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SE402459B - 3,4-dihydro-2h-1,2-bensotiazin-1,1-dioxider till anvendning sasom mellanprodukter vid framstellning av motsvarande karboxamider - Google Patents

3,4-dihydro-2h-1,2-bensotiazin-1,1-dioxider till anvendning sasom mellanprodukter vid framstellning av motsvarande karboxamider

Info

Publication number
SE402459B
SE402459B SE7300511A SE7300511A SE402459B SE 402459 B SE402459 B SE 402459B SE 7300511 A SE7300511 A SE 7300511A SE 7300511 A SE7300511 A SE 7300511A SE 402459 B SE402459 B SE 402459B
Authority
SE
Sweden
Prior art keywords
benzotiazine
dioxides
dihydro
preparation
intermediate products
Prior art date
Application number
SE7300511A
Other languages
English (en)
Inventor
J G Lombardino
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE402459B publication Critical patent/SE402459B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
SE7300511A 1968-08-27 1973-01-15 3,4-dihydro-2h-1,2-bensotiazin-1,1-dioxider till anvendning sasom mellanprodukter vid framstellning av motsvarande karboxamider SE402459B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76759468A 1968-08-27 1968-08-27

Publications (1)

Publication Number Publication Date
SE402459B true SE402459B (sv) 1978-07-03

Family

ID=25079964

Family Applications (2)

Application Number Title Priority Date Filing Date
SE6911871A SE373854B (sv) 1968-08-27 1969-08-27
SE7300511A SE402459B (sv) 1968-08-27 1973-01-15 3,4-dihydro-2h-1,2-bensotiazin-1,1-dioxider till anvendning sasom mellanprodukter vid framstellning av motsvarande karboxamider

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE6911871A SE373854B (sv) 1968-08-27 1969-08-27

Country Status (18)

