RS61607B1 - Kompozicije i postupci za nanočestične liofilne oblike - Google Patents
Kompozicije i postupci za nanočestične liofilne oblikeInfo
- Publication number
- RS61607B1 RS61607B1 RS20210355A RSP20210355A RS61607B1 RS 61607 B1 RS61607 B1 RS 61607B1 RS 20210355 A RS20210355 A RS 20210355A RS P20210355 A RSP20210355 A RS P20210355A RS 61607 B1 RS61607 B1 RS 61607B1
- Authority
- RS
- Serbia
- Prior art keywords
- nanoparticle
- compositions
- methods
- lyophile forms
- lyophile
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 239000002105 nanoparticle Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562195356P | 2015-07-22 | 2015-07-22 | |
EP16828602.9A EP3324932B1 (en) | 2015-07-22 | 2016-07-22 | Compositions and methods for nanoparticle lyophile forms |
PCT/US2016/043537 WO2017015552A1 (en) | 2015-07-22 | 2016-07-22 | Compositions and methods for nanoparticle lyophile forms |
Publications (1)
Publication Number | Publication Date |
---|---|
RS61607B1 true RS61607B1 (sr) | 2021-04-29 |
Family
ID=57834582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20210355A RS61607B1 (sr) | 2015-07-22 | 2016-07-22 | Kompozicije i postupci za nanočestične liofilne oblike |
Country Status (23)
Country | Link |
---|---|
US (3) | US10300018B2 (sr) |
EP (1) | EP3324932B1 (sr) |
JP (2) | JP6875373B2 (sr) |
KR (1) | KR102716928B1 (sr) |
CN (2) | CN108024957B (sr) |
AU (1) | AU2016297153B2 (sr) |
CA (1) | CA2992849C (sr) |
CY (1) | CY1123984T1 (sr) |
DK (1) | DK3324932T3 (sr) |
EA (1) | EA035761B1 (sr) |
ES (1) | ES2862191T3 (sr) |
HR (1) | HRP20210523T1 (sr) |
HU (1) | HUE053990T2 (sr) |
IL (2) | IL288342B2 (sr) |
LT (1) | LT3324932T (sr) |
MX (1) | MX373982B (sr) |
PL (1) | PL3324932T3 (sr) |
PT (1) | PT3324932T (sr) |
RS (1) | RS61607B1 (sr) |
SI (1) | SI3324932T1 (sr) |
SM (1) | SMT202100196T1 (sr) |
TW (1) | TWI732773B (sr) |
WO (1) | WO2017015552A1 (sr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6875373B2 (ja) * | 2015-07-22 | 2021-05-26 | 日東電工株式会社 | ナノ粒子凍結乾燥形態のための組成物および方法 |
BR112020011895A2 (pt) | 2017-12-12 | 2020-11-24 | Lead Biotherapeutics Ltd. | nanopartícula de lipídeo sólido para liberação intracelular de substâncias ativas e método para produção da mesma |
CN108813619A (zh) * | 2018-07-19 | 2018-11-16 | 广州市汉廷食品有限公司 | 一种无公害食品添加剂及其制备工艺 |
JP7418419B2 (ja) | 2018-09-28 | 2024-01-19 | ナットクラッカー セラピューティクス, インコーポレイテッド | 核酸送達のための第三級アミノ脂質化カチオン性ペプチド |
ES2972334T3 (es) * | 2018-11-16 | 2024-06-12 | Nitto Denko Corp | Formulación y métodos de administración de interferencia de ARN para tumores malignos |
WO2021060440A1 (ja) * | 2019-09-26 | 2021-04-01 | 日油株式会社 | 脂質ナノ粒子の凍結乾燥組成物 |
WO2022036170A1 (en) | 2020-08-14 | 2022-02-17 | Arcturus Therapeutics, Inc. | Method of lyophilizing lipid nanoparticles |
WO2023064891A1 (en) | 2021-10-14 | 2023-04-20 | Hemoshear Therapeutics, Inc. | Compositions and methods of treating diseases associated with bile acid transporter |
KR102712873B1 (ko) * | 2021-12-20 | 2024-10-04 | 고려자연식품(주) | 과일향기 포집을 위한 나노 지질 전달체 제조와 분말화 방법 |
CN116643056B (zh) * | 2022-02-15 | 2025-02-18 | 厦门万泰凯瑞生物技术有限公司 | 促甲状腺激素受体复合物、试剂盒、制备方法和用途 |
US20240254485A1 (en) | 2023-01-13 | 2024-08-01 | Hemoshear Therapeutics, Inc. | Sirnas targeting slc10a1 transcripts, compositions and uses thereof |
WO2025015189A1 (en) * | 2023-07-13 | 2025-01-16 | Comanche Biopharma Corp. | Formulations of nucleic acid compounds and uses thereof |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4537683A (en) | 1982-02-01 | 1985-08-27 | Rohm And Haas Company | Trihalomethane precursor removal using ion exchange emulsions |
US4537883A (en) | 1982-11-12 | 1985-08-27 | Mead Johnson & Company | Lyophilized cyclophosphamide |
US4927571A (en) | 1987-05-18 | 1990-05-22 | Liposome Technology, Inc. | Preparation of injectable doxorubicin/liposome suspension |
US20040121983A1 (en) | 2002-08-12 | 2004-06-24 | Council Of Scientific And Industrial Research | Method for treating leishmaniasis using methyl-beta-cyclodextrin |
