RS64708B1 - Benzoimidazol-1,2-il amidi kao aktivatori kv7 kanala - Google Patents
Benzoimidazol-1,2-il amidi kao aktivatori kv7 kanalaInfo
- Publication number
- RS64708B1 RS64708B1 RS20230951A RSP20230951A RS64708B1 RS 64708 B1 RS64708 B1 RS 64708B1 RS 20230951 A RS20230951 A RS 20230951A RS P20230951 A RSP20230951 A RS P20230951A RS 64708 B1 RS64708 B1 RS 64708B1
- Authority
- RS
- Serbia
- Prior art keywords
- benzoimidazol
- amides
- channel activators
- activators
- channel
- Prior art date
Links
- 239000012190 activator Substances 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462050023P | 2014-09-12 | 2014-09-12 | |
| EP19185319.1A EP3572405B9 (en) | 2014-09-12 | 2015-09-14 | Benzoimidazol-1,2-yl amides as kv7 channel activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS64708B1 true RS64708B1 (sr) | 2023-11-30 |
Family
ID=55454102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20230951A RS64708B1 (sr) | 2014-09-12 | 2015-09-14 | Benzoimidazol-1,2-il amidi kao aktivatori kv7 kanala |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US9481653B2 (sr) |
| EP (3) | EP3191457B1 (sr) |
| DK (2) | DK3191457T3 (sr) |
| ES (2) | ES2960991T3 (sr) |
| FI (1) | FI3572405T3 (sr) |
| HR (1) | HRP20231071T1 (sr) |
| HU (1) | HUE064331T2 (sr) |
| LT (1) | LT3572405T (sr) |
| PL (1) | PL3572405T3 (sr) |
| PT (1) | PT3572405T (sr) |
| RS (1) | RS64708B1 (sr) |
| SI (1) | SI3572405T1 (sr) |
| SM (1) | SMT202300362T1 (sr) |
| WO (2) | WO2016040952A2 (sr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9650376B2 (en) * | 2013-03-15 | 2017-05-16 | Knopp Biosciences Llc | Imidazo(4,5-B) pyridin-2-yl amides as KV7 channel activators |
| RS64708B1 (sr) | 2014-09-12 | 2023-11-30 | Biohaven Therapeutics Ltd | Benzoimidazol-1,2-il amidi kao aktivatori kv7 kanala |
| SMT202300235T1 (it) * | 2018-02-20 | 2023-11-13 | H Lundbeck As | Derivati alcolici come farmaci che agiscono sui canali del potassio kv7 |
| US10590067B2 (en) | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
| CN112771039A (zh) * | 2018-03-19 | 2021-05-07 | 诺普生物科学有限责任公司 | Kv7通道激活剂组合物和使用方法 |
| AR119521A1 (es) | 2019-08-02 | 2021-12-22 | H Lundbeck As | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
| WO2021041536A1 (en) * | 2019-08-28 | 2021-03-04 | Ferro Therapeutics, Inc. | Benzimidazole and hydrogenated carbazole derivatives as gpx4 inhibitors |
| JP7607864B2 (ja) | 2019-09-17 | 2025-01-06 | バイオヘイブン・セラピューティクス・リミテッド | Ｋｖ７チャネル活性化剤の使用方法 |
| CN118510777A (zh) * | 2022-01-07 | 2024-08-16 | 拜奥海芬治疗学有限公司 | 作为Kv7通道激活剂的吡唑并[1,5-A]吡啶-2,3-基酰胺 |
| WO2024054811A1 (en) * | 2022-09-06 | 2024-03-14 | Biohaven Therapeutics Ltd. | Combination therapies including metal channel activators |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1022554A (en) | 1973-03-07 | 1977-12-13 | Haukur Kristinsson | 1-carbamoyl-2-alkoxycarbonylaminoimidazo (4,5-b) pyridines |
| US4002623A (en) | 1974-08-07 | 1977-01-11 | Pfizer Inc. | Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines |
| ES473201A1 (es) | 1977-09-26 | 1979-03-16 | Degussa | Procedimiento para la preparacion de 7-azabencimidazoles |
