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SE9503924D0 - Novel opioid peptides - Google Patents

Novel opioid peptides

Info

Publication number
SE9503924D0
SE9503924D0 SE9503924A SE9503924A SE9503924D0 SE 9503924 D0 SE9503924 D0 SE 9503924D0 SE 9503924 A SE9503924 A SE 9503924A SE 9503924 A SE9503924 A SE 9503924A SE 9503924 D0 SE9503924 D0 SE 9503924D0
Authority
SE
Sweden
Prior art keywords
peptides
pain
opioid
preparation
treatment
Prior art date
Application number
SE9503924A
Other languages
English (en)
Swedish (sv)
Inventor
John Dimaio
Wuyi Wang
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9502877A external-priority patent/SE9502877D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9503924A priority Critical patent/SE9503924D0/xx
Publication of SE9503924D0 publication Critical patent/SE9503924D0/xx
Priority to ARP960103900A priority patent/AR003475A1/es
Priority to EP96927978A priority patent/EP0845003B1/en
Priority to NZ315809A priority patent/NZ315809A/xx
Priority to CZ1998401A priority patent/CZ287299B6/cs
Priority to JP9509209A priority patent/JPH11512086A/ja
Priority to EE9800048A priority patent/EE9800048A/xx
Priority to BR9610248A priority patent/BR9610248A/pt
Priority to ES96927978T priority patent/ES2171224T3/es
Priority to US08/718,585 priority patent/US6337319B1/en
Priority to HU9901209A priority patent/HUP9901209A3/hu
Priority to AU67600/96A priority patent/AU711862B2/en
Priority to SK203-98A priority patent/SK282469B6/sk
Priority to KR1019980701156A priority patent/KR19990037677A/ko
Priority to DE69617699T priority patent/DE69617699T2/de
Priority to PCT/SE1996/001011 priority patent/WO1997007130A1/en
Priority to AT96927978T priority patent/ATE210148T1/de
Priority to RU98104253/04A priority patent/RU2165432C2/ru
Priority to PL96325113A priority patent/PL325113A1/xx
Priority to CA002229797A priority patent/CA2229797A1/en
Priority to IL12325896A priority patent/IL123258A/xx
Priority to CN96197625A priority patent/CN1200127A/zh
Priority to DK96927978T priority patent/DK0845003T3/da
Priority to TR1998/00258T priority patent/TR199800258T1/xx
Priority to TW085109918A priority patent/TW424095B/zh
Priority to IS4664A priority patent/IS4664A/is
Priority to NO980592A priority patent/NO980592L/no
Priority to US09/994,078 priority patent/US20030032774A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE9503924A 1994-02-21 1995-11-07 Novel opioid peptides SE9503924D0 (sv)

Priority Applications (28)

