Schering Corp Anticuerpos anti-interleucina-23p19 manipulados por ingenieria genetica.
AU2008229141B2 (en) * 2007-03-20 2013-02-07 Eli Lilly And Company Anti-sclerostin antibodies
EP2144628B1 (en) 2007-05-08 2012-10-17 Genentech, Inc. Cysteine engineered anti-muc16 antibodies and antibody drug conjugates
WO2009082624A2 (en) * 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonists of il-17a, il-17f, and il-23 and methods of using the same
WO2010142534A1 (en) * 2009-05-27 2010-12-16 Ablynx Nv Biparatopic protein constructs directed against il-23
KR102049223B1 (ko) * 2010-11-04 2019-11-28 베링거 인겔하임 인터내셔날 게엠베하 항-il-23 항체
ES2567276T3 (es) 2011-05-12 2016-04-21 Genentech, Inc. Método de LC-MS/MS de monitoreo de múltiples reacciones para detectar anticuerpos terapéuticos en muestras de animales usando péptidos de cambio de marco

Also Published As

Publication number Publication date
EP2964258A4 (en) 2016-10-12
KR101775115B1 (ko) 2017-09-05
JP6096938B2 (ja) 2017-03-15
CY1123589T1 (el) 2022-03-24
US20170275356A1 (en) 2017-09-28
AU2014226094A1 (en) 2015-08-27
US20140255422A1 (en) 2014-09-11
SI2964258T1 (sl) 2020-10-30
NO2023037I1 (no) 2023-10-04
EP4311558A3 (en) 2024-04-10
WO2014137962A1 (en) 2014-09-12
EA031524B1 (ru) 2019-01-31
CY2023021I2 (el) 2024-09-20
ZA201505285B (en) 2017-11-29
MA38382A1 (fr) 2017-11-30
AR094877A1 (es) 2015-09-02
US9023358B2 (en) 2015-05-05
PH12015501994B1 (en) 2023-03-01
FR23C1036I1 (fr) 2023-12-08
ECSP15038626A (es) 2015-11-30
KR20150113202A (ko) 2015-10-07
NL301247I2 (nl) 2023-11-01
EP3789037A1 (en) 2021-03-10
AP2015008708A0 (en) 2015-09-30
LT2964258T (lt) 2020-10-12
NZ711147A (en) 2021-03-26
RS60928B1 (sr) 2020-11-30
US20150232552A1 (en) 2015-08-20
FIC20230030I1 (fi) 2023-10-03
AU2014226094B2 (en) 2016-06-23
CL2015002388A1 (es) 2016-03-04
JP2016510744A (ja) 2016-04-11
TN2015000348A1 (en) 2017-01-03
CY2023021I1 (el) 2024-02-16
CN105307681B (zh) 2018-06-26
PE20151529A1 (es) 2015-10-28
US9688753B2 (en) 2017-06-27
IL240731B (he) 2020-01-30
MY171226A (en) 2019-10-03
EA201591368A1 (ru) 2015-12-30
FR23C1036I2 (fr) 2024-10-04
CN105307681A (zh) 2016-02-03
IL240731A0 (he) 2015-10-29
PL2964258T3 (pl) 2021-02-08
TW201520225A (zh) 2015-06-01
PH12015501994A1 (en) 2016-01-11
UA123198C2 (uk) 2021-03-03
HUE051357T2 (hu) 2021-03-01
IL272042B (he) 2021-07-29
NL301247I1 (nl) 2023-10-11
HUS2300036I1 (hu) 2024-07-28
KR20170103037A (ko) 2017-09-12
AU2014226094C1 (en) 2024-10-24
DK2964258T3 (da) 2020-09-14
IL272042A (he) 2020-02-27
MX370396B (es) 2019-12-11
TWI636063B (zh) 2018-09-21
BR112015019611A2 (pt) 2017-08-22
HK1212252A1 (en) 2016-06-10
CA2901462C (en) 2017-07-25
MX2015011959A (es) 2016-04-07
EP2964258B1 (en) 2020-09-02
ES2822662T3 (es) 2021-05-04
EP4311558A2 (en) 2024-01-31
JOP20140049B1 (ar) 2021-08-17
BR112015019611B1 (pt) 2023-05-02
HRP20201633T1 (hr) 2020-12-25
PT2964258T (pt) 2020-11-06
CA2901462A1 (en) 2014-09-12
EP2964258A1 (en) 2016-01-13

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