SE9500778D0 - Process for producing a protein - Google Patents
Process for producing a proteinInfo
- Publication number
- SE9500778D0 SE9500778D0 SE9500778A SE9500778A SE9500778D0 SE 9500778 D0 SE9500778 D0 SE 9500778D0 SE 9500778 A SE9500778 A SE 9500778A SE 9500778 A SE9500778 A SE 9500778A SE 9500778 D0 SE9500778 D0 SE 9500778D0
- Authority
- SE
- Sweden
- Prior art keywords
- apoe
- apoa
- matrix
- endotoxins
- aqueous solution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9500778A SE9500778D0 (sv) | 1995-03-03 | 1995-03-03 | Process for producing a protein |
IL11732096A IL117320A (en) | 1995-03-03 | 1996-02-29 | PROCESS FOR PURIFYING APOLIPOPROTEINS ApoA AND ApoE OR MIXTURES THEREOF, SUBSTANTIALLY ENDOTOXIN-FREE ApoA OR ApoE PRODUCED BY THIS PROCESS AND THE USE OF APOLIPOPROTEINS PRODUCED BY THIS PROCESS IN THE PREPARATION OF A MEDICAMENT |
PT96906136T PT813541E (pt) | 1995-03-03 | 1996-03-01 | Processo de producao de uma proteina |
NZ303325A NZ303325A (en) | 1995-03-03 | 1996-03-01 | Preparation of an endotoxin-free apolipoprotein a or apolipoprotein e |
AT96906136T ATE240348T1 (de) | 1995-03-03 | 1996-03-01 | Verfahren zur herstellung eines proteins |
DE69628148T DE69628148T2 (de) | 1995-03-03 | 1996-03-01 | Verfahren zur herstellung eines proteins |
AU49607/96A AU694623B2 (en) | 1995-03-03 | 1996-03-01 | Process for producing a protein |
US08/875,125 US5834596A (en) | 1995-03-03 | 1996-03-01 | Process for purifying ApoA or ApoE |
PCT/SE1996/000271 WO1996027608A1 (en) | 1995-03-03 | 1996-03-01 | Process for producing a protein |
JP8526799A JPH11501046A (ja) | 1995-03-03 | 1996-03-01 | タンパク質の製造法 |
EP96906136A EP0813541B1 (en) | 1995-03-03 | 1996-03-01 | Process for producing a protein |
DK96906136T DK0813541T3 (da) | 1995-03-03 | 1996-03-01 | Fremgangsmåde til fremstilling af et protein |
ES96906136T ES2199284T3 (es) | 1995-03-03 | 1996-03-01 | Procedimiento para producir una proteina. |
ZA961679A ZA961679B (en) | 1995-03-03 | 1996-03-01 | Process for producing a protein |
CA002212125A CA2212125A1 (en) | 1995-03-03 | 1996-03-01 | Process for producing a protein |
US09/129,720 US5990081A (en) | 1995-03-03 | 1998-08-05 | Purified APO A and APO E compounds and methods for using them |
US09/444,816 US6506879B1 (en) | 1995-03-03 | 1999-11-22 | Purified Apo A and Apo E compounds and methods for using them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9500778A SE9500778D0 (sv) | 1995-03-03 | 1995-03-03 | Process for producing a protein |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9500778D0 true SE9500778D0 (sv) | 1995-03-03 |
Family
ID=20397430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9500778A SE9500778D0 (sv) | 1995-03-03 | 1995-03-03 | Process for producing a protein |
Country Status (15)
Country | Link |
---|---|
US (3) | US5834596A (sv) |
EP (1) | EP0813541B1 (sv) |
JP (1) | JPH11501046A (sv) |
AT (1) | ATE240348T1 (sv) |
AU (1) | AU694623B2 (sv) |
CA (1) | CA2212125A1 (sv) |
DE (1) | DE69628148T2 (sv) |
DK (1) | DK0813541T3 (sv) |
ES (1) | ES2199284T3 (sv) |
IL (1) | IL117320A (sv) |
NZ (1) | NZ303325A (sv) |
PT (1) | PT813541E (sv) |
SE (1) | SE9500778D0 (sv) |
WO (1) | WO1996027608A1 (sv) |
ZA (1) | ZA961679B (sv) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9500778D0 (sv) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
SE9603068D0 (sv) | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
SE9603304D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a compound |
SE9603303D0 (sv) * | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a protein |
DE19859703B4 (de) * | 1998-12-23 | 2009-10-29 | Macherey, Nagel Gmbh & Co. Handelsgesellschaft | Verfahren zur Aufreinigung von Nukleinsäuren sowie Anionenaustauscher zur Durchführung dieses Verfahrens |