| US4391811A (en) | 1981-10-02 | 1983-07-05 | Sterling Drug Inc. | 2-Amino-6-(pyridinyl)-3H-imidazo[4,5-b]pyridines and their cardiotonic use |
| JPH0772181B2 (ja) * | 1989-06-26 | 1995-08-02 | 株式会社大塚製薬工場 | ベンズイミダゾール誘導体 |
| JPH0772181A (ja) | 1993-09-03 | 1995-03-17 | Advantest Corp | 電位波形測定方法および装置 |
| GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
| SK285357B6 (sk) | 1997-09-26 | 2006-11-03 | Zentaris Gmbh | Zlúčeniny na báze azabenzimidazolu modulujúce funkciu serínovej/treonínovej proteínkinázy |
| US20030109549A1 (en) * | 1999-08-05 | 2003-06-12 | Fumitaka Ito | 2-Substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists |
| JP2001199968A (ja) | 2000-01-18 | 2001-07-24 | Teijin Ltd | アミノベンズイミダゾール誘導体 |
| US6384049B1 (en) | 2000-05-25 | 2002-05-07 | The Procter & Gamble Company | Cancer treatment |
| US6855714B2 (en) | 2001-07-06 | 2005-02-15 | Schering Aktiengesellschaft | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives |
| FR2846656B1 (fr) | 2002-11-05 | 2004-12-24 | Servier Lab | Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| SE0301701D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| WO2005021547A2 (en) | 2003-08-28 | 2005-03-10 | Pharmaxis Pty Ltd. | Heterocyclic cannabinoid cb2 receptor antagonists |
| CN101084209A (zh) | 2004-12-21 | 2007-12-05 | 德福根有限公司 | 具有Kv4离子通道活性的化合物 |
| WO2007022305A2 (en) | 2005-08-16 | 2007-02-22 | Pharmacopeia, Inc. | 2-aminoimidazopyridines for treating neurodegenerative diseases |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| CN101778833A (zh) * | 2007-08-10 | 2010-07-14 | 日本曹达株式会社 | 含氮杂环化合物和有害生物防除剂 |
| EP2178373B1 (en) | 2007-08-17 | 2013-01-23 | Icagen, Inc. | Heterocycles as potassium channel modulators |
| PT2409975E (pt) * | 2007-11-22 | 2015-07-27 | Zenyaku Kogyo Kk | Dispersões sólidas compreendendo um corpo amorfo composto por um composto antitumoral heterocíclico |
| GB0723794D0 (en) | 2007-12-05 | 2008-01-16 | Lectus Therapeutics Ltd | Potassium ion channel modulators and uses thereof |
| PE20091268A1 (es) * | 2007-12-19 | 2009-09-19 | Amgen Inc | Derivados heterociclicos como inhibidores de pi3 quinasa |
| WO2010051819A1 (en) * | 2008-11-10 | 2010-05-14 | Neurosearch A/S | Novel 2,3-diamino-quinazolinone derivatives and their medical use |
| US8232273B2 (en) * | 2008-12-19 | 2012-07-31 | Genentech, Inc. | Heterocyclic compounds and methods of use |
| WO2010094645A1 (en) | 2009-02-17 | 2010-08-26 | Neurosearch A/S | Substituted pyridine derivatives and their medical use |
| AR078833A1 (es) | 2009-10-29 | 2011-12-07 | Palau Pharma Sa | Derivados de heteroarilos que contienen nitrogeno como inhibidores dela cinasa jak3 |
| WO2012003576A1 (en) | 2010-07-06 | 2012-01-12 | Université de Montréal | Imidazopyridine, imidazopyrimidine and imidazopyrazine derivatives as melanocortin-4 receptor modulators |
| JP5763758B2 (ja) * | 2010-07-08 | 2015-08-12 | ファイザー・インク | Ｋｖ７カリウムチャネル開口薬としてのピペリジニルピリミジンアミド |
| WO2012018668A1 (en) * | 2010-08-05 | 2012-02-09 | Amgen Inc. | Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase |
