RU93055131A - QUARTERLY AMIDES OF BASIC CHARACTER, METHOD OF THEIR PRODUCTION AND CONTAINING THEIR PHARMACEUTICAL COMPOSITION - Google Patents
QUARTERLY AMIDES OF BASIC CHARACTER, METHOD OF THEIR PRODUCTION AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONInfo
- Publication number
- RU93055131A RU93055131A RU93055131/04A RU93055131A RU93055131A RU 93055131 A RU93055131 A RU 93055131A RU 93055131/04 A RU93055131/04 A RU 93055131/04A RU 93055131 A RU93055131 A RU 93055131A RU 93055131 A RU93055131 A RU 93055131A
- Authority
- RU
- Russia
- Prior art keywords
- group
- denotes
- production
- amides
- quarterly
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 1,2-ethylene, 1,3-propylene Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 102000003141 Tachykinin Human genes 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004196 benzothienyl group Chemical class S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000001041 indolyl group Chemical class 0.000 claims 1
- 125000001624 naphthyl group Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 108060008037 tachykinin Proteins 0.000 claims 1
- 125000001544 thienyl group Chemical class 0.000 claims 1
Claims (1)
в которой: Ar обозначает ароматическую или гетероароматическую, моно-, ди-, или трициклическую, в известных случаях замещенную, группу; Т обозначает прямую связь, гидроксиметилуновую группу, алкоксиметиленовую группу, алкоксильная группа которой содержит 1 - 4 С - атома; или С1 - С5 - алкиленовую группу; Ar′ обозначает незамещенный или одно- или многократно замещенный фенил, тиенил, бензотиенил, нафтил или индолил; R обозначает водород или C1 - C4 - алкил; Q обозначает водород; или Q и R вместе образуют 1,2-этиленовую, 1,3-пропиленовую или 1,4-бутиленовую группу; Ax обозначает радикал:
в которой X1, X2, X3 вместе и с атомом азота, с которым они связаны, образуют азабициклическую или азатрициклическую систему, в известных случаях замещенную фенильной группой; A⊖ обозначает фармацевтически приемлемый анион. Эти соединения пригодны для получения медикаментов, предназначенных для лечения патологий, связанных с системой тахикининов.The invention relates to basic Quaternary amides of the formula:
in which: Ar denotes an aromatic or heteroaromatic, mono-, di-, or tricyclic, optionally substituted, group; T denotes a direct bond, a hydroxymethylune group, an alkoxymethylene group, the alkoxy group of which contains 1-4C-atoms; or C 1 - C 5 - alkylene group; Ar ′ is unsubstituted or mono- or multi-substituted phenyl, thienyl, benzothienyl, naphthyl, or indolyl; R denotes hydrogen or C 1 - C 4 - alkyl; Q is hydrogen; or Q and R together form a 1,2-ethylene, 1,3-propylene or 1,4-butylene group; A x denotes the radical:
in which X 1 , X 2 , X 3 together with the nitrogen atom to which they are bound, form an azabicyclic or azatricyclic system, in some cases substituted by a phenyl group; A ⊖ denotes a pharmaceutically acceptable anion. These compounds are suitable for the production of drugs intended for the treatment of pathologies associated with the system of tachykinins.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9212083A FR2696178B1 (en) | 1992-09-30 | 1992-09-30 | Quaternary basic amides, process for their preparation and pharmaceutical compositions containing them. |
| FR9212083 | 1992-09-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93055131A true RU93055131A (en) | 1996-04-27 |
| RU2120436C1 RU2120436C1 (en) | 1998-10-20 |
Family
ID=9434374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93055131/04A RU2120436C1 (en) | 1992-09-30 | 1993-09-29 | Basic type tertiary amides, methods of preparing thereof, and pharmaceutical composition comprising said compounds |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0591040B1 (en) |
| JP (2) | JP2857041B2 (en) |
| KR (1) | KR100279084B1 (en) |
| CN (1) | CN1036652C (en) |
| AT (1) | ATE176469T1 (en) |
| AU (1) | AU674875B2 (en) |
| BR (1) | BR9303982A (en) |
