RU2009102845A - Терапевтическое средство при повреждении спинного мозга, включающее антагонист интерлейкина-6 - Google Patents
Терапевтическое средство при повреждении спинного мозга, включающее антагонист интерлейкина-6 Download PDFInfo
- Publication number
- RU2009102845A RU2009102845A RU2009102845/15A RU2009102845A RU2009102845A RU 2009102845 A RU2009102845 A RU 2009102845A RU 2009102845/15 A RU2009102845/15 A RU 2009102845/15A RU 2009102845 A RU2009102845 A RU 2009102845A RU 2009102845 A RU2009102845 A RU 2009102845A
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- RU
- Russia
- Prior art keywords
- antagonist
- interleukin
- differentiation
- subject
- damage
- Prior art date
Links
- 229940124103 Interleukin 6 antagonist Drugs 0.000 title claims abstract 22
- 239000003814 drug Substances 0.000 title 1
- 210000000278 spinal cord Anatomy 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 102000004889 Interleukin-6 Human genes 0.000 claims abstract 15
- 108090001005 Interleukin-6 Proteins 0.000 claims abstract 15
- 230000004069 differentiation Effects 0.000 claims abstract 8
- 210000005036 nerve Anatomy 0.000 claims abstract 6
- 210000004498 neuroglial cell Anatomy 0.000 claims abstract 6
- 210000000130 stem cell Anatomy 0.000 claims abstract 6
- 239000004480 active ingredient Substances 0.000 claims abstract 4
- 230000024245 cell differentiation Effects 0.000 claims abstract 4
- 239000003112 inhibitor Substances 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 239000005557 antagonist Substances 0.000 claims abstract 3
- 229940100601 interleukin-6 Drugs 0.000 claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 claims abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
1. Модулятор дифференцировки нервных стволовых клеток, включающий антагонист интерлейкина-6 (IL-6) в качестве активного ингредиента. ! 2. Ингибитор дифференцировки глиальных клеток, включающий антагонист интерлейкина-6 (IL-6) в качестве активного ингредиента. ! 3. Применение антагониста интерлейкина-6 (IL-6) для приготовления модулятора дифференцировки нервных стволовых клеток. ! 4. Применение антагониста интерлейкина-6 (IL-6) для приготовления ингибитора дифференцировки глиальных клеток. ! 5. Способ модуляции дифференцировки нервных стволовых клеток субъекта, который включает введение субъекту антагониста интерлейкина-6 (IL-6). ! 6. Способ ингибирования дифференцировки глиальных клеток у субъекта, включающий введение субъекту антагониста интерлейкина-6 (IL-6).
Claims (6)
1. Модулятор дифференцировки нервных стволовых клеток, включающий антагонист интерлейкина-6 (IL-6) в качестве активного ингредиента.
2. Ингибитор дифференцировки глиальных клеток, включающий антагонист интерлейкина-6 (IL-6) в качестве активного ингредиента.
3. Применение антагониста интерлейкина-6 (IL-6) для приготовления модулятора дифференцировки нервных стволовых клеток.
4. Применение антагониста интерлейкина-6 (IL-6) для приготовления ингибитора дифференцировки глиальных клеток.
5. Способ модуляции дифференцировки нервных стволовых клеток субъекта, который включает введение субъекту антагониста интерлейкина-6 (IL-6).