MXPA01009893A (es) | 1999-04-01 | 2003-07-28 | Esperion Therapeutics Inc | Compuestos con eter, composiciones y usos de estos. |
US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
JP4344136B2 (ja) | 2000-11-10 | 2009-10-14 | エフ・ホフマン−ラ・ロシュ・リミテッド | アポリポタンパク質類似体 |
US8119590B2 (en) * | 2001-09-28 | 2012-02-21 | Cedars-Sinai Medical Center | Prevention and treatment of restenosis by local administration of drug |
US7470659B2 (en) * | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
WO2003049685A2 (en) * | 2001-12-07 | 2003-06-19 | The Regents Of The University Of California | Treatment for age-related macular degeneration |
US20030229062A1 (en) * | 2001-12-07 | 2003-12-11 | The Regents Of The University Of California | Treatments for age-related macular degeneration (AMD) |
CA2485989A1 (en) * | 2002-05-17 | 2003-11-27 | Esperion Therapeutics, Inc. | Methods and compositions for the treatment of ischemic reperfusion |
EP2402300B1 (en) | 2003-01-23 | 2016-05-25 | Esperion Therapeutics Inc. | Hydroxyl compounds and compositions for cholesterol management and related uses |
TW200526778A (en) * | 2003-11-14 | 2005-08-16 | Sembiosys Genetics Inc | Methods for the production of apolipoproteins in transgenic plants |
US20050176623A1 (en) * | 2004-02-11 | 2005-08-11 | Neil Wagle | Non-invasive treatment of disease using amphipathic compounds |
US8926958B2 (en) * | 2004-04-06 | 2015-01-06 | Cedars-Sinai Medical Center | Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein A-I and apolipoprotein A-I milano |
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NZ580954A (en) | 2005-04-29 | 2011-05-27 | Univ California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
US20080199398A1 (en) * | 2006-06-16 | 2008-08-21 | Brewer H Bryan | Novel Peptides That Promote Lipid Efflux |
US20080206142A1 (en) * | 2006-06-16 | 2008-08-28 | Lipid Sciences, Inc. | Novel Peptides That Promote Lipid Efflux |
US20080227686A1 (en) * | 2006-06-16 | 2008-09-18 | Lipid Sciences, Inc. | Novel Peptides that Promote Lipid Efflux |
AU2007272494B2 (en) | 2006-07-14 | 2011-07-28 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
EP2049137A4 (en) | 2006-08-08 | 2013-05-01 | Univ California | SALICYLANILIDES AS AMPLIFIERS OF THE ORAL RELEASE OF THERAPEUTIC PEPTIDES |
WO2008039843A2 (en) * | 2006-09-26 | 2008-04-03 | Lipid Sciences, Inc. | Novel peptides that promote lipid efflux |
CN100586958C (zh) * | 2006-12-20 | 2010-02-03 | 上海莱士血液制品股份有限公司 | 高纯度载脂蛋白a-i的制备方法 |
US8013122B2 (en) * | 2006-12-20 | 2011-09-06 | Kieu Hoang | Method of purifying apolipoprotein A-1 |
JP2010538005A (ja) | 2007-08-28 | 2010-12-09 | ユーエービー リサーチ ファウンデーション | 合成アポリポ蛋白質e模倣ポリペプチドおよび使用方法 |
AU2008296487A1 (en) | 2007-08-28 | 2009-03-12 | The Uab Research Foundation | Synthetic apolipoprotein E mimicking polypeptides and methods of use |
JP5774486B2 (ja) | 2008-11-10 | 2015-09-09 | テクミラ ファーマシューティカルズ コーポレイションTekmira Pharmaceuticals Corporation | 治療薬を送達するための新規な脂質及び組成物 |
US20120101148A1 (en) | 2009-01-29 | 2012-04-26 | Alnylam Pharmaceuticals, Inc. | lipid formulation |
EP2406376A1 (en) | 2009-03-12 | 2012-01-18 | Alnylam Pharmaceuticals, Inc. | LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES |
KR20240015723A (ko) | 2009-05-05 | 2024-02-05 | 알닐람 파마슈티칼스 인코포레이티드 | 지질 조성물 |
CN102625696B (zh) | 2009-06-10 | 2015-06-03 | 阿尔尼拉姆医药品有限公司 | 改进的脂质制剂 |
EP2464336A4 (en) | 2009-08-14 | 2013-11-20 | Alnylam Pharmaceuticals Inc | COMPOSITIONS FORMULATED IN LIPIDS AND METHODS OF INHIBITING THE EXPRESSION OF EBOLA VIRUS GENE |
AU2010328336B2 (en) | 2009-12-07 | 2017-03-02 | Arbutus Biopharma Corporation | Compositions for nucleic acid delivery |