EP2402036B1 (en) | 2002-09-06 | 2018-02-14 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for delivering the therapeutic agents covalently attached thereto |
CA2528411C (en) | 2003-06-04 | 2012-09-04 | Georgetown University | Method for improving stability and shelf-life of liposome complexes |
AU2005302255A1 (en) | 2004-10-28 | 2006-05-11 | Alza Corporation | Lyophilized liposome formulations and method |
CA2587337A1 (en) * | 2004-11-19 | 2006-05-26 | Novosom Ag | Improvements in or relating to pharmaceutical compositions for local administration |
JP5334170B2 (ja) | 2007-02-09 | 2013-11-06 | 国立大学法人 奈良先端科学技術大学院大学 | C70含有リポソームおよびその製造方法、並びにその利用 |
JP5891175B2 (ja) * | 2009-12-11 | 2016-03-22 | バインド セラピューティックス インコーポレイテッド | 治療用粒子の凍結乾燥に対する安定製剤 |
WO2011103150A2 (en) | 2010-02-18 | 2011-08-25 | Cephalon, Inc. | Lyophilized preparations of bendamustine |
US20110237686A1 (en) * | 2010-03-26 | 2011-09-29 | Cerulean Pharma Inc | Formulations and methods of use |
CN102018672B (zh) * | 2010-11-29 | 2013-09-18 | 广州朗圣药业有限公司 | 一种水溶性药物的脂质体冻干组合物及其制备方法 |
ES2795110T3 (es) * | 2011-06-08 | 2020-11-20 | Translate Bio Inc | Lípidos escindibles |
US9011903B2 (en) | 2011-06-08 | 2015-04-21 | Nitto Denko Corporation | Cationic lipids for therapeutic agent delivery formulations |
PT2768484T (pt) | 2011-10-21 | 2019-10-28 | Jazz Pharmaceuticals Res Llc | Lipossomas liofilizados |
EP2773326B1 (en) * | 2011-11-04 | 2019-02-20 | Nitto Denko Corporation | Method for sterilely producing lipid-nucleic acid particles |
US9579338B2 (en) | 2011-11-04 | 2017-02-28 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
RS54513B1 (sr) | 2012-03-28 | 2016-06-30 | Discovery Laboratories, Inc. | Liofilizacija sintetičkog lipozomalnog plućnog surfaktanta |
JP6211054B2 (ja) * | 2012-03-29 | 2017-10-11 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 脂質誘導される中性ナノ粒子 |
RU2658007C2 (ru) | 2012-06-08 | 2018-06-19 | Нитто Денко Корпорейшн | Липиды для композиций для доставки терапевтических агентов |
US20140271815A1 (en) | 2013-03-15 | 2014-09-18 | Aryo Sorayya | Heat-and freeze-stable vaccines and methods of making and using same |
JP6875373B2 (ja) * | 2015-07-22 | 2021-05-26 | 日東電工株式会社 | ナノ粒子凍結乾燥形態のための組成物および方法 |
-
2016
- 2016-07-22 JP JP2018503253A patent/JP6875373B2/ja active Active
- 2016-07-22 US US15/217,098 patent/US10300018B2/en active Active
- 2016-07-22 CN CN201680054543.9A patent/CN108024957B/zh active Active
- 2016-07-22 WO PCT/US2016/043537 patent/WO2017015552A1/en active Application Filing
- 2016-07-22 PL PL16828602T patent/PL3324932T3/pl unknown
- 2016-07-22 KR KR1020187005141A patent/KR102716928B1/ko active Active
- 2016-07-22 EA EA201890367A patent/EA035761B1/ru not_active IP Right Cessation
- 2016-07-22 SI SI201631140T patent/SI3324932T1/sl unknown
- 2016-07-22 SM SM20210196T patent/SMT202100196T1/it unknown
- 2016-07-22 HU HUE16828602A patent/HUE053990T2/hu unknown
- 2016-07-22 LT LTEP16828602.9T patent/LT3324932T/lt unknown
- 2016-07-22 AU AU2016297153A patent/AU2016297153B2/en active Active
- 2016-07-22 ES ES16828602T patent/ES2862191T3/es active Active
- 2016-07-22 MX MX2018000891A patent/MX373982B/es active IP Right Grant
- 2016-07-22 EP EP16828602.9A patent/EP3324932B1/en active Active
- 2016-07-22 IL IL288342A patent/IL288342B2/en unknown
- 2016-07-22 RS RS20210355A patent/RS61607B1/sr unknown
- 2016-07-22 CA CA2992849A patent/CA2992849C/en active Active
- 2016-07-22 TW TW105123227A patent/TWI732773B/zh active
- 2016-07-22 DK DK16828602.9T patent/DK3324932T3/da active
- 2016-07-22 PT PT168286029T patent/PT3324932T/pt unknown
- 2016-07-22 CN CN202110916430.8A patent/CN113679689B/zh active Active
-
2018
- 2018-01-18 IL IL257029A patent/IL257029B/en unknown
-
2019
- 2019-04-05 US US16/377,032 patent/US11737982B2/en active Active
-
2021
- 2021-03-31 CY CY20211100280T patent/CY1123984T1/el unknown
- 2021-03-31 HR HRP20210523TT patent/HRP20210523T1/hr unknown
- 2021-04-22 JP JP2021072339A patent/JP7268079B2/ja active Active
-
2023
- 2023-06-30 US US18/346,115 patent/US20240000710A1/en active Pending
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