| US9650376B2 (en) | 2013-03-15 | 2017-05-16 | Knopp Biosciences Llc | Imidazo(4,5-B) pyridin-2-yl amides as KV7 channel activators |
| RS64708B1 (sr) | 2014-09-12 | 2023-11-30 | Biohaven Therapeutics Ltd | Benzoimidazol-1,2-il amidi kao aktivatori kv7 kanala |
| CN112771039A (zh) * | 2018-03-19 | 2021-05-07 | 诺普生物科学有限责任公司 | Kv7通道激活剂组合物和使用方法 |
| JP7607864B2 (ja) * | 2019-09-17 | 2025-01-06 | バイオヘイブン・セラピューティクス・リミテッド | Ｋｖ７チャネル活性化剤の使用方法 |
-
2015
- 2015-09-14 RS RS20230951A patent/RS64708B1/sr unknown
- 2015-09-14 SI SI201531964T patent/SI3572405T1/sl unknown
- 2015-09-14 EP EP15840730.4A patent/EP3191457B1/en active Active
- 2015-09-14 WO PCT/US2015/050027 patent/WO2016040952A2/en active Application Filing
- 2015-09-14 EP EP23182255.2A patent/EP4289822A3/en active Pending
- 2015-09-14 ES ES19185319T patent/ES2960991T3/es active Active
- 2015-09-14 DK DK15840730.4T patent/DK3191457T3/da active
- 2015-09-14 HU HUE19185319A patent/HUE064331T2/hu unknown
- 2015-09-14 LT LTEP19185319.1T patent/LT3572405T/lt unknown
- 2015-09-14 DK DK19185319.1T patent/DK3572405T3/da active
- 2015-09-14 FI FIEP19185319.1T patent/FI3572405T3/fi active
- 2015-09-14 PL PL19185319.1T patent/PL3572405T3/pl unknown
- 2015-09-14 HR HRP20231071TT patent/HRP20231071T1/hr unknown
- 2015-09-14 SM SM20230362T patent/SMT202300362T1/it unknown
- 2015-09-14 ES ES15840730T patent/ES2749103T3/es active Active
- 2015-09-14 US US14/853,815 patent/US9481653B2/en active Active
- 2015-09-14 PT PT191853191T patent/PT3572405T/pt unknown
- 2015-09-14 EP EP19185319.1A patent/EP3572405B9/en active Active
-
2016
- 2016-10-31 US US15/339,590 patent/US9914708B2/en active Active
-
2017
- 2017-10-31 WO PCT/US2017/059393 patent/WO2018081825A1/en active Application Filing
-
2018
- 2018-01-25 US US15/879,792 patent/US10385025B2/en active Active
-
2019
- 2019-07-02 US US16/460,449 patent/US10906877B2/en active Active
-
2020
- 2020-12-18 US US17/127,231 patent/US11834418B2/en active Active
-
2023
- 2023-10-20 US US18/490,942 patent/US20240300903A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG10201913708XA (en) | Headgear clip arrangement | |
| HK1253372A1 (zh) | 作為bace1抑制劑的2-氨基-3-氟-3-(氟甲基)-6-甲基-6-苯基-3，4，5，6-四氫吡啶 | |
| PL3572405T3 (pl) | Amidy benzoimidazol-1,2-ylowe jako aktywatory kanału kv7 | |
| HK1251395A1 (zh) | 用於多rat聚合的基於多用戶的分離 | |
| ZA201703498B (en) | Kcnq2-5 channel activator | |
| EP3102364B8 (en) | Tensioner | |
| GB201521751D0 (en) | Novel uses | |
| GB201502252D0 (en) | Carrier | |
| AU361320S (en) | Hammock | |
| GB2553987B (en) | Near isothermal machine | |
| GB201503023D0 (en) | Chromosomal instability | |
| GB201401978D0 (en) | Hammock | |
| PL3175066T3 (pl) | Rolka | |
| GB201509039D0 (en) | Near isothermal machine | |
| GB2557371B (en) | Millinery block | |
| PH32015000976S1 (en) | Front-lighted backpack | |
| GB2540733B (en) | Variator | |
| GB201517950D0 (en) | Rucksacks | |
| GB201516198D0 (en) | Rucksacks | |
| GB201512740D0 (en) | Near isothermal machine | |
| ZA201503816B (en) | Tensioning unit | |
| GB201508318D0 (en) | Variators | |
| GB201509327D0 (en) | Variator | |
| AU358031S (en) | Hammock | |
| AU357750S (en) | Hammock |