RU2295967C1 - Mouth cavity treatment agent for aged and old individuals - Google Patents

Abstract

FIELD: pharmacology, stomatology.

SUBSTANCE: claimed agent represents aqueous extract of common Saint-John's wort grass, burnet bloodwort rootstock, common juniper fruits, and foalfoot leaves taken in equal ratio. Agent of present invention is useful in prophylaxis and treatment of mouth cavity mucous and periodontum tissues in aged and old individuals which use dental prosthesis.

EFFECT: agent of excellent anti-inflammation, antibacterial, anthemorrhagic action without losses of natural microflora in mouth cavity.

2 ex, 2 tbl

Description

The invention relates to medicine, in particular to dentistry, and for the creation of collections of medicinal plants, which can be used for the treatment and prevention of inflammatory diseases of the oral cavity.

The contingent of elderly and senile patients using various orthopedic structures is constantly increasing. Removable and non-removable prostheses and the materials from which they are made can have a negative effect on the mucous membrane of the oral cavity and periodontal tissue, which causes inflammatory processes (5). At the same time, the attention of an orthopedic surgeon is often directed to the treatment of complications that arose after the application of prostheses, while their prevention is no less important. If prophylactic measures are not taken before and after prosthetics that strengthen the oral mucosa and periodontal tissue, then the resulting inflammatory phenomena cause discomfort to the patient and contribute to the enhanced development of the bacterial flora in the oral cavity (2). With the unhygienic content of the oral cavity, the therapeutic goals of prosthetics cannot be achieved (3).

Mechanical cleaning of the oral cavity using toothbrushes and toothpicks is not enough, especially for people using removable dentures. In these cases, liquid oral hygiene products are used.

At present, decoctions and infusions from plant materials, for example, oak bark, sage leaves, eucalyptus, chamomile flowers, marigold, St. John's wort and other plants, are widely used to rinse the oral cavity (6).

It is known to use calendula as an anti-inflammatory and bactericidal agent for the treatment and prevention of stomatitis and gingivitis. To rinse the mouth, use an aqueous infusion (10 g of calendula flowers per 1 cup of boiling water) or tincture (1 teaspoon per 1 cup of warm water). Rinsing the mouth is carried out in the morning and in the evening (1).

The disadvantage of this tool is that it has a wide range of therapeutic effects in diseases of the oral cavity. In addition, the use in the composition for rinsing only one of the plant components does not have the proper therapeutic effect in inflammatory diseases of the oral cavity.

The well-known "Composition for the prevention and treatment of diseases of the oral cavity and care for teeth and oral cavity" (RF patent No. 2180555, A 61 K 7/26, 2000. This composition is an aqueous extract of herbs of chamomile, St. John's wort perforated, dried marshmallow, echinacea purpurea, sage leaves, bark of common oak, rhizome of calamus swamp.

The disadvantage of this drug is its lack of antibacterial and salivary fluid.

The basis of the invention is the task of developing an agent with anti-inflammatory, antibacterial, wound healing, hemostatic and salivary fluid action to reduce plaque formation while preserving the natural microflora of the oral cavity, as well as expanding the arsenal of agents for treating inflammatory diseases of the oral cavity in elderly and senile people age using dentures.

The objective is achieved in that the individual oral hygiene in this contingent of persons is carried out using the developed mouth rinse, which is an aqueous extract of the collection of St. John's wort, perforated rhizome, common juniper fruit, coltsfoot leaves at a ratio components 1: 1: 1: 1.

An aqueous extract was prepared as follows: each of the plants was crushed to particle sizes, according to the requirements of the State. Pharmacopoeia XI Edition 2 issues, and prepared from the prepared components collection. One tablespoon of the collection was poured with water (250 ml), insisted on a boiling water bath for 30 minutes, removed from the water bath, cooled at room temperature, filtered, the remainder of the raw material was squeezed and brought up to a volume of 250 ml with hot water. Ready aqueous extract was recommended to rinse the oral cavity 3-4 times a day after meals, and especially at night.

The herb of St. John's wort perforated and the rhizome of the hemorrhagic medicinal have pronounced anti-inflammatory, antibacterial, wound healing and hemostatic properties. Fruits of juniper ordinary - antibacterial and anti-inflammatory effect. Leaves of coltsfoot - anti-inflammatory, antibacterial, wound healing and thinning saliva properties.

This tool does not lead to dysbiosis in the oral cavity, does not irritate the mucous membrane of the oral cavity and periodontal tissue with prolonged use, does not have an allergenic effect.

Good compatibility of these components of the claimed composition with known medicinal properties provides a synergistic effect, leading to the emergence of new properties and a wide range of pharmacological effects leading to the achievement of a technical result.

