SA521422733B1 - مشتقات 1-((2-(2,2,2-تراي فلورو إيثوكسي) بيريدينـ-4-ـيل) ميثيل) kcnq يوريا كمقويات لـ - Google Patents
مشتقات 1-((2-(2,2,2-تراي فلورو إيثوكسي) بيريدينـ-4-ـيل) ميثيل) kcnq يوريا كمقويات لـInfo
- Publication number
- SA521422733B1 SA521422733B1 SA521422733A SA521422733A SA521422733B1 SA 521422733 B1 SA521422733 B1 SA 521422733B1 SA 521422733 A SA521422733 A SA 521422733A SA 521422733 A SA521422733 A SA 521422733A SA 521422733 B1 SA521422733 B1 SA 521422733B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- kcnq
- trifluoroethoxy
- hardeners
- pyridin
- urea
- Prior art date
Links
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 239000004202 carbamide Substances 0.000 title 1
- 239000004848 polyfunctional curative Substances 0.000 title 1
- 206010001497 Agitation Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000002161 motor neuron Anatomy 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 102000004257 Potassium Channel Human genes 0.000 abstract 1
- 208000032319 Primary lateral sclerosis Diseases 0.000 abstract 1
- 206010046298 Upper motor neurone lesion Diseases 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 201000010901 lateral sclerosis Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000005264 motor neuron disease Diseases 0.000 abstract 1
- 108020001213 potassium channel Proteins 0.000 abstract 1
- 201000002241 progressive bulbar palsy Diseases 0.000 abstract 1
- 201000008752 progressive muscular atrophy Diseases 0.000 abstract 1
- 201000000196 pseudobulbar palsy Diseases 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 208000002320 spinal muscular atrophy Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
إن قدرات الجزيء الصغير على قنوات البوتاسيوم potassium channels (مثل إمكانات Kv7-التي تسمى أيضا قدرات KCNQ) potentiators ، وتركيبات تتضمن هذه المركبات، وطرق استخدام هذه المركبات لمعالجة التصلب الجانبي الضموري amyotrophic lateral sclerosis والأمراض العصبية neurological diseases الأخرى الناتجة عن التغيرات في الاستثارية العصبية الحركية motor neuron excitability ، بما في ذلك، على سبيل المثال لا الحصر، التصلب الجانبي الأساسي primary lateral sclerosis ، الشلل الكاذب pseudobulbar palsy ، الشلل الضموري التدريجي progressive bulbar palsy ، الضمور العضلي التدريجي progressive muscular atrophy والصرع epilepsy.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962801716P | 2019-02-06 | 2019-02-06 | |
| US201962811038P | 2019-02-27 | 2019-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA521422733B1 true SA521422733B1 (ar) | 2024-02-08 |
Family
ID=69743945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA521422733A SA521422733B1 (ar) | 2019-02-06 | 2021-08-05 | مشتقات 1-((2-(2,2,2-تراي فلورو إيثوكسي) بيريدينـ-4-ـيل) ميثيل) kcnq يوريا كمقويات لـ |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US11208383B2 (ar) |
| EP (1) | EP3921030B1 (ar) |
| JP (2) | JP7451543B2 (ar) |
| KR (1) | KR20210126040A (ar) |
| CN (1) | CN113692304B (ar) |
| AU (1) | AU2020218180A1 (ar) |
| BR (1) | BR112021015544A2 (ar) |
| CA (1) | CA3128975A1 (ar) |
| DK (1) | DK3921030T3 (ar) |