| CA (1) | CA2107432C (en) |
| CZ (1) | CZ287272B6 (en) |
| DE (1) | DE69323375T2 (en) |
| DK (1) | DK0591040T3 (en) |
| ES (1) | ES2130238T3 (en) |
| FI (1) | FI114474B (en) |
| FR (1) | FR2696178B1 (en) |
| GR (1) | GR3030000T3 (en) |
| HU (2) | HU215848B (en) |
| IL (1) | IL107158A0 (en) |
| MX (1) | MX9306024A (en) |
| MY (1) | MY108881A (en) |
| NO (1) | NO304888B1 (en) |
| NZ (1) | NZ248821A (en) |
| OA (1) | OA09869A (en) |
| RU (1) | RU2120436C1 (en) |
| SG (1) | SG47807A1 (en) |
| SI (1) | SI9300513B (en) |
| TW (1) | TW242625B (en) |
| ZA (1) | ZA937276B (en) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583134A (en) * | 1992-09-30 | 1996-12-10 | Sanofi | 1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present |
| FR2717802B1 (en) * | 1994-03-25 | 1996-06-21 | Sanofi Sa | New aromatic compounds, process for their preparation and pharmaceutical compositions containing them. |
| FR2717804B1 (en) * | 1994-03-25 | 1996-06-21 | Sanofi Sa | Salts of substituted nitrogen heteroaromatic compounds, process for their preparation and pharmaceutical compositions containing them. |
| IL113472A0 (en) | 1994-04-29 | 1995-07-31 | Lilly Co Eli | Non-peptidyl tachykinin receptor antogonists |
| PL180866B1 (en) | 1994-07-12 | 2001-04-30 | Lilly Co Eli | Heterocyclic antagonists of tachykinin receptors |
| FR2725900B1 (en) * | 1994-10-21 | 1997-07-18 | Sanofi Sa | USE OF NK1 RECEPTOR ANTAGONISTS FOR THE PREPARATION OF DRUGS WITH CARDIOREGULATORY ACTION |
| GB9421709D0 (en) * | 1994-10-27 | 1994-12-14 | Zeneca Ltd | Therapeutic compounds |
| US6008223A (en) * | 1994-10-27 | 1999-12-28 | Zeneca Limited | Therapeutic compounds |
| EP0714891A1 (en) * | 1994-11-22 | 1996-06-05 | Eli Lilly And Company | Heterocyclic tachykinin receptor antagonists |
| FR2751654B1 (en) * | 1996-07-26 | 1998-10-23 | Sanofi Sa | SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2729954B1 (en) * | 1995-01-30 | 1997-08-01 | Sanofi Sa | SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2729951B1 (en) * | 1995-01-30 | 1997-04-18 | Sanofi Sa | NOVEL HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| FR2729952B1 (en) * | 1995-01-30 | 1997-04-18 | Sanofi Sa | SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US5654316A (en) * | 1995-06-06 | 1997-08-05 | Schering Corporation | Piperidine derivatives as neurokinin antagonists |
| DE69626123T2 (en) * | 1995-06-06 | 2003-10-09 | Schering Corp., Kenilworth | SUBSTITUTED BENZO-CONDENSED HETEROCYCLES AS NEUROKININ ANTAGONISTS |
| FR2745811B1 (en) | 1996-03-07 | 1998-05-22 | Sanofi Sa | DISSUBSTITUTED GLUTARIMIDE PROCESS FOR ITS PREPARATION, AND ITS USE |
| CA2255910A1 (en) * | 1996-05-24 | 1997-11-27 | Mitchell Irvin Steinberg | Methods of treating hypertension |
| US5691362A (en) * | 1996-06-05 | 1997-11-25 | Schering-Plough Corporation | Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists |
| GB9617730D0 (en) * | 1996-08-23 | 1996-10-02 | Pfizer Ltd | Quarternary ammonium compounds |
| FR2759584B1 (en) * | 1997-02-17 | 1999-06-11 | Sanofi Sa | PHARMACEUTICAL COMPOSITION FOR THE ORAL ADMINISTRATION OF HETEROCYCLIC COMPOUNDS IN QUATERNARY AMMONIUM FORM |
| FR2759585B1 (en) | 1997-02-17 | 1999-06-11 | Sanofi Sa | PHARMACEUTICAL FORMULATIONS PRESENTED IN A DRY FORM FOR THE ORAL ADMINISTRATION OF A CYCLIC QUATERNARY AMMONIUM COMPOUND |
| AU744261B2 (en) * | 1997-04-24 | 2002-02-21 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating eating disorders |
| GB9712882D0 (en) * | 1997-06-18 | 1997-08-20 | Pfizer Ltd | Quaternary ammonium compounds |
| AU738047B2 (en) * | 1997-08-04 | 2001-09-06 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating mania |
| GB9716463D0 (en) * | 1997-08-04 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic agents |
| GB9716457D0 (en) * | 1997-08-04 | 1997-10-08 | Merck Sharp & Dohme | Therapeutic agents |
| AU737019B2 (en) * | 1997-08-04 | 2001-08-09 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating aggressive behaviour disorders |
