SG10201402867TA - Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors - Google Patents
Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitorsInfo
- Publication number
- SG10201402867TA SG10201402867TA SG10201402867TA SG10201402867TA SG10201402867TA SG 10201402867T A SG10201402867T A SG 10201402867TA SG 10201402867T A SG10201402867T A SG 10201402867TA SG 10201402867T A SG10201402867T A SG 10201402867TA SG 10201402867T A SG10201402867T A SG 10201402867TA
- Authority
- SG
- Singapore
- Prior art keywords
- pkb
- akt
- pyrimidin
- dihydro
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0903239A FR2947547B1 (fr) | 2009-07-02 | 2009-07-02 | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt (pkb) |
| US24110009P | 2009-09-10 | 2009-09-10 | |
| FR0957070A FR2951169B1 (fr) | 2009-10-09 | 2009-10-09 | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201402867TA true SG10201402867TA (en) | 2014-08-28 |
Family
ID=42635553
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201402867TA SG10201402867TA (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
| SG2011097938A SG177469A1 (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2011097938A SG177469A1 (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US8791255B2 (es) |
| EP (1) | EP2448927B1 (es) |
| JP (1) | JP5680638B2 (es) |
| KR (1) | KR20120106714A (es) |
| CN (1) | CN102548970B (es) |
| AR (1) | AR077364A1 (es) |
| AU (1) | AU2010267816B2 (es) |
| CA (1) | CA2767064C (es) |
| CL (1) | CL2012000003A1 (es) |
| CO (1) | CO6480974A2 (es) |
| CR (1) | CR20110703A (es) |
| DK (1) | DK2448927T3 (es) |
| DO (1) | DOP2011000407A (es) |
| EA (1) | EA021088B1 (es) |
| EC (1) | ECSP12011570A (es) |
| ES (1) | ES2464125T3 (es) |
| HK (1) | HK1169110A1 (es) |
| HN (1) | HN2011003482A (es) |
| HR (1) | HRP20140478T1 (es) |
| IL (2) | IL217295A (es) |
| MA (1) | MA33501B1 (es) |
| ME (1) | ME01885B (es) |
| MX (1) | MX2012000094A (es) |
| MY (1) | MY153042A (es) |
| NI (1) | NI201200002A (es) |
| NZ (1) | NZ597579A (es) |
| PE (1) | PE20120640A1 (es) |
| PL (1) | PL2448927T3 (es) |
| PT (1) | PT2448927E (es) |
| RS (1) | RS53317B (es) |
| SG (2) | SG10201402867TA (es) |
| SI (1) | SI2448927T1 (es) |
| SM (1) | SMT201400084B (es) |
| TW (1) | TWI466883B (es) |
| UY (1) | UY32755A (es) |
| WO (1) | WO2011001114A1 (es) |
| ZA (1) | ZA201200026B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2969614A1 (fr) * | 2010-12-28 | 2012-06-29 | Sanofi Aventis | Nouveaux derives de pyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| US9133168B2 (en) | 2010-12-28 | 2015-09-15 | Sanofi | Pyrimidine derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
| FR2969609B1 (fr) * | 2010-12-28 | 2013-02-08 | Sanofi Aventis | Nouveaux derives de 6-oxo-dihydro-pyrimidine, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR2969610B1 (fr) * | 2010-12-28 | 2013-04-05 | Sanofi Aventis | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-indolinamide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| KR20140063509A (ko) * | 2011-02-11 | 2014-05-27 | 다나-파버 캔서 인스티튜트 인크. | 과오종 종양 세포의 억제 방법 |
| EP2570127A1 (en) * | 2011-09-16 | 2013-03-20 | Sanofi | Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors |
| SG11201506688PA (en) | 2013-03-15 | 2015-09-29 | Sanofi Sa | Anti-tumoral composition comprising a pi3kbeta inhibitor and a raf inhibitor, to overcome cancer cells resistance |
| RU2015142258A (ru) | 2013-04-05 | 2017-05-12 | Санофи | Противоопухолевая композиция, включающая pi3k бета-селективный ингибитор и pi3k альфа-селективный ингибитор |
| CA2966224C (en) | 2014-12-02 | 2019-05-07 | Halliburton Energy Services, Inc. | Liquefied natural gas vaporizer for downhole oil or gas applications |
| TW202033516A (zh) | 2018-11-20 | 2020-09-16 | 義大利商Ｔｅｓ製藥（股份）責任有限公司 | α-胺基-β-羧基己二烯二酸半醛去羧酶之抑制劑 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI241298B (en) * | 1998-09-25 | 2005-10-11 | Mitsubishi Chem Corp | Pyrimidone derivatives |
