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SE8802926L - ESTERS AND AMIDES OF CYCLIC CARBOXYLIC ACIDS AND CYCLIC ALCOHOLS AND AMINES - Google Patents

ESTERS AND AMIDES OF CYCLIC CARBOXYLIC ACIDS AND CYCLIC ALCOHOLS AND AMINES

Info

Publication number
SE8802926L
SE8802926L SE8802926A SE8802926A SE8802926L SE 8802926 L SE8802926 L SE 8802926L SE 8802926 A SE8802926 A SE 8802926A SE 8802926 A SE8802926 A SE 8802926A SE 8802926 L SE8802926 L SE 8802926L
Authority
SE
Sweden
Prior art keywords
carbon atoms
bridge
ring
cyclic
group
Prior art date
Application number
SE8802926A
Other languages
Swedish (sv)
Other versions
SE8802926D0 (en
Inventor
G J Rosenberger
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SE8802926D0 publication Critical patent/SE8802926D0/en
Publication of SE8802926L publication Critical patent/SE8802926L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compounds of formula A min -B min -C min -D min wherein A min is a mono- or bi-cyclic group, containing the maximum number of double bonds in the ring, and, if it is heterocyclic containing only one or two heteroatoms chosen from nitrogen, oxygen and sulphur, with the proviso that if the monocyclic group is a phenyl group then the ring is substituted by at least one substituent and this is other than hydroxy, B min is -CO- or -SO2-, C min is -O-, -NH- or a bond, D min is an alkylene bridged piperidyl group wherein the alkylene bridge is between 2 ring carbon atoms and additionally contains an epoxy substituent attached to adjacent carbon atoms of the bridge or a double bond between adjacent carbon atoms in the bridge, in free base form, acid addition salt form or in quaternary ammonium salt form, are useful as 5 HT3 antagonists. The compounds may be used as gastric motility or gastric or gastric emptying stimulators, anti-dyspepsia agents and antiemetics and they may be used against gastro-oesophageal reflex and for inhibiting emesis caused by a cytostatic.
SE8802926A 1987-08-20 1988-08-18 ESTERS AND AMIDES OF CYCLIC CARBOXYLIC ACIDS AND CYCLIC ALCOHOLS AND AMINES SE8802926L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3727733 1987-08-20

Publications (2)

Publication Number Publication Date
SE8802926D0 SE8802926D0 (en) 1988-08-18
SE8802926L true SE8802926L (en) 1989-02-21

Family

ID=6334102

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8802926A SE8802926L (en) 1987-08-20 1988-08-18 ESTERS AND AMIDES OF CYCLIC CARBOXYLIC ACIDS AND CYCLIC ALCOHOLS AND AMINES

Country Status (17)

