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RS57791B1 - Postupci dobijanja za kontrolu sadržaja c-terminalnog lizina, galaktoze i sijalinske kiseline u rekombinovanim proteinima - Google Patents

Postupci dobijanja za kontrolu sadržaja c-terminalnog lizina, galaktoze i sijalinske kiseline u rekombinovanim proteinima

Info

Publication number
RS57791B1
RS57791B1 RS20181228A RSP20181228A RS57791B1 RS 57791 B1 RS57791 B1 RS 57791B1 RS 20181228 A RS20181228 A RS 20181228A RS P20181228 A RSP20181228 A RS P20181228A RS 57791 B1 RS57791 B1 RS 57791B1
Authority
RS
Serbia
Prior art keywords
galactose
control
acid content
sialic acid
manufacturing methods
Prior art date
Application number
RS20181228A
Other languages
English (en)
Inventor
Marcel Flikweert
Charles Goochee
Francis Maslanka
Francisus Johannes Ignatius Nagel
James Ryland
Eugene Schafer
Original Assignee
Janssen Biotech Inc
Janssen Biologics B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51528780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS57791(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Biotech Inc, Janssen Biologics B V filed Critical Janssen Biotech Inc
Publication of RS57791B1 publication Critical patent/RS57791B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54F(ab')2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
RS20181228A 2013-03-15 2014-03-07 Postupci dobijanja za kontrolu sadržaja c-terminalnog lizina, galaktoze i sijalinske kiseline u rekombinovanim proteinima RS57791B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791094P 2013-03-15 2013-03-15
PCT/US2014/021574 WO2014149935A1 (en) 2013-03-15 2014-03-07 Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins
EP14768761.0A EP2970980B2 (en) 2013-03-15 2014-03-07 Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins

Publications (1)

Publication Number Publication Date
RS57791B1 true RS57791B1 (sr) 2018-12-31

Family

ID=51528780

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20181228A RS57791B1 (sr) 2013-03-15 2014-03-07 Postupci dobijanja za kontrolu sadržaja c-terminalnog lizina, galaktoze i sijalinske kiseline u rekombinovanim proteinima

Country Status (27)

