[go: up one dir, main page]

RU2018128384A - Конъюгат антитело-лекарственное средство - Google Patents

Конъюгат антитело-лекарственное средство Download PDF

Info

Publication number
RU2018128384A
RU2018128384A RU2018128384A RU2018128384A RU2018128384A RU 2018128384 A RU2018128384 A RU 2018128384A RU 2018128384 A RU2018128384 A RU 2018128384A RU 2018128384 A RU2018128384 A RU 2018128384A RU 2018128384 A RU2018128384 A RU 2018128384A
Authority
RU
Russia
Prior art keywords
connugate
medicinal product
drug
compound
following formula
Prior art date
Application number
RU2018128384A
Other languages
English (en)
Other versions
RU2776489C2 (ru
RU2018128384A3 (ru
Inventor
Такеси МАСУДА
Хиройуки НАИТО
Такаси НАКАДА
Масао Йосида
Синдзи АСИДА
Хидеки МИЯЗАКИ
Юдзи КАСУЯ
Кодзи МОРИТА
Юки АБЕ
Юсуке ОГИТАНИ
Original Assignee
Дайити Санкио Компани, Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50477169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2018128384(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дайити Санкио Компани, Лимитед filed Critical Дайити Санкио Компани, Лимитед
Publication of RU2018128384A publication Critical patent/RU2018128384A/ru
Publication of RU2018128384A3 publication Critical patent/RU2018128384A3/ru
Application granted granted Critical
Publication of RU2776489C2 publication Critical patent/RU2776489C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68037—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a camptothecin [CPT] or derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Claims (9)

1. Соединение HO-CH2-C(=O)-(NH-DX),
где -(NH-DX) представляет собой группу, представленную следующей формулой:
Figure 00000001
где атом азота аминогруппы в положении 1 является положением присоединения.
2. Применение соединения HO-CH2-C(=O)-(NH-DX) для лечения опухоли и/или рака,
где -(NH-DX) представляет собой группу, представленную следующей формулой:
Figure 00000001
где атом азота аминогруппы в положении 1 является положением присоединения.
3. Применение по п. 2, где при переносе противоопухолевого лекарственного средства внутрь опухолевых и/или раковых клеток противоопухолевое лекарственное средство высвобождает производное лекарственного средства NH2-CH2-O-CH2-C(=O)-(NH-DX), где производное лекарственного средства подвергается саморазрушению с высвобождением соединения.
RU2018128384A 2012-10-11 2013-10-10 Конъюгат антитело-лекарственное средство RU2776489C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012225887 2012-10-11
JP2012-225887 2012-10-11

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2015113767A Division RU2664465C2 (ru) 2012-10-11 2013-10-10 Конъюгат антитело-лекарственное средство

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2022119352A Division RU2022119352A (ru) 2012-10-11 2022-07-15 Конъюгат антитело - лекарственное средство

Publications (3)

Publication Number Publication Date
RU2018128384A true RU2018128384A (ru) 2018-10-02
RU2018128384A3 RU2018128384A3 (ru) 2021-12-20
RU2776489C2 RU2776489C2 (ru) 2022-07-21

