SG11201408251SA - A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota - Google Patents
A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiotaInfo
- Publication number
- SG11201408251SA SG11201408251SA SG11201408251SA SG11201408251SA SG11201408251SA SG 11201408251S A SG11201408251S A SG 11201408251SA SG 11201408251S A SG11201408251S A SG 11201408251SA SG 11201408251S A SG11201408251S A SG 11201408251SA SG 11201408251S A SG11201408251S A SG 11201408251SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pharmaceutical composition
- nicotinamide
- composition containing
- nicotinic acid
- Prior art date
Links
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title abstract 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 244000005709 gut microbiome Species 0.000 title abstract 3
- 235000005152 nicotinamide Nutrition 0.000 title abstract 3
- 239000011570 nicotinamide Substances 0.000 title abstract 3
- 229960003512 nicotinic acid Drugs 0.000 title abstract 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title abstract 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003966 nicotinamide Drugs 0.000 title abstract 2
- TVZRAEYQIKYCPH-UHFFFAOYSA-N 3-(trimethylsilyl)propane-1-sulfonic acid Chemical compound C[Si](C)(C)CCCS(O)(=O)=O TVZRAEYQIKYCPH-UHFFFAOYSA-N 0.000 abstract 4
- 101150054399 ace2 gene Proteins 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 235000001968 nicotinic acid Nutrition 0.000 abstract 2
- 239000011664 nicotinic acid Substances 0.000 abstract 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000002429 large intestine Anatomy 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/186355 A1 (51) International Patent Classification: A61K31/405 (2006.01) A61P 35/00 (2006.01) A61K31/455 (2006.01) 46 IK 9/00 (2006.01) (21) International Application Number: PCT/EP2013/062363 (22) International Filing Date: 14 June 2013 (14.06.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10 2012 011 890.2 15 June 2012 (15.06.2012) DE (71) Applicant: CONARIS RESEARCH INSTITUTE AG [DE/DE]; Schauenburgerstr. 116, 24118 Kiel (DE). (72) Inventors: WAETZIG, Georg; Elfriede-Dietrich-Str. 77, 24106 Kiel (DE). SEEGERT, Dirk; Paul-Schroder-Str. 30, 24229 Danischenhagen (DE). (74) Agents: DORFF, Gemot et al.; Eisenfuhr, Speiser & Part ner, P. O. Box 10 60 78, 28060 Bremen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: A PHARMACEUTICAL COMPOSITION CONTAINING NICOTINIC ACID AND/OR NICOTINAMIDE AND/OR TRYPTOPHAN FOR POSITIVELY INFLUENCING THE INTESTINAL MICROBIOTA m 00 i-H en i-H o CJ o & Fig. 1 *&~Ace2*y / Vehicle ce2 'y + Vehicle -*-Ace2\"'y Vehicle -o-4ce2^' MAM HaM ce2~V NAM Days after DSS e »&Mce2\" ;y Trp+ f ss ^StAce2^ Trp+ M >\" Ace2 ^ Control \ Mce2-''v Control £ Days after DSS Days after DSS (57) Abstract: The present invention relates to a new pharmaceutical composition containing nicotinic acid, nicotinamide, tryptophanor related compounds for posit ively influencing the intestinal microbiota. In certain em bodiments,the pharmaceutical composition is partially or entirely released into the small intestine or large intestine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102012011890 | 2012-06-15 | ||
| PCT/EP2013/062363 WO2013186355A1 (en) | 2012-06-15 | 2013-06-14 | A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201408251SA true SG11201408251SA (en) | 2015-01-29 |
Family
ID=47002494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201408251SA SG11201408251SA (en) | 2012-06-15 | 2013-06-14 | A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US10426765B2 (en) |
| EP (2) | EP2861229B1 (en) |
| JP (3) | JP6855165B2 (en) |
| KR (2) | KR20150021071A (en) |
| CN (2) | CN104363907A (en) |
| AR (1) | AR091465A1 (en) |
| AU (1) | AU2013276451B2 (en) |
| BR (1) | BR112014030835B1 (en) |
| CA (1) | CA2876540C (en) |
| CY (1) | CY1123999T1 (en) |
| DK (1) | DK2861229T3 (en) |
| ES (1) | ES2859758T3 (en) |
| HR (1) | HRP20210090T1 (en) |
| HU (1) | HUE053359T2 (en) |
| IL (1) | IL236205B (en) |
| IN (1) | IN2014DN10260A (en) |
| JO (1) | JO3578B1 (en) |
| LT (1) | LT2861229T (en) |
| MX (1) | MX370795B (en) |
| NZ (1) | NZ702297A (en) |
| PH (1) | PH12014502744A1 (en) |