Application Number Priority Date Filing Date Title
SE9503924A SE9503924D0 (sv) 1995-08-18 1995-11-07 Novel opioid peptides
ARP960103900A AR003475A1 (es) 1995-08-18 1996-08-06 Nuevos peptidos opiaceos, composiciones farmaceuticas que los contienen, el uso de los mismos en la preparacion de formulaciones y un metodo para su preparacion.
DK96927978T DK0845003T3 (da) 1995-08-18 1996-08-14 Hidtil ukendte opioid-peptider
TR1998/00258T TR199800258T1 (xx) 1995-08-18 1996-08-14 Yeni opioid peptidler.
AU67600/96A AU711862B2 (en) 1995-08-18 1996-08-14 Novel opioid peptides
PCT/SE1996/001011 WO1997007130A1 (en) 1995-08-18 1996-08-14 Novel opioid peptides
CZ1998401A CZ287299B6 (en) 1995-08-18 1996-08-14 Opioidal peptide, pharmaceutical preparation containing thereof and use of this peptide
JP9509209A JPH11512086A (ja) 1995-08-18 1996-08-14 新規なオピオイドペプチド
EE9800048A EE9800048A (et) 1995-08-18 1996-08-14 Uudsed opioidpeptiidid
BR9610248A BR9610248A (pt) 1995-08-18 1996-08-14 Composto composição farmacêutica processos para o tratamento da dor e para a preparação de um composto e uso do composto
ES96927978T ES2171224T3 (es) 1995-08-18 1996-08-14 Nuevos peptidos opioides.
US08/718,585 US6337319B1 (en) 1995-08-18 1996-08-14 μ-Selective opioid peptides
HU9901209A HUP9901209A3 (en) 1995-08-18 1996-08-14 Opioid-like peptide compounds, process for producing them and pharmaceutical compositions containing them
EP96927978A EP0845003B1 (en) 1995-08-18 1996-08-14 Novel opioid peptides
SK203-98A SK282469B6 (sk) 1995-08-18 1996-08-14 Opiátové peptidy, farmaceutická kompozícia s ich obsahom a ich použitie
KR1019980701156A KR19990037677A (ko) 1995-08-18 1996-08-14 신규 오피오이드 펩티드
DE69617699T DE69617699T2 (de) 1995-08-18 1996-08-14 Neuartige opioid-peptide
NZ315809A NZ315809A (en) 1995-08-18 1996-08-14 Opiate tetrapeptides with a tyr (or 2',6'-dimethyl tyr) at one terminus and an optionally substituted amino at the other terminus
AT96927978T ATE210148T1 (de) 1995-08-18 1996-08-14 Neuartige opioid-peptide
RU98104253/04A RU2165432C2 (ru) 1995-08-18 1996-08-14 Новые опиоидоподобные пептиды, способ их получения, фармацевтическая композиция
PL96325113A PL325113A1 (en) 1995-08-18 1996-08-14 Novell opiodic peptides
CA002229797A CA2229797A1 (en) 1995-08-18 1996-08-14 Novel opioid peptides
IL12325896A IL123258A (en) 1995-08-18 1996-08-14 PEPTIDES SELECTIVE FOR mu-OPIOID RECEPTORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
CN96197625A CN1200127A (zh) 1995-08-18 1996-08-14 新的阿片样肽
TW085109918A TW424095B (en) 1995-08-18 1996-08-15 Novel opioid peptides
IS4664A IS4664A (is) 1995-08-18 1998-02-04 Ný peptíð-ópíóíð
NO980592A NO980592L (no) 1995-08-18 1998-02-11 Nye opioidpeptider
US09/994,078 US20030032774A1 (en) 1994-02-21 2001-11-26 Novel opioid peptides for the treatment of pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9502877A SE9502877D0 (sv) 1995-08-18 1995-08-18 Novel opioid peptides
SE9503924A SE9503924D0 (sv) 1995-08-18 1995-11-07 Novel opioid peptides

Publications (1)

Publication Number Publication Date
SE9503924D0 true SE9503924D0 (sv) 1995-11-07

Family

ID=26662362

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9503924A SE9503924D0 (sv) 1994-02-21 1995-11-07 Novel opioid peptides

Country Status (27)

Country Link
US (1) US6337319B1 (zh)
EP (1) EP0845003B1 (zh)
JP (1) JPH11512086A (zh)
KR (1) KR19990037677A (zh)
CN (1) CN1200127A (zh)
AR (1) AR003475A1 (zh)
AT (1) ATE210148T1 (zh)
AU (1) AU711862B2 (zh)
BR (1) BR9610248A (zh)
CA (1) CA2229797A1 (zh)
CZ (1) CZ287299B6 (zh)
DE (1) DE69617699T2 (zh)
DK (1) DK0845003T3 (zh)
EE (1) EE9800048A (zh)
ES (1) ES2171224T3 (zh)
HU (1) HUP9901209A3 (zh)
IL (1) IL123258A (zh)
IS (1) IS4664A (zh)
NO (1) NO980592L (zh)
NZ (1) NZ315809A (zh)
PL (1) PL325113A1 (zh)
RU (1) RU2165432C2 (zh)
SE (1) SE9503924D0 (zh)
SK (1) SK282469B6 (zh)
TR (1) TR199800258T1 (zh)
TW (1) TW424095B (zh)
WO (1) WO1997007130A1 (zh)