Family

ID=

Also Published As

Publication number Publication date
KR20220146669A (ko) 2022-11-01
AU2020200548B2 (en) 2022-08-25
CN109081871A (zh) 2018-12-25
SMT201800344T1 (it) 2018-09-13
TWI696611B (zh) 2020-06-21
PH12018501433A1 (en) 2019-02-27
RS60000B1 (sr) 2020-04-30
AU2020200548A1 (en) 2020-02-13
NZ746439A (en) 2019-11-29
TW202448462A (zh) 2024-12-16
KR20180105271A (ko) 2018-09-27
KR101901558B1 (ko) 2018-09-21
KR20210132240A (ko) 2021-11-03
PH12015500667A1 (en) 2015-05-18
EP3632471A1 (en) 2020-04-08
KR102709509B1 (ko) 2024-09-24
BR112015006521B1 (pt) 2022-03-03
AU2018200308B2 (en) 2019-11-07
JP2017036274A (ja) 2017-02-16
DK3342785T3 (da) 2020-03-23
TW201920098A (zh) 2019-06-01
LT3342785T (lt) 2020-02-10
MX2019004502A (es) 2019-08-21
DK2907824T3 (en) 2018-07-23
AU2018200308A1 (en) 2018-02-01
TW202448521A (zh) 2024-12-16
US10973924B2 (en) 2021-04-13
JP6186045B2 (ja) 2017-08-23
KR102237639B1 (ko) 2021-04-07
EP2907824A4 (en) 2016-06-08
US20150297748A1 (en) 2015-10-22
KR102584005B1 (ko) 2023-09-27
EP2907824B1 (en) 2018-04-11
HK1210477A1 (en) 2016-04-22
HRP20180870T1 (hr) 2018-07-13
IL238143B (en) 2020-01-30
RU2015113767A (ru) 2016-12-10
SI3342785T1 (sl) 2020-02-28
US20240082413A1 (en) 2024-03-14
KR20180030734A (ko) 2018-03-23
RS57278B1 (sr) 2018-08-31
KR102052319B1 (ko) 2019-12-05
IL271760B (en) 2022-08-01
US12186310B2 (en) 2025-01-07
JP2020180124A (ja) 2020-11-05
CN113929738B (zh) 2024-05-17
KR20220029776A (ko) 2022-03-08
KR20220100727A (ko) 2022-07-15
BR122021014365B1 (pt) 2022-07-05
BR122021014396B1 (pt) 2022-07-05
TW202033499A (zh) 2020-09-16
MX364484B (es) 2019-04-29
US20190008981A1 (en) 2019-01-10
JP2023011799A (ja) 2023-01-24
IL294622A (en) 2022-09-01
US20200282073A1 (en) 2020-09-10
KR102498405B1 (ko) 2023-02-09
PL2907824T3 (pl) 2018-08-31
TW202444366A (zh) 2024-11-16
NZ705394A (en) 2018-10-26
KR102540419B1 (ko) 2023-06-05
JP2022008581A (ja) 2022-01-13
PT3342785T (pt) 2020-02-25
HUE039000T2 (hu) 2018-12-28
JP6371452B2 (ja) 2018-08-08
JP2018008982A (ja) 2018-01-18
US20250049782A1 (en) 2025-02-13
KR20230142808A (ko) 2023-10-11
KR20240144454A (ko) 2024-10-02
LT2907824T (lt) 2018-06-11
RU2664465C2 (ru) 2018-08-17
CN104755494A (zh) 2015-07-01
CA3021435C (en) 2021-10-12
TW202448464A (zh) 2024-12-16
TW201811746A (zh) 2018-04-01
TWI615152B (zh) 2018-02-21
IL271760A (en) 2020-02-27
TW202448463A (zh) 2024-12-16
JP5953378B2 (ja) 2016-07-20
PH12015500667B1 (en) 2019-03-06
HK1256631A1 (zh) 2019-09-27
JP7523506B2 (ja) 2024-07-26
HUE048748T2 (hu) 2020-08-28
AU2022203560A1 (en) 2022-06-16
ES2773710T3 (es) 2020-07-14
CA2885800A1 (en) 2014-04-17
MY170251A (en) 2019-07-13
TWI650312B (zh) 2019-02-11
IL302494B1 (en) 2024-07-01
NZ740948A (en) 2019-11-29
KR20230024433A (ko) 2023-02-20
KR20150067149A (ko) 2015-06-17
KR20230086800A (ko) 2023-06-15
BR112015006521A2 (ru) 2017-09-05
IL313147A (en) 2024-07-01
TW202448522A (zh) 2024-12-16
MX2020010964A (es) 2020-11-09
KR101841818B1 (ko) 2018-03-26
JP6715888B2 (ja) 2020-07-01
EP3342785B1 (en) 2019-12-25
AU2013328111A1 (en) 2015-03-12
ZA201900820B (en) 2022-08-31
TW202444429A (zh) 2024-11-16
CN109081871B (zh) 2023-07-14
JP2016196484A (ja) 2016-11-24
TW201420117A (zh) 2014-06-01
KR102369419B1 (ko) 2022-03-02
JP6952835B2 (ja) 2021-10-27
KR102417310B1 (ko) 2022-07-05
TR201809636T4 (tr) 2018-07-23
TWI757740B (zh) 2022-03-11
SMT202000138T1 (it) 2020-05-08
IL294622B1 (en) 2023-06-01
KR20200026323A (ko) 2020-03-10
SI2907824T1 (en) 2018-06-29
US20160279259A1 (en) 2016-09-29
JP6030267B1 (ja) 2016-11-24
US11633493B2 (en) 2023-04-25
AU2013328111B2 (en) 2017-11-02
CA3021435A1 (en) 2014-04-17
CN113929738A (zh) 2022-01-14
JP2018188455A (ja) 2018-11-29
JP7170812B2 (ja) 2022-11-14
IL238143A0 (en) 2015-05-31
SG11201502887WA (en) 2015-05-28
TW202448523A (zh) 2024-12-16
TW202444367A (zh) 2024-11-16
KR20190135559A (ko) 2019-12-06
MX2015003903A (es) 2015-07-17
CA2885800C (en) 2018-12-04
AU2022203560B2 (en) 2025-02-06
IL294622B2 (en) 2023-10-01
IL302494A (en) 2023-06-01
IL302494B2 (en) 2024-11-01
TW202444428A (zh) 2024-11-16
RU2018128384A3 (ru) 2021-12-20
CN104755494B (zh) 2018-09-07
CN115960111A (zh) 2023-04-14
CY1120363T1 (el) 2019-07-10
EP3342785A1 (en) 2018-07-04
ZA201501825B (en) 2022-05-25
KR20210038728A (ko) 2021-04-07
EP2907824A1 (en) 2015-08-19
US9808537B2 (en) 2017-11-07
JPWO2014057687A1 (ja) 2016-09-05
KR102320907B1 (ko) 2021-11-02
CY1122789T1 (el) 2021-05-05
KR102456726B1 (ko) 2022-10-20
PT2907824T (pt) 2018-06-07
NZ746440A (en) 2019-11-29
US10195288B2 (en) 2019-02-05
HRP20200353T1 (hr) 2020-06-12
ES2671644T3 (es) 2018-06-07
TW202233186A (zh) 2022-09-01
KR102087017B1 (ko) 2020-03-10
JP2024147681A (ja) 2024-10-16
WO2014057687A1 (ja) 2014-04-17
SG10201804788XA (en) 2018-07-30
PL3342785T3 (pl) 2020-09-07

