RU95108330A - Фармацевтическая композиция, предназначенная для торможения зависимой от интерлейкина-2 пролиферации опухолевых клеток. увеличения содержания гамма -интерферона, лечения воспалительных заболеваний кишечника, потенцирования торможения производства цитокина и ограничения или торможения аллергической реакции замедленного типа - Google Patents
Фармацевтическая композиция, предназначенная для торможения зависимой от интерлейкина-2 пролиферации опухолевых клеток. увеличения содержания гамма -интерферона, лечения воспалительных заболеваний кишечника, потенцирования торможения производства цитокина и ограничения или торможения аллергической реакции замедленного типаInfo
- Publication number
- RU95108330A RU95108330A RU95108330/14A RU95108330A RU95108330A RU 95108330 A RU95108330 A RU 95108330A RU 95108330/14 A RU95108330/14 A RU 95108330/14A RU 95108330 A RU95108330 A RU 95108330A RU 95108330 A RU95108330 A RU 95108330A
- Authority
- RU
- Russia
- Prior art keywords
- inhibition
- interleukin
- pharmaceutical composition
- allergic reaction
- cytokin
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
Объектом изобретения является фармацевтическая композиция, предназначенная для торможения зависимой от интерлейкина-2 пролиферации опухолевых клеток, увеличения содержания гамма-интерферона, лечения воспалительных заболеваний кишечника, потенцирования торможения производства цитокина и ограничения или торможения аллергической реакции замедленного типа, содержащая по меньшей мере один фармацевтически приемлемый носитель и активное вещество, при этом в качестве активного вещества она содержит вещество из группы, включающей интерлейкин-4, интерлейкин-10, комбинацию интерлейкина-4 и интерлейкина-10 и антитела против интерлейкина-4 и интерлейкина-10, в эффективном количестве.
Claims (1)
- Объектом изобретения является фармацевтическая композиция, предназначенная для торможения зависимой от интерлейкина-2 пролиферации опухолевых клеток, увеличения содержания гамма-интерферона, лечения воспалительных заболеваний кишечника, потенцирования торможения производства цитокина и ограничения или торможения аллергической реакции замедленного типа, содержащая по меньшей мере один фармацевтически приемлемый носитель и активное вещество, при этом в качестве активного вещества она содержит вещество из группы, включающей интерлейкин-4, интерлейкин-10, комбинацию интерлейкина-4 и интерлейкина-10 и антитела против интерлейкина-4 и интерлейкина-10, в эффективном количестве.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/932,900 US5368854A (en) | 1992-08-20 | 1992-08-20 | Use of IL-10 to treat inflammatory bowel disease |
| US07/932,900 | 1992-08-20 | ||
| US93346292A | 1992-08-21 | 1992-08-21 | |
| US93395092A | 1992-08-21 | 1992-08-21 | |
| US93341992A | 1992-08-21 | 1992-08-21 | |
| US07/933,462 | 1992-08-21 | ||
| US07/933,419 | 1992-08-21 | ||
| US07/933,950 | 1992-08-21 | ||
| PCT/US1993/007646 WO1994004180A2 (en) | 1992-08-20 | 1993-08-18 | Novel uses of il-4 and/or il-10, and antibodies against the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU95108330A true RU95108330A (ru) | 1996-11-27 |
| RU2120802C1 RU2120802C1 (ru) | 1998-10-27 |
Family
ID=27506019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95108330/14A RU2120802C1 (ru) | 1992-08-20 | 1993-08-18 | Фармацевтическая композиция, предназначенная для торможения зависимой от интерлейкина-2 пролиферации опухолевых клеток, увеличения содержания интерферона, лечения воспалительных заболеваний кишечника, потенцирования торможения производства цитокина и ограничения или торможения аллергической реакции замедленного типа |
Country Status (23)
| Country | Link |
|---|---|
