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RU94040386A - Синтетический пептид, синтетический липопептид, иммуногенный коньюгат, вектор, диагностический реагент, метод определения инфекций, антитета, способ получения олигомера, синтетическая вакцина против haemophilus influenzae, защищенный полисахарид - Google Patents

Синтетический пептид, синтетический липопептид, иммуногенный коньюгат, вектор, диагностический реагент, метод определения инфекций, антитета, способ получения олигомера, синтетическая вакцина против haemophilus influenzae, защищенный полисахарид

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Publication number
RU94040386A
RU94040386A RU94040386/13A RU94040386A RU94040386A RU 94040386 A RU94040386 A RU 94040386A RU 94040386/13 A RU94040386/13 A RU 94040386/13A RU 94040386 A RU94040386 A RU 94040386A RU 94040386 A RU94040386 A RU 94040386A
Authority
RU
Russia
Prior art keywords
synthetic
haemophilus influenzae
vaccine against
antibodies
vector
Prior art date
Application number
RU94040386/13A
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English (en)
Other versions
RU2141527C1 (ru
Inventor
Чонг Пеле
Ca]
Кандил Али
Сайа Чарльз
Х.Клейн Майкл
Gb]
Original Assignee
Коннот Лабораториз Лимитед (CA)
Коннот Лабораториз Лимитед
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Publication of RU94040386A publication Critical patent/RU94040386A/ru
Application granted granted Critical
Publication of RU2141527C1 publication Critical patent/RU2141527C1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/851—Haemophilus

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
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  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
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  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
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Abstract

Синтетический пептид имеет аминокислотную последовательность, относящуюся по крайней мере к одной антигенной детерминанте по крайней мере одного белка, обычно структурного, в особенности Р1, Р2 и Р6 -белкам Haemophilus influenzae (Нi ), в частности типа В, и используется в виде химерной липофильной Т-В-формы, привязанной к молекуле носителя, например синтетической PRP-молекуле, и/или полимеризованного и образующего молекулярные агрегаты, как вакцина против Hi.

Claims (1)

  1. Синтетический пептид имеет аминокислотную последовательность, относящуюся по крайней мере к одной антигенной детерминанте по крайней мере одного белка, обычно структурного, в особенности Р1, Р2 и Р6 -белкам Haemophilus influenzae (Нi ), в частности типа В, и используется в виде химерной липофильной Т-В-формы, привязанной к молекуле носителя, например синтетической PRP-молекуле, и/или полимеризованного и образующего молекулярные агрегаты, как вакцина против Hi.
RU94040386A 1992-02-03 1993-02-03 Синтетический пептид, синтетический липопептид, иммуногенный конъюгат (варианты), способ получения олигомера, защищенный твердым монометиловым эфиром полиэтиленгликоля полисахарид RU2141527C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9202219.3 1992-02-03
GB929202219A GB9202219D0 (en) 1992-02-03 1992-02-03 A synthetic heamophilus influenzae conjugate vaccine
PCT/CA1993/000041 WO1993015205A2 (en) 1992-02-03 1993-02-03 Synthetic haemophilus influenzae conjugate vaccine

Publications (2)

Publication Number Publication Date
RU94040386A true RU94040386A (ru) 1996-05-10
RU2141527C1 RU2141527C1 (ru) 1999-11-20

Family

ID=10709711

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94040386A RU2141527C1 (ru) 1992-02-03 1993-02-03 Синтетический пептид, синтетический липопептид, иммуногенный конъюгат (варианты), способ получения олигомера, защищенный твердым монометиловым эфиром полиэтиленгликоля полисахарид

Country Status (11)

Country Link
US (3) US6018019A (ru)
EP (1) EP0625203A1 (ru)
JP (4) JP3421337B2 (ru)
KR (1) KR100246122B1 (ru)
AU (1) AU669354B2 (ru)
CA (1) CA2129101C (ru)
FI (1) FI943591L (ru)
GB (1) GB9202219D0 (ru)
NO (1) NO942867L (ru)
RU (1) RU2141527C1 (ru)
WO (1) WO1993015205A2 (ru)

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US5972349A (en) 1999-10-26
US6018019A (en) 2000-01-25
US5679352A (en) 1997-10-21
JPH11269188A (ja) 1999-10-05
FI943591A7 (fi) 1994-09-28
KR950700416A (ko) 1995-01-16
NO942867D0 (ru) 1994-08-02
FI943591A0 (fi) 1994-08-02
RU2141527C1 (ru) 1999-11-20
JP3421337B2 (ja) 2003-06-30
FI943591L (fi) 1994-09-28
JP2001064201A (ja) 2001-03-13
CA2129101C (en) 2004-08-10
KR100246122B1 (ko) 2000-03-15
WO1993015205A2 (en) 1993-08-05
EP0625203A1 (en) 1994-11-23
WO1993015205A3 (en) 1994-03-03
NO942867L (no) 1994-10-03
AU3446993A (en) 1993-09-01
JPH07505522A (ja) 1995-06-22
CA2129101A1 (en) 1993-08-05
GB9202219D0 (en) 1992-03-18
AU669354B2 (en) 1996-06-06
JP2006131642A (ja) 2006-05-25

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