| PL (1) | PL2861229T3 (en) |
| PT (1) | PT2861229T (en) |
| RS (1) | RS61288B1 (en) |
| RU (1) | RU2657797C2 (en) |
| SA (1) | SA113340643B1 (en) |
| SG (1) | SG11201408251SA (en) |
| SI (1) | SI2861229T1 (en) |
| SM (1) | SMT202100248T1 (en) |
| TW (1) | TWI624260B (en) |
| WO (1) | WO2013186355A1 (en) |
| ZA (1) | ZA201408922B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2861229T (en) | 2012-06-15 | 2021-01-25 | Conaris Research Institute Ag | PHARMACEUTICAL COMPOSITION INCLUDING NICOTIC ACID AND / OR NICOTINAMIDE AND / OR TRYPTOPHANE FOR POSITIVE EFFECTS ON INTESTINAL MICROBIOTICS |
| PH12015502717B1 (en) * | 2013-06-05 | 2023-09-13 | Univ British Columbia | Anti-fibrogenic compounds, methods and uses thereof |
| EP3007680B1 (en) * | 2013-06-14 | 2020-02-19 | CONARIS research institute AG | Extended release nicotinamide formulation |
| JP6554468B6 (en) | 2013-12-13 | 2019-09-11 | コナリス リサーチ インスティチュート アーゲー | A pharmaceutical composition comprising a combination of nicotinamide and 5-aminosalicylic acid for beneficially affecting the gut microbiota and / or treating gastrointestinal inflammation |
| JP6895752B2 (en) * | 2013-12-13 | 2021-06-30 | コナリス リサーチ インスティチュート アーゲー | A pharmaceutical composition comprising nicotinic acid and / or nicotinamide for beneficially affecting blood lipid levels by modifying the gut microbiota. |
| EP2884282A1 (en) | 2013-12-13 | 2015-06-17 | CONARIS research institute AG | Use of tryptophan as a biomarker for patient selection, dosing and therapy monitoring for pharmaceutical compositions targeting the intestinal microbiota in diseases featuring tryptophan deficiency |
| EP3107553B1 (en) * | 2014-02-18 | 2021-12-01 | Universitätsklinikum Jena | Methods and compositions for intestinal microenvironment transfer |
| CN113908074A (en) * | 2014-05-12 | 2022-01-11 | 联合利华知识产权控股有限公司 | Nicotinamide for Inducing Antimicrobial Peptide Production |
| CN105287561A (en) * | 2015-11-25 | 2016-02-03 | 上海交通大学医学院附属瑞金医院 | Pharmaceutical composition for treating ulcerative colitis |
| ES2981479T3 (en) * | 2016-04-14 | 2024-10-09 | Chromadex Inc | Infant formula comprising nicotinamide riboside |
| KR102381586B1 (en) | 2016-04-19 | 2022-04-04 | 훼링 비.브이. | Oral pharmaceutical composition of mesalazine |
| AU2017252407A1 (en) | 2016-04-19 | 2018-11-01 | Ferring B.V. | Oral pharmaceutical compositions of nicotinamide |
| CN109718234A (en) * | 2017-10-31 | 2019-05-07 | 中国农业大学 | L-Trp is alleviating the application in intestinal inflammation and barrier function disorder |
| CN108935981A (en) * | 2018-06-05 | 2018-12-07 | 西北农林科技大学 | Perinatal period milch goat adds influence and its mechanism of the niacinamide to lamb glycolipid metabolism |
| CN113438896B (en) * | 2019-02-12 | 2024-10-29 | 田中惠 | Infant food or beverage, method for improving infant intestinal environment and method for enhancing infant immunity |
| US12357612B2 (en) | 2019-03-28 | 2025-07-15 | Tohoku University | Prophylactic or therapeutic agent for cancer |
| CN113398130A (en) * | 2020-03-16 | 2021-09-17 | 广州市妇女儿童医疗中心（广州市妇幼保健院、广州市儿童医院、广州市妇婴医院、广州市妇幼保健计划生育服务中心） | Use of nicotinamide for the prevention and treatment of gastrointestinal disorders |
| US20230414599A1 (en) * | 2020-11-27 | 2023-12-28 | Conaris Research Institute Ag | Nicotinamide, nicotinamide precursors and nicotinamide metabolites and compositions thereof for reducing the time to resolution of symptoms in patients with covid-19 and other viral infections |
| TW202308605A (en) * | 2021-07-19 | 2023-03-01 | 日商明治控股股份有限公司 | Composition for preventing or ameliorating inflammatory bowel disease and composition for regulating intestinal bacterial flora |
| JP2025511241A (en) * | 2022-03-30 | 2025-04-15 | コナリス リサーチ インスティテュート アクチェンゲゼルシャフト | Compositions comprising nicotinamide, nicotinamide precursors, nicotinamide metabolites, or combinations thereof for preventing or reducing one or more post-acute symptoms of an infectious disease |
| KR102789810B1 (en) | 2023-02-06 | 2025-03-31 | 한림대학교 산학협력단 | Biomarker for diagnosis of atopic dermatitis |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| DE19524928A1 (en) * | 1995-07-08 | 1997-01-09 | Basf Ag | Process for the rectification of mixtures of high-boiling air and / or temperature sensitive substances, which require a high separation performance, in a fine vacuum, as well as columns suitable for this process |
