RS20050793A - 8beta-vinil-11beta-(omega- supstituisani)alkil-estra-1,3,5 (10)- trieni - Google Patents
8beta-vinil-11beta-(omega- supstituisani)alkil-estra-1,3,5 (10)- trieniInfo
- Publication number
- RS20050793A RS20050793A YUP-2005/0793A YUP20050793A RS20050793A RS 20050793 A RS20050793 A RS 20050793A YU P20050793 A YUP20050793 A YU P20050793A RS 20050793 A RS20050793 A RS 20050793A
- Authority
- RS
- Serbia
- Prior art keywords
- trienes
- estra
- vinyl
- substituted
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010073260 Ovarian granulosa cell tumour Diseases 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 230000002254 contraceptive effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 208000015124 ovarian disease Diseases 0.000 abstract 1
- 208000029749 ovarian granulosa cell tumor Diseases 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Predloženi pronalazak se odnosi na 8β-vinil-11 β-(ω-supstituisane)alkil-estratriene opšte formule (I) sa ERβ-antagonističkom aktivnošću, postupak za njihovo dobijanje, njihove međuproizvode, farmaceutske preparate koji sadrže jedinjenja prema pronalasku, kao i njihovu primenu za proizvodnju lekova. Nova jedinjenja se mogu upotrebiti kod muškaraca i žena za kontracepciju, bez da utiču na druge estrogen-senzitivne organe, kao što jetra ili uterus. Ona su takođe pogodna za lečenje dobroćudnih ili zloćudnih proliferativnih oboljenja ovarijuma, kao karcinoma ovarijuma i granuloznih ćelijskih tumora.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10318896A DE10318896A1 (de) | 2003-04-22 | 2003-04-22 | 8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene |
| PCT/EP2004/004086 WO2004094451A2 (de) | 2003-04-22 | 2004-04-16 | 8beta-vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS20050793A true RS20050793A (sr) | 2008-04-04 |
Family
ID=33304956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YUP-2005/0793A RS20050793A (sr) | 2003-04-22 | 2004-04-16 | 8beta-vinil-11beta-(omega- supstituisani)alkil-estra-1,3,5 (10)- trieni |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7375098B2 (sr) |
| EP (1) | EP1622924A2 (sr) |
| JP (1) | JP2006524202A (sr) |
| KR (1) | KR20060005386A (sr) |
| CN (1) | CN100381457C (sr) |
| AR (1) | AR044056A1 (sr) |
| AU (1) | AU2004232462A1 (sr) |
| BR (1) | BRPI0409794A (sr) |
| CA (1) | CA2522354A1 (sr) |
| CL (1) | CL2004000856A1 (sr) |
| CR (1) | CR8053A (sr) |
| DE (1) | DE10318896A1 (sr) |
| EA (1) | EA009606B1 (sr) |
| EC (1) | ECSP056180A (sr) |
| MX (1) | MXPA05011386A (sr) |
| NO (1) | NO20055493L (sr) |
| PE (1) | PE20050423A1 (sr) |
| RS (1) | RS20050793A (sr) |
| UY (1) | UY28284A1 (sr) |
| WO (1) | WO2004094451A2 (sr) |
| ZA (1) | ZA200509447B (sr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1272504T3 (da) * | 2000-04-12 | 2007-10-01 | Bayer Schering Pharma Ag | 8.Beta-hydrocarbylsubstituerede östradiener til anvendelse som selektive östrogener |
| CA2578164A1 (en) | 2004-09-07 | 2006-03-16 | Wyeth | 6h-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents |
