RU2492867C1 - Biologically active additive - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely a general tonic biologically active additive. The general tonic biologically active additive is presented in the form of a capsule containing antler deer's lyophilised blood plasma, vitamin E, zinc citrate trihydrate, lycopene, L-arginine and additive agents in the specific proportions.

EFFECT: biologically active additive has general tonic action.

Description

The invention relates to the food industry, namely to biologically active additives made on the basis of antler deer blood, in particular, on the basis of blood plasma.

The last decades in the world there is a very difficult environmental situation. According to the World Health Organization, poor-quality habitat provoked the occurrence of 60% of various diseases. The situation is aggravated by numerous food products with an abundance of preservatives and other chemicals. Recently, the number of patients suffering from anemia, a general loss of strength, decreased working capacity and body resistance to infections and environmental influences is quite large and has a tendency to progressively increase among people of all age categories.

Since ancient times in folk medicine, the blood of warm-blooded animals, mainly cattle, and pigs, has been used as a general strengthening agent in such conditions. Blood is an environmentally friendly complex of blood cells, proteins, amino acids, including essential minerals, minerals, vitamins, hormones, hormone-like substances, including sex hormones - steroids. Moreover, all these components are in the blood in balanced amounts necessary for life. The blood of slaughtered animals (cattle, pigs) in the USSR was widely used for the production of medicinal products: blood substitutes, hematogen, hemostimulin, high-nutritional food: sausages, pastes, etc., feed, enriching the diet of farm animals and birds, stimulating fattening and the development of young animals. The nutritional value of blood is also known. Dried blood - food albumin - is widely used in the food industry, dried serum or blood plasma are substitutes for egg yolk.

However, in the course of further studies, it was found that antler deer blood (red deer, red deer, sika deer) has a much wider spectrum of effects on the human body due to the higher biological activity of antler deer blood substances in comparison with the blood of cattle or pigs. Preparations containing the blood of antler deer increase the body's efficiency, enhance its vital activity and resistance to disease.

Known complex biologically active drug "FERROHEM" containing pantohematogen - dry blood extract of Altai maral, iron sulfate, ascorbic acid and glucose with an appropriate ratio of components. The drug makes up for iron deficiency in the body and improves its absorption.

Known complex iron-containing product "FERROPAN" containing pantohematogen - dry blood extract of Altai maral, iron (II) sulfate and ascorbic acid with an appropriate ratio of components. The product is used for iron deficiency in the body.

Known psychostimulating agent "pantogematogen" (RF patent No. 20088008) containing diffibrinated blood of deer, deer or sika deer, sugar syrup, 96% ethyl alcohol, fruit essence and ascorbic acid with an appropriate ratio of components. The tool is intended for the treatment of anemia and general loss of strength after infectious diseases.

Closest to the claimed technical solution is the biologically active additive "Plasmaral" (http://altaybuket.ru/produkciya pantovogo maralovodstv ...), which is a powder of lyophilized maral blood plasma. Plasmaral is an effective tonic and biostimulating agent, as well as an agent used for healing and tissue repair, has a beneficial effect on the skin, development of muscle and cartilage tissue, accelerates the healing of fractures, wound cuts, burns, bedsores, and can also be used as a biologically active substance in cosmetics, in particular in creams, gels.

However, the known biologically active additive has an insufficiently wide spectrum of action. This is primarily due to the fact that the dietary supplement formulation contains the minimum amount of ingredients - dry maral blood plasma. It should be noted that at present, preference is given to multicomponent preparations, since in them there is a mutual strengthening or softening of the action of their constituent components. In this case, the resulting drugs can be recommended to a wider circle of people due to the multivalency of their pharmacological action. The rational selection of ingredients of a particular therapeutic orientation with a low level of toxicity and side effects makes the long-term use of such drugs safe, which is very important for normalizing the body's adaptation mechanisms, as well as for the prevention of chronic diseases.