| ES (1) | ES2968807T3 (ar) |
| FI (1) | FI3921030T3 (ar) |
| HR (1) | HRP20240012T1 (ar) |
| HU (1) | HUE064734T2 (ar) |
| IL (1) | IL285113B1 (ar) |
| LT (1) | LT3921030T (ar) |
| MX (1) | MX2021009396A (ar) |
| PL (1) | PL3921030T3 (ar) |
| PT (1) | PT3921030T (ar) |
| RS (1) | RS65040B1 (ar) |
| SA (1) | SA521422733B1 (ar) |
| SG (1) | SG11202108599SA (ar) |
| SI (1) | SI3921030T1 (ar) |
| SM (1) | SMT202400003T1 (ar) |
| WO (1) | WO2020163268A1 (ar) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021009396A (es) * | 2019-02-06 | 2021-09-10 | Lilly Co Eli | Derivados de 1 - ((2- (2,2,2-trifluoroetoxi) piridin-4-yl) metil) urea como potenciadores kcnq. |
| CN115702141A (zh) | 2020-06-25 | 2023-02-14 | 爱杜西亚药品有限公司 | 环丁基-脲衍生物 |
| WO2023054626A1 (ja) * | 2021-09-30 | 2023-04-06 | 住友ファーマ株式会社 | シクロプロパンアミド誘導体 |
| EP4433472A1 (en) | 2021-11-19 | 2024-09-25 | Icagen, LLC | Pyridine compounds as kv7.2 enhancers |
| CN118525003A (zh) | 2021-11-19 | 2024-08-20 | 伊卡根有限责任公司 | 作为kv7.2抑制剂的新型杂芳基脲化合物 |
| EP4452944A1 (en) | 2021-12-22 | 2024-10-30 | Icagen, LLC | Cyclopropyl compounds |
| JP2025506201A (ja) | 2022-02-15 | 2025-03-07 | アイカジェン・エルエルシー | 新規なビシクロペンタン誘導体 |
| IT202200024948A1 (it) * | 2022-12-05 | 2024-06-05 | Angelini Pharma S P A | Composti attivatori dei canali potassio KV7.2/KV7.3 |
| IT202200024963A1 (it) * | 2022-12-05 | 2024-06-05 | Angelini Pharma S P A | Composti attivatori dei canali potassio Kv7.2/Kv7.3 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9808042A (pt) * | 1997-03-25 | 2000-03-08 | Astra Pharma Prod | Composto, composição farmacêutica, e, processo para preparação de compostos. |
| CN100345823C (zh) * | 2003-01-14 | 2007-10-31 | 赛特凯恩蒂克公司 | 化合物、组合物及方法 |
| RU2006139933A (ru) | 2004-04-13 | 2008-05-20 | Икаген, Инк. (Us) | Полициклические пиридины как модуляторы калиевых ионных каналов |
| US7879839B2 (en) * | 2004-07-29 | 2011-02-01 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
| WO2010036316A1 (en) | 2008-09-24 | 2010-04-01 | Yangbo Feng | Urea and carbamate compounds and analogs as kinase inhibitors |
| KR20120031170A (ko) * | 2009-06-08 | 2012-03-30 | 길리애드 사이언시즈, 인코포레이티드 | 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물 |
| ES2786298T3 (es) * | 2011-03-03 | 2020-10-09 | Zalicus Pharmaceuticals Ltd | Inhibidores de benzimidazol del canal de sodio |
| AR090151A1 (es) | 2012-03-07 | 2014-10-22 | Lilly Co Eli | Compuestos inhibidores de raf |
| CN103709097A (zh) | 2012-09-28 | 2014-04-09 | 中国科学院上海药物研究所 | 1,3-取代脲或硫脲化合物、其制备方法、药物组合物和应用 |
| CA2903288C (en) | 2013-03-15 | 2021-09-21 | Deciphera Pharmaceuticals, Llc | N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities |
| JP6577479B2 (ja) | 2014-02-27 | 2019-09-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｎａｖ チャンネル阻害剤としてのヘテロ環化合物及びその使用 |
| US9809544B2 (en) | 2014-10-24 | 2017-11-07 | Ono Pharmaceutical Co., Ltd. | KCNQ2-5 channel activator |
| WO2017183723A1 (ja) | 2016-04-22 | 2017-10-26 | 小野薬品工業株式会社 | Ｋｃｎｑ２～５チャネル活性化剤 |
| MX2021009396A (es) * | 2019-02-06 | 2021-09-10 | Lilly Co Eli | Derivados de 1 - ((2- (2,2,2-trifluoroetoxi) piridin-4-yl) metil) urea como potenciadores kcnq. |
