RU2022100782A - Способы лечения злокачественной опухоли с использованием соединений пиримидина и пиридина с btk ингибирующей активностью - Google Patents
Способы лечения злокачественной опухоли с использованием соединений пиримидина и пиридина с btk ингибирующей активностью Download PDFInfo
- Publication number
- RU2022100782A RU2022100782A RU2022100782A RU2022100782A RU2022100782A RU 2022100782 A RU2022100782 A RU 2022100782A RU 2022100782 A RU2022100782 A RU 2022100782A RU 2022100782 A RU2022100782 A RU 2022100782A RU 2022100782 A RU2022100782 A RU 2022100782A
- Authority
- RU
- Russia
- Prior art keywords
- pyrimidine
- phenoxyphenyl
- amino
- methyl
- pharmaceutically acceptable
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (5)
1. Применение терапевтически эффективного количества соединения, выбранного из N-[(1-акрилоилпиперидин-4-ил)метил]-5-(4-феноксифенил)пиримидин-4,6-диамина (А250) и 1-(4-(((6-амино-5-(4-феноксифенил)пиримидин-4-ил)амино)метил)-4-фторпиперидин-1-ил)проп-2-ен-1-она (А225), их фармацевтически пригодных солей, таутомеров и стереоизомеров, в том числе их смесей во всех соотношениях, для лечения или предотвращения миелопролиферативных нарушений или злокачественной опухоли.
2. Применение по п.1, где соединение представляет собой N-[(1-акрилоилпиперидин-4-ил)метил]-5-(4-феноксифенил)пиримидин-4,6-диамин (А250), его фармацевтически пригодные соли, таутомеры и стереоизомеры, в том числе их смеси во всех соотношениях.
3. Применение по п.1, где соединение представляет собой 1-(4-(((6-амино-5-(4-феноксифенил)пиримидин-4-ил)амино)метил)-4-фторпиперидин-1-ил)проп-2-ен-1-он (А225), его фармацевтически пригодные соли, таутомеры и стереоизомеры, в том числе их смеси во всех соотношениях.
4. Применение по пп. 1, 2 или 3, где соединение применяют в качестве компонента фармацевтической композиции в сочетании с фармацевтически приемлемым носителем.
5. Применение по пп. 1, 2, 3 или 4, где злокачественная опухоль выбрана из острого миелолейкоза и хронического лимфоцитарного лейкоза.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562250575P | 2015-11-04 | 2015-11-04 | |
| US62/250,575 | 2015-11-04 | ||
| US201662296143P | 2016-02-17 | 2016-02-17 | |
| US62/296,143 | 2016-02-17 | ||
| US201662341189P | 2016-05-25 | 2016-05-25 | |
| US62/341,189 | 2016-05-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018120153A Division RU2765154C2 (ru) | 2015-11-04 | 2016-11-04 | Способы лечения злокачественной опухоли с использованием соединений пиримидина и пиридина с btk ингибирующей активностью |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2022100782A true RU2022100782A (ru) | 2022-02-03 |
Family
ID=57442803
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2022100782A RU2022100782A (ru) | 2015-11-04 | 2016-11-04 | Способы лечения злокачественной опухоли с использованием соединений пиримидина и пиридина с btk ингибирующей активностью |
| RU2018120153A RU2765154C2 (ru) | 2015-11-04 | 2016-11-04 | Способы лечения злокачественной опухоли с использованием соединений пиримидина и пиридина с btk ингибирующей активностью |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018120153A RU2765154C2 (ru) | 2015-11-04 | 2016-11-04 | Способы лечения злокачественной опухоли с использованием соединений пиримидина и пиридина с btk ингибирующей активностью |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US20170119766A1 (ru) |
