SE306392B - - Google Patents
Info
- Publication number
- SE306392B SE306392B SE13542/62A SE1354262A SE306392B SE 306392 B SE306392 B SE 306392B SE 13542/62 A SE13542/62 A SE 13542/62A SE 1354262 A SE1354262 A SE 1354262A SE 306392 B SE306392 B SE 306392B
- Authority
- SE
- Sweden
- Prior art keywords
- cytochrome
- alkali metal
- quantities
- solution
- stabilizer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/80—Cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Aqueous solutions of cytochrome C (haematic protein) stable to light and heat are prepared by dissolving in the aqueous solution a stabilizing agent selected from alkali metal sulphites, alkali metal bisulphides, alkali metal hydrosulphites and alkali metal metabisulphites. Auxiliary stabilizing agents selected from glycine, serine, alanine, hydroxy proline, glycyl glycine, glycylglycylglycine, alanylglycylglycine and leucylglycylglycine may also be present. Preferably, the aqueous solution of cytochrome C should be saturated with an inert gas such as nitrogen prior to the addition of the stabilizing agent. Advantageously, the pH of the solution should be adjusted to 7,0. The cytochrome C is used in quantities of 10 to 20% and, based on the cytochrome C content, the stabilizer in quantities of 2 to 20% and the auxiliary stabilizer in quantities of 100 to 300% by weight. The solution is used medicinally in diseases caused by insufficiency in respiratory oxidation of the cell.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4556161 | 1961-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE306392B true SE306392B (en) | 1968-11-25 |
Family
ID=12722753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE13542/62A SE306392B (en) | 1961-12-15 | 1962-12-15 |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | AT241690B (en) |
| BE (1) | BE626085A (en) |
| DK (1) | DK104530C (en) |
| GB (1) | GB990209A (en) |
| NL (1) | NL286788A (en) |
| SE (1) | SE306392B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114557983B (en) * | 2022-03-18 | 2022-12-27 | 北京诺和德美医药科技有限公司 | Stable bromhexine hydrochloride solution for inhalation and preparation method thereof |
-
0
- NL NL286788D patent/NL286788A/xx unknown
- BE BE626085D patent/BE626085A/xx unknown
-
1962
- 1962-12-11 GB GB46791/62A patent/GB990209A/en not_active Expired
- 1962-12-14 DK DK542662AA patent/DK104530C/en active
- 1962-12-14 AT AT977662A patent/AT241690B/en active
- 1962-12-15 SE SE13542/62A patent/SE306392B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL286788A (en) | |
| DK104530C (en) | 1966-05-31 |
| GB990209A (en) | 1965-04-28 |
| BE626085A (en) | |
| AT241690B (en) | 1965-08-10 |
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