SG11201407459QA - System and method for predicting the immunogenicity of a peptide - Google Patents
System and method for predicting the immunogenicity of a peptideInfo
- Publication number
- SG11201407459QA SG11201407459QA SG11201407459QA SG11201407459QA SG11201407459QA SG 11201407459Q A SG11201407459Q A SG 11201407459QA SG 11201407459Q A SG11201407459Q A SG 11201407459QA SG 11201407459Q A SG11201407459Q A SG 11201407459QA SG 11201407459Q A SG11201407459Q A SG 11201407459QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- peptide
- immunogenicity
- rule
- predicting
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 230000005847 immunogenicity Effects 0.000 title abstract 4
- 108091008874 T cell receptors Proteins 0.000 abstract 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 241001379910 Ephemera danica Species 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 230000037213 diet Effects 0.000 abstract 1
- 230000009878 intermolecular interaction Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Theoretical Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Abstract
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/176756 A1 (51) International Patent Classification: G06F19/10 (201 1.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/031661 14 March 2013 (14.03.2013) English English (30) Priority Data: 61/652,076 25 May 2012 (25.05.2012) US (71) Applicant: BAYER HEALTHCARE LLC [US/US]; 880 Dwight Way, B64, Berkeley, CA 94710 (US). (72) Inventors: PAZ, Pedro; 133 Rocky Pointe Ct., Hercules, CA 94547 (US). ASWAD, Fred, Jullien; 2121 Drake Drive, Oakland, CA 94611 (US). (74) Agent: KEDDIE, James, S.; 1900 University Avenue, Suite 200, East Palo Alto, CA 94303 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (54) Title: SYSTEM AND METHOD FOR PREDICTING THE IMMUNOGENICITY OF A PEPTIDE 'FOR ENT E, i> i> (57) Abstract: A system, computer readable storage medium and method of predicting the immunogenicity of a peptide are provided. In certain cases the system includes: a) a model of a peptide, a model of MHCII a protein and a model of a T cell receptor; and b) an executable program for: (i) evaluating the strength of intermolecular interactions of complex containing a the pep - tide, the MHCII protein and the T cell receptor to provide a score that pre - diets the immunogenicity of the peptide; and (ii) outputting the score. i-H o CJ o &
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261652076P | 2012-05-25 | 2012-05-25 | |
| PCT/US2013/031661 WO2013176756A1 (en) | 2012-05-25 | 2013-03-14 | System and method for predicting the immunogenicity of a peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201407459QA true SG11201407459QA (en) | 2014-12-30 |
Family
ID=49624222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201407459QA SG11201407459QA (en) | 2012-05-25 | 2013-03-14 | System and method for predicting the immunogenicity of a peptide |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20150205911A1 (en) |
| EP (1) | EP2856374A4 (en) |
| JP (1) | JP2015526775A (en) |
| KR (1) | KR20150021528A (en) |
| CN (1) | CN104487979A (en) |
| AU (1) | AU2013266850A1 (en) |
| BR (1) | BR112014029235A2 (en) |
| CA (1) | CA2874542A1 (en) |
| IL (1) | IL235815A0 (en) |
| MX (1) | MX2014014199A (en) |
| NZ (1) | NZ702084A (en) |
| RU (1) | RU2014152463A (en) |
| SG (1) | SG11201407459QA (en) |
| WO (1) | WO2013176756A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180006945A (en) | 2015-05-13 | 2018-01-19 | 아게누스 인코포레이티드 | Vaccine for cancer treatment and prevention |
| GB201607521D0 (en) * | 2016-04-29 | 2016-06-15 | Oncolmmunity As | Method |
| CN112313749B (en) * | 2018-04-13 | 2025-02-07 | 香港理工大学 | Data storage using peptides |
| AU2019261451A1 (en) | 2018-04-26 | 2020-12-03 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