-
2020
- 2020-02-04 MX MX2021009396A patent/MX2021009396A/es unknown
- 2020-02-04 EP EP20709409.5A patent/EP3921030B1/en active Active
- 2020-02-04 ES ES20709409T patent/ES2968807T3/es active Active
- 2020-02-04 WO PCT/US2020/016499 patent/WO2020163268A1/en active Application Filing
- 2020-02-04 US US16/781,148 patent/US11208383B2/en active Active
- 2020-02-04 HU HUE20709409A patent/HUE064734T2/hu unknown
- 2020-02-04 CA CA3128975A patent/CA3128975A1/en active Pending
- 2020-02-04 PT PT207094095T patent/PT3921030T/pt unknown
- 2020-02-04 LT LTEPPCT/US2020/016499T patent/LT3921030T/lt unknown
- 2020-02-04 SG SG11202108599SA patent/SG11202108599SA/en unknown
- 2020-02-04 RS RS20240009A patent/RS65040B1/sr unknown
- 2020-02-04 HR HRP20240012TT patent/HRP20240012T1/hr unknown
- 2020-02-04 AU AU2020218180A patent/AU2020218180A1/en active Pending
- 2020-02-04 KR KR1020217028040A patent/KR20210126040A/ko active Pending
- 2020-02-04 PL PL20709409.5T patent/PL3921030T3/pl unknown
- 2020-02-04 SM SM20240003T patent/SMT202400003T1/it unknown
- 2020-02-04 BR BR112021015544-9A patent/BR112021015544A2/pt unknown
- 2020-02-04 CN CN202080012797.0A patent/CN113692304B/zh active Active
- 2020-02-04 JP JP2021546360A patent/JP7451543B2/ja active Active
- 2020-02-04 FI FIEP20709409.5T patent/FI3921030T3/fi active
- 2020-02-04 DK DK20709409.5T patent/DK3921030T3/da active
- 2020-02-04 SI SI202030316T patent/SI3921030T1/sl unknown
- 2020-02-04 IL IL285113A patent/IL285113B1/en unknown
-
2021
- 2021-08-05 SA SA521422733A patent/SA521422733B1/ar unknown
- 2021-11-19 US US17/531,000 patent/US11840516B2/en active Active
-
2023
- 2023-11-09 US US18/388,299 patent/US12344584B2/en active Active
-
2024
- 2024-03-06 JP JP2024033668A patent/JP2024063191A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US11840516B2 (en) | 2023-12-12 |
| MX2021009396A (es) | 2021-09-10 |
| PL3921030T3 (pl) | 2024-05-06 |
| AU2020218180A1 (en) | 2021-08-19 |
| JP2024063191A (ja) | 2024-05-10 |
| CN113692304B (zh) | 2025-03-18 |
| IL285113B1 (en) | 2025-06-01 |
| HUE064734T2 (hu) | 2024-04-28 |
| LT3921030T (lt) | 2024-01-25 |
| CA3128975A1 (en) | 2020-08-13 |
| PT3921030T (pt) | 2024-01-12 |
| HRP20240012T1 (hr) | 2024-03-29 |
| SI3921030T1 (sl) | 2024-03-29 |
| BR112021015544A2 (pt) | 2021-10-26 |
| JP7451543B2 (ja) | 2024-03-18 |
| FI3921030T3 (fi) | 2024-01-08 |
| US11208383B2 (en) | 2021-12-28 |
| RS65040B1 (sr) | 2024-02-29 |
| ES2968807T3 (es) | 2024-05-14 |
| US20240076269A1 (en) | 2024-03-07 |
| JP2022519744A (ja) | 2022-03-24 |
| US12344584B2 (en) | 2025-07-01 |
| US20200247752A1 (en) | 2020-08-06 |
| EP3921030A1 (en) | 2021-12-15 |
| US20220073464A1 (en) | 2022-03-10 |
| DK3921030T3 (da) | 2024-01-02 |
| SMT202400003T1 (it) | 2024-03-13 |
| WO2020163268A1 (en) | 2020-08-13 |
| EP3921030B1 (en) | 2023-10-11 |
| SG11202108599SA (en) | 2021-09-29 |
| CN113692304A (zh) | 2021-11-23 |
| IL285113A (en) | 2021-09-30 |
| KR20210126040A (ko) | 2021-10-19 |
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