The technical problem underlying the present invention is to expand the range of biologically active additives made on the basis of lyophilized antler deer blood plasma by creating a new biologically active supplement with a wide spectrum of effects on the human body, which has a beneficial effect on the nervous, cardiovascular, and urogenital and the human immune system.

The problem is solved by the proposed dietary supplement formulation made in the form of a capsule containing lyophilized antler deer blood plasma, vitamin E, zinc source, lycopene, L-arginine and excipients in the following ratio of components in grams per 1 capsule weighing 0.27 g:

Lyophilized Plasma antler deer blood 0.05-0.1 Vitamin E 0.001-0.01 Source of zinc 0.0012-0.012 Lycopene 0.0005-0.015 L-arginine 0.05-0.1 Excipients rest

Moreover, as a source of zinc, the additive contains organic zinc salts.

Excipients are known excipients that are widely used in the pharmaceutical industry in the manufacture of solid dosage forms in the form of capsules in quantities that provide known technologies for their manufacture. In this case, the following standard fillers can be used as auxiliary substances in the manufacture of capsules: microcrystalline cellulose, anhydrous calcium hydrogen phosphate, calcium stearate, etc.

The proposed dietary supplement has a wide range of effects on the human body. This is due primarily to its constituent components and their quantitative ratio.

Blood plasma of antler deer. The millennial use of antlers and blood of antlers is described in many ancient recipes of Tibet, Korea, and China. The characteristics of the organism of antler deer, associated with the specifics of the environment and physiology, cause unusually high concentrations in the blood of biologically active substances (BAS), which are not found in other animals. Not a single tissue, not a single organ of these animals has such fast, powerful growth as antlers. Collected during their rapid growth, blood has a unique healing effect on the human body. This environmentally friendly product is an effective adaptogen of a new generation.

The antler deer blood plasma made using the unique technology using freeze drying maximally preserves the whole complex of the most valuable biologically active substances, which determines the variety of its amazing healing properties. Plasma contains a huge amount of chemicals necessary for human life.

In its composition:

- Amino acids, which are active participants in all the most important processes in the body. Not only the growth of muscle strength and "mass" of muscles depends on them, but also the restoration of physical and mental tone, catabolism of subcutaneous fat, as well as the full functioning of the brain. Amino acids carry out the function of intensive nutrition and regeneration of the cellular systems of the skin, promote the assimilation of vitamins and minerals, and better fulfillment of all their useful functions.

- Macronutrients (sodium, potassium, calcium, magnesium) are necessary to stimulate blood circulation and the formation of new cells;

- Proteins - are necessary for every cell in the body. This is the main material for building growing and reproduction of collapsing tissues. They participate in the formation of enzymes, antibodies that protect the body from various kinds of influences, hormones that support the normal functioning of all systems and organs of the body. Of all the proteins, albumin is present in the highest concentration in plasma. It is necessary to maintain osmotic balance, ensuring a normal distribution of fluid between the blood vessels and extravascular space. In other words, albumin does not allow blood to turn into jelly. Globulins are also present in the plasma, which determine the immune properties of the body, blood coagulation, and also participate in the transport of iron and other processes;

Fibrinogen is a soluble plasma protein. Is a factor I blood coagulation. The main function of fibrinogen is the conversion of liquid blood into an elastic clot. This is a protective reaction of the body that prevents blood loss. Fibrinogen is used to stop bleeding during operations, with hemophilia, diseases associated with a low content of fibrin in the blood.

- Phospholipids. Despite the fact that the human body has the ability to synthesize phospholipids itself, its capabilities in this regard are far from unlimited. The introduction of phospholipids into the body from the outside is a very good help for him, they are absorbed very quickly and “patch” membrane defects, wherever the affected cells are. Phospholipids have a pronounced antioxidant effect, reducing the formation of highly toxic free radicals in the body. Free radicals damage all cell membranes, contribute to the development of age-related diseases such as atherosclerosis, cancer, hypertension, diabetes mellitus, etc. Among all types of age-related pathology, free radical oxidation is leading, and the onset of certain age-related disorders depends on its severity. The role of “phospholipid nutrition” in the prevention of general aging of the body and the development of age-related diseases is very great. It is very significant that phospholipids delay the development of cancerous tumors even at the very last stages of the development of the disease. All phospholipids have the ability to remove cholesterol from atherosclerotic plaques. They literally “knock out” cholesterol from them, which leads to resorption of soft atherosclerotic plaques and, accordingly, delay the development of atherosclerosis.