6. Способ ингибирования дифференцировки глиальных клеток у субъекта, включающий введение субъекту антагониста интерлейкина-6 (IL-6).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003046214 | 2003-02-24 | ||
| JP2003-046214 | 2003-02-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005130011/15A Division RU2358761C2 (ru) | 2003-02-24 | 2004-02-24 | Терапевтическое средство при повреждении спинного мозга, включающее антагонист интерлейкина-6 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009102845A true RU2009102845A (ru) | 2010-08-10 |
Family
ID=32905544
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005130011/15A RU2358761C2 (ru) | 2003-02-24 | 2004-02-24 | Терапевтическое средство при повреждении спинного мозга, включающее антагонист интерлейкина-6 |
| RU2009102845/15A RU2009102845A (ru) | 2003-02-24 | 2009-01-28 | Терапевтическое средство при повреждении спинного мозга, включающее антагонист интерлейкина-6 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005130011/15A RU2358761C2 (ru) | 2003-02-24 | 2004-02-24 | Терапевтическое средство при повреждении спинного мозга, включающее антагонист интерлейкина-6 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20060165696A1 (ru) |
| EP (1) | EP1607100A4 (ru) |
| JP (1) | JP4555924B2 (ru) |
| KR (1) | KR101142624B1 (ru) |
| CN (2) | CN100340294C (ru) |
| AU (1) | AU2004212843B2 (ru) |
| BR (1) | BRPI0407747A (ru) |
| CA (1) | CA2516945A1 (ru) |
| HR (1) | HRP20050837A2 (ru) |
| IL (3) | IL170399A (ru) |
| MX (1) | MXPA05008713A (ru) |
| NO (1) | NO20054072L (ru) |
| NZ (1) | NZ541928A (ru) |
| PL (1) | PL378199A1 (ru) |
| RU (2) | RU2358761C2 (ru) |
| WO (1) | WO2004073741A1 (ru) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU736282B2 (en) | 1997-03-21 | 2001-07-26 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| JP4364645B2 (ja) | 2002-02-14 | 2009-11-18 | 中外製薬株式会社 | 抗体含有溶液製剤 |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| WO2005090405A1 (ja) | 2004-03-24 | 2005-09-29 | Chugai Seiyaku Kabushiki Kaisha | インターロイキン－６受容体に対するヒト型化抗体のサブタイプ |
| BRPI0617378B8 (pt) * | 2005-10-14 | 2022-09-20 | Chugai Pharmaceutical Co Ltd | Uso de um inibidor de il-6 para produzir uma composição farmacêutica para suprimir dano a um ilhota transplantada depois do transplante de ilhota; e aperfeiçoar a viabilidade de uma ilhota em um transplante de ilhota |
| US8945558B2 (en) * | 2005-10-21 | 2015-02-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for treating myocardial infarction comprising administering an IL-6 inhibitor |
| AR057582A1 (es) * | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
| EP1967209B1 (en) * | 2005-11-25 | 2012-06-06 | Keio University | Therapeutic agent for prostate cancer |
| CN104189907A (zh) | 2006-01-27 | 2014-12-10 | 学校法人庆应义塾 | 伴有脉络膜血管生成的疾病的治疗药 |
| JP5754875B2 (ja) | 2006-04-07 | 2015-07-29 | 国立大学法人大阪大学 | 筋再生促進剤 |
| US20080015465A1 (en) * | 2006-06-15 | 2008-01-17 | Scuderi Gaetano J | Methods for diagnosing and treating pain in the spinal cord |
| CA2657763C (en) * | 2006-08-03 | 2016-05-31 | Vaccinex Inc. | Anti-il-6 monoclonal antibodies and uses thereof |
| CA2675625C (en) * | 2007-01-23 | 2016-09-13 | Shinshu University | Chronic rejection inhibitor |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US7906117B2 (en) * | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| HUE032563T2 (en) * | 2007-05-21 | 2017-09-28 | Alderbio Holdings Llc | Antibodies to IL-6 and their use |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| KR20170036814A (ko) * | 2007-05-21 | 2017-04-03 | 앨더바이오 홀딩스 엘엘씨 | 신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체 |
