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SG10201913978RA - Anti-mutated kras t cell receptors - Google Patents

Anti-mutated kras t cell receptors

Info

Publication number
SG10201913978RA
SG10201913978RA SG10201913978RA SG10201913978RA SG10201913978RA SG 10201913978R A SG10201913978R A SG 10201913978RA SG 10201913978R A SG10201913978R A SG 10201913978RA SG 10201913978R A SG10201913978R A SG 10201913978RA SG 10201913978R A SG10201913978R A SG 10201913978RA
Authority
SG
Singapore
Prior art keywords
cell receptors
mutated kras
kras
mutated
receptors
Prior art date
Application number
SG10201913978RA
Inventor
Qiong J Wang
Zhiya Yu
James C Yang
Original Assignee
The United States Of America As Represented By The Secretary
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Of America As Represented By The Secretary filed Critical The United States Of America As Represented By The Secretary
Publication of SG10201913978RA publication Critical patent/SG10201913978RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A61K39/001164—GTPases, e.g. Ras or Rho
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A61K40/4253—GTPases, e.g. Ras or Rho
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/54—Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
SG10201913978RA 2014-11-26 2015-11-24 Anti-mutated kras t cell receptors SG10201913978RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462084654P 2014-11-26 2014-11-26
US201562171321P 2015-06-05 2015-06-05

Publications (1)

Publication Number Publication Date
SG10201913978RA true SG10201913978RA (en) 2020-03-30

Family

ID=54838442

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201704155UA SG11201704155UA (en) 2014-11-26 2015-11-24 Anti-mutated kras t cell receptors
SG10201913978RA SG10201913978RA (en) 2014-11-26 2015-11-24 Anti-mutated kras t cell receptors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201704155UA SG11201704155UA (en) 2014-11-26 2015-11-24 Anti-mutated kras t cell receptors

Country Status (17)

Country Link
US (2) US11207394B2 (en)
EP (3) EP4286407A3 (en)
JP (2) JP6863893B2 (en)
KR (1) KR102622784B1 (en)
CN (3) CN113956349B (en)
AU (3) AU2015353720B2 (en)
CA (1) CA2968399A1 (en)
ES (2) ES2784261T3 (en)
HU (1) HUE065689T2 (en)
IL (1) IL252258B (en)
MX (1) MX384919B (en)
PL (1) PL3223850T3 (en)
PT (1) PT3223850T (en)
SA (1) SA517381608B1 (en)
SG (2) SG11201704155UA (en)
SI (1) SI3223850T1 (en)
WO (1) WO2016085904A1 (en)

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ES2960313T3 (en) 2017-10-05 2024-03-04 Us Health Methods to selectively expand cells expressing a TCR with a murine constant region
BR112020011111A2 (en) * 2017-12-04 2020-11-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services class i hla-restricted t cell receptors against mutated ras
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CN112646024B (en) * 2019-10-10 2023-03-24 香雪生命科学技术（广东）有限公司 T cell receptor for identifying KRAS mutation and coding sequence thereof
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AU2023200614A1 (en) 2023-03-09
EP3223850B1 (en) 2020-01-08
CA2968399A1 (en) 2016-06-02
MX2017006865A (en) 2018-01-11
SG11201704155UA (en) 2017-06-29
NZ732045A (en) 2024-04-26
EP3666288B1 (en) 2023-09-27
PT3223850T (en) 2020-04-13
EP3666288A1 (en) 2020-06-17
JP2017536825A (en) 2017-12-14
IL252258B (en) 2021-12-01
EP3223850A1 (en) 2017-10-04
KR102622784B1 (en) 2024-01-09
US12312391B2 (en) 2025-05-27
CN113956349A (en) 2022-01-21
JP6863893B2 (en) 2021-04-21
JP2021104044A (en) 2021-07-26
CN118994363A (en) 2024-11-22
EP4286407A3 (en) 2024-03-06
WO2016085904A1 (en) 2016-06-02
US20170304421A1 (en) 2017-10-26
ES2784261T3 (en) 2020-09-23
AU2020203465A1 (en) 2020-06-18
ES2965689T3 (en) 2024-04-16
AU2015353720A1 (en) 2017-06-08
JP7297807B2 (en) 2023-06-26
MX384919B (en) 2025-03-14
IL252258A0 (en) 2017-07-31
PL3223850T3 (en) 2020-08-24
HK1243642A1 (en) 2018-07-20
SI3223850T1 (en) 2020-09-30
US11207394B2 (en) 2021-12-28
CN113956349B (en) 2024-09-06
EP4286407A2 (en) 2023-12-06
KR20170099905A (en) 2017-09-01
CN107223134B (en) 2021-11-16
US20220088164A1 (en) 2022-03-24
AU2020203465B2 (en) 2022-11-17
HUE065689T2 (en) 2024-06-28
AU2015353720B2 (en) 2020-02-27
SA517381608B1 (en) 2021-03-11
CN107223134A (en) 2017-09-29

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