| MX2007006653A (es) * | 2005-10-05 | 2009-02-17 | Sicor Inc | Separacion de isomeros de fulvestrant. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE50014299D1 (de) * | 1999-11-02 | 2007-06-14 | Bayer Schering Pharma Ag | 18-nor-steroide als selektiv wirksame estrogene |
| DK1272504T3 (da) * | 2000-04-12 | 2007-10-01 | Bayer Schering Pharma Ag | 8.Beta-hydrocarbylsubstituerede östradiener til anvendelse som selektive östrogener |
| DE10151114A1 (de) * | 2001-10-15 | 2003-04-17 | Schering Ag | 8ß-Substituierte-11ß-aryl-estra-2,3,5(10)-trienderivate |
-
2003
- 2003-04-22 DE DE10318896A patent/DE10318896A1/de not_active Withdrawn
-
2004
- 2004-04-16 WO PCT/EP2004/004086 patent/WO2004094451A2/de active Application Filing
- 2004-04-16 CN CNB2004800106636A patent/CN100381457C/zh not_active Expired - Fee Related
- 2004-04-16 CA CA002522354A patent/CA2522354A1/en not_active Abandoned
- 2004-04-16 JP JP2006505174A patent/JP2006524202A/ja active Pending
- 2004-04-16 AU AU2004232462A patent/AU2004232462A1/en not_active Abandoned
- 2004-04-16 BR BRPI0409794-7A patent/BRPI0409794A/pt not_active IP Right Cessation
- 2004-04-16 RS YUP-2005/0793A patent/RS20050793A/sr unknown
- 2004-04-16 EP EP04727876A patent/EP1622924A2/de not_active Withdrawn
- 2004-04-16 EA EA200501568A patent/EA009606B1/ru not_active IP Right Cessation
- 2004-04-16 KR KR1020057020022A patent/KR20060005386A/ko not_active Application Discontinuation
- 2004-04-16 MX MXPA05011386A patent/MXPA05011386A/es unknown
- 2004-04-22 CL CL200400856A patent/CL2004000856A1/es unknown
- 2004-04-22 US US10/829,390 patent/US7375098B2/en not_active Expired - Fee Related
- 2004-04-22 UY UY28284A patent/UY28284A1/es not_active Application Discontinuation
- 2004-04-22 PE PE2004000399A patent/PE20050423A1/es not_active Application Discontinuation
- 2004-04-22 AR ARP040101360A patent/AR044056A1/es unknown
-
2005
- 2005-10-21 CR CR8053A patent/CR8053A/es not_active Application Discontinuation
- 2005-11-21 NO NO20055493A patent/NO20055493L/no not_active Application Discontinuation
- 2005-11-21 EC EC2005006180A patent/ECSP056180A/es unknown
- 2005-11-22 ZA ZA200509447A patent/ZA200509447B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20050065135A1 (en) | 2005-03-24 |
| MXPA05011386A (es) | 2006-04-18 |
| JP2006524202A (ja) | 2006-10-26 |
| CN100381457C (zh) | 2008-04-16 |
| WO2004094451A2 (de) | 2004-11-04 |
| BRPI0409794A (pt) | 2006-05-30 |
| DE10318896A1 (de) | 2004-11-25 |
| NO20055493L (no) | 2006-01-18 |
| EP1622924A2 (de) | 2006-02-08 |
| AU2004232462A1 (en) | 2004-11-04 |
| PE20050423A1 (es) | 2005-08-13 |
| CL2004000856A1 (es) | 2005-03-28 |
| ZA200509447B (en) | 2009-08-26 |
| AR044056A1 (es) | 2005-08-24 |
| UY28284A1 (es) | 2004-11-30 |
| EA009606B1 (ru) | 2008-02-28 |
| US7375098B2 (en) | 2008-05-20 |
| CN1777618A (zh) | 2006-05-24 |
| ECSP056180A (es) | 2006-04-19 |
| CR8053A (es) | 2006-05-29 |
| WO2004094451A3 (de) | 2004-12-23 |
| KR20060005386A (ko) | 2006-01-17 |
| EA200501568A1 (ru) | 2006-06-30 |
| CA2522354A1 (en) | 2004-11-04 |
| NO20055493D0 (no) | 2005-11-21 |
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