| CN109002689B (en) * | 2018-07-23 | 2020-10-09 | 西安交通大学医学院第一附属医院 | T cell data processing method and device |
| EP3894188A4 (en) * | 2018-12-10 | 2022-11-16 | University of Notre Dame du Lac | PREDICTION OF AFFINITY USING STRUCTURAL AND PHYSICAL MODELING |
| EP3909052A4 (en) * | 2018-12-10 | 2022-10-26 | University of Notre Dame du Lac | Predicting immunogenic peptides using structural and physical modeling |
| CN110007067A (en) * | 2019-03-11 | 2019-07-12 | 江苏理工学院 | A kind of protein molecule docking detection device |
| KR102425492B1 (en) * | 2020-04-27 | 2022-07-26 | 한림대학교 산학협력단 | Development method of epitope-base peptide vaccine against sars-cov-2 virus |
| US20220130490A1 (en) * | 2020-10-27 | 2022-04-28 | Nec Laboratories America, Inc. | Peptide-based vaccine generation |
| WO2023249440A1 (en) * | 2022-06-24 | 2023-12-28 | 지니너스 주식회사 | Method and device for estimating binding between peptide and t cell receptor |
| KR102611717B1 (en) * | 2022-11-08 | 2023-12-08 | 주식회사 제로믹스 | Method for predicting immunogenic epitope and device using the same |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU736549B2 (en) * | 1997-05-21 | 2001-08-02 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Method for the production of non-immunogenic proteins |
| EP1330766A2 (en) * | 2000-07-10 | 2003-07-30 | Xencor | Method for designing protein libraries with altered immunogenicity |
| JP2007520423A (en) * | 2001-07-10 | 2007-07-26 | ゼンコー・インコーポレイテッド | Protein design automation to design modified immunogenic protein libraries |
| AU2004204942A1 (en) * | 2003-01-08 | 2004-07-29 | Xencor, Inc | Novel proteins with altered immunogenicity |
| WO2006124408A2 (en) * | 2005-05-12 | 2006-11-23 | Merck & Co., Inc. | System and method for automated selection of t-cell epitopes |
| CN103541018A (en) * | 2006-10-02 | 2014-01-29 | 航道生物技术有限责任公司 | Design and construction of diverse synthetic peptide and polypeptide librarie |
| CA2700892A1 (en) * | 2007-09-26 | 2009-04-02 | Dana-Farber Cancer Institute, Inc. | Reagents for inducing an immune response |
| CN101289496B (en) * | 2008-05-30 | 2011-06-29 | 中国医学科学院医学生物学研究所 | Antigen epitope screening method capable of stimulating the body's protective immune response against Mycobacterium tuberculosis and its use |
-
2013
- 2013-03-14 RU RU2014152463A patent/RU2014152463A/en not_active Application Discontinuation
- 2013-03-14 NZ NZ702084A patent/NZ702084A/en not_active IP Right Cessation
- 2013-03-14 AU AU2013266850A patent/AU2013266850A1/en not_active Abandoned
- 2013-03-14 SG SG11201407459QA patent/SG11201407459QA/en unknown
- 2013-03-14 CA CA2874542A patent/CA2874542A1/en not_active Abandoned
- 2013-03-14 BR BR112014029235A patent/BR112014029235A2/en not_active IP Right Cessation
- 2013-03-14 KR KR20147035884A patent/KR20150021528A/en not_active Withdrawn
- 2013-03-14 MX MX2014014199A patent/MX2014014199A/en unknown
- 2013-03-14 EP EP13793593.8A patent/EP2856374A4/en not_active Withdrawn
- 2013-03-14 US US14/398,965 patent/US20150205911A1/en not_active Abandoned
- 2013-03-14 WO PCT/US2013/031661 patent/WO2013176756A1/en active Application Filing
- 2013-03-14 CN CN201380039722.1A patent/CN104487979A/en active Pending
- 2013-03-14 JP JP2015514009A patent/JP2015526775A/en active Pending
-
2014
- 2014-11-20 IL IL235815A patent/IL235815A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013266850A1 (en) | 2014-12-04 |
| JP2015526775A (en) | 2015-09-10 |
| KR20150021528A (en) | 2015-03-02 |
| MX2014014199A (en) | 2015-02-12 |
| RU2014152463A (en) | 2016-07-20 |
| EP2856374A4 (en) | 2016-04-20 |
| BR112014029235A2 (en) | 2019-01-29 |
| US20150205911A1 (en) | 2015-07-23 |
| EP2856374A1 (en) | 2015-04-08 |
| NZ702084A (en) | 2016-09-30 |
| IL235815A0 (en) | 2015-01-29 |
| CA2874542A1 (en) | 2013-11-28 |
| WO2013176756A1 (en) | 2013-11-28 |
| CN104487979A (en) | 2015-04-01 |
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