| ES2306671T3 (es) | 1999-10-07 | 2008-11-16 | Amgen Inc. | Inhibidores de triazina quinasa. |
| CN1891693A (zh) | 2000-01-24 | 2007-01-10 | 基纳西亚股份有限公司 | 用于治疗的吗啉代基取代的化合物 |
| GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| US7365069B2 (en) * | 2002-04-10 | 2008-04-29 | Bexel Pharmaceuticals Inc. | Pyrimidone derivatives |
| WO2004016607A1 (en) | 2002-08-16 | 2004-02-26 | Kinacia Pty Ltd. | Inhibition of phosphoinositide 3-kinase beta |
| DE602004007284T2 (de) * | 2003-10-31 | 2008-02-28 | Warner-Lambert Company Llc | PYRIMIDINE ALS INHIBITOREN VON PHOSPHOINOSITID-3-KINASEN (PI3Ks) |
| GB0415365D0 (en) | 2004-07-09 | 2004-08-11 | Astrazeneca Ab | Pyrimidine derivatives |
| AR053358A1 (es) | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
| JP2008542253A (ja) | 2005-05-26 | 2008-11-27 | クドス ファーマシューティカルズ リミテッド | Ｄｎａ損傷癌療法に対してａｔｍ欠損癌を感作するためのｄｎａ−ｐｋ阻害の使用 |
| US7700592B2 (en) | 2005-08-25 | 2010-04-20 | Schering Corporation | α2C adrenoreceptor agonists |
| GB0520657D0 (en) | 2005-10-11 | 2005-11-16 | Ludwig Inst Cancer Res | Pharmaceutical compounds |
| US7745477B2 (en) | 2006-02-07 | 2010-06-29 | Hoffman-La Roche Inc. | Heteroaryl and benzyl amide compounds |
| WO2008064244A2 (en) | 2006-11-20 | 2008-05-29 | The Trustees Of Columbia University In The City Of New York | Phosphoinositide modulation for the treatment of neurodegenerative diseases |
| WO2008148074A2 (en) | 2007-05-24 | 2008-12-04 | Research Foundation Of State University Of New York | Inhibitors of mtor and methods of treatment using same |
| EA201000092A1 (ru) | 2007-07-09 | 2010-06-30 | Астразенека Аб | Тризамещенные пиримидиновые производные для лечения пролиферативных заболеваний |
| ES2385692T3 (es) | 2007-07-09 | 2012-07-30 | Astrazeneca Ab | Derivados de morfolino pirimidina usados en enfermedades relacionadas con mTOR quinasa y/o PI3K |
| CN101801963A (zh) | 2007-07-09 | 2010-08-11 | 阿斯利康(瑞典)有限公司 | 用于治疗增殖性疾病的三取代的嘧啶衍生物 |
| JP2010533159A (ja) * | 2007-07-09 | 2010-10-21 | アストラゼネカ アクチボラグ | 化合物９４７ |
| AR074072A1 (es) | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
-
2010
- 2010-07-01 NZ NZ597579A patent/NZ597579A/xx not_active IP Right Cessation
- 2010-07-01 EP EP10742014.3A patent/EP2448927B1/fr active Active
- 2010-07-01 ME MEP-2014-62A patent/ME01885B/me unknown
- 2010-07-01 RS RS20140306A patent/RS53317B/en unknown
- 2010-07-01 PT PT107420143T patent/PT2448927E/pt unknown
- 2010-07-01 DK DK10742014.3T patent/DK2448927T3/da active
- 2010-07-01 ES ES10742014.3T patent/ES2464125T3/es active Active
- 2010-07-01 AU AU2010267816A patent/AU2010267816B2/en not_active Ceased
- 2010-07-01 MX MX2012000094A patent/MX2012000094A/es active IP Right Grant
- 2010-07-01 KR KR1020127002839A patent/KR20120106714A/ko active IP Right Grant
- 2010-07-01 SG SG10201402867TA patent/SG10201402867TA/en unknown
- 2010-07-01 PE PE2012000004A patent/PE20120640A1/es not_active Application Discontinuation
- 2010-07-01 PL PL10742014T patent/PL2448927T3/pl unknown
- 2010-07-01 MA MA34593A patent/MA33501B1/fr unknown
- 2010-07-01 CA CA2767064A patent/CA2767064C/fr not_active Expired - Fee Related
- 2010-07-01 SG SG2011097938A patent/SG177469A1/en unknown
- 2010-07-01 MY MYPI2011006377 patent/MY153042A/en unknown
- 2010-07-01 SI SI201030607T patent/SI2448927T1/sl unknown
- 2010-07-01 WO PCT/FR2010/051375 patent/WO2011001114A1/fr active Application Filing
- 2010-07-01 EA EA201270111A patent/EA021088B1/ru not_active IP Right Cessation
- 2010-07-01 AR ARP100102350A patent/AR077364A1/es unknown
- 2010-07-01 CN CN201080039214.XA patent/CN102548970B/zh not_active Expired - Fee Related
- 2010-07-01 JP JP2012518120A patent/JP5680638B2/ja not_active Expired - Fee Related
- 2010-07-02 UY UY0001032755A patent/UY32755A/es not_active Application Discontinuation
- 2010-07-02 TW TW99121906A patent/TWI466883B/zh not_active IP Right Cessation
-
2011
- 2011-12-21 CR CR20110703A patent/CR20110703A/es unknown
