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SE384504B - 6-substituerade-4-halogen-1,2-dihydro-1-hydroxi-2-iminopyrimidiner till anvendning vid framstellning av motsvarande 4-aminoforeningar - Google Patents

6-substituerade-4-halogen-1,2-dihydro-1-hydroxi-2-iminopyrimidiner till anvendning vid framstellning av motsvarande 4-aminoforeningar

Info

Publication number
SE384504B
SE384504B SE7317494A SE1749473A SE384504B SE 384504 B SE384504 B SE 384504B SE 7317494 A SE7317494 A SE 7317494A SE 1749473 A SE1749473 A SE 1749473A SE 384504 B SE384504 B SE 384504B
Authority
SE
Sweden
Prior art keywords
iminopyrimidines
dihydro
hydroxy
halogen
substituted
Prior art date
Application number
SE7317494A
Other languages
English (en)
Inventor
W C Anthony
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of SE384504B publication Critical patent/SE384504B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Phase Diffusion Into Metallic Material Surfaces (AREA)
SE7317494A 1970-03-31 1971-03-26 6-substituerade-4-halogen-1,2-dihydro-1-hydroxi-2-iminopyrimidiner till anvendning vid framstellning av motsvarande 4-aminoforeningar SE384504B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2435170A 1970-03-31 1970-03-31

Publications (1)

Publication Number Publication Date
SE384504B true SE384504B (sv) 1976-05-10

Family

ID=21820134

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7103975A SE384368B (sv) 1970-03-31 1971-03-26 Forfarande for framstellning av 6-substituerade - 4 - amino- 1,2 - dihydro - 1 - hydroxi - 2 - iminopyrimidiner
SE7317494A SE384504B (sv) 1970-03-31 1971-03-26 6-substituerade-4-halogen-1,2-dihydro-1-hydroxi-2-iminopyrimidiner till anvendning vid framstellning av motsvarande 4-aminoforeningar

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7103975A SE384368B (sv) 1970-03-31 1971-03-26 Forfarande for framstellning av 6-substituerade - 4 - amino- 1,2 - dihydro - 1 - hydroxi - 2 - iminopyrimidiner

Country Status (10)

Country Link
US (1) US3644364A (sv)
JP (1) JPS551259B1 (sv)
CH (1) CH551979A (sv)
DE (1) DE2114887C3 (sv)
DK (2) DK128116B (sv)
FI (1) FI55194C (sv)
FR (1) FR2087936A5 (sv)
NL (1) NL7104019A (sv)
NO (2) NO131420C (sv)
SE (2) SE384368B (sv)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931181A (en) * 1973-07-27 1976-01-06 Hoffmann-La Roche Inc. 2,4-Diamino-5-benzylpyrimidines
US4013778A (en) * 1974-08-05 1977-03-22 Warner-Lambert Company Method for reducing blood pressure
US4175189A (en) * 1977-02-04 1979-11-20 Hoffmann-La Roche Inc. 6-Chloro-2,4-pyrimidine-dicarbamate-3-oxides
US4175190A (en) * 1977-02-04 1979-11-20 Hoffmann-La Roche Inc. 6-Chloro-2,4-pyrimidine-dicarbamate-3-oxides
US5196533A (en) * 1983-04-11 1993-03-23 South Alabama Medical Science Foundation, Usa Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines
HU196067B (en) * 1986-07-10 1988-09-28 Richter Gedeon Vegyeszet Process for production of 6-amin-1,2-dihydro-1-hydroxi-2-imino-4-piperidin-piramidin
FI864046A (fi) * 1986-10-07 1988-04-08 Farmos Oy Foerfarande foer framstaellning av en terapeutiskt aktiv foerening.
US6465514B1 (en) 1986-12-29 2002-10-15 Kenneth M. Hallam Methods and compositions for the promotion of hair growth
US4927626A (en) * 1988-10-28 1990-05-22 Devillez Richard L Method for enhancement of unguis growth
JPH02225474A (ja) * 1989-01-04 1990-09-07 Lonza Ag ２，４―ジアミノ―６―ピペリジニル―ピリミジン―３―ｎ―オキシドの製造方法
FR2651122B1 (fr) * 1989-08-29 1994-10-28 Oreal Compositions destinees a etre utilisees pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives de l'amino-2 pyrimidine oxyde-3 et nouveaux composes derives de l'amino-2 pyrimidine oxyde-3.
DE69108402T2 (de) * 1990-11-14 1995-10-05 Upjohn Co 5-fluor-2,4,6-pyrimidinthiaminderivate zur verhinderung des haarsausfalls.
US5502050A (en) * 1993-11-29 1996-03-26 Cornell Research Foundation, Inc. Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
FR2753378B1 (fr) * 1996-09-17 1998-11-20 Oreal Utilisation dans une composition en tant que stimulateur de tyrosinase d'au moins un derive de pyrimidine 3-oxyde, substitue en 6
US20050163811A1 (en) * 2004-01-23 2005-07-28 Richard Lee Topical solutions comprising high concentrations of piperidinopyrimidine derivatives and methods of use thereof
EP2730271B1 (en) 2012-11-11 2018-01-24 Symrise AG Aqeuous compositions
CN107129470A (zh) * 2017-06-12 2017-09-05 常州市天华制药有限公司 一种米诺地尔的合成与精制方法
CN107235919B (zh) * 2017-06-22 2020-05-12 安徽拜善晟制药有限公司 一种米诺地尔的合成工艺
CN114213340B (zh) * 2022-02-22 2022-06-07 北京蓝晶微生物科技有限公司 2,4-二氨基嘧啶氧化物的制备方法
CN115572265A (zh) * 2022-10-10 2023-01-06 江苏海悦康医药科技有限公司 一种高纯度米诺地尔的绿色合成工艺

Also Published As

Publication number Publication date
DE2114887B2 (de) 1980-01-17
NO140011C (no) 1979-06-20
NO741201L (no) 1971-10-01
DK128116B (da) 1974-03-04
US3644364A (en) 1972-02-22
FR2087936A5 (sv) 1971-12-31
DK128539B (da) 1974-05-20
NL7104019A (sv) 1971-10-04
NO140011B (no) 1979-03-12
DE2114887C3 (de) 1980-09-11
DE2114887A1 (de) 1971-10-14
SE384368B (sv) 1976-05-03
NO131420B (sv) 1975-02-17
JPS551259B1 (sv) 1980-01-12
FI55194C (fi) 1981-05-18
CH551979A (de) 1974-07-31
NO131420C (sv) 1975-05-28
FI55194B (fi) 1979-02-28

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