| EP (2) | EP0671933B1 (ru) |
| JP (1) | JP3494647B2 (ru) |
| KR (1) | KR0170037B1 (ru) |
| CN (1) | CN1090204A (ru) |
| AT (1) | ATE162947T1 (ru) |
| AU (1) | AU680628B2 (ru) |
| CA (1) | CA2142861C (ru) |
| CZ (1) | CZ283488B6 (ru) |
| DE (1) | DE69316921T2 (ru) |
| DK (1) | DK0671933T3 (ru) |
| ES (1) | ES2111769T3 (ru) |
| FI (1) | FI950697A (ru) |
| GR (1) | GR3026635T3 (ru) |
| HK (1) | HK1004326A1 (ru) |
| HU (1) | HU220103B (ru) |
| IL (1) | IL106725A (ru) |
| MX (1) | MX9305054A (ru) |
| MY (1) | MY111402A (ru) |
| PL (1) | PL307566A1 (ru) |
| RU (1) | RU2120802C1 (ru) |
| SK (1) | SK21195A3 (ru) |
| TW (1) | TW243415B (ru) |
| WO (1) | WO1994004180A2 (ru) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6000894A (en) * | 1993-02-01 | 1994-08-29 | Michel Goldman | Use of a pharmaceutical composition comprising an effective amount of interleukin-10, an analog and/or an agonist of interleukin-10 |
| HU220344B (hu) * | 1994-07-05 | 2001-12-28 | Steeno Research Group A/S | Immunmodulátorok |
| US6410008B1 (en) | 1994-12-12 | 2002-06-25 | Beth Israel Hospital Association | Chimeric IL-10 proteins and uses thereof |
| WO1996018412A1 (en) | 1994-12-12 | 1996-06-20 | Beth Israel Hospital Association | Chimeric cytokines and uses thereof |
| US5770190A (en) * | 1995-07-14 | 1998-06-23 | Schering Corporation | Method of treatment of acute leukemia with inteleukin-10 |
| EP0756871A1 (en) * | 1995-08-01 | 1997-02-05 | Institut Pasteur | Use of a pharmaceutical composition comprising an effective amount of interleukin-10, an analog and/or an agonist of interleukin-10 |
| CA2251733A1 (en) * | 1996-04-17 | 1997-10-23 | Patrick T. Prendergast | Dhea combination therapy |
| AU5532098A (en) * | 1996-12-20 | 1998-07-17 | Magainin Pharmaceuticals, Inc. | A method for diagnosis and treatment of inflammatory bowel diseases including crohn's disease and chronic ulcerative colitis |
| AU5221998A (en) * | 1997-04-17 | 1998-11-13 | Patrick T. Prendergast | Combination therapy utilising 17-ketosteroids and interleukin inhibitors, or interleukin-10 potionally with interleukin inhibitors |
| US8563522B2 (en) | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
| US6001651A (en) * | 1998-03-20 | 1999-12-14 | Isis Pharmaceuticals Inc. | Antisense modulation of LFA-3 |
| DE69914932T2 (de) * | 1998-10-20 | 2004-12-09 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis |
| WO2000047558A1 (fr) | 1999-02-10 | 2000-08-17 | Welfide Corporation | Composes amide et leur utilisation medicinale |
| ES2395991T3 (es) * | 1999-12-03 | 2013-02-18 | Baxter International Inc. | Ensayo de pirogenicidad para su uso con sistemas de inmunoensayo automáticos |
| BR0109705A (pt) | 2000-03-31 | 2005-01-11 | Idec Pharma Corp | Uso combinado de anticorpos ou antagonistas anti-citocina e anticd20 para o tratamento de linfoma de célula b |
| CN1441675A (zh) | 2000-05-12 | 2003-09-10 | 贝斯以色列护理医疗中心有限公司 | 免疫抑制组合物及方法 |
| US20040197304A1 (en) | 2003-04-01 | 2004-10-07 | The Procter & Gamble Company And Alimentary Health, Ltd. | Methods of determining efficacy of treatments of inflammatory diseases of the bowel |
| US7261882B2 (en) * | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| PE20090046A1 (es) * | 2003-11-10 | 2009-01-26 | Schering Corp | Anticuerpo recombinante humanizado anti-interleuquina 10 |
| US8894991B2 (en) | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
| US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| US20050152884A1 (en) | 2003-12-19 | 2005-07-14 | The Procter & Gamble Company | Canine probiotic Bifidobacteria globosum |
| US7785635B1 (en) | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
| AR050044A1 (es) | 2004-08-03 | 2006-09-20 | Novartis Ag | Anticuerpo especifico de il-4 |
