SG10201913747PA - Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases - Google Patents
Novel hybrid actriib ligand trap proteins for treating muscle wasting diseasesInfo
- Publication number
- SG10201913747PA SG10201913747PA SG10201913747PA SG10201913747PA SG10201913747PA SG 10201913747P A SG10201913747P A SG 10201913747PA SG 10201913747P A SG10201913747P A SG 10201913747PA SG 10201913747P A SG10201913747P A SG 10201913747PA SG 10201913747P A SG10201913747P A SG 10201913747PA
- Authority
- SG
- Singapore
- Prior art keywords
- muscle wasting
- novel hybrid
- treating muscle
- actriib ligand
- wasting diseases
- Prior art date
Links
- 206010028289 Muscle atrophy Diseases 0.000 title 1
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 201000000585 muscular atrophy Diseases 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562150994P | 2015-04-22 | 2015-04-22 | |
| US201562262356P | 2015-12-02 | 2015-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201913747PA true SG10201913747PA (en) | 2020-03-30 |
Family
ID=57144520
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201708351XA SG11201708351XA (en) | 2015-04-22 | 2016-04-12 | Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases |
| SG10201913747PA SG10201913747PA (en) | 2015-04-22 | 2016-04-12 | Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201708351XA SG11201708351XA (en) | 2015-04-22 | 2016-04-12 | Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US10913782B2 (en) |
| EP (2) | EP3878857A1 (en) |
| JP (2) | JP6959487B2 (en) |
| KR (1) | KR102777477B1 (en) |
| CN (1) | CN107683287B (en) |
| AU (2) | AU2016251640B2 (en) |
| BR (1) | BR112017022658A2 (en) |
| CA (1) | CA2983440C (en) |
| CY (1) | CY1124124T1 (en) |
| DK (1) | DK3286206T3 (en) |
| ES (1) | ES2856001T3 (en) |
| HK (1) | HK1251588A1 (en) |
| HR (1) | HRP20210725T1 (en) |
| HU (1) | HUE054232T2 (en) |
| IL (1) | IL255070B (en) |
| LT (1) | LT3286206T (en) |
| MX (1) | MX2017013520A (en) |
| PL (1) | PL3286206T3 (en) |
| PT (1) | PT3286206T (en) |
| RS (1) | RS61881B1 (en) |
| RU (1) | RU2733492C2 (en) |
| SG (2) | SG11201708351XA (en) |
| SI (1) | SI3286206T1 (en) |
| SM (1) | SMT202100294T1 (en) |
| WO (1) | WO2016171948A1 (en) |
| ZA (2) | ZA201707821B (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| WO2015192111A1 (en) | 2014-06-13 | 2015-12-17 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| MA41919A (en) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | ALK4 HETEROMULTIMERS: ACTRIIB AND THEIR USES |
| HRP20210411T1 (en) | 2015-04-06 | 2021-04-30 | Acceleron Pharma Inc. | SINGLE-HANDED TYPE I AND TYPE II FUSION PROTEIN RECEPTORS AND THEIR USE |
| EA202190016A1 (en) | 2015-04-06 | 2021-08-31 | Акселерон Фарма Инк. | HETEROMULTIMERS OF TYPE I AND TYPE II RECEPTOR PROTEINS OF THE TGF-BETA SUPERFAMILY |
| EP3496739B1 (en) | 2016-07-15 | 2021-04-28 | Acceleron Pharma Inc. | Compositions comprising actriia polypeptides for use in treating pulmonary hypertension |
| EA201990226A1 (en) | 2016-07-27 | 2019-08-30 | Акселерон Фарма Инк. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF MYELOFIBROSIS |
| KR102595559B1 (en) | 2016-10-05 | 2023-10-30 | 악셀레론 파마 인코포레이티드 | Variant ACTRIIB proteins and uses thereof |
| TW201813978A (en) | 2016-10-05 | 2018-04-16 | 美商艾瑟勒朗法瑪公司 | ALK4: ActRIIB heteromultimer and its use |
| JOP20190085A1 (en) * | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | Methods for treating muscle wasting and bone disease using novel hybrid actriib ligand trap proteins |