US20130017223A1 (en) | 2009-12-18 | 2013-01-17 | The University Of British Columbia | Methods and compositions for delivery of nucleic acids |
WO2011139911A2 (en) | 2010-04-29 | 2011-11-10 | Isis Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
WO2011143362A1 (en) | 2010-05-11 | 2011-11-17 | Esperion Therapeutics, Inc. | Dimeric oxidation-resistant apolipoprotein a1 variants |
EP4481047A2 (en) | 2010-06-03 | 2024-12-25 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
US20130202652A1 (en) | 2010-07-30 | 2013-08-08 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
WO2012016184A2 (en) | 2010-07-30 | 2012-02-02 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for delivery of active agents |
CN110123830A (zh) | 2010-11-09 | 2019-08-16 | 阿尔尼拉姆医药品有限公司 | 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法 |
EP2663548B1 (en) | 2011-01-11 | 2017-04-05 | Alnylam Pharmaceuticals, Inc. | Pegylated lipids and their use for drug delivery |
RU2017126088A (ru) | 2011-02-07 | 2019-01-31 | Серени Терапеутикс Холдинг С.А. | Липопротеиновые комплексы и их получение и применения |
EP3456317A1 (en) | 2011-09-27 | 2019-03-20 | Alnylam Pharmaceuticals, Inc. | Di-aliphatic substituted pegylated lipids |
MX359171B (es) | 2011-12-12 | 2018-09-18 | Melior Pharmaceuticals I Inc | Tratamiento para diabetes tipo i y tipo ii. |
JP2015519361A (ja) | 2012-05-31 | 2015-07-09 | エイジェンシー・フォー・サイエンス,テクノロジー・アンド・リサーチ | 正電荷有機添加剤での処理によるタンパク質製剤におけるタンパク質−不純物複合体及び凝集体のレベルを低下させるための方法 |
US9610324B2 (en) | 2012-07-11 | 2017-04-04 | Esperion Therapeutics, Inc. | Apolipoprotein mixtures |
KR20170003611A (ko) | 2014-05-02 | 2017-01-09 | 세레니스 쎄라퓨틱스 홀딩 에스에이 | Hdl 요법 마커 |
US10653747B2 (en) | 2014-07-31 | 2020-05-19 | Uab Research Foundation | ApoE mimetic peptides and higher potency to clear plasma cholesterol |
BR112017019358A2 (pt) | 2015-03-13 | 2018-05-08 | Esperion Therapeutics Inc | combinações e formulações de dose fixa compreendendo etc1002 e ezetimiba e métodos de tratamento ou redução do risco de doença cardiovascular |
MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
CN107033237B (zh) * | 2017-05-11 | 2021-07-20 | 深圳市卫光生物制品股份有限公司 | 一种人血浆载脂蛋白a-i的分离纯化方法 |
US20230141635A1 (en) | 2019-06-21 | 2023-05-11 | Esperion Therapeutics, Inc. | Salt forms of bempedoic acid and methods for using the same |
CA3188232A1 (en) * | 2020-08-10 | 2022-02-17 | Kushee-Nidhi Kush KUMAR | Antifungal matrix formed from peptide hydrogels |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU587989B2 (en) * | 1984-10-16 | 1989-09-07 | Mitsubishi Chemical Corporation | DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins |
JPS6196998A (ja) | 1984-10-16 | 1986-05-15 | Mitsubishi Chem Ind Ltd | ヒトアポリポプロテインa−i様蛋白の産生方法 |
SE462100B (sv) * | 1985-08-08 | 1990-05-07 | Perstorp Ab | Komposition och dess anvaendning i ett tvaa- eller flerfassystem |
EP0262651A3 (en) * | 1986-09-30 | 1990-06-20 | Union Carbide Corporation | Isolation of enzyme values from solution |
GB8625435D0 (en) * | 1986-10-23 | 1986-11-26 | Erba Farmitalia | Human apolipoprotein ai |
US5128318A (en) * | 1987-05-20 | 1992-07-07 | The Rogosin Institute | Reconstituted HDL particles and uses thereof |
GB8712540D0 (en) * | 1987-05-28 | 1987-07-01 | Ucb Sa | Expression of human proapolipoprotein a-i |
JP2606228B2 (ja) * | 1987-09-18 | 1997-04-30 | 三菱化学株式会社 | ヒトプロアポリポプロテインa−i様蛋白の産生法 |
JP2561674B2 (ja) | 1987-10-06 | 1996-12-11 | 三菱化学株式会社 | 蛋白質の産生方法 |
CA1335077C (en) * | 1988-02-08 | 1995-04-04 | Henri Isliker | Process for the manufacture of apolipoproteins from human blood plasma or serum |
JPH01238534A (ja) * | 1988-03-17 | 1989-09-22 | Mitsui Toatsu Chem Inc | エンドトキシンの除去方法 |