| US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
| US8252286B2 (en) * | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US7709215B2 (en) * | 2007-06-01 | 2010-05-04 | Cytonics Corporation | Method for diagnosing and treating acute joint injury |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| AU2009246430B2 (en) | 2008-05-13 | 2015-07-02 | Novimmune S.A. | Anti-IL-6/IL-6R antibodies and methods of use thereof |
| TW201503898A (zh) | 2008-06-05 | 2015-02-01 | Chugai Pharmaceutical Co Ltd | 神經浸潤抑制劑 |
| US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| US8323649B2 (en) * | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| CA2773522C (en) | 2009-10-26 | 2023-04-18 | Chugai Seiyaku Kabushiki Kaisha | Method for the production of a glycosylated immunoglobulin |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| US9468676B2 (en) | 2009-11-24 | 2016-10-18 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| HUE060454T2 (hu) | 2010-05-28 | 2023-03-28 | Chugai Pharmaceutical Co Ltd | Daganatellenes T-sejt-választ fokozó szer |
| US8580264B2 (en) | 2010-11-08 | 2013-11-12 | Genentech, Inc. | Subcutaneously administered anti-IL-6 receptor antibody |
| CA2818814A1 (en) | 2010-11-23 | 2012-05-31 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of anemia |
| MX342810B (es) * | 2011-03-03 | 2016-10-13 | Apexigen Inc | Anticuerpos del receptor anti-interleucina-6 (anti-il-6) y sus metodos de uso. |
| WO2015000865A1 (en) | 2013-07-04 | 2015-01-08 | F. Hoffmann-La Roche Ag | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples |
| US11484591B2 (en) | 2016-02-22 | 2022-11-01 | Ohio State Innovation Foundation | Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites |
| WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
| CN110603057A (zh) | 2017-03-17 | 2019-12-20 | 俄亥俄州创新基金会 | 用于递送化学预防剂的纳米颗粒 |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| WO2020201362A2 (en) | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| KR20220064039A (ko) | 2020-11-11 | 2022-05-18 | 정성삼 | 척수 손상 예방 또는 치료용 조성물 |
| KR102320780B1 (ko) | 2021-01-29 | 2021-11-02 | 정성삼 | 척추 통증 완화 및 척추 유연성 개선을 위한 조성물 및 이의 제조방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US521628A (en) | 1894-06-19 | Housekeeping-cabinet | ||
| JP2898040B2 (ja) | 1990-01-26 | 1999-05-31 | 忠三 岸本 | ｇｐ１３０蛋白質に対する抗体 |
| KR100249937B1 (ko) * | 1991-04-25 | 2000-04-01 | 나가야마 오사무 | 인간 인터루킨-6 수용체에 대한 재구성 인간 항체 |
| FR2694767B1 (fr) | 1992-08-13 | 1994-10-21 | Innotherapie Lab Sa | Anticorps monoclonaux anti-IL6R, et leurs applications. |
| US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| WO1995009873A1 (en) | 1993-10-06 | 1995-04-13 | Board Of Regents, The University Of Texas System | A monoclonal anti-human il-6 receptor antibody |
| IT1274350B (it) | 1994-12-06 | 1997-07-17 | Angeletti P Ist Richerche Bio | Antagonisti di interleuchina-6(il-6) che consistono di forme solubili del ricettore alfa di il-6, mutate nell'interfaccia che si lega a gp 130 |
| IT1274782B (it) | 1994-12-14 | 1997-07-24 | Angeletti P Ist Richerche Bio | Metodo per selezionare superagonisti, antagonisti e superantagonisti di ormoni del cui complesso recettoriale fa parte gp 130 |