| CN119241685A (en) | 2016-11-10 | 2025-01-03 | 科乐斯疗法公司 | Activin receptor type IIA variants and methods of use thereof |
| CA3054837A1 (en) | 2017-03-24 | 2018-09-27 | Novartis Ag | Methods for preventing and treating heart disease |
| US11484573B2 (en) | 2017-11-09 | 2022-11-01 | Keros Therapeutics, Inc. | Activin receptor type IIa variants and methods of use thereof |
| WO2019140283A1 (en) * | 2018-01-12 | 2019-07-18 | Keros Therapeutics, Inc. | Activin receptor type iib variants and methods of use thereof |
| CA3098679A1 (en) | 2018-05-09 | 2019-11-14 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| WO2020243448A1 (en) * | 2019-05-30 | 2020-12-03 | Acceleron Pharma Inc. | Actrii-binding proteins and uses thereof |
| BR112022015387A2 (en) * | 2020-02-03 | 2022-10-11 | Acceleron Pharma Inc | VARIANTS ACTRIIB PROTEINS AND USES OF THEM |
| EP4100430A4 (en) * | 2020-02-03 | 2024-04-03 | Acceleron Pharma Inc. | COMPOSITIONS AND METHODS FOR TREATING PULMONARY HYPERTENSION |
| CN115768457A (en) * | 2020-03-20 | 2023-03-07 | 科乐斯疗法公司 | Activin receptor type II chimeras and methods of use thereof |
| KR20230003502A (en) * | 2020-04-13 | 2023-01-06 | 셀진 코포레이션 | Methods of Anemia Treatment Using the ACTRIIB Ligand Trap and Fedratinib |
| AU2021270458A1 (en) | 2020-05-13 | 2022-11-10 | AbbVie Deutschland GmbH & Co. KG | Anti-hemojuvelin (HJV) antibodies for treating myelofibrosis |
| MX2023001734A (en) * | 2020-08-20 | 2023-03-31 | Regeneron Pharma | Methods for preventing and treating cardiac dysfunction and covid-19 with activin a antagonists. |
| US20240181007A1 (en) * | 2021-01-08 | 2024-06-06 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| IL314280A (en) * | 2022-01-28 | 2024-09-01 | 35Pharma Inc | Activin receptor type iib variants and uses thereof |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| JP2877509B2 (en) | 1989-05-19 | 1999-03-31 | アムジエン・インコーポレーテツド | Metalloproteinase inhibitors |
| US5885794A (en) | 1991-05-10 | 1999-03-23 | The Salk Institute For Biological Studies | Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily |
| US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| DE60027135T2 (en) | 1999-01-21 | 2007-01-11 | Metamorphix, Inc. | INHIBITORS FOR GROWTH DIFFERENTIATION FACTOR AND ITS APPLICATIONS |
| JP4487376B2 (en) | 2000-03-31 | 2010-06-23 | 味の素株式会社 | Kidney disease treatment |
| BR0207854A (en) * | 2001-03-07 | 2004-08-24 | Merck Patent Gmbh | Expression technology for proteins containing a hybrid isotype antibody moiety |
| AU2012204098B2 (en) | 2001-04-24 | 2014-05-15 | The Johns Hopkins University | Use of follistatin to increase muscle mass |
| US20040223966A1 (en) | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| CA2526669A1 (en) | 2003-06-02 | 2004-12-16 | Wyeth | Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders |
| ATE522548T1 (en) * | 2003-11-13 | 2011-09-15 | Hanmi Holdings Co Ltd | METHOD FOR MASS PRODUCTION OF CONSTANT REGION OF IMMUNOLOBULIN |
| ES2426005T3 (en) | 2004-07-23 | 2013-10-18 | Acceleron Pharma Inc. | ACTRII receptor polypeptides, procedures and compositions |
| AU2015200950B2 (en) | 2004-07-23 | 2017-04-27 | Acceleron Pharma Inc. | ActRII receptor polypeptides, methods and compositions |
| AU2005272646A1 (en) | 2004-08-12 | 2006-02-23 | Wyeth | Combination therapy for diabetes, obesity, and cardiovascular diseases using GDF-8 inhibitors |
| US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
| US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