- 2011-12-26 DO DO2011000407A patent/DOP2011000407A/es unknown
- 2011-12-27 US US13/338,011 patent/US8791255B2/en not_active Expired - Fee Related
- 2011-12-29 IL IL217295A patent/IL217295A/en not_active IP Right Cessation
- 2011-12-29 CO CO11180700A patent/CO6480974A2/es active IP Right Grant
- 2011-12-30 HN HN2011003482A patent/HN2011003482A/es unknown
-
2012
- 2012-01-01 IL IL217321A patent/IL217321A0/en unknown
- 2012-01-02 CL CL2012000003A patent/CL2012000003A1/es unknown
- 2012-01-03 ZA ZA2012/00026A patent/ZA201200026B/en unknown
- 2012-01-03 EC EC2012011570A patent/ECSP12011570A/es unknown
- 2012-01-05 NI NI201200002A patent/NI201200002A/es unknown
- 2012-10-05 HK HK12109790.9A patent/HK1169110A1/xx not_active IP Right Cessation
-
2014
- 2014-05-28 HR HRP20140478AT patent/HRP20140478T1/hr unknown
- 2014-06-23 US US14/312,124 patent/US8993565B2/en not_active Expired - Fee Related
- 2014-06-26 SM SM201400084T patent/SMT201400084B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG10201402867TA (en) | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors | |
| HK1164050A1 (en) | Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof | |
| IL220863A (en) | Oxazole derivatives of kinase inhibitors, medicinal preparations containing them and their uses | |
| SI2658844T1 (sl) | Novi derivati pirimidina, njihova priprava in njihova farmacevtska uporaba kot inhibitorje AKT(PKB) fosforilacije | |
| HK1162352A1 (en) | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof -3- | |
| TWI562992B (en) | Indazole derivative, pharmaceutical composition thereof, and use thereof as inhibitors of kinase activity | |
| IL214175A (en) | Derivatives of aminotetralin, their pharmaceutical compositions and their use | |
| AP3179A (en) | Benzofuranyl derivatives used as glucokinase inhibitors | |
| ZA201206223B (en) | Certain kynurenine-3-monooxygenase inhibitors,pharmaceutical compositions, and methods of use thereof | |
| ZA201202906B (en) | Novel naphthyridine derivatives and the use thereof as kinase inhibitors | |
| WO2011153157A3 (en) | Benzoquinolone inhibitors of vmat2 | |
| IL224288A (en) | Derivatives of converted pyrazolamide, pharmaceutical preparations containing them and their use | |
| IL209258A (en) | Derivatives of Pyrolopyridine, Pharmaceutical Preparations Containing Them, Processes for their Preparation and Uses | |
| IL211018A (en) | Inhibitors, processes for making them, medicinal preparations containing them and their use | |
| IL206394A (en) | Derivatives of 2-Benzylpyridine Filtration as Met Kinase Inhibitors, Process for their Preparation, Medication and Use | |
| EP2365809B8 (en) | Pyrazinopyrazines and derivatives as kinase inhibitors | |
| ZA201008387B (en) | Azacarboline derivatives,preparation thereof,and therapeutic use thereof as kinase inhibitors | |
| IL216113A (en) | Processed derivatives of indazole and azaza-indazole, pharmaceutical preparations containing them and their uses | |
| EP2447253A4 (en) | DIHYDROPYRIMIDIN COMPOUNDS AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | |
| IL211713A (en) | History of Anilinopyrimidine Converted to Sulfoxaamine as CDK Inhibitors, Manufactured and Used as Drugs | |
| PT2504331E (pt) | Composto, novas formas desse composto, composições farmacêuticas desse composto e métodos de preparação e utilização | |
| EP2320738A4 (en) | SUBSTITUTED AMINOTHIAZOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF AND USE THEREOF | |
| ZA201203531B (en) | Certain crystalline hydrates, pharmaceutical compositions thereof and methods for preparation and use thereof | |
| IL206936A0 (en) | 2-amino-2-phenylalkanol derivatives, preparation thereof and pharmaceutical compositions containing same | |
| ZA201204339B (en) | Novel (heterocycle-tetrahydropyridine)(piperazinyl)-1-alcanone and (heterocycle-dihydropyrrolidine)(piperazinyl)-1-alcanone derivatives,and use thereof as p75 inhibitors |