| US5846983A (en) | 1996-02-09 | 1998-12-08 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
| US5736532A (en) * | 1996-02-14 | 1998-04-07 | Furda; Ivan | Multifunctional fat absorption and blood cholesterol reducing formulation comprising chitosan |
| GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| DE69903661T2 (en) * | 1998-12-23 | 2003-07-03 | G.D. Searle Llc, Chicago | COMBINATIONS OF ILEUMGALLIC ACID TRANSPORTS INHIBITORS AND NICOTIC ACID DERIVATIVES FOR CARDIOVASCULAR INDICATIONS |
| US6713057B1 (en) | 1999-02-24 | 2004-03-30 | The Johns Hopkins University | Compositions and methods for modulating serum cholesterol |
| GB0015242D0 (en) | 2000-06-22 | 2000-08-16 | Nycomed Amersham Plc | Stabiliser for radiopharmaceuticals |
| AU2001278699A1 (en) * | 2000-08-08 | 2002-02-18 | Shionogi And Co., Ltd. | Inflammatory cytokine production inhibitors |
| US20040185097A1 (en) | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
| WO2005072113A2 (en) | 2004-01-20 | 2005-08-11 | Harty Richard F | Compositions and methods of treatment for inflammatory diseases |
| US20060264409A1 (en) | 2004-01-20 | 2006-11-23 | Harty Richard F | Compositions and methods of treatment for inflammatory diseases |
| EP1751096A4 (en) | 2004-05-27 | 2009-01-07 | Antibe Therapeutics Inc | SALT OF 4- OR 5-AMINOSALICYLIC ACID |
| EP2322146B1 (en) * | 2004-09-27 | 2012-12-12 | Sigmoid Pharma Limited | Microcapsule formulations comprising two pharmaceutically active ingredients |
| WO2007004613A1 (en) * | 2005-07-01 | 2007-01-11 | Ajinomoto Co., Inc. | THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE AND TNF-α PRODUCTION INHIBITOR |
| AU2007223787A1 (en) * | 2006-03-08 | 2007-09-13 | Pharmena North America Inc. | Combination therapy with non-selective COX inhibitors to prevent COX-related gastric injuries |
| ITMI20061932A1 (en) | 2006-10-09 | 2008-04-10 | Carlo Ghisalberti | CHARGE TRANSFER COMPLEXES FOR MEDICAL USE |
| EP1935422A1 (en) * | 2006-12-20 | 2008-06-25 | PEJO Iserlohn Heilmittel-und Diät-GmbH & Co.KG | Pharmaceutical composition comprising nicotinamide or nicotinic acid |
| US20090104171A1 (en) * | 2007-10-19 | 2009-04-23 | Pardee Joel D | Metabolic Enhancement Therapy |
| EP2276491A4 (en) * | 2008-04-25 | 2011-08-17 | Karolinska Inst Innovations Ab | New therapy of treatment of the irritable bowel syndrome. |
| WO2009142731A2 (en) * | 2008-05-20 | 2009-11-26 | Cerenis Therapeutics S.A. | Niacin and nsaid combination therapy |
| AU2009256394A1 (en) | 2008-06-02 | 2009-12-10 | Dr. Reddy's Laboratories Ltd. | Modified release niacin formulations |
| EA022886B1 (en) | 2008-10-03 | 2016-03-31 | Др. Фальк Фарма Гмбх | Method of maintaining remission of ulcerative colitis in patients |
| JP2011121889A (en) | 2009-12-09 | 2011-06-23 | En Otsuka Pharmaceutical Co Ltd | Amino acid composition for inflammatory bowel disease |
| JP2012102054A (en) | 2010-11-11 | 2012-05-31 | Kyodo Milk Industry Co Ltd | In-intestine polyamine fortifier |
| WO2012090224A1 (en) | 2010-12-29 | 2012-07-05 | Nutracryst Therapeutics Private Limited | Novel cocrystals / molecular salts of mesalamine to be used as improved anti-inflammatory drug |
| LT2861229T (en) | 2012-06-15 | 2021-01-25 | Conaris Research Institute Ag | PHARMACEUTICAL COMPOSITION INCLUDING NICOTIC ACID AND / OR NICOTINAMIDE AND / OR TRYPTOPHANE FOR POSITIVE EFFECTS ON INTESTINAL MICROBIOTICS |
| EP3007680B1 (en) | 2013-06-14 | 2020-02-19 | CONARIS research institute AG | Extended release nicotinamide formulation |
| AU2017252407A1 (en) | 2016-04-19 | 2018-11-01 | Ferring B.V. | Oral pharmaceutical compositions of nicotinamide |
| US20230414599A1 (en) * | 2020-11-27 | 2023-12-28 | Conaris Research Institute Ag | Nicotinamide, nicotinamide precursors and nicotinamide metabolites and compositions thereof for reducing the time to resolution of symptoms in patients with covid-19 and other viral infections |
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