| US20100028332A1 (en) | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| PL2468290T3 (en) | 2006-12-18 | 2015-08-31 | Acceleron Pharma Inc | Activin-ActRII antagonists for use in the treatment of anemia |
| TW201907946A (en) | 2007-02-02 | 2019-03-01 | 美商艾瑟勒朗法瑪公司 | Variants derived from ActRIIB and their uses |
| TWI454479B (en) * | 2007-03-06 | 2014-10-01 | Amgen Inc | Mutant activin receptor polypeptide and use thereof |
| CN101861161B (en) * | 2007-09-18 | 2017-04-19 | 阿塞勒隆制药公司 | Activin-ACTRIIA antagonists and uses for decreasing or inhibiting FSH secretion |
| PE20091163A1 (en) | 2007-11-01 | 2009-08-09 | Wyeth Corp | ANTIBODIES FOR GDF8 |
| NZ590326A (en) | 2008-06-26 | 2013-05-31 | Acceleron Pharma Inc | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| CA2729100C (en) | 2008-06-26 | 2018-01-02 | Acceleron Pharma Inc. | Methods for dosing an activin-actriia antagonist and monitoring of treated patients |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| JP5922928B2 (en) | 2008-08-14 | 2016-05-24 | アクセルロン ファーマ， インコーポレイテッド | Use of GDF traps to increase red blood cell levels |
| SI2370463T1 (en) | 2008-11-26 | 2017-01-31 | Amgen Inc. | A stabilized variant of activin iib receptor |
| EP2387412A4 (en) | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | Methods for increasing adiponectin |
| EP3275900A1 (en) | 2009-04-27 | 2018-01-31 | Novartis AG | Compositions and methods for increasing muscle growth |
| KR20120049214A (en) | 2009-06-08 | 2012-05-16 | 악셀레론 파마 인코포레이티드 | Methods for increasing thermogenic adipocytes |
| KR20120028358A (en) | 2009-06-12 | 2012-03-22 | 악셀레론 파마 인코포레이티드 | Truncated actriib-fc fusion proteins |
| BR122020019169B1 (en) | 2009-08-13 | 2022-09-27 | Acceleron Pharma Inc | POLYPEPTIDE |
| KR20200086378A (en) | 2009-09-09 | 2020-07-16 | 악셀레론 파마 인코포레이티드 | Actriib antagonists and dosing and uses thereof |
| JP5836961B2 (en) | 2009-11-03 | 2015-12-24 | アクセルロン ファーマ， インコーポレイテッド | Method for treating fatty liver disease |
| EP3332796A1 (en) | 2009-11-17 | 2018-06-13 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| US20110268736A1 (en) | 2010-04-30 | 2011-11-03 | Children's Medical Center Corporation | Method for treating congenital myopathy |
| WO2012027065A2 (en) | 2010-08-27 | 2012-03-01 | Celgene Corporation | Combination therapy for treatment of disease |
| WO2013059347A1 (en) | 2011-10-17 | 2013-04-25 | Acceleron Pharma, Inc. | Methods and compositions for treating ineffective erythropoiesis |
| US8765385B2 (en) | 2011-10-27 | 2014-07-01 | Ravindra Kumar | Method of detection of neutralizing anti-actriib antibodies |
| HUE038570T2 (en) * | 2011-11-14 | 2018-10-29 | Regeneron Pharma | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
| GR1007832B (en) | 2011-11-21 | 2013-02-14 | Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων, | Activin neutralisers and uses thereof for treatment of diseases associated with aberrant "host defence response" activation |
| JP6145112B2 (en) * | 2011-12-19 | 2017-06-07 | アムジエン・インコーポレーテツド | Mutant activin receptor polypeptide, alone or in combination with chemotherapy, and uses thereof |
| US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| ES3031001T3 (en) | 2012-10-24 | 2025-07-03 | Celgene Corp | Biomarker for use in treating anemia |
| ES2884095T3 (en) | 2012-11-02 | 2021-12-10 | Celgene Corp | Activin-actrii antagonists and uses for treating bone and other disorders |
| EP3985024A1 (en) * | 2013-02-01 | 2022-04-20 | Atara Biotherapeutics, Inc. | Anti-activin-a compounds for the treatment of ovarian cancer |