| GB9816897D0 (en) * | 1998-08-04 | 1998-09-30 | Merck Sharp & Dohme | Therapeutic use |
| GB9927125D0 (en) | 1999-11-16 | 2000-01-12 | Univ Reading The | Placental human neurokinin B precursor |
| EP1754701A4 (en) * | 2004-02-25 | 2007-10-03 | Sankyo Co | Sulfonyloxy derivatives |
| JP2008534504A (en) | 2005-03-22 | 2008-08-28 | アゼヴァン ファーマスーティカルズ，インコーポレイテッド | Β-Lactamyl alkanoic acid for treating premenstrual disorders |
| SI1910346T1 (en) | 2005-07-19 | 2019-08-30 | Azevan Pharmaceuticals, Inc. | Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonist |
| JP2010516731A (en) | 2007-01-24 | 2010-05-20 | グラクソ グループ リミテッド | Pharmaceutical composition comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-1-yl) -benzyl]-(2S-phenyl-piperidin-3S-yl) -amine |
| UA105182C2 (en) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Benzoxazines, benzothiazines, and related compounds having nos inhibitory activity |
| RU2623209C9 (en) | 2010-07-01 | 2018-01-22 | Азеван Фармасьютикалз, Инк. | Method for ptsd treatment |
| FI3122743T3 (en) | 2014-03-28 | 2023-03-02 | Azevan Pharmaceuticals Inc | Compositions and methods for treating neurodegenerative diseases |
| CA3047023C (en) * | 2016-12-14 | 2022-05-31 | Beijing Showby Pharmaceutical Co., Ltd. | Class of bifunctional compounds with quaternary ammonium salt structure |
| US11628160B2 (en) | 2017-09-15 | 2023-04-18 | Azevan Pharmaceuticals, Inc. | Compositions and methods for treating brain injury |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| FR2666185B1 (en) * | 1990-08-21 | 1992-12-04 | Sgs Thomson Microelectronics | INTERPOLATION ANALOG / DIGITAL CONVERTER. |
| IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical compositions containing them |
-
1992
- 1992-09-30 FR FR9212083A patent/FR2696178B1/en not_active Expired - Fee Related
-
1993
- 1993-09-13 TW TW082107498A patent/TW242625B/zh active
- 1993-09-28 SG SG1996004468A patent/SG47807A1/en unknown
- 1993-09-28 AT AT93402362T patent/ATE176469T1/en not_active IP Right Cessation
- 1993-09-28 EP EP93402362A patent/EP0591040B1/en not_active Expired - Lifetime
- 1993-09-28 DK DK93402362T patent/DK0591040T3/en active
- 1993-09-28 ES ES93402362T patent/ES2130238T3/en not_active Expired - Lifetime
- 1993-09-28 KR KR1019930020216A patent/KR100279084B1/en not_active IP Right Cessation
- 1993-09-28 DE DE69323375T patent/DE69323375T2/en not_active Expired - Fee Related
- 1993-09-29 NO NO933481A patent/NO304888B1/en not_active IP Right Cessation
- 1993-09-29 IL IL107158A patent/IL107158A0/en not_active IP Right Cessation
- 1993-09-29 CN CN93118177A patent/CN1036652C/en not_active Expired - Fee Related
- 1993-09-29 FI FI934273A patent/FI114474B/en active IP Right Grant
- 1993-09-29 MX MX9306024A patent/MX9306024A/en not_active IP Right Cessation
- 1993-09-29 OA OA60420A patent/OA09869A/en unknown
- 1993-09-29 MY MYPI93001979A patent/MY108881A/en unknown
- 1993-09-29 CZ CZ19932035A patent/CZ287272B6/en not_active IP Right Cessation
- 1993-09-29 RU RU93055131/04A patent/RU2120436C1/en not_active IP Right Cessation
- 1993-09-30 NZ NZ248821A patent/NZ248821A/en not_active IP Right Cessation
- 1993-09-30 BR BR9303982A patent/BR9303982A/en not_active Application Discontinuation
- 1993-09-30 HU HUP9302770A patent/HU215848B/en not_active IP Right Cessation
- 1993-09-30 AU AU48708/93A patent/AU674875B2/en not_active Ceased
- 1993-09-30 CA CA002107432A patent/CA2107432C/en not_active Expired - Fee Related
- 1993-09-30 SI SI9300513A patent/SI9300513B/en not_active IP Right Cessation
- 1993-09-30 JP JP5268295A patent/JP2857041B2/en not_active Expired - Fee Related
- 1993-09-30 ZA ZA937276A patent/ZA937276B/en unknown
-
1995
- 1995-06-28 HU HU95P/P00518P patent/HU211889A9/en unknown
-
1997
- 1997-12-25 JP JP35863297A patent/JP3243212B2/en not_active Expired - Fee Related
-
1999
- 1999-04-20 GR GR990401079T patent/GR3030000T3/en unknown
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