| EP (2) | EP3371165B1 (ru) |
| JP (4) | JP6913100B2 (ru) |
| KR (1) | KR20180073599A (ru) |
| CN (1) | CN108779095A (ru) |
| AU (3) | AU2016349584B9 (ru) |
| BR (1) | BR112018007604B1 (ru) |
| CA (1) | CA3001735A1 (ru) |
| CY (1) | CY1125116T1 (ru) |
| DK (1) | DK3371165T3 (ru) |
| ES (1) | ES2912059T3 (ru) |
| HU (1) | HUE058323T2 (ru) |
| IL (2) | IL293093B2 (ru) |
| LT (1) | LT3371165T (ru) |
| MX (2) | MX2018005461A (ru) |
| NZ (1) | NZ741293A (ru) |
| PL (1) | PL3371165T3 (ru) |
| RS (1) | RS63146B1 (ru) |
| RU (2) | RU2022100782A (ru) |
| SG (2) | SG11201802927VA (ru) |
| SI (1) | SI3371165T1 (ru) |
| TW (2) | TWI783915B (ru) |
| WO (1) | WO2017079542A1 (ru) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2022100782A (ru) * | 2015-11-04 | 2022-02-03 | Мерк Патент Гмбх | Способы лечения злокачественной опухоли с использованием соединений пиримидина и пиридина с btk ингибирующей активностью |
| NZ741294A (en) * | 2015-11-17 | 2023-07-28 | Merck Patent Gmbh | Methods for treating multiple sclerosis using pyrimidine and pyridine compounds with btk inhibitory activity |
| AU2018263921A1 (en) * | 2017-05-03 | 2019-12-05 | Vivace Therapeutics, Inc. | Non-fused tricyclic compounds |
| CA3104191A1 (en) * | 2018-06-19 | 2019-12-26 | Merck Patent Gmbh | Novel crystalline forms of 1-(4-{[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-4-fluoro-piperidin-1-yl)-propenone, salt forms thereof, and processes to obtain |
| CR20210045A (es) | 2018-07-25 | 2021-06-18 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
| AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
| BR112023002031A2 (pt) | 2020-08-14 | 2023-03-07 | Novartis Ag | Derivados de espiropiperidinila substituídos por heteroarila e usos farmacêuticos dos mesmos |
| CN112250666B (zh) * | 2020-10-09 | 2022-01-14 | 广东东阳光药业有限公司 | 取代的嘧啶类化合物及其用途 |
| WO2022206939A1 (zh) * | 2021-04-03 | 2022-10-06 | 海南耀臻生物医药科技有限公司 | 作为fgfr抑制剂的杂环化合物及其应用 |
| US11866421B2 (en) | 2021-05-31 | 2024-01-09 | Epigen Biosciences, Inc. | Pyrimidine and pyridine amine compounds and usage thereof in disease treatment |
| WO2023247774A1 (en) | 2022-06-24 | 2023-12-28 | Merck Patent Gmbh | Treatment regimen for autoimmune diseases and inflammatory diseases |
| US20240067627A1 (en) | 2022-08-03 | 2024-02-29 | Novartis Ag | Nlrp3 inflammasome inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19649896A1 (de) * | 1996-12-02 | 1998-06-04 | Henkel Kgaa | Geformte Seifenprodukte |
| TW520362B (en) * | 1996-12-05 | 2003-02-11 | Amgen Inc | Substituted pyrimidine compounds and pharmaceutical composition comprising same |
| JP4937112B2 (ja) * | 2004-03-30 | 2012-05-23 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｊａｋおよび他のプロテインキナーゼの阻害剤として有用なアザインドール |
| EP2211615A4 (en) * | 2007-10-22 | 2010-10-13 | Glaxosmithkline Llc | PYRIDOSULFONAMIDE DERIVATIVES AS PI3 KINASE INHIBITORS |
| AR071717A1 (es) | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
| SG194219A1 (en) * | 2011-06-10 | 2013-11-29 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
| TW201414734A (zh) * | 2012-07-10 | 2014-04-16 | Takeda Pharmaceutical | 氮雜吲哚衍生物 |