To determine the effectiveness of these properties of the claimed composition was determined by the Green-Vermillion Hygiene Index (OHI-S), PMA index, Schiller-Pisarev test and microbiological study in comparison with the control (prototype).

We judged the reduction in plaque formation by the Green-Vermillion Hygiene Index (OHI-S) after one and three months.

First, the plaque index was determined by the intensity of staining of the vestibular surface of 16, 11, 21, 26 teeth and lingual surface of 46, 36 teeth. The tartar index and overall index were then determined. Normally, the IG is not more than 1 point. Teeth were stained with Schiller-Pisarev solution, consisting of 1 g of crystalline iodine, 2 g of potassium iodide, 40 ml of distilled water.

Three months after rinsing with the claimed composition in the main group of patients, hygiene index indicators indicated good oral care and corresponded to the optimal value. In about half of the patients in the control group, the IG values after rinsing in the same periods were slightly increased (Table 1).

Table 1. Comparative evaluation of the effectiveness of the claimed and known compositions according to indicators of the hygiene index OHI-S Group IG indicators, points The main (claimed composition) to rinse 2.65 ± 0.11 after rinsing through: 4 weeks 1.05 ± 0.05 3 months 1.00 ± 0.01 Control (known composition) 2.23 ± 0.12 to rinse after rinsing through: 4 weeks 1.16 ± 0.05 3 months 1.52 ± 0.08

The indicated result is also presented in clinical examples. The studies were carried out on the basis of the dental clinic of the Ryazan Acad. I.P. Pavlova.

Example 1

Patient S., 65 years old, turned to the orthopedic dentistry clinic with complaints of difficulty in chewing food. The patient has not been prosthetized before, the allergic history is not burdened.

Objectively:

Dental formula

The bite is orthognathic. The mucous membrane of the oral cavity is pale pink, moderately moist, without pathological changes.

IG (OHI-S) was 2.2 points (poor oral hygiene). The Schiller-Pisarev test is negative.

Diagnosis: partial absence of teeth in the lower jaw, Kennedy class I.

Recommended: to restore the dentition of the lower jaw with a clasp prosthesis with a clam fixation for 45 and 34 teeth.

Treatment: taking impressions from the upper and lower jaws with an alginate mass “Alligat”.

Second visit: fitting and applying a clasp prosthesis to the lower jaw with a clam fixation on 45 and 34 teeth. After applying the finished prosthesis, recommendations were given for the care of the oral cavity and prosthesis. A repeat visit was scheduled after three days.

Three days later: the patient complained of constant severe pain in the lower jaw on the right, which intensified when chewing.

Objectively: on the mucous membrane of the lower jaw from the lingual side in the region of missing 46, 47 teeth there was an aft of 1 × 0.5 cm in size, bleeding when touched, the mucous membrane in the region of the absent 35, 36, 37 and 38 is hyperemic, edematous. A pronounced inflammation of the mucous membrane in the lower jaw was detected, i.e. Schiller-Pisarev test is strongly positive. IG (OHI-S) was 2.5 points (poor oral hygiene).

Treatment: they performed the correction of the clasp prosthesis and prescribed rinsing of the oral cavity with the proposed tool at least 3 times a day.

Next visit: already on the second day after applying the proposed remedy, the pain was weak and only when chewing. With an objective study, the afta significantly decreased in size, did not bleed when touched, the Schiller-Pisarev test was weakly positive. IG (OHI-S) was 1.6 points (satisfactory hygiene). Prosthesis correction was no longer performed.

2 weeks after rinsing: the patient did not show complaints. Objectively: aphthae and new pathological elements were not found, the Schiller-Pisarev test is negative. IG (OHI-S) amounted to 1.03 points (good hygienic condition), which indicates the complete elimination of the inflammatory process in the oral mucosa and a decrease in the formation of plaque.

The patient was under observation for 3 months with a follow-up examination 1 and 3 months after rinsing. Complaints are not noted.

Objectively: the Schiller-Pisarev test is negative, the IG (OHI-S) was 1.0 points, i.e. stable good hygienic condition, the mucous membrane of the oral cavity is pale pink, without pathological changes, i.e. fine.

Example 2

Patient K., 60 years old, turned to the orthopedic dentistry clinic with complaints of difficulty chewing food, aesthetic deficiency, bleeding gums when brushing your teeth. Previously prosthetized 10 years ago, an allergic history is not burdened.

Objectively:

Dental formula

The bite is straight.

Crowns on the 17th, 14th, 23rd and 26th teeth do not reach the level of the gingival margin by 2 mm. The mucous membrane of the gums in the region of 17, 14, 23 and 26 teeth is hyperemic, edematous, bleeds when probed. When conducting the PMA index revealed a moderate severity of gingivitis. IG (OHI-S) was 2.4 points (poor oral hygiene).