Country Link
US (3) US20140273092A1 (sr)
EP (1) EP2970980B2 (sr)
JP (1) JP2016512029A (sr)
KR (1) KR102216003B1 (sr)
CN (1) CN105378086B (sr)
AR (2) AR095660A1 (sr)
AU (2) AU2014237635B2 (sr)
BR (1) BR112015022971B1 (sr)
CA (1) CA2907140A1 (sr)
CY (1) CY1120980T1 (sr)
DK (1) DK2970980T3 (sr)
EA (1) EA201591807A1 (sr)
ES (1) ES2690047T3 (sr)
HR (1) HRP20181741T1 (sr)
IL (1) IL240689B (sr)
LT (1) LT2970980T (sr)
MX (1) MX366910B (sr)
PH (1) PH12015501837B1 (sr)
PL (1) PL2970980T3 (sr)
PT (1) PT2970980T (sr)
RS (1) RS57791B1 (sr)
SG (1) SG11201507577RA (sr)
SI (1) SI2970980T1 (sr)
SM (1) SMT201800550T1 (sr)
TW (1) TWI630216B (sr)
WO (1) WO2014149935A1 (sr)
ZA (1) ZA201507671B (sr)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
US9334319B2 (en) 2012-04-20 2016-05-10 Abbvie Inc. Low acidic species compositions
US9505833B2 (en) 2012-04-20 2016-11-29 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
SG11201507577RA (en) * 2013-03-15 2015-10-29 Janssen Biotech Inc Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins
EP3036254A1 (en) 2013-08-20 2016-06-29 LEK Pharmaceuticals d.d. Cell culture medium and process for controlling -amidation and/or c-terminal amino acid cleavage of polypeptides
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
BR112018008867A8 (pt) 2015-11-03 2019-02-26 Janssen Biotech Inc anticorpos que se ligam especificamente a pd-1 e seus usos
WO2017083224A1 (en) * 2015-11-09 2017-05-18 Bristol-Myers Squibb Company Methods to manipulate quality attributes of polypeptides produced in cho cells
KR20180087430A (ko) 2015-12-17 2018-08-01 얀센 바이오테크 인코포레이티드 Hla-dr에 특이적으로 결합하는 항체 및 이의 용도
SG11201900744SA (en) 2016-08-12 2019-02-27 Janssen Biotech Inc Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them
KR102587941B1 (ko) 2016-08-12 2023-10-11 얀센 바이오테크 인코포레이티드 향상된 효능작용 및 이펙터 기능을 갖는 조작된 항체 및 다른 Fc-도메인 함유 분자
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
EP3634995A4 (en) 2017-06-05 2021-06-09 Janssen Biotech, Inc. ANTIBODIES BINDING SPECIFICALLY TO PD-1 AND THEIR METHODS OF USE
CN110785185B (zh) 2017-06-05 2024-05-24 詹森生物科技公司 具有非对称ch2-ch3区突变的工程化多特异性抗体和其他多聚体蛋白
WO2019077628A1 (en) * 2017-10-16 2019-04-25 Council Of Scientific & Industrial Research ZINC SUPPLEMENTATION TO DECREASE GALACTOSYLATION OF RECOMBINANT GLYCOPROTEINS
JOP20200295A1 (ar) 2018-05-24 2020-11-22 Janssen Biotech Inc أجسام أحادية النوعية ومتعددة النوعية مضادة لـ tmeff2 المضاد واستخداماتها
EA202191840A1 (ru) * 2018-12-31 2021-09-03 Момента Фармасьютикалз, Инк. Способы получения устекинумаба
JP2022541332A (ja) 2019-07-26 2022-09-22 ヤンセン バイオテツク,インコーポレーテツド カリクレイン関連ペプチダーゼ2抗原結合ドメインを含むタンパク質及びその使用
KR20220062494A (ko) 2019-08-15 2022-05-17 얀센 바이오테크 인코포레이티드 개선된 단일 사슬 가변 단편을 위한 재료 및 방법
KR20230051615A (ko) 2020-03-13 2023-04-18 얀센 바이오테크 인코포레이티드 Siglec-3/cd33을 결합시키기 위한 물질 및 방법
KR20230017841A (ko) 2020-05-27 2023-02-06 얀센 바이오테크 인코포레이티드 Cd3 항원 결합 도메인을 포함하는 단백질 및 이의 용도
WO2022024024A2 (en) 2020-07-29 2022-02-03 Janssen Biotech, Inc. Proteins comprising hla-g antigen binding domains and their uses
WO2022081516A1 (en) 2020-10-13 2022-04-21 Janssen Biotech, Inc. Bioengineered t cell mediated immunity, materials and other methods for modulating cluster of differentiation iv &/or viii
US20240025992A1 (en) 2020-10-22 2024-01-25 Janssen Biotech, Inc. Proteins comprising delta-like ligand 3 (dll3) antigen binding domains and their uses
AU2022214491A1 (en) 2021-01-28 2023-09-14 Janssen Biotech, Inc. Psma binding proteins and uses thereof
AU2022244453A1 (en) 2021-03-24 2023-11-09 Janssen Biotech, Inc. Antibody targeting cd22 and cd79b
CN117377694A (zh) 2021-03-24 2024-01-09 詹森生物科技公司 包含cd3抗原结合结构域的蛋白质及其用途
JP2024533457A (ja) 2021-09-13 2024-09-12 ヤンセン バイオテツク,インコーポレーテツド がんの治療のためのCD33×Vδ2多重特異性抗体
US20250019455A1 (en) 2021-09-24 2025-01-16 Pharmaceutica Nv Proteins comprising cd20 binding domains, and uses thereof
AU2022392829A1 (en) 2021-11-22 2024-07-11 Janssen Biotech, Inc. Compositions comprising enhanced multispecific binding agents for an immune response
WO2024089551A1 (en) 2022-10-25 2024-05-02 Janssen Biotech, Inc. Msln and cd3 binding agents and methods of use thereof
WO2025032510A1 (en) 2023-08-07 2025-02-13 Janssen Biotech, Inc. Stabilized cd3 antigen binding agents and methods of use thereof
WO2025032508A1 (en) 2023-08-07 2025-02-13 Janssen Biotech, Inc. Enpp3 and cd3 binding agents and methods of use thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4870163A (en) 1985-08-29 1989-09-26 New York Blood Center, Inc. Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor
DE3631229A1 (de) 1986-09-13 1988-03-24 Basf Ag Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung
EP0288088B1 (en) 1987-04-24 1994-03-09 Teijin Limited Detection of tumor necrosis factor; monoclonal antibody and kit
AU640400B2 (en) 1989-08-07 1993-08-26 Peptide Technology Ltd. Tumour necrosis factor binding ligands
US5919452A (en) 1991-03-18 1999-07-06 New York University Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
DE07006112T1 (de) * 1991-03-18 2010-01-21 New York University Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor
US7192584B2 (en) 1991-03-18 2007-03-20 Centocor, Inc. Methods of treating psoriasis with anti-TNF antibodies
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
CA2450289A1 (en) 2003-03-20 2005-05-19 Imclone Systems Incorporated Method of producing an antibody to epidermal growth factor receptor
US20040185047A1 (en) 2003-03-21 2004-09-23 Jill Giles-Komar Anti- TNF antibodies, compositions, methods and uses
ZA200702434B (en) 2004-11-02 2008-08-27 Ares Trading Sa Serum-free cell culture medium for mammalian cells
ES2517603T3 (es) * 2008-04-07 2014-11-03 Bayer Healthcare, Llc Procedimientos de producción recombinante de glucoproteínas
PL2702164T3 (pl) * 2011-04-29 2016-06-30 Biocon Res Limited Sposób obniżania heterogeniczności przeciwciał i sposób ich wytwarzania
US9475858B2 (en) 2011-07-08 2016-10-25 Momenta Pharmaceuticals, Inc. Cell culture process
US9181572B2 (en) * 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
SG11201507577RA (en) * 2013-03-15 2015-10-29 Janssen Biotech Inc Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins

Also Published As

Publication number Publication date
MX366910B (es) 2019-07-30
DK2970980T3 (en) 2018-10-22
US20160237149A1 (en) 2016-08-18
LT2970980T (lt) 2018-10-25
PL2970980T3 (pl) 2019-01-31
EP2970980A4 (en) 2016-09-07
SG11201507577RA (en) 2015-10-29
US11149085B2 (en) 2021-10-19
CA2907140A1 (en) 2014-09-25
SMT201800550T1 (it) 2019-01-11
WO2014149935A1 (en) 2014-09-25
PH12015501837A1 (en) 2015-11-09
AR095660A1 (es) 2015-11-04
KR20150129025A (ko) 2015-11-18
CN105378086A (zh) 2016-03-02
AR124871A2 (es) 2023-05-17
PH12015501837B1 (en) 2022-02-11
US20220089712A1 (en) 2022-03-24
PT2970980T (pt) 2018-11-19
TW201441263A (zh) 2014-11-01
BR112015022971A2 (pt) 2017-11-14
IL240689B (en) 2021-12-01
EP2970980A1 (en) 2016-01-20
AU2014237635B2 (en) 2020-03-12
KR102216003B1 (ko) 2021-02-16
US20140273092A1 (en) 2014-09-18
EA201591807A1 (ru) 2016-02-29
AU2014237635A1 (en) 2015-09-03
ES2690047T3 (es) 2018-11-19
IL240689A0 (en) 2015-10-29
HRP20181741T1 (hr) 2018-12-28
AU2020203864A1 (en) 2020-07-02
TWI630216B (zh) 2018-07-21
CY1120980T1 (el) 2019-12-11
MX2015012361A (es) 2016-04-28
ZA201507671B (en) 2017-11-29
JP2016512029A (ja) 2016-04-25
SI2970980T1 (sl) 2018-11-30
EP2970980B2 (en) 2022-07-27
BR112015022971B1 (pt) 2022-05-17
CN105378086B (zh) 2019-05-28
AU2020203864B2 (en) 2022-05-26
EP2970980B1 (en) 2018-08-15

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