Thus, the blood plasma of antler deer, thanks to the biologically active substances contained in it: positively affects the metabolism, activates cellular metabolism, has pronounced anti-anemic properties, increases mental and physical performance. It eases the burden on the cardiovascular system, increases the body's own protective functions.

Lycopene is a natural carotene pigment that gives red-orange-yellow coloration to fruits and vegetables. It is the strongest carotenoid - an antioxidant present in human blood. By biological activity, it is three times higher than β-carotene. Lycopene is not produced by the human body, so it must be ingested with food. As a structural antioxidant, lycopene is part of the cell’s biomembranes. By binding active oxygen species and free radicals, it effectively maintains antioxidant status, reducing the risk of cardiovascular diseases, cancer, liver pathologies, endocrine systems, etc. Lycopene is recommended for all persons at risk for cardiovascular and oncological diseases, with problems of the prostate and potency. In addition, a unique property was discovered in lycopene - it contributes to the production in the cells of their own interferon, their own protective agent that enhances human immunity.

Vitamin E is one of our most powerful allies in protecting our body against free radicals. Free radicals are extremely unstable and destructive molecules, leading our body cells to oxidative stress, causing continuous damage to them, which ultimately leads to cell death. Vitamin E protects cell membranes. Due to this property, it improves blood circulation, helps prevent blood clots, improves immunity, improves brain function, is effective in various skin diseases, has a rejuvenating effect, and delays the aging process. Vitamin E deficiency reduces the seed concentration in men, disrupts the regularity of the cycle in women.

L-arginine is an essential amino acid that is part of many proteins, including connective tissue.

At one time, arginine was called the most powerful amino acid in cardiology. This amino acid regulates the state of the vascular bed, improves blood microcirculation, participates in the process of regulating blood pressure, and is able to affect vascular tone. It is essential for the normal functioning of the cardiovascular system, nervous system and liver. Relaxing the smooth muscles of all blood vessels, arginine provides normal blood flow and oxygen delivery to the brain, heart muscle, and limbs. Arginine safely lowers cholesterol and prevents the development of atherosclerosis.

In addition, L-arginine has a detoxifying, immunomodulating, geroprotective, reparative and wound healing property. Restores the structure of bone tissue, stimulates the production of growth hormone, increases muscle mass, while reducing the mass of adipose tissue, helps to normalize the condition of connective tissue, increases potency and stimulates spermatogenesis.

Zinc is one of the vital trace elements. It is necessary for the normal functioning of any cell in the body.

Most of it is located in the skin, liver, kidneys, retina, and in men, in addition, in the prostate gland.

It has been established that with age, the level of zinc in the body decreases. Dizziness, constant tinnitus, hearing loss, fragility of skin capillaries - all these are possible consequences of zinc deficiency in the body. Age-related progression of atherosclerosis, weakened immunity, and protracted infectious diseases are also associated with zinc deficiency.

Zinc is indicated for enlarged prostate gland (prostate adenoma). It helps to reduce it and alleviates the symptoms of the disease. Zinc helps get rid of acne. Zinc deficiency weakens the gum's resistance to bacteria, as a result of which chronic gum infections can develop.

Zinc deficiency also disrupts the absorption of glucose by the lens cells of the eye and contributes to the formation of cataracts. Even a slight lack of zinc in the body can lower the ability of the immune system to resist tumor cells. In patients with lung cancer, prostate cancer and colon cancer, zinc levels are often lowered. It is believed that zinc also has antioxidant properties, and also improves the action of other antioxidants, in particular, helps to absorb vitamin E and maintain a normal concentration of this vitamin in the blood.