Country Link
JP (1) JPS6471874A (en)
KR (1) KR950000509B1 (en)
AU (1) AU2110588A (en)
DE (1) DE3827253A1 (en)
DK (1) DK465188A (en)
FI (1) FI883838A (en)
FR (1) FR2619565A1 (en)
GB (1) GB2208862A (en)
GR (1) GR880100538A (en)
IL (1) IL87489A0 (en)
IT (1) IT1226742B (en)
LU (1) LU87314A1 (en)
NL (1) NL8802059A (en)
PL (1) PL274318A1 (en)
PT (1) PT88296B (en)
SE (1) SE8802926L (en)
ZA (1) ZA886180B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0669963B2 (en) 1989-04-21 1994-09-07 サンド・アクチエンゲゼルシャフト 5HT-Bottom 3 Therapeutic use of receptor antagonists
US5225419A (en) * 1989-10-14 1993-07-06 John Wyeth & Brother, Limited Certain 1,8-ethano or propano-1,4-dihydro-4-oxo-quinoline-3-carboxamides and derivatives thereof
GB2236751B (en) * 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
US5225412A (en) * 1991-04-29 1993-07-06 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
DE4126999A1 (en) * 1991-08-16 1993-02-18 Basf Ag HERBICIDE AGENT, CONTAINING 3-AMINOBENZO (B) THIOPHENE AS ANTIDOTS
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
DE10164139A1 (en) 2001-12-27 2003-07-10 Bayer Ag 2-heteroaryl carboxamides
PT2489659T (en) 2004-06-24 2018-03-07 Vertex Pharma Modulators of atp-binding cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
SI3219705T1 (en) 2005-12-28 2020-08-31 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of the amorphous form of n-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide
WO2008005910A2 (en) 2006-07-06 2008-01-10 Bristol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
MX2009008253A (en) 2007-01-31 2009-10-12 Vertex Pharma Kinase inhibitors.
EP2318407B1 (en) 2008-07-23 2013-01-02 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
CA2731498A1 (en) 2008-07-23 2010-01-28 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
MX2011001319A (en) 2008-08-06 2011-04-05 Vertex Pharma Aminopyridine kinase inhibitors.
EP2355822B1 (en) 2008-11-19 2012-10-10 Envivo Pharmaceuticals, Inc. Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
SG193156A1 (en) 2009-03-20 2013-09-30 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
AU2010245914A1 (en) 2009-05-06 2011-12-15 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
EP2528917B1 (en) 2010-01-27 2016-10-19 Vertex Pharmaceuticals Incorporated Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases
EP2582702A1 (en) 2010-01-27 2013-04-24 Vertex Pharmaceuticals Incorporated Pyrazolopyrimidine kinase inhibitors
EP2550272A1 (en) 2010-01-27 2013-01-30 Vertex Pharmaceuticals Incorporated Pyrazolopyrazine kinase inhibitors
CN103221411B (en) 2010-05-17 2016-05-11 富瑞姆制药公司 (R) crystal formation of the chloro-N-of-7-(quinuclidine-3-yl) benzo [b] thiophene-2-carboxamide derivatives hydrochloride monohydrate
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CN109966264A (en) 2012-02-27 2019-07-05 沃泰克斯药物股份有限公司 Pharmaceutical composition and its application
WO2013169646A1 (en) 2012-05-08 2013-11-14 Envivo Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
ES2702288T3 (en) 2014-10-07 2019-02-28 Vertex Pharma Co-crystals of transmembrane conductance regulator modulators of cystic fibrosis
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
KR20220087497A (en) 2019-10-18 2022-06-24 더 리전츠 오브 더 유니버시티 오브 캘리포니아 Compounds and methods for targeting pathogenic blood vessels

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0095262B1 (en) * 1982-05-11 1986-12-03 Beecham Group Plc Azabicycloalkane derivatives, their preparation and medicaments containing them
FR2531083B1 (en) * 1982-06-29 1986-11-28 Sandoz Sa NOVEL PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES
CH664567A5 (en) * 1983-08-26 1988-03-15 Sandoz Ag AROMATIC CARBONIC ACID AND SULPHONIC ACID ESTERS OR AMIDES.

Also Published As

Publication number Publication date
LU87314A1 (en) 1989-03-08
DK465188A (en) 1989-02-21
ZA886180B (en) 1990-07-25
IL87489A0 (en) 1989-01-31
GR880100538A (en) 1989-05-25
JPS6471874A (en) 1989-03-16
AU2110588A (en) 1989-03-23
PT88296A (en) 1989-06-30
FI883838A0 (en) 1988-08-18
PT88296B (en) 1995-03-31
FI883838A (en) 1989-02-21
NL8802059A (en) 1989-03-16
IT1226742B (en) 1991-02-05
KR950000509B1 (en) 1995-01-24
FR2619565A1 (en) 1989-02-24
IT8821719A0 (en) 1988-08-19
GB2208862A (en) 1989-04-19
KR890003679A (en) 1989-04-17
DK465188D0 (en) 1988-08-18
SE8802926D0 (en) 1988-08-18
GB8819438D0 (en) 1988-09-21
DE3827253A1 (en) 1989-03-02
PL274318A1 (en) 1989-04-17

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