| BRPI0611492B1 (pt) | 2005-05-31 | 2021-10-13 | Mars, Incorporated | Bifidobactéria probiótica felina |
| EP2261323A1 (en) | 2005-05-31 | 2010-12-15 | The Iams Company | Feline probiotic lactobacilli |
| EP1931762B1 (en) * | 2005-10-03 | 2012-12-05 | Actogenix N.V. | Use of recombinant yeast strain producing an anti -inflammatory compound in the manufacture of a medicament to treat colitis |
| WO2008054585A2 (en) * | 2006-09-28 | 2008-05-08 | Schering Corporation | Use of pegylated il-10 to treat cancer |
| EP2124966B1 (en) | 2007-02-01 | 2015-09-09 | IAMS Europe B.V. | Method for decreasing inflammation and stress in a mammal using glucose antimetabolites, avocado or avocado extracts |
| US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
| US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
| AU2014254019B2 (en) * | 2013-04-18 | 2018-09-27 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| JP2016528879A (ja) | 2013-06-17 | 2016-09-23 | アルモ・バイオサイエンシーズ・インコーポレイテッド | タンパク質の同一性および安定性を評価する方法 |
| EP3021873B8 (en) | 2013-07-18 | 2018-10-24 | Xalud Therapeutics, Inc. | Composition for the treatment of inflammatory joint disease |
| CN105658232A (zh) | 2013-08-30 | 2016-06-08 | 阿尔莫生物科技股份有限公司 | 使用白细胞介素-10治疗疾病和病症的方法 |
| KR20180038553A (ko) | 2015-08-25 | 2018-04-16 | 아르모 바이오사이언시스 인코포레이티드 | 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법 |
| CN114349858B (zh) * | 2022-01-26 | 2022-07-01 | 优睿赛思(武汉)生物科技有限公司 | 抗人白介素-10高亲和力兔单克隆抗体及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94878A (en) * | 1989-06-28 | 2003-01-12 | Schering Corp | Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same |
| DE69201128T2 (de) * | 1991-01-16 | 1995-05-24 | Schering Corp | Behandlung von neoplastischen krankenheiten mit interleukin-10. |
| GB9207732D0 (en) * | 1992-04-06 | 1992-05-27 | Isis Innovation | Wound repair |
-
1993
- 1993-08-18 HU HU9500467A patent/HU220103B/hu not_active IP Right Cessation
- 1993-08-18 SK SK211-95A patent/SK21195A3/sk unknown
- 1993-08-18 EP EP93920050A patent/EP0671933B1/en not_active Expired - Lifetime
- 1993-08-18 KR KR1019950700624A patent/KR0170037B1/ko not_active IP Right Cessation
- 1993-08-18 DE DE69316921T patent/DE69316921T2/de not_active Expired - Lifetime
- 1993-08-18 CZ CZ95441A patent/CZ283488B6/cs not_active IP Right Cessation
- 1993-08-18 MY MYPI93001646A patent/MY111402A/en unknown
- 1993-08-18 JP JP50643794A patent/JP3494647B2/ja not_active Expired - Fee Related
- 1993-08-18 WO PCT/US1993/007646 patent/WO1994004180A2/en active IP Right Grant
- 1993-08-18 EP EP97108651A patent/EP0801951A3/en not_active Withdrawn
- 1993-08-18 AU AU50108/93A patent/AU680628B2/en not_active Ceased
- 1993-08-18 ES ES93920050T patent/ES2111769T3/es not_active Expired - Lifetime
- 1993-08-18 IL IL10672593A patent/IL106725A/xx not_active IP Right Cessation
- 1993-08-18 TW TW082106627A patent/TW243415B/zh active
- 1993-08-18 AT AT93920050T patent/ATE162947T1/de not_active IP Right Cessation
- 1993-08-18 RU RU95108330/14A patent/RU2120802C1/ru not_active IP Right Cessation
- 1993-08-18 DK DK93920050T patent/DK0671933T3/da active
- 1993-08-18 PL PL93307566A patent/PL307566A1/xx unknown
- 1993-08-18 CA CA002142861A patent/CA2142861C/en not_active Expired - Fee Related
- 1993-08-19 MX MX9305054A patent/MX9305054A/es not_active IP Right Cessation
- 1993-08-19 CN CN93117631A patent/CN1090204A/zh active Pending
-
1995
- 1995-02-16 FI FI950697A patent/FI950697A/fi not_active Application Discontinuation
-
1998
- 1998-04-14 GR GR980400834T patent/GR3026635T3/el unknown
- 1998-04-23 HK HK98103387A patent/HK1004326A1/xx not_active IP Right Cessation
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