Thus, the introduction of lycopene, zinc, vitamin E, and L-arginine into the dietary supplement formulation together with lyophilized antler deer blood plasma allows one to obtain a biologically active supplement with a favorable complex of effects on the human body.

The claimed formulation of dietary supplements is optimized by the quantitative ratio of its constituent ingredients. An increase in the amount of additives of animal origin (blood plasma) in excess of the declared impractical, because according to the total number of biologically active substances, the composition will be closer to drugs in action. Reducing the amount of additives below the stated is also impractical, because leads to a decrease in its biological value.

Due to the fact that the daily dose of vitamins, amino acids, carotenoids and minerals must be regulated, the quantitative composition of vitamin E, L-arginine, lycopene and zinc is limited by the proposed formulation.

A dietary supplement contains components that provide a wide range of effects on the human body, due to the fact that each component in the formulation performs several functions.

The claimed biologically active additive has a tonic, restorative, immunostimulating, antioxidant, and adaptogenic effect. Compensates for energy consumption during mental and physical overwork, is an additional source of L-arginine, vitamin E and zinc, supports the nervous, cardiovascular and genitourinary systems. The drug regulates various biological processes, protects the body from foreign elements, viruses, bacteria, has anti-anemic and anti-aging effect.

Thus, the complex, combined use of vitamin E, zinc, lycopene, L-arginine and lyophilized antler deer blood plasma containing substances of various biological activity, together allow you to get a new biologically active supplement with a wide spectrum of effects on the human body, which beneficially affects nervous, cardiovascular, immune and genitourinary systems, as well as expand the range of dietary supplements, i.e. solve the problem.

In more detail, the proposed solution is described using an example of a specific implementation, not limiting the invention.

Norms of loading on 27 kg:

Lyophilized Plasma maral blood 10.0 kg Vitamin E 0.9 kg Zinc citrate trihydrate (source of zinc) 1.2 kg Lycopene 1,5 kg L-arginine 5.0 kg Microcrystalline cellulose 3.6 kg Calcium stearate 0.25 kg Calcium hydrogen phosphate 4,55 kg

The preparation of dietary supplements in the form of capsules is carried out according to known technology using standard excipients. In this example, it can be: microcrystalline cellulose, calcium stearate, anhydrous calcium hydrogen phosphate.

Lyophilized maral blood plasma is sieved through a sieve with a hole diameter of 1 mm, L-arginine through a silk sieve No. 11, microcrystalline cellulose, zinc citrate trihydrate and vitamin E through a silk sieve No. 23, calcium stearate and calcium hydrogen phosphate anhydrous through a silk sieve No. 38.

Next, the estimated amount of ingredients is loaded into a mixer for bulk powder products CM-V100 RE and mixed for 30 minutes. The resulting mixture, the mixture is Packed in hard gelatin capsules No. 0. Capsules are polished by passing through a polishing machine and packaged in blisters.

Industrial applicability.

The components of the dietary supplement are manufactured by industry. Production of dietary supplements is carried out in a manner known in the art using known equipment, that is, the proposal has industrial applicability.

The beneficial effect of using the invention is that the range of domestic biologically active additives is expanding, which have a beneficial effect on the nervous, cardiovascular, genitourinary and immune systems of a person.

Claims (1)

A biologically active additive of general strengthening action, characterized in that it is made in the form of a capsule containing lyophilized blood plasma of antler deer, vitamin E, zinc citrate trihydrate, lycopene, L-arginine and excipients in the following ratio of components in grams per capsule, weight 0 , 27 g:
Lyophilized Plasma antler deer blood 0.05-0.1 Vitamin E 0.001-0.01 Zinc citrate trihydrate 0.0012-0.012 Lycopene 0.0005-0.015 L-arginine 0.05-0.1 Excipients Rest