Diagnosis: partial absence of teeth in the upper jaw, Kennedy class III.

Recommended by:

1) removal of the "old" stamped-brazed bridges with support for 17, 14, 23 and 26 teeth;

2) the manufacture of new stamped-brazed bridges with support for 17, 14, 23 and 26 teeth.

Treatment: removal of stamped-brazed bridges with support on 17, 14, 23 and 26 teeth; preparation of 17, 14, 23 and 26 teeth for stamped metal crowns, casting of impressions from the upper and lower jaws with the Alginate alginate mass. It was recommended to rinse the oral cavity with the proposed tool 3 times a day.

The second visit in five days: Objectively: revealed a decrease in inflammation of the mucous membrane of the gums in the area of the prepared teeth: swelling and bleeding were absent. After the RMA index, a mild severity of gingivitis was revealed. IG (OHI-S) was 1.7 points (satisfactory hygiene).

Treatment: fitting stamped metal crowns for 17, 14, 23 and 26 teeth, taking an impression from the upper jaw with the Alginate alginate mass. Continue rinsing the oral cavity with the proposed composition.

Next visit after 3 days: the patient had no complaints. Objectively: the signs of inflammation were completely eliminated, the gums in the areas of 17, 14, 23 and 26 were pale pink. After the RMA index, the mucous membrane of the gum was colored straw yellow, i.e. no signs of gingivitis were detected. IG - 1.02 points, which corresponded to good oral hygiene.

Treatment: fitting stamped-brazed bridges with support for 17, 14, 23 and 26 teeth.

After one and three months: Objectively: the PMA index is a negative sample, i.e. no signs of gingivitis. IG - 1.0 point, i.e. good hygiene, the mucous membrane of the gums is pale pink, i.e. fine.

As a result of rinsing with the proposed agent after a microbiological study, the composition of the natural microflora of the oral cavity has not changed. The inventive tool kills more than 10 pathogens, including fungi. Together with this, it promotes the growth of lactobacilli - 10 ³ , i.e. preserves the natural microflora. This property allows you to restore the normal microbiocenosis of the oral cavity.

Thus, the above examples indicate a positive effect of the new composition on the tissues of the teeth and periodontium in the elderly and those using dentures. The proposed composition was applied in 15 patients. The results of these observations are presented in Tables 1, 2.

Table 2. Comparative evaluation of the effectiveness of the claimed and known compositions according to the indicators of the RMA index Group of patients Number of patients RMA index,% before treatment after treatment Main (claimed composition) fifteen 36.5 ± 2.8 9.1 ± 0.8 Control (known composition) fifteen 35.6 ± 2.3 20.3 ± 1.7

Thus, the claimed tool leads to a decrease in the formation of plaque, thereby reducing the intense damage to teeth by caries, unlike control, and allows to reduce the spread and intensity of inflammation in the gums, as evidenced by the dynamics of the PMA index.

This tool has a pronounced anti-inflammatory, antibacterial, wound healing, hemostatic and saliva-thinning effect, which allowed it to be successfully used for the prevention and treatment of diseases of the oral mucosa, periodontium and teeth in elderly and elderly people who use dentures, with the achievement of an effect superior to such known means used for a similar purpose.

Information sources

1. N.V. Kuryakina, N.A. Saveliev. Dentistry is prophylactic. - Publishing house NGMA, 2005 - p.210-214.

2. Yu.U. Ergashev. Hygienic evaluation of the effectiveness of the use of decoctions from plants for inflammation of the oral mucosa and bleeding of the gums after prosthetics // Siberia-East.-July-August 2001. - P.32-33.

3. Kratochivil F.J. Partial removable dentures. Partial removable prosthodontics. Philadelphia, 1988.207 RUR

4. V. G. Makarova, E. N. Yakusheva, D. G. Uzbekova, K. V. Savilov, A. A. Nikiforov Recipe, textbook. pos. - Ryazan, 2005 - p.127-129.

5. Gozhaya L.D., Isaeva N.P., Gozhiy A.G. The state of factors of nonspecific resistance of the body in elderly and senile patients with prosthetic stomatitis - Dentistry - 1995 - No. 6. S.52-54.

6. N.V. Kuryakina, O.A. Alekseeva, T.A. Tretyakova, V.G. Makarova. Medicinal plants and beekeeping products used in dentistry. - M.: Medical book, N. Novgorod, Publishing House NGMA, 2000 - p.22-180.

Claims (1)

Means for rinsing the oral cavity for the elderly and senile, characterized in that it is an aqueous extract of perforated St. John's wort grass, the blood rhizome rhizome, common juniper fruit and coltsfoot leaves in the following ratio of components, parts by weight: Hypericum perforatum herb one Rhizome one Juniperus fruits one Leaves mother and stepmother one