EP0345155B1 (en) * | 1988-05-31 | 1994-08-10 | Mitsubishi Kasei Corporation | Process for producing natural human apolipoprotein e-like proteins |
DE3819463A1 (de) * | 1988-06-08 | 1989-12-14 | Behringwerke Ag | Expressionsvektoren zur herstellung unfusionierter proteine in mikroorganismen |
IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
WO1991006655A1 (en) * | 1989-10-31 | 1991-05-16 | Schering Corporation | E. coli secretory strains |
SE468881B (sv) * | 1991-01-09 | 1993-04-05 | Kabi Pharmacia Ab | Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar |
WO1993000443A1 (en) * | 1991-06-26 | 1993-01-07 | Bio-Technology General Corp. | Purification of recombinant apolipoprotein e from bacteria |
SE9103701D0 (sv) * | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
JPH07507554A (ja) * | 1992-06-12 | 1995-08-24 | エヌ・ブイ・イノゲネテイクス・エス・エイ | 新規ペプチドおよびタンパク質,それらの調製方法,ならびにコレステロール受容体としてのそれらの使用 |
SE9203753D0 (sv) * | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
JP3491917B2 (ja) * | 1993-02-05 | 2004-02-03 | メビオール株式会社 | 熱可逆性ハイドロゲル材料 |
US5643757A (en) * | 1994-03-21 | 1997-07-01 | American Cyanamid Company | High yield production of human apolipoprotein A1 in E. coli. |
JP3514514B2 (ja) * | 1994-06-14 | 2004-03-31 | 財団法人化学及血清療法研究所 | ヒト血漿からのアポリポ蛋白a−1の製造方法 |
SE9500724D0 (sv) * | 1994-06-23 | 1995-02-24 | Pharmacia Ab | Filtrering |
AU3151495A (en) * | 1994-08-01 | 1996-03-04 | James T Hsu | Lipoprotein cholesterol assays |
SE9500778D0 (sv) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
US5672685A (en) * | 1995-10-04 | 1997-09-30 | Duke University | Source of apolipoprotein E and method of isolating apolipoprotein E |
SE9603068D0 (sv) * | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
-
1995
- 1995-03-03 SE SE9500778A patent/SE9500778D0/sv unknown
-
1996
- 1996-02-29 IL IL11732096A patent/IL117320A/en not_active IP Right Cessation
- 1996-03-01 DK DK96906136T patent/DK0813541T3/da active
- 1996-03-01 ES ES96906136T patent/ES2199284T3/es not_active Expired - Lifetime
- 1996-03-01 PT PT96906136T patent/PT813541E/pt unknown
- 1996-03-01 NZ NZ303325A patent/NZ303325A/xx unknown
- 1996-03-01 US US08/875,125 patent/US5834596A/en not_active Expired - Lifetime
- 1996-03-01 AU AU49607/96A patent/AU694623B2/en not_active Ceased
- 1996-03-01 WO PCT/SE1996/000271 patent/WO1996027608A1/en active IP Right Grant
- 1996-03-01 ZA ZA961679A patent/ZA961679B/xx unknown
- 1996-03-01 CA CA002212125A patent/CA2212125A1/en not_active Abandoned
- 1996-03-01 EP EP96906136A patent/EP0813541B1/en not_active Expired - Lifetime
- 1996-03-01 JP JP8526799A patent/JPH11501046A/ja active Pending
- 1996-03-01 DE DE69628148T patent/DE69628148T2/de not_active Expired - Fee Related
- 1996-03-01 AT AT96906136T patent/ATE240348T1/de not_active IP Right Cessation
-
1998
- 1998-08-05 US US09/129,720 patent/US5990081A/en not_active Expired - Lifetime
-
1999
- 1999-11-22 US US09/444,816 patent/US6506879B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL117320A0 (en) | 1996-06-18 |
JPH11501046A (ja) | 1999-01-26 |
ES2199284T3 (es) | 2004-02-16 |
NZ303325A (en) | 1998-12-23 |
DK0813541T3 (da) | 2003-09-15 |
ZA961679B (en) | 1996-10-07 |
DE69628148T2 (de) | 2004-01-08 |
DE69628148D1 (de) | 2003-06-18 |
PT813541E (pt) | 2003-09-30 |
EP0813541A1 (en) | 1997-12-29 |
AU4960796A (en) | 1996-09-23 |
IL117320A (en) | 2001-06-14 |
EP0813541B1 (en) | 2003-05-14 |
AU694623B2 (en) | 1998-07-23 |
US5834596A (en) | 1998-11-10 |
WO1996027608A1 (en) | 1996-09-12 |
CA2212125A1 (en) | 1996-09-12 |
US5990081A (en) | 1999-11-23 |
US6506879B1 (en) | 2003-01-14 |
ATE240348T1 (de) | 2003-05-15 |
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