Country Link
US (1) US3591584A (sv)
JP (2) JPS50677B1 (sv)
AT (2) AT298503B (sv)
BE (1) BE737962A (sv)
BR (1) BR6911817D0 (sv)
CH (1) CH520705A (sv)
DE (2) DE1967325C2 (sv)
DK (1) DK145297C (sv)
ES (1) ES370861A1 (sv)
FI (1) FI51189C (sv)
FR (1) FR2016455B1 (sv)
GB (1) GB1257180A (sv)
IL (1) IL32836A (sv)
MY (1) MY7300310A (sv)
NL (1) NL157013B (sv)
NO (1) NO129746B (sv)
PH (1) PH10029A (sv)
SE (2) SE373854B (sv)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692780A (en) * 1970-10-14 1972-09-19 Warner Lambert Pharmaceutical 4-substituted-2-alkyl-3-phenyl-2h-1,2-benzothiazine-1,1-dioxides and processes for their production
US3862319A (en) * 1971-02-09 1975-01-21 Pfizer Benzothiazine dioxides as anti-thromobotic agents
US3787324A (en) * 1971-03-01 1974-01-22 Warner Lambert Co 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production
DK153148C (da) * 1971-03-01 1988-10-31 Warner Lambert Co Analogifremgangsmaade til fremstilling af 4-hydroxy-3-(3-isoxazolcarbamyl)-2h-1,2-benzothiazin-1,1-d ioxider eller alkalimetal-, jordalkalimetal- eller aminsalte deraf
US3769292A (en) * 1972-04-28 1973-10-30 Warner Lambert Co N-(pyridyl)2h 1-benzothiopyran-3-carboxamide-4-hydroxy 1,1-dioxides
US3853862A (en) * 1973-04-23 1974-12-10 Pfizer Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
US3927002A (en) * 1973-04-23 1975-12-16 Pfizer N-(pyridyl)-N{40 -alkyl-N{40 -(2-alkoxycarbonylbenzenesulfonyl)-glycineamides and derivatives
SE411208B (sv) * 1973-06-15 1979-12-10 Merck & Co Inc Forfarande for framstellning av merkaptoalkylpyridiner med en etenylsubstituent
US3891637A (en) * 1974-10-01 1975-06-24 Pfizer Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides
DE2539112C2 (de) * 1975-09-03 1983-12-15 Dr. Karl Thomae Gmbh, 7950 Biberach 4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazin-3-carboxamid-1,1-dioxide, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SE421792B (sv) * 1976-01-12 1982-02-01 Pfizer Forfarande for framstellning av n-(2-pyridyl)-4-hydroxi-2-metyl-2h-1,2-benso-tiazin-3-karboxamid-1,1-dioxid
MC1135A1 (fr) * 1976-02-23 1977-11-18 Hoffmann La Roche Derives de thiazine
US4100347A (en) 1976-06-10 1978-07-11 Pfizer Inc. 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide
JPS5342370U (sv) * 1976-09-16 1978-04-12
LU78009A1 (de) * 1977-08-22 1979-05-23 Hoffmann La Roche Verfahren zur herstellung von thiazinderivaten
DE2756113A1 (de) * 1977-12-16 1979-06-21 Thomae Gmbh Dr K Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4213980A (en) * 1978-01-30 1980-07-22 Ciba-Geigy Corporation Azathianaphthalenes
US4246263A (en) 1979-10-15 1981-01-20 Pfizer Inc. Antiinflammatory and immunoregulatory pyrimidines, their method of use and pharmaceutical compositions
JPS57140785A (en) * 1981-02-24 1982-08-31 Mitsui Toatsu Chem Inc Benzothiazine derivative, its preparation, and pharmaceutical composition containing the same
JPS5714589A (en) * 1980-06-27 1982-01-25 Mitsui Toatsu Chem Inc Benzothiazine derivative, its preparation and drug composition
GB2078738B (en) * 1980-06-27 1983-11-30 Mitsui Toatsu Chemicals Benzothiazine derivatives
US4289879A (en) * 1980-09-29 1981-09-15 Pfizer Inc. Synthetic method and intermediate for piroxicam
US4309427A (en) * 1981-01-15 1982-01-05 Pfizer Inc. Benzothiazine dioxide derivatives
US4434164A (en) 1981-06-01 1984-02-28 Pfizer Inc. Crystalline benzothiazine dioxide salts
US4474955A (en) * 1981-06-17 1984-10-02 Vincenzo Iannella Process for preparing 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-[N-(2-pyridinyl)carboxamide]-1,1-dioxide, and its phosphoric ester
GT198276334A (es) * 1981-08-03 1984-01-10 Procedimiento e inter-medios para la produccion de carboxamidas de benzotiazina.
IN159273B (sv) * 1981-10-05 1987-04-25 Pfizer
CA1197244A (en) * 1982-04-16 1985-11-26 Medichem, S.A. Process for the preparation of 4-hydroxy-2-methyl-2h- 1,2-benzothiazine-3-carboxamide-1,1-dioxides
SU1306476A3 (ru) * 1982-06-17 1987-04-23 Пфайзер,Инк (Фирма) Способ получени 2-метил-3- @ -(2-пиридил)-карбамоил-3,4-дигидро-2 @ -1,2-бензтиазин-1,1-диоксида
EP0098422B1 (de) * 1982-07-07 1987-12-09 Siegfried Aktiengesellschaft Verfahren zur Herstellung von 4-Hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazin-3-carboxamid 1,1-dioxid
JPS5913714A (ja) * 1982-07-13 1984-01-24 Taito Pfizer Kk 外用消炎鎮痛剤
US4483982A (en) * 1982-09-02 1984-11-20 Pfizer Inc. Processes for preparing piroxicam and intermediates leading thereto
DE3237473A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 4-hydroxy-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltende arzneimittel
IT1153293B (it) * 1982-10-22 1987-01-14 Francia Famaceutici S R L Derivati del 4-idrossi-2-metil-2h-1, 2-benzotiazina-3-carbossamide 1, 1-biossido e procedimento per la loro preparazione
JPS59193879A (ja) * 1983-03-31 1984-11-02 Fujisawa Pharmaceut Co Ltd トロポン誘導体
JPS59179683U (ja) * 1983-05-19 1984-11-30 寺田毛織株式会社 貼り合わせふとん
GR80576B (en) * 1983-10-17 1984-11-29 Fujisawa Pharmaceutical Co Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4656265A (en) * 1984-06-21 1987-04-07 Pfizer Inc. Cyclic prodrugs of antiinflammatory oxicams
DE3437232A1 (de) * 1984-10-10 1986-04-17 Mack Chem Pharm Stabilisierte injektionsloesungen von piroxicam
US4582831A (en) * 1984-11-16 1986-04-15 Pfizer Inc. Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor
CH663899A5 (fr) * 1985-03-20 1988-01-29 Nestle Sa Procede pour la preparation d'une composition a base d'un principe actif de faible hydrosolubilite finement divise.
US4623486A (en) 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
US4761424A (en) * 1985-10-01 1988-08-02 Warner-Lambert Company Enolamides, pharmaceutical compositions and methods for treating inflammation
HU199833B (en) * 1986-05-16 1990-03-28 Pfizer Process for producing benzothiazine dioxide derivatives
ES2031514T3 (es) * 1986-08-29 1992-12-16 Pfizer Inc. 2-guanidino-4-ariltiazoles para el tratamiento de ulceras pepticas.
US5196410A (en) * 1986-10-31 1993-03-23 Pfizer Inc. Transdermal flux enhancing compositions
HU203762B (en) * 1987-06-10 1991-09-30 Pfizer Process for producing 3,4-dihydro-2-alkyl-3-oxo-n-aryl2h-(1)-benzothieno(3,2-e)-1,2-thiazino-4- -carboxamide-1,1-dioxides and pharmaceutical compositions containing them
US5081118A (en) * 1987-10-26 1992-01-14 Pfizer Inc. Benzothiazine dioxide derivatives
JPH0629271B2 (ja) * 1988-03-09 1994-04-20 株式会社日本ハイポックス ベンゾチアジン―１，１―ジオキシド誘導体及びそれを含有する医薬組成物
HU200926B (en) * 1988-10-28 1990-09-28 Egyt Gyogyszervegyeszeti Gyar Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules
JPH0717589B2 (ja) * 1990-01-22 1995-03-01 ファイザー製薬株式会社 新規１，３―ジカルボニル化合物およびその組成物
JP2988739B2 (ja) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 １，８−ナフチリジン−２−オン誘導体
DE4141218A1 (de) * 1991-12-13 1993-06-17 Luitpold Werk Chem Pharm Thiadiazincarbonsaeureamidderivate, verfahren zu ihrer herstellung und arzneimittel
JP2964195B2 (ja) * 1992-04-28 1999-10-18 エスエス製薬株式会社 ピロキシカム錠及びその製造法
US5362758A (en) * 1992-09-18 1994-11-08 Pfizer Inc. Ophthalmic piroxicam solution
US5420124A (en) * 1994-01-12 1995-05-30 Kim; Young S. Stable, painless piroxicam potassium injectable composition
US5436241A (en) * 1994-01-14 1995-07-25 Bristol-Myers Squibb Company Topical anti-inflammatory compositions containing piroxicam
WO1997046532A1 (en) * 1996-06-03 1997-12-11 Boehringer Ingelheim Pharmaceuticals, Inc. 2-benzyl-4-sulfonyl-4h-isoquinolin-1,3-diones and their use as anti-inflammatory agents
US5952328A (en) * 1997-11-12 1999-09-14 Cephalon, Inc. Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors
US6297260B1 (en) 1998-10-30 2001-10-02 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
IT1318673B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Farmaci per le disfunzioni sessuali.
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
ITMI20020773A1 (it) * 2002-04-11 2003-10-13 Nicox Sa Farmaci per il trattamento dell'artrite
MXPA06001480A (es) * 2003-08-06 2006-05-15 Pfizer Prod Inc Compuestos de oxazol para el tratamiento de trastornos neurodegenerativos.
US20060047171A1 (en) * 2003-12-22 2006-03-02 Harold Meckler Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
US20050222227A1 (en) * 2004-04-01 2005-10-06 Pfizer Inc Oxazole-amine compounds for the treatment of neurodegenerative disorders
JP2009529057A (ja) 2006-03-08 2009-08-13 コートリア・コーポレーシヨン Ｃｏｘ−関連胃損傷を予防するための非−選択的ｃｏｘ阻害剤との組み合わせ療法
FR2942797B1 (fr) * 2009-03-03 2011-04-29 Pf Medicament Derives de benzothiazines, leur preparation et leur application a titre de medicaments
CN101665472B (zh) * 2009-06-15 2011-08-24 威海迪素制药有限公司 2-甲基-3，4-二氢-4-氧代-2h-1，2-苯并噻嗪-3-羧酸乙酯-1,1-二氧化物的制备方法
ITUB20152229A1 (it) * 2015-07-16 2017-01-16 Edmond Pharma Srl Processo per la preparazione di farmaci antiinfiammatori non steroidei della classe oxicam