| WO2014093230A2 (en) * | 2012-12-10 | 2014-06-19 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
| US8895750B2 (en) * | 2013-03-14 | 2014-11-25 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as BTK inhibitors |
| JP6494633B2 (ja) * | 2013-09-22 | 2019-04-03 | キャリター・サイエンシーズ・リミテッド・ライアビリティ・カンパニーＣａｌｉｔｏｒ Ｓｃｉｅｎｃｅｓ， Ｌｌｃ | 置換されているアミノピリミジン化合物および使用方法 |
| GB201404987D0 (en) * | 2014-03-20 | 2014-05-07 | Redx Pharma Ltd | Compounds |
| RU2022100782A (ru) * | 2015-11-04 | 2022-02-03 | Мерк Патент Гмбх | Способы лечения злокачественной опухоли с использованием соединений пиримидина и пиридина с btk ингибирующей активностью |
| NZ741294A (en) * | 2015-11-17 | 2023-07-28 | Merck Patent Gmbh | Methods for treating multiple sclerosis using pyrimidine and pyridine compounds with btk inhibitory activity |
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- 2016-11-04 RU RU2022100782A patent/RU2022100782A/ru unknown
- 2016-11-04 PL PL16804956T patent/PL3371165T3/pl unknown
- 2016-11-04 KR KR1020187013350A patent/KR20180073599A/ko active Pending
- 2016-11-04 CA CA3001735A patent/CA3001735A1/en active Pending
- 2016-11-04 HU HUE16804956A patent/HUE058323T2/hu unknown
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- 2016-11-04 DK DK16804956.7T patent/DK3371165T3/da active
- 2016-11-04 CN CN201680077336.5A patent/CN108779095A/zh active Pending
- 2016-11-04 RS RS20220376A patent/RS63146B1/sr unknown
- 2016-11-04 RU RU2018120153A patent/RU2765154C2/ru active
- 2016-11-04 LT LTEPPCT/US2016/060508T patent/LT3371165T/lt unknown
- 2016-11-04 SI SI201631518T patent/SI3371165T1/sl unknown
- 2016-11-04 EP EP16804956.7A patent/EP3371165B1/en active Active
- 2016-11-04 TW TW105135943A patent/TWI783915B/zh active
- 2016-11-04 MX MX2018005461A patent/MX2018005461A/es unknown
- 2016-11-04 BR BR112018007604-0A patent/BR112018007604B1/pt active IP Right Grant
- 2016-11-04 ES ES16804956T patent/ES2912059T3/es active Active
- 2016-11-04 JP JP2018543055A patent/JP6913100B2/ja active Active
- 2016-11-04 WO PCT/US2016/060508 patent/WO2017079542A1/en active Application Filing
- 2016-11-04 EP EP22152631.2A patent/EP4014977A1/en active Pending
- 2016-11-04 IL IL293093A patent/IL293093B2/en unknown
- 2016-11-04 SG SG10202005292UA patent/SG10202005292UA/en unknown
- 2016-11-04 US US15/343,570 patent/US20170119766A1/en not_active Abandoned
- 2016-11-04 NZ NZ741293A patent/NZ741293A/en unknown
- 2016-11-04 TW TW111140026A patent/TWI858413B/zh active
- 2016-11-04 AU AU2016349584A patent/AU2016349584B9/en active Active
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- 2018-04-26 IL IL258979A patent/IL258979B/en unknown
- 2018-04-30 MX MX2021015826A patent/MX2021015826A/es unknown
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- 2020-03-05 US US16/809,850 patent/US11491153B2/en active Active
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- 2021-04-16 US US17/232,383 patent/US20210244736A1/en not_active Abandoned
- 2021-07-09 JP JP2021113947A patent/JP7295169B2/ja active Active
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- 2023-05-30 AU AU2023203377A patent/AU2023203377A1/en active Pending
- 2023-06-08 JP JP2023094794A patent/JP2023105214A/ja active Pending
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