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SE380517B - Forfarande for framstellning av fluoren-2-ettiksyraderivat med antiinflammatorisk verkan - Google Patents

Forfarande for framstellning av fluoren-2-ettiksyraderivat med antiinflammatorisk verkan

Info

Publication number
SE380517B
SE380517B SE7111396A SE1139671A SE380517B SE 380517 B SE380517 B SE 380517B SE 7111396 A SE7111396 A SE 7111396A SE 1139671 A SE1139671 A SE 1139671A SE 380517 B SE380517 B SE 380517B
Authority
SE
Sweden
Prior art keywords
fluorene
procedure
preparation
acid derivatives
inflammatory effect
Prior art date
Application number
SE7111396A
Other languages
English (en)
Inventor
E T Stiller
S D Levine
P A Principe
P A Diassi
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of SE380517B publication Critical patent/SE380517B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C07C57/50—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE7111396A 1970-09-09 1971-09-08 Forfarande for framstellning av fluoren-2-ettiksyraderivat med antiinflammatorisk verkan SE380517B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US070913A US3859340A (en) 1970-09-09 1970-09-09 ' -methylfluorene-2-acetic acid

Publications (1)

Publication Number Publication Date
SE380517B true SE380517B (sv) 1975-11-10

Family

ID=22098125

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7111396A SE380517B (sv) 1970-09-09 1971-09-08 Forfarande for framstellning av fluoren-2-ettiksyraderivat med antiinflammatorisk verkan

Country Status (17)

Country Link
US (1) US3859340A (sv)
AR (1) AR192948A1 (sv)
AU (1) AU461519B2 (sv)
BE (1) BE772417A (sv)
CA (1) CA998400A (sv)
CH (6) CH551940A (sv)
DE (1) DE2143600A1 (sv)
DK (1) DK135230B (sv)
ES (1) ES394885A1 (sv)
FR (1) FR2106396B1 (sv)
GB (1) GB1364516A (sv)
HU (1) HU163350B (sv)
IE (1) IE36766B1 (sv)
NL (1) NL7112404A (sv)
PH (2) PH10599A (sv)
SE (1) SE380517B (sv)
ZA (1) ZA715474B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903145A (en) * 1971-06-18 1975-09-02 Squibb & Sons Inc 9-Substituted fluorene-2-acetic acid derivatives
US3989841A (en) * 1972-10-16 1976-11-02 E. R. Squibb & Sons, Inc. Method of using fluorene-2-acetic acid derivatives
NZ538307A (en) * 2002-09-09 2008-04-30 Janssen Pharmaceutica Nv Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
JP5727139B2 (ja) * 2006-11-28 2015-06-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ ３−（３−アミノ−２−（ｒ）−ヒドロキシ−プロピル）−１−（４−フルオロ−フェニル）−８−（８−メチル−ナフタレン−１−イルメチル）−１，３，８−トリアザ−スピロ［４．５］デカン−４−オンの塩
WO2008124209A1 (en) * 2007-04-09 2008-10-16 Janssen Pharmaceutica, N.V. 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3457300A (en) * 1965-06-11 1969-07-22 Merck & Co Inc Acetic acid type compounds
FR1531370A (fr) * 1966-10-24 1968-07-05 Rhone Poulenc Sa Nouveaux dérivés du dibenzocycloheptatriène et du dibenzocycloheptadiène et leur préparation
NL6903272A (sv) * 1968-03-21 1969-09-23
US3709994A (en) * 1969-03-12 1973-01-09 Ciba Geigy Corp Hydrogenated araliphatic acids as anti-inflammatory agents

Also Published As

Publication number Publication date
CH548369A (fr) 1974-04-30
ZA715474B (en) 1972-04-26
CA998400A (en) 1976-10-12
CH548362A (fr) 1974-04-30
IE36766B1 (en) 1977-02-16
PH11416A (en) 1978-01-09
DK135230C (sv) 1977-09-12
CH548363A (fr) 1974-04-30
CH551940A (fr) 1974-07-31
HU163350B (sv) 1973-07-28
AU461519B2 (en) 1975-05-29
BE772417A (fr) 1972-03-10
FR2106396B1 (sv) 1975-04-18
US3859340A (en) 1975-01-07
ES394885A1 (es) 1974-12-16
CH564505A5 (sv) 1975-07-31
DK135230B (da) 1977-03-21
FR2106396A1 (sv) 1972-05-05
PH10599A (en) 1977-07-15
NL7112404A (sv) 1972-03-13
AR192948A1 (es) 1973-03-21
CH563332A5 (sv) 1975-06-30
DE2143600A1 (de) 1972-03-16
GB1364516A (en) 1974-08-21
AU3324671A (en) 1973-03-15

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