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1302858B (sv) * 1962-09-21 1972-05-04

Also Published As

Publication number Publication date
FR2016455A1 (sv) 1970-05-08
IL32836A (en) 1972-08-30
FI51189C (sv) 1976-11-10
DE1967325C2 (de) 1982-03-18
MY7300310A (en) 1973-12-31
AT298503B (de) 1972-05-10
DK145297B (da) 1982-10-25
FR2016455B1 (sv) 1974-02-01
BE737962A (sv) 1970-02-26
NO129746B (sv) 1974-05-20
PH10029A (en) 1976-07-13
DE1943265C3 (de) 1982-02-04
DE1943265B2 (de) 1981-05-14
FI51189B (sv) 1976-08-02
ES370861A1 (es) 1971-07-01
JPS5142114B1 (sv) 1976-11-13
AT294113B (de) 1971-11-10
BR6911817D0 (pt) 1973-02-13
JPS50677B1 (sv) 1975-01-10
SE373854B (sv) 1975-02-17
IL32836A0 (en) 1969-11-12
CH520705A (fr) 1972-03-31
US3591584A (en) 1971-07-06
NL157013B (nl) 1978-06-15
DE1943265A1 (de) 1970-08-13
NL6912981A (sv) 1970-03-03
DE1967325B2 (de) 1981-08-13
GB1257180A (sv) 1971-12-15
DK145297C (da) 1983-03-14

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