| US6261560B1 (en) * | 1995-02-13 | 2001-07-17 | Chugai Seiyaku Kabushiki Kaisha | Method for inhibiting muscle protein proteolysis with antibodies to interleukin-6 receptor |
| FR2733250B1 (fr) | 1995-04-21 | 1997-07-04 | Diaclone | Anticorps monoclonaux anti-gp130, et leurs utilisations |
| US5571513A (en) | 1995-05-31 | 1996-11-05 | The Board Of Regents Of The University Of Oklahoma | Anti-gp130 monoclonal antibodies |
| WO1999021574A2 (en) * | 1997-10-27 | 1999-05-06 | Creative Biomolecules, Inc. | Enhancement of morphogen activity |
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| US6419944B2 (en) * | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | Cytokine antagonists for the treatment of localized disorders |
-
2004
- 2004-02-24 CN CNB2004800050170A patent/CN100340294C/zh not_active Expired - Fee Related
- 2004-02-24 PL PL378199A patent/PL378199A1/pl unknown
- 2004-02-24 JP JP2006519063A patent/JP4555924B2/ja not_active Expired - Fee Related
- 2004-02-24 HR HR20050837A patent/HRP20050837A2/xx not_active Application Discontinuation
- 2004-02-24 BR BRPI0407747-4A patent/BRPI0407747A/pt not_active IP Right Cessation
- 2004-02-24 RU RU2005130011/15A patent/RU2358761C2/ru not_active IP Right Cessation
- 2004-02-24 CN CNA2007101481808A patent/CN101130077A/zh active Pending
- 2004-02-24 MX MXPA05008713A patent/MXPA05008713A/es active IP Right Grant
- 2004-02-24 CA CA002516945A patent/CA2516945A1/en not_active Abandoned
- 2004-02-24 NZ NZ541928A patent/NZ541928A/xx not_active IP Right Cessation
- 2004-02-24 US US10/546,149 patent/US20060165696A1/en not_active Abandoned
- 2004-02-24 KR KR1020057015579A patent/KR101142624B1/ko not_active Expired - Fee Related
- 2004-02-24 EP EP04714014A patent/EP1607100A4/en not_active Withdrawn
- 2004-02-24 WO PCT/JP2004/002111 patent/WO2004073741A1/ja active Application Filing
- 2004-02-24 AU AU2004212843A patent/AU2004212843B2/en not_active Ceased
-
2005
- 2005-08-21 IL IL170399A patent/IL170399A/en not_active IP Right Cessation
- 2005-09-01 NO NO20054072A patent/NO20054072L/no not_active Application Discontinuation
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2009
- 2009-01-28 RU RU2009102845/15A patent/RU2009102845A/ru not_active Application Discontinuation
- 2009-07-28 IL IL200098A patent/IL200098A/en not_active IP Right Cessation
-
2010
- 2010-05-09 IL IL205618A patent/IL205618A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2004073741A1 (ja) | 2007-08-23 |
| HRP20050837A2 (en) | 2005-12-31 |
| MXPA05008713A (es) | 2005-09-20 |
| CN100340294C (zh) | 2007-10-03 |
| NZ541928A (en) | 2009-06-26 |
| PL378199A1 (pl) | 2006-03-06 |
| AU2004212843A1 (en) | 2004-09-02 |
| JP4555924B2 (ja) | 2010-10-06 |
| IL200098A (en) | 2012-10-31 |
| IL170399A (en) | 2011-02-28 |
| AU2004212843B2 (en) | 2009-06-25 |
| CN1753694A (zh) | 2006-03-29 |
| NO20054072L (no) | 2005-10-25 |
| NO20054072D0 (no) | 2005-09-01 |
| EP1607100A4 (en) | 2007-06-13 |
| IL205618A (en) | 2012-02-29 |
| CA2516945A1 (en) | 2004-09-02 |
| CN101130077A (zh) | 2008-02-27 |
| KR20060006004A (ko) | 2006-01-18 |
| WO2004073741A1 (ja) | 2004-09-02 |
| RU2358761C2 (ru) | 2009-06-20 |
| US20060165696A1 (en) | 2006-07-27 |
| HK1088230A1 (zh) | 2006-11-03 |
| KR101142624B1 (ko) | 2012-06-15 |
| RU2005130011A (ru) | 2006-02-10 |
| WO2004073741A8 (ja) | 2005-04-07 |
| EP1607100A1 (en) | 2005-12-21 |
| BRPI0407747A (pt) | 2006-02-14 |
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