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US20030032774A1 (en) * 1994-02-21 2003-02-13 Astrazeneca Ab Novel opioid peptides for the treatment of pain
US5885958A (en) 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
SE9701718D0 (sv) * 1997-05-07 1997-05-07 Astra Ab Analgesic peptidomimetic compounds
SE9800865D0 (sv) * 1998-03-16 1998-03-16 Astra Ab New Process
AU6730500A (en) * 1999-08-25 2001-03-19 Daiichi Fine Chemical Co., Ltd. Medicinal composition for percutaneous/permucosal absorption
AU1623801A (en) 1999-11-19 2001-05-30 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
AU2001277908A1 (en) 2000-07-18 2002-01-30 Cornell Research Foundation Inc. Medicinal uses of mu-opioid receptor agonists
JP2002069059A (ja) * 2000-08-28 2002-03-08 Teikoku Seiyaku Co Ltd ピラジノン環を含む新規なオピオイドペプチド誘導体
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (de) * 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
JP2008514612A (ja) * 2004-09-23 2008-05-08 ミシャロウ、アレクサンダー 対抗適応を誘発することにより神経伝達物質系を調節する方法
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
DE102005005449A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US7825231B2 (en) 2005-06-01 2010-11-02 Darren P. Wolfe Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy
EP1782819A1 (en) 2005-11-03 2007-05-09 Cognis IP Management GmbH Oligopeptides and their use
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
CA2667155C (en) 2006-11-10 2016-05-10 Cara Therapeutics, Inc. Synthetic peptide amides
JP5774853B2 (ja) 2008-01-25 2015-09-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 医薬投薬形
EP2273983B1 (en) * 2008-05-09 2016-07-20 Grünenthal GmbH Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
EP2997965B1 (en) 2009-07-22 2019-01-02 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive opioids
CA2765971C (en) 2009-07-22 2017-08-22 Gruenenthal Gmbh Hot-melt extruded controlled release dosage form
US9579285B2 (en) * 2010-02-03 2017-02-28 Gruenenthal Gmbh Preparation of a powdery pharmaceutical composition by means of an extruder
US20160176930A1 (en) 2010-07-09 2016-06-23 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins
PE20131102A1 (es) 2010-09-02 2013-10-12 Gruenenthal Chemie Forma de dosificacion resistente a manipulacion que comprende una sal inorganica
AR082862A1 (es) 2010-09-02 2013-01-16 Gruenenthal Gmbh Forma de dosificacion resistente a alteracion que comprende un polimero anionico
EA201400172A1 (ru) 2011-07-29 2014-06-30 Грюненталь Гмбх Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
AR087359A1 (es) 2011-07-29 2014-03-19 Gruenenthal Gmbh Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco
EP2819656A1 (en) 2012-02-28 2015-01-07 Grünenthal GmbH Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
AU2013248351B2 (en) 2012-04-18 2018-04-26 Grunenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CN102964279B (zh) * 2012-12-12 2014-05-07 中国药科大学 一类具有外周镇痛作用的κ阿片受体激动剂
AR096438A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso
AU2014273227B2 (en) 2013-05-29 2019-08-15 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
KR20160031526A (ko) 2013-07-12 2016-03-22 그뤼넨탈 게엠베하 에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
BR112016010482B1 (pt) 2013-11-26 2022-11-16 Grünenthal GmbH Preparação de uma composição farmacêutica em pó por meio de criomoagem
AU2015261060A1 (en) 2014-05-12 2016-11-03 Grunenthal Gmbh Tamper resistant immediate release capsule formulation comprising Tapentadol
MX2016015417A (es) 2014-05-26 2017-02-22 Gruenenthal Gmbh Multiparticulas protegidas contra vertido de dosis etanolico.
WO2016170097A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant dosage form with immediate release and resistance against solvent extraction
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護

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SG64368A1 (en) * 1988-06-30 1999-04-27 Astra Ab Dermorphin analogs their methods of preparation pharmaceutical compositions and methods of therapeutic treatment using the same
IS4261A (is) 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra

Also Published As

Publication number Publication date
NZ315809A (en) 1999-05-28
AU6760096A (en) 1997-03-12
TR199800258T1 (xx) 1998-05-21
EP0845003A1 (en) 1998-06-03
BR9610248A (pt) 1999-07-06
US6337319B1 (en) 2002-01-08
HUP9901209A2 (hu) 1999-08-30
CZ40198A3 (cs) 1998-08-12
DK0845003T3 (da) 2002-07-15
ATE210148T1 (de) 2001-12-15
TW424095B (en) 2001-03-01
DE69617699D1 (de) 2002-01-17
CA2229797A1 (en) 1997-02-27
RU2165432C2 (ru) 2001-04-20
SK282469B6 (sk) 2002-02-05
JPH11512086A (ja) 1999-10-19
IS4664A (is) 1998-02-04
WO1997007130A1 (en) 1997-02-27
AU711862B2 (en) 1999-10-21
EE9800048A (et) 1998-08-17
NO980592D0 (no) 1998-02-11
CN1200127A (zh) 1998-11-25
IL123258A0 (en) 1998-09-24
PL325113A1 (en) 1998-07-06
IL123258A (en) 2003-03-12
AR003475A1 (es) 1998-08-05
DE69617699T2 (de) 2003-08-07
CZ287299B6 (en) 2000-10-11
KR19990037677A (ko) 1999-05-25
ES2171224T3 (es) 2002-09-01
NO980592L (no) 1998-02-11
HUP9901209A3 (en) 2000-12-28
EP0845003B1 (en) 2001-12-05
SK20398A3 (en) 1998-12-02

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