Similar Documents

Publication Publication Date Title
GEP20237479B (en) Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
RU2019131148A (ru) Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
ME02558B (me) Inhibitori replikacije virusa gripa
NZ729243A (en) Novel glycan conjugates and use thereof
JP2017508782A5 (ru)
AR098912A1 (es) Inhibidores de syk
NZ626618A (en) Hydroxamic acid derivatives and uses thereof
AR110418A1 (es) Conjugados de conector-principio activo (adcs) con grupos escindibles enzimáticamente
EA201300200A1 (ru) N-((6-аминопиридин-3-ил)метил)гетероарилкарбоксамиды в качестве ингибиторов калликреина в плазме
RU2012148909A (ru) Новый синтез соединений тиазолидиндиона
AR087451A1 (es) Derivado de 1,2,3,4-tetrahidroquinolina util para tratamiento de diabetes
CY1119296T1 (el) Ενωση δικαρβοξυλικου οξεος
AR095727A1 (es) Preparación de intermediarios de pirimidina
NZ602710A (en) Use of novel pan-cdk inhibitors for treating tumors
RU2017141536A (ru) Замещенные производные индол-5-ола и их терапевтические применения
TR201900371T4 (tr) Alkilamin türevi.
AR086803A1 (es) Derivados de oxazetidinas, composiciones farmaceuticas y cosmeticas que los contienen y uso de los mismos para tratar enfermedades dermatologicas fundamentalmente, y del aparato respiratorio, digestivo y cardiovascular, entre otras
CY1120728T1 (el) Παραγωγα διαζεπινονης χρησιμα για τη θεραπεια του συνδρομου ευθραυστου χ, της νοσου toy parkinson ή της γαστρο-οισοφαγικης παλινδρομησης
RU2018128384A (ru) Конъюгат антитело-лекарственное средство
AR092627A1 (es) Derivados glucopiranosidos de urea
AR098134A1 (es) Compuestos de urea
WO2013074905A3 (en) Compounds, compositions, pharmaceutical compositions, and methods of use
EA201400269A1 (ru) Способ синтеза соединений 7,8-диметокси -1,3-дигидро-2h-3-бензазепин-2-она и применение в синтезе ивабрадина
MX376321B (es) Usos para el tratamiento de cancer.
WO2012098172A3 (en) N-arylaminomethylene benzothiophenones for treatment of cardiovascular disease