| US20140220033A1 (en) | 2013-02-01 | 2014-08-07 | Santa Maria Biotherapeutics, Inc. | Administration of an Anti-Activin-A Compound to a Subject |
| US20150148345A1 (en) | 2013-11-26 | 2015-05-28 | Gilead Sciences, Inc. | Therapies for treating myeloproliferative disorders |
| EP3119418B1 (en) | 2014-03-21 | 2022-02-23 | Acceleron Pharma Inc. | Composition for use in a method of treating or preventing anemia by inhibiting activin b and gdf11 |
| MX388380B (en) | 2014-04-18 | 2025-03-19 | Acceleron Pharma Inc | COMPOSITIONS FOR USE IN INCREASING RED BLOOD CELL LEVELS AND TREATING SICKLE CELL DISEASE. |
| JP2017519009A (en) | 2014-06-13 | 2017-07-13 | サンタ マリア バイオセラピューティクス インコーポレイテッド | Formulated receptor polypeptides and related methods |
| WO2015192111A1 (en) | 2014-06-13 | 2015-12-17 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| US20160075772A1 (en) | 2014-09-12 | 2016-03-17 | Regeneron Pharmaceuticals, Inc. | Treatment of Fibrodysplasia Ossificans Progressiva |
| ES2946160T3 (en) | 2014-12-03 | 2023-07-13 | Celgene Corp | Activin-ActRII Antagonists and Uses to Treat Myelodysplastic Syndrome |
| EA202190016A1 (en) | 2015-04-06 | 2021-08-31 | Акселерон Фарма Инк. | HETEROMULTIMERS OF TYPE I AND TYPE II RECEPTOR PROTEINS OF THE TGF-BETA SUPERFAMILY |
| MA41919A (en) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | ALK4 HETEROMULTIMERS: ACTRIIB AND THEIR USES |
| EP3344660B1 (en) | 2015-08-31 | 2025-03-05 | National Research Council of Canada | Tgf-beta-receptor ectodomain fusion molecules and uses thereof |
| EP3370754A4 (en) | 2015-11-04 | 2019-10-23 | Acceleron Pharma Inc. | METHODS FOR INCREASING ERYTHROCYTE RATES AND TREATING INEFFECTIVE ERYTHROPOISIS |
| CN108697793B (en) | 2015-11-23 | 2023-08-01 | 阿塞勒隆制药公司 | Methods of treating eye diseases |
| KR20180128405A (en) | 2016-02-22 | 2018-12-03 | 악셀레론 파마 인코포레이티드 | ActRII antagonists for use in increasing immune activity |
| US20170306027A1 (en) | 2016-04-06 | 2017-10-26 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
| KR102595559B1 (en) | 2016-10-05 | 2023-10-30 | 악셀레론 파마 인코포레이티드 | Variant ACTRIIB proteins and uses thereof |
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2016
- 2016-04-12 EP EP21156657.5A patent/EP3878857A1/en not_active Withdrawn
- 2016-04-12 PL PL16783603T patent/PL3286206T3/en unknown
- 2016-04-12 RS RS20210563A patent/RS61881B1/en unknown
- 2016-04-12 HR HRP20210725TT patent/HRP20210725T1/en unknown
- 2016-04-12 DK DK16783603.0T patent/DK3286206T3/en active
- 2016-04-12 CN CN201680036599.1A patent/CN107683287B/en active Active
- 2016-04-12 MX MX2017013520A patent/MX2017013520A/en unknown
- 2016-04-12 HK HK18110975.8A patent/HK1251588A1/en unknown
- 2016-04-12 WO PCT/US2016/027046 patent/WO2016171948A1/en active Application Filing
- 2016-04-12 AU AU2016251640A patent/AU2016251640B2/en active Active
- 2016-04-12 BR BR112017022658A patent/BR112017022658A2/en active Search and Examination
- 2016-04-12 SG SG11201708351XA patent/SG11201708351XA/en unknown
- 2016-04-12 RU RU2017138537A patent/RU2733492C2/en active
- 2016-04-12 LT LTEP16783603.0T patent/LT3286206T/en unknown
- 2016-04-12 SG SG10201913747PA patent/SG10201913747PA/en unknown
- 2016-04-12 EP EP16783603.0A patent/EP3286206B1/en active Active
- 2016-04-12 US US15/568,232 patent/US10913782B2/en active Active
- 2016-04-12 ES ES16783603T patent/ES2856001T3/en active Active
- 2016-04-12 SI SI